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  1. Article: Should ocrelizumab be used in non-active primary progressive multiple sclerosis? Time for a re-assessment.

    Manouchehri, Navid / Stüve, Olaf

    Therapeutic advances in neurological disorders

    2021  Volume 14, Page(s) 1756286421990500

    Language English
    Publishing date 2021-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/1756286421990500
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  2. Article ; Online: Choroid plexus volumetrics and brain inflammation in multiple sclerosis.

    Manouchehri, Navid / Stüve, Olaf

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 40

    MeSH term(s) Brain ; Choroid Plexus ; Encephalitis ; Humans ; Multiple Sclerosis
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2115221118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: To the editors: Impact of mass vaccination on SARS-CoV-2 infections among multiple sclerosis patients taking immunomodulatory disease-modifying therapies in England.

    Tugemann, Bastian / Manouchehri, Navid / Stuve, Olaf

    Multiple sclerosis and related disorders

    2022  Volume 59, Page(s) 103541

    MeSH term(s) COVID-19/prevention & control ; Humans ; Mass Vaccination ; Multiple Sclerosis/drug therapy ; SARS-CoV-2 ; Vaccination
    Language English
    Publishing date 2022-01-19
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2022.103541
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  4. Article: The devastating impact of unresectable infectious undifferentiated pleomorphic sarcoma in the gluteal region: A case report.

    Goli, Rasoul / Torabzadeh, Aysan / Hassanpour, Amireh / Jafarimaraghoush, Alireza / Manouchehri, Elaheh / Faraji, Navid

    International journal of surgery case reports

    2024  Volume 118, Page(s) 109592

    Abstract: Introduction and importance: Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma (MFH), is a highly aggressive soft tissue sarcoma characterized by its pleomorphic histology and lack of differentiation.: Case ...

    Abstract Introduction and importance: Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma (MFH), is a highly aggressive soft tissue sarcoma characterized by its pleomorphic histology and lack of differentiation.
    Case presentation: A 35-year-old man visited our oncology department with a complaint of a growing mass in his left buttock area. The mass had been increasing in size for the past six months, affected by local and systemic infection. While it was initially painless, the patient started feeling discomfort during sitting and physical activities a few weeks, but later the complication of tumor became more aggressive.
    Clinical discussion: UPS can arise in various anatomical sites, including the extremities, trunk, retroperitoneum, and head and neck region. Clinically, UPS may present as a rapidly growing mass, often with pain and limited range of motion. However, the presentation may vary depending on the site of origin. Treatment for UPS typically involves surgical resection, aiming to remove the tumor completely. Depending on the size, location, and aggressiveness of the tumor, additional treatments such as radiation therapy or chemotherapy may be recommended.
    Conclusion: Undifferentiated pleomorphic sarcoma (UPS) represents a rare and aggressive soft tissue sarcoma requiring prompt and accurate diagnosis for appropriate management. With its non-specific clinical presentation and histological features, UPS can be challenging to differentiate from other soft tissue tumors.
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109592
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  5. Article ; Online: Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity.

    Manouchehri, Navid / Salinas, Victor H / Hussain, Rehana Z / Stüve, Olaf

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 6, Page(s) e2212696120

    Abstract: In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified a ... ...

    Abstract In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified a myeloid cell subset in the brain and spinal cord that expresses the surface markers CD88 and CD317 and is associated with the onset and persistence of clinical disease in the murine model of the human CNS autoimmune disorder, experimental autoimmune encephalomyelitis (EAE). We employed an experimental platform utilizing single-cell transcriptomic and epigenomic profiling of bone marrow-chimeric mice to categorically distinguish BMC from microglia during CNS autoimmunity. Analysis of gene expression and chromosomal accessibility identified CD88
    MeSH term(s) Mice ; Humans ; Animals ; Microglia/metabolism ; Bone Marrow/metabolism ; Autoimmunity/genetics ; Transcriptome ; Epigenomics ; Mice, Inbred C57BL ; Central Nervous System ; Encephalomyelitis, Autoimmune, Experimental ; Myeloid Cells/metabolism
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2212696120
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Trials and therapies in secondary progressive MS, simplified.

    Manouchehri, Navid / Stüve, Olaf

    Nature reviews. Neurology

    2019  Volume 15, Issue 8, Page(s) 431–432

    MeSH term(s) Azetidines/therapeutic use ; Benzyl Compounds/therapeutic use ; Cladribine/therapeutic use ; Clinical Trials as Topic ; Drug Approval ; Humans ; Immunosuppressive Agents/therapeutic use ; Multiple Sclerosis, Chronic Progressive/diagnosis ; Multiple Sclerosis, Chronic Progressive/drug therapy ; Treatment Outcome ; United States
    Chemical Substances Azetidines ; Benzyl Compounds ; Immunosuppressive Agents ; Cladribine (47M74X9YT5) ; siponimod (RR6P8L282I)
    Language English
    Publishing date 2019-07-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-019-0233-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6257: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 88: Show issues

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  7. Article ; Online: Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapy.

    Lambracht-Washington, Doris / Fu, Min / Manouchehri, Navid / Hynan, Linda S / Stuve, Olaf / Rosenberg, Roger N

    Aging brain

    2023  Volume 3, Page(s) 100066

    Abstract: Background: To investigate how changes in expression of glial genes relate to a progression of Alzheimer's disease (AD) pathology, and how anti-Aβ immunotherapy impact these changes, we conducted a transcriptomic analysis for brains from cohorts of 2-, ... ...

    Abstract Background: To investigate how changes in expression of glial genes relate to a progression of Alzheimer's disease (AD) pathology, and how anti-Aβ immunotherapy impact these changes, we conducted a transcriptomic analysis for brains from cohorts of 2-, 10-, and 20 month old 3xTg-AD mice, and a cross-sectional study in groups of 20 month-old mice treated with active DNA Aβ42 immunization, passive immunotherapy, untreated, and wild-type (wt) controls.
    Methods: Twenty-four Formalin-Fixed Paraffin-Embedded (FFPE) mouse brain sections were used for the gene expression analyses (nanostring). Adjacent sections from these and additional mouse brains were stained for microglia using antibodies detecting IbaI and Gal3. For a semi-quantitative analysis of increased tau and amyloid pathology with aging and disease progression, a comparison of ELISA results from brains of 12 and 20 months old 3xTg-AD mice were shown.
    Results: Based on the different comparisons of transcript numbers found the 3xTg-AD age groups with the senescent 20 months old wt control mouse brains, and the 20 months old 3xTg-AD mouse brains with the 20 months old wt control mouse brains, genes were assigned as upregulated due to aging, or due to disease progression, or due to both. The immunohistochemistry of microglia markers revealed that Gal3 might be an important marker for phagocytosing microglia around amyloid plaques. The comparison of the two anti-Aβ immunotherapy approaches showed a differential downregulation of inflammatory glial genes.
    Conclusion: These results are relevant for future clinical trials using active anti-amyloid immunotherapy.
    Language English
    Publishing date 2023-01-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2589-9589
    ISSN (online) 2589-9589
    DOI 10.1016/j.nbas.2023.100066
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  8. Article ; Online: Biological Significance of Anti-SARS-CoV-2 Antibodies: Lessons Learned From Progressive Multifocal Leukoencephalopathy.

    Manouchehri, Navid / Steinman, Lawrence / Stuve, Olaf

    Neurology(R) neuroimmunology & neuroinflammation

    2020  Volume 8, Issue 2

    Abstract: Objective: To discuss the pathogenic and diagnostic relevance of cellular and humoral immune responses against severe acute respiratory syndrome novel coronavirus (SARS-COV-2) and pertinent observations made in progressive multifocal leukoencephalopathy ...

    Abstract Objective: To discuss the pathogenic and diagnostic relevance of cellular and humoral immune responses against severe acute respiratory syndrome novel coronavirus (SARS-COV-2) and pertinent observations made in progressive multifocal leukoencephalopathy (PML).
    Methods: Review of pertinent literature
    Conclusion: Based on pathogenic lessons learned from PML under natalizumab therapy, we suggest the incorporation of functional assays that determine neutralizing properties of SARS-CoV-2-specific antibodies. In addition, we outline the potential role of T-cell detection assays in determining herd immunity in a given population or in studying therapeutic responses to vaccines.
    MeSH term(s) Adaptive Immunity/immunology ; Antibodies, Viral/immunology ; Antibody Formation/immunology ; Humans ; Immunity, Humoral/immunology ; Leukoencephalopathy, Progressive Multifocal/drug therapy ; Leukoencephalopathy, Progressive Multifocal/immunology ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2020-12-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2767740-0
    ISSN 2332-7812 ; 2332-7812
    ISSN (online) 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000000935
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  9. Article: Efficacy of Disease Modifying Therapies in Progressive MS and How Immune Senescence May Explain Their Failure.

    Manouchehri, Navid / Salinas, Victor H / Rabi Yeganeh, Negar / Pitt, David / Hussain, Rehana Z / Stuve, Olaf

    Frontiers in neurology

    2022  Volume 13, Page(s) 854390

    Abstract: The advent of disease modifying therapies (DMT) in the past two decades has been the cornerstone of successful clinical management of multiple sclerosis (MS). Despite the great strides made in reducing the relapse frequency and occurrence of new signal ... ...

    Abstract The advent of disease modifying therapies (DMT) in the past two decades has been the cornerstone of successful clinical management of multiple sclerosis (MS). Despite the great strides made in reducing the relapse frequency and occurrence of new signal changes on neuroimaging in patients with relapsing remitting MS (RRMS) by approved DMT, it has been challenging to demonstrate their effectiveness in non-active secondary progressive MS (SPMS) and primary progressive MS (PPMS) disease phenotypes. The dichotomy of DMT effectiveness between RRMS and progressive MS informs on distinct pathogeneses of the different MS phenotypes. Conversely, factors that render patients with progressive MS resistant to therapy are not understood. Thus far, age has emerged as the main correlate of the transition from RRMS to SPMS. Whether it is aging and age-related factors or the underlying immune senescence that qualitatively alter immune responses as the disease transitions to SPMS, that diminish DMT effectiveness, or both, is currently not known. Here, we will discuss the role of immune senescence on different arms of the immune system, and how it may explain relative DMT resistance.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.854390
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  10. Article: Application of the Intracranial Arterial Pulsatility Index for Determination of Prognosis after Lacunar Infarct.

    Saadatnia, Mohammad / Zandifar, Alireza / Alizadeh, Maryam / Kim, Jorge Du Ub / Shafaat, Omid / Tierradentro-García, Luis Octavio / Manouchehri, Navid / Khorvash, Fariborz

    Advanced biomedical research

    2023  Volume 12, Page(s) 136

    Abstract: Background: We aimed to investigate the usefulness of intracranial arterial pulsatility index to assess the prognosis of lacunar infarcts.: Materials and methods: Forty-nine patients with confirmed acute lacunar infarct were enrolled in the study. A ... ...

    Abstract Background: We aimed to investigate the usefulness of intracranial arterial pulsatility index to assess the prognosis of lacunar infarcts.
    Materials and methods: Forty-nine patients with confirmed acute lacunar infarct were enrolled in the study. A transcranial color-coded sonography was performed to assess the pulsatility index of bilateral middle cerebral, posterior cerebral, vertebral, and proximal internal carotid arteries. Patients' clinical status was assessed using a modified Rankin scale. Spearman correlation was used for reporting the relation between quantitative data. Statistical significance was defined as a two-tail
    Results: The mean age ± standard deviation was 64.1 ± 9.07 years old, and 57.1% of the patients were male. Upon discharge, only 8.2% of the patients were ranked as 0 on the modified Rankin scale; however, after a 6-month follow-up period, this number increased to 49%. There were no significant differences between the left and right pulsatility index measurements in any of the assessed arteries. Patients with vertebral artery pulsatility indexes >1 on their primary assessment had significantly worse outcomes during the first, third, and sixth months follow-up (all
    Conclusion: Sonography-assisted assessment of the vertebral artery blood flow during the early stage of lacunar infarct provides a reliable reference for prognosis estimation.
    Language English
    Publishing date 2023-05-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2672524-1
    ISSN 2277-9175
    ISSN 2277-9175
    DOI 10.4103/abr.abr_69_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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