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  1. Article ; Online: The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin.

    Nijenhuis-Noort, Eline C / Berk, Kirsten A / Neggers, Sebastian J C M M / Lely, Aart J van der

    Endocrinology and metabolism (Seoul, Korea)

    2024  Volume 39, Issue 1, Page(s) 83–89

    Abstract: This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important. This might ... ...

    Abstract This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important. This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases. We will specifically address the interplay between GH, IGF-1, and insulin in type 1 and 2 diabetes mellitus, liver cirrhosis, and acromegaly as examples in which this knowledge is truly necessary.
    MeSH term(s) Humans ; Growth Hormone ; Insulin ; Insulin-Like Growth Factor I ; Insulin-Like Peptides ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Human Growth Hormone
    Chemical Substances Growth Hormone (9002-72-6) ; Insulin ; Insulin-Like Growth Factor I (67763-96-6) ; Insulin-Like Peptides ; Human Growth Hormone (12629-01-5)
    Language English
    Publishing date 2024-01-09
    Publishing country Korea (South)
    Document type Review ; Journal Article
    ZDB-ID 2802452-7
    ISSN 2093-5978 ; 2093-5978
    ISSN (online) 2093-5978
    ISSN 2093-5978
    DOI 10.3803/EnM.2024.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: How gut and brain control metabolism

    Delhanty, Patric J. D. / Lely, Aart Jan van der

    3 tables

    (Frontiers of hormone research ; 42)

    2014  

    Author's details volume ed. Patric J. D. Delhanty ; Aart J. van der Lely
    Series title Frontiers of hormone research ; 42
    Collection
    Keywords Gastrointestinal Hormones / metabolism ; Brain / metabolism ; Receptors, Gastrointestinal Hormone / metabolism ; Neuropeptides / metabolism ; Gehirn ; Darm ; Wirkung ; Stoffwechsel ; Fettsucht ; Metabolisches Syndrom
    Subject Adipositas ; Fettleibigkeit ; Korpulenz ; Obesität ; Obesity ; Metabolismus ; Verstoffwechselung ; Metabolische Regulation ; Effekt ; Wirkungen ; Effekte ; Darmtrakt ; Intestinum ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse
    Language English
    Size IX, 191 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Includes bibliographical references and indexes
    HBZ-ID HT018242537
    ISBN 978-3-318-02638-2 ; 9783318026399 ; 3-318-02638-7 ; 3318026395
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 1738 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive Population-Is There a Link?

    Muzurović, Emir / van der Lely, Aart J / Gurnell, Mark

    Angiology

    2021  Volume 72, Issue 10, Page(s) 905–907

    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Peripheral Arterial Disease/epidemiology
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197211004387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.61: Show issues Location:
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  4. Article ; Online: Approach to the Patient With Treatment-resistant Acromegaly.

    Coopmans, Eva C / van der Lely, Aart J / Neggers, Sebastian J C M M

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 6, Page(s) 1759–1766

    Abstract: Although most tumors in patients with acromegaly are benign and are cured or controlled by surgery and/or first-generation somatostatin receptor ligands therapy, some can behave more aggressively and are resistant to these standard therapies. Acromegaly, ...

    Abstract Although most tumors in patients with acromegaly are benign and are cured or controlled by surgery and/or first-generation somatostatin receptor ligands therapy, some can behave more aggressively and are resistant to these standard therapies. Acromegaly, if left untreated, is a rare and chronic disorder, commonly caused by a GH-producing pituitary adenoma and is associated with significant comorbidities and an increased mortality. Transsphenoidal surgery is considered the mainstay of acromegaly management, but medical therapy has an increasingly important role. However, disease activity is not fully controlled in a significant number of patients treated with surgery and/or high-dose first-generation somatostatin receptor ligand monotherapy. In these circumstances, therefore, repeated surgery, second-line medical therapy, and radiotherapy, alone or combined as multimodal therapeutic strategies should be considered, in a patient-centered perspective.
    MeSH term(s) Acromegaly/drug therapy ; Human Growth Hormone/therapeutic use ; Humans ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/therapy ; Receptors, Somatostatin ; Somatostatin
    Chemical Substances Receptors, Somatostatin ; Human Growth Hormone (12629-01-5) ; Somatostatin (51110-01-1)
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Endocrine and non-endocrine causes of fatigue in adults with Neurofibromatosis type 1.

    Rosenberg, Anna G W / Mochèl, Ké / Hähner, Lorena M / Ruules, Lara / Davidse, Kirsten / Bos-Roubos, Anja G / van Dijk, Sarah A / Zillikens, M Carola / Taal, Walter / van der Lely, Aart J / de Graaff, Laura C G

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1119159

    Abstract: Context: Neurofibromatosis type 1 (NF1) is a complex system disorder, caused by alterations in RAS pathways. NF1 adults often suffer from chronic and severe fatigue, for which they are frequently referred to Internal Medicine/Endocrinology. Seeking ... ...

    Abstract Context: Neurofibromatosis type 1 (NF1) is a complex system disorder, caused by alterations in RAS pathways. NF1 adults often suffer from chronic and severe fatigue, for which they are frequently referred to Internal Medicine/Endocrinology. Seeking medical help often leads to (invasive) diagnostic procedures. To prevent the personal and financial burden of this disabling fatigue, it is crucial to know the causes.
    Objective: To explore somatic causes and provide practical recommendations for the approach to fatigue in adults with NF1.
    Design: Cross-sectional. All adults with NF1 (N = 133) who visited our Endocrinology department underwent a systematic health screening, including a medical questionnaire, structured interview, complete physical examination, biochemical measurements and additional tests if indicated.
    Main outcome measure: Prevalence of endocrine and non-endocrine health problems between NF1 adults with and without fatigue.
    Results: In our cohort, 75% of NF1 adults experienced fatigue. The most frequent endocrine disorders were vitamin D deficiency (28%), obesity (18%) and hypothyroidism (8%). The most frequent non-endocrine internal disorder was high blood pressure (42%). None of the disorders differed significantly between adults with and without fatigue.
    Conclusions: Endocrine and non-endocrine disorders were equally present in our cohort of NF1 adults with and without fatigue. This suggests that the high prevalence of fatigue in NF1 adults is not explained by these somatic disorders. An alternative explanation for fatigue might be deficits in cognitive functioning and other neuropsychological processes in NF1. Based on our results and review of the literature, we provide a clinical algorithm for the approach to fatigue in NF1 adults, including somatic and psychological assessment.
    MeSH term(s) Adult ; Humans ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/epidemiology ; Cross-Sectional Studies ; Cognition ; Causality ; Hypertension
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1119159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Health differences between adults with and without intellectual disabilities at the internal medicine department: A first step to improve awareness of intellectual disabilities among healthcare professionals.

    Rosenberg, Anna G W / Langendoen, Wesley / van der Lely, Aart J / Veenland, Jifke F / de Graaff, Laura C G

    European journal of internal medicine

    2022  Volume 106, Page(s) 154–157

    MeSH term(s) Adult ; Humans ; Intellectual Disability ; Health Personnel ; Internal Medicine ; Delivery of Health Care
    Language English
    Publishing date 2022-09-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.08.032
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  7. Article ; Online: Pegvisomant for acromegaly: does it always works?

    Neggers, Sebastian J / Lely, Aart J van der

    Archives of endocrinology and metabolism

    2019  Volume 63, Issue 4, Page(s) 318–319

    MeSH term(s) Acromegaly ; Brazil ; Human Growth Hormone/analogs & derivatives ; Humans ; Insulin-Like Growth Factor I
    Chemical Substances Human Growth Hormone (12629-01-5) ; Insulin-Like Growth Factor I (67763-96-6) ; pegvisomant (N824AOU5XV)
    Language English
    Publishing date 2019-08-22
    Publishing country Brazil
    Document type Editorial ; Comment
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Corrigendum: Kidney disease in adults with Prader-Willi syndrome: international cohort study and systematic literature review.

    van Abswoude, Denise H / Pellikaan, Karlijn / Nguyen, Naomi / Rosenberg, Anna G W / Davidse, Kirsten / Hoekstra, Franciska M E / Rood, Ilse M / Poitou, Christine / Grugni, Graziano / Høybye, Charlotte / Markovic, Tania P / Caixàs, Assumpta / Crinò, Antonino / van den Berg, Sjoerd A A / van der Lely, Aart J / de Graaff, Laura C G

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1357219

    Abstract: This corrects the article DOI: 10.3389/fendo.2023.1168648.]. ...

    Abstract [This corrects the article DOI: 10.3389/fendo.2023.1168648.].
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1357219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: ACRODAT® and AcroVoice: an insight into a holistic approach to the management of acromegaly.

    Lundie, Mark / Sisco, Jill / van der Lely, Aart J

    Pituitary

    2019  Volume 22, Issue 6, Page(s) 647–648

    MeSH term(s) Acromegaly ; Humans ; Insulin-Like Growth Factor I
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-019-00994-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 6139: Show issues Location:
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  10. Article ; Online: Comment on Moriconi et al. Very-Low-Calorie Ketogenic Diet as a Safe and Valuable Tool for Long-Term Glycemic Management in Patients with Obesity and Type 2 Diabetes.

    Berk, Kirsten A / van der Louw, Elles J T M / Olieman, Joanne F / van der Lely, Aart J

    Nutrients

    2021  Volume 13, Issue 10

    Abstract: With interest, we have read the article of Moriconi et al. [ ... ]. ...

    Abstract With interest, we have read the article of Moriconi et al. [...].
    MeSH term(s) Blood Glucose/metabolism ; Cohort Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diet therapy ; Diet, Ketogenic ; Diet, Reducing ; Humans ; Obesity/blood ; Obesity/diet therapy
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13103613
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