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  1. Article: Membrane Vesicles of Clostridioides difficile and Other Clostridial Species.

    Goh, Shan / Inal, Jameel

    Advances in experimental medicine and biology

    2024  Volume 1435, Page(s) 315–327

    Abstract: Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles of Clostridioides difficile ... ...

    Abstract Membrane vesicles are secreted by growing bacterial cells and are important components of the bacterial secretome, with a role in delivering effector molecules that ultimately enable bacterial survival. Membrane vesicles of Clostridioides difficile likely contribute to pathogenicity and is a new area of research on which there is currently very limited information. This chapter summarizes the current knowledge on membrane vesicle formation, content, methods of characterization and functions in Clostridia and model Gram-positive species.
    MeSH term(s) Clostridioides ; Clostridioides difficile ; Biological Transport ; Endocytosis ; Knowledge
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-42108-2_14
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    Zs.A 3192: Show issues Location:
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  2. Article ; Online: Biological Factors Linking ApoE ε4 Variant and Severe COVID-19.

    Inal, Jameel

    Current atherosclerosis reports

    2020  Volume 22, Issue 11, Page(s) 70

    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-020-00896-y
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    Zs.A 5534: Show issues Location:
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  3. Article ; Online: Complement-mediated Extracellular Vesicle release as a measure of endothelial dysfunction and prognostic marker for COVID-19 in peripheral blood - Letter to the Editor.

    Inal, Jameel

    Clinical hemorheology and microcirculation

    2020  Volume 75, Issue 4, Page(s) 383–386

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Extracellular Vesicles ; Microcirculation ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2 ; Ultrasonography
    Keywords covid19
    Language English
    Publishing date 2020-10-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1381750-4
    ISSN 1875-8622 ; 1386-0291
    ISSN (online) 1875-8622
    ISSN 1386-0291
    DOI 10.3233/CH-200958
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    Zs.A 1623: Show issues Location:
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  4. Article ; Online: COVID-19 comorbidities, associated procoagulant extracellular vesicles and venous thromboembolisms: a possible link with ethnicity?

    Inal, Jameel

    British journal of haematology

    2020  Volume 190, Issue 4, Page(s) e218–e220

    MeSH term(s) COVID-19/blood ; COVID-19/complications ; COVID-19/ethnology ; COVID-19/mortality ; Ethnicity ; Extracellular Vesicles/metabolism ; Female ; Humans ; Male ; SARS-CoV-2 ; Venous Thromboembolism/blood ; Venous Thromboembolism/ethnology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/mortality
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17011
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  5. Article ; Online: Animal Models of Human Disease.

    Lange, Sigrun / Inal, Jameel M

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled "Animal Models of Human Disease" ... ...

    Abstract The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled "Animal Models of Human Disease" aimed to collect state-of-the-art primary research studies and review articles from international experts and leading groups using animal models to study human diseases. Submissions were welcomed on a wide range of animal models and pathologies, including infectious disease, acute injury, regeneration, cancer, autoimmunity, degenerative and chronic disease. Seven participating MDPI journals supported the Special Topic, namely:
    MeSH term(s) Animals ; Humans ; Publications ; Translational Research, Biomedical ; Mitochondrial Diseases ; Models, Animal ; Communicable Diseases ; Neoplasms/genetics
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115821
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  6. Article ; Online: Animal Models of Human Disease

    Sigrun Lange / Jameel M. Inal

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    2023  Volume 15821

    Abstract: The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled “Animal Models of Human Disease” ... ...

    Abstract The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled “Animal Models of Human Disease” aimed to collect state-of-the-art primary research studies and review articles from international experts and leading groups using animal models to study human diseases. Submissions were welcomed on a wide range of animal models and pathologies, including infectious disease, acute injury, regeneration, cancer, autoimmunity, degenerative and chronic disease. Seven participating MDPI journals supported the Special Topic, namely: Biomedicines , Cells , Current Issues in Molecular Biology , Diagnostics , Genes , the International Journal of Molecular Sciences , and the International Journal of Translational Medicine . In total, 46 papers were published in this Special Topic, with 37 full length original research papers, 2 research communications and 7 reviews. These contributions cover a wide range of clinically relevant, translatable, and comparative animal models, as well as furthering understanding of fundamental sciences, covering topics on physiological processes, on degenerative, inflammatory, infectious, autoimmune, neurological, metabolic, heamatological, hormonal and mitochondrial disorders, developmental processes and diseases, cardiology, cancer, trauma, stress, and ageing.
    Keywords animal models ; pathobiology ; chronic disease ; regeneration ; infectious disease ; cancer ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy.

    Inal, Jameel M

    Clinical science (London, England : 1979)

    2020  Volume 134, Issue 12, Page(s) 1301–1304

    Abstract: The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes ... ...

    Abstract The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment of the spike (S) protein of the virus, is angiotensin-converting enzyme 2 (ACE2). In a recent article published by Batlle et al. (Clin. Sci. (Lond.) (2020) 134, 543-545) it was suggested that soluble recombinant ACE2 could be used as a novel biological therapeutic to intercept the virus, limiting the progression of infection and reducing lung injury. Another way, discussed here, to capture SARS-CoV-2, as an adjunct or alternative, would be to use ACE2+-small extracellular vesicles (sEVs). A competitive inhibition therapy could therefore be developed, using sEVs from engineered mesenchymal stromal/stem cells (MSCs), overexpressing ACE2.
    MeSH term(s) Angiotensins ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Extracellular Vesicles ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2
    Chemical Substances Angiotensins ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20200623
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  10. Article: Complement-mediated Extracellular Vesicle release as a measure of endothelial dysfunction and prognostic marker for COVID-19 in peripheral blood - Letter to the Editor

    Inal, Jameel

    Clin Hemorheol Microcirc

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #807301
    Database COVID19

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