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  1. Book: Gap junction protocols

    Vinken, Mathieu / Johnstone, Scott R.

    (Methods in molecular biology ; 1437 ; Springer protocols)

    2016  

    Series title Methods in molecular biology ; 1437
    Springer protocols
    Collection
    Keywords Cell signaling ; Connexin expression ; Connexons ; GJIC regulation ; Gap junctional intercellular communication
    Language English
    Size XIII, 235 S. : Ill., graph. Darst., 25.4 cm x 17.8 cm, 0 g
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019015922
    ISBN 978-1-4939-3662-5 ; 1-4939-3662-X ; 9781493936649 ; 1493936646
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1437- verfügbar in Königswinter Königswinter

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  2. Book: Crimes of passion

    Böni, Oliver / Johnstone, Japhet / Spector, Scott

    Repräsentationen der Sexualpathologie im frühen 20. Jahrhundert

    (Spectrum Literaturwissenschaft ; 50)

    2015  

    Author's details hrsg. von Oliver Böni und Japhet Johnstone. Mit einem Vorw. von Scott Spector
    Series title Spectrum Literaturwissenschaft ; 50
    Collection
    Keywords Sexualstörung ; Literatur ; Geschichte 1860-1920
    Subject Belletristik ; Dichtung ; Schöne Literatur ; Sprachkunst ; Wortkunst
    Language German ; English
    Size IX, 370 S. : Ill., graph. Darst.
    Publisher De Gruyter
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018805992
    ISBN 978-3-11-041990-0 ; 978-3-11-042014-2 ; 978-3-11-042016-6 ; 3-11-041990-4 ; 3-11-042014-7 ; 3-11-042016-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 500 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Vertical Rectus Abdominis Myocutaneous Versus Alternative Flaps for Perineal Repair After Abdominoperineal Excision of the Rectum in the Era of Laparoscopic Surgery.

    Johnstone, Mark Scott

    Annals of plastic surgery

    2017  Volume 79, Issue 1, Page(s) 101–106

    Abstract: Aims: Plastic surgical reconstruction of the perineum is often required after abdominoperineal excision of the rectum. Options for this reconstruction include a vertical rectus abdominis myocutaneous (VRAM) flap, gluteal fasciocutaneous flap, and ... ...

    Abstract Aims: Plastic surgical reconstruction of the perineum is often required after abdominoperineal excision of the rectum. Options for this reconstruction include a vertical rectus abdominis myocutaneous (VRAM) flap, gluteal fasciocutaneous flap, and gracilis myocutaneous flap. Although the VRAM flap is well established at most centers, less experience exists with the gluteal and gracilis flaps. In the era of laparoscopic colorectal resection, plastic surgeons are being forced to use gluteal and gracilis flaps because the VRAM flap must be tunnelled intra-abdominally requiring laparotomy. We therefore aimed to systematically review the evidence comparing VRAM, gluteal, and gracilis flaps.
    Methods: A comprehensive, structured literature search was conducted using Medline, Google Scholar, and Science Direct. Studies included were randomized control trials and observational studies documenting complication rates associated with the VRAM, gluteal, or gracilis flap.
    Results: Eleven studies meeting all inclusion and exclusion criteria were identified. When meta-analyzed, the overall rate of any perineal wound or flap complication among VRAM patients (35.8%) was significantly lower than gluteal flap (43.7%) and gracilis flap patients (52.9%) (P = 0.041).
    Conclusions: The VRAM flap is well established for perineal reconstruction, and this study suggests that it may be superior to the gluteal and gracilis flaps in terms perineal wound and flap complication rates. This should be taken into account when weighing up the risks and benefits of a laparoscopic approach to abdominoperineal excision of the rectum. Large studies making direct comparisons between the flap options should be conducted.
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000001137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Infant Cognitive Development and Stimulating Parenting Practices in Rural China.

    Johnstone, Hannah / Yang, Yi / Xue, Hao / Rozelle, Scott

    International journal of environmental research and public health

    2021  Volume 18, Issue 10

    Abstract: This study examines the prevalence of cognitive delay among infants and toddlers in rural China and its relationship with one of the potential sources of the observed delay: low levels of stimulating parenting practices (SPPs). Data were compiled from ... ...

    Abstract This study examines the prevalence of cognitive delay among infants and toddlers in rural China and its relationship with one of the potential sources of the observed delay: low levels of stimulating parenting practices (SPPs). Data were compiled from five distinct studies, resulting in a pooled sample of 4436 caregivers of 6-29-month-old infants. The sampling sites span five provinces in rural China. According to the data, on average, rates of delay are high-51 percent. The low rates of SPPs among our sample demonstrate that this may be one source of the high prevalence of delays. The results of the multivariate regression analysis reveal that reading books and singing songs are each significantly associated with an increase in infant cognitive score by 1.62 points (
    MeSH term(s) Child Development ; Child, Preschool ; China/epidemiology ; Cognition ; Female ; Humans ; Infant ; Parenting ; Rural Population
    Language English
    Publishing date 2021-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18105277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure.

    Mezache, Louisa / Soltisz, Andrew M / Johnstone, Scott R / Isakson, Brant E / Veeraraghavan, Rengasayee

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 12, Page(s) 2444–2458

    Abstract: Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is widely associated with inflammation, vascular dysfunction, and elevated levels of the vascular leak-inducing cytokine, vascular endothelial growth factor (VEGF). Mechanisms ... ...

    Abstract Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is widely associated with inflammation, vascular dysfunction, and elevated levels of the vascular leak-inducing cytokine, vascular endothelial growth factor (VEGF). Mechanisms underlying AF are poorly understood and current treatments only manage this progressive disease, rather than arresting the underlying pathology. The authors previously identified edema-induced disruption of sodium channel (NaV1.5)-rich intercalated disk nanodomains as a novel mechanism for AF initiation secondary to acute inflammation. Therefore, we hypothesized that protecting the vascular barrier can prevent vascular leak-induced atrial arrhythmias.
    Objectives: In this study the authors tested the hypothesis that protecting the vascular barrier can prevent vascular leak-induced atrial arrhythmias. They identified 2 molecular targets for vascular barrier protection, connexin43 (Cx43) hemichannels and pannexin-1 (Panx1) channels, which have been implicated in cytokine-induced vascular leak.
    Methods: The authors undertook in vivo electrocardiography, electron microscopy, and super-resolution light microscopy studies in mice acutely treated with a clinically relevant level of VEGF.
    Results: AF incidence was increased in untreated mice exposed to VEGF relative to vehicle control subjects. VEGF also increased the average number of AF episodes. VEGF shifted Na
    Conclusions: These results highlight vascular barrier protection as an antiarrhythmic strategy following inflammation-induced vascular leak.
    MeSH term(s) Animals ; Humans ; Mice ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation ; Connexin 43/chemistry ; Connexin 43/metabolism ; Connexin 43/pharmacology ; Connexins/metabolism ; Connexins/pharmacology ; Cytokines ; Inflammation/metabolism ; Myocytes, Cardiac ; Nanostructures ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/pharmacology ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/pharmacology
    Chemical Substances Anti-Arrhythmia Agents ; Connexin 43 ; Connexins ; Cytokines ; Nerve Tissue Proteins ; Panx1 protein, mouse ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.10.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preserving Endothelial Integrity in Human Saphenous Veins during Preparation for Coronary Bypass Surgery.

    Sedovy, Meghan W / Leng, Xinyan / Iqbal, Farwah / Renton, Mark C / Leaf, Melissa / Roberts, Kailynn / Malek, Arya / Arnold, W Scott / Wyatt, David A / Choate, Cynthia W / Rowe, Joseph F / Baker, Joseph W / Johnstone, Scott R / Joseph, Mark

    Journal of vascular research

    2024  Volume 61, Issue 2, Page(s) 68–76

    Abstract: Introduction: While multiple factors influence coronary artery bypass graft (CABG) success rates, preserving saphenous vein endothelium during surgery may improve patency. Standard preparations include saphenous vein preparation in heparinized saline ( ... ...

    Abstract Introduction: While multiple factors influence coronary artery bypass graft (CABG) success rates, preserving saphenous vein endothelium during surgery may improve patency. Standard preparations include saphenous vein preparation in heparinized saline (saline) which can result in endothelial loss and damage. Here, we investigated the impact of preparing saphenous graft vessels in heparinized patient blood (blood) versus saline.
    Methods: Saphenous vein tissues from a total of 23 patients undergoing CABG were split into 2 groups (1) saline and (2) heparinized patient blood. Excess tissue was fixed for analysis immediately following surgery. Level of endothelial coverage, oxidative stress marker 4-hydroxynonenal (4HNE), and oxidative stress protective marker nuclear factor erythroid 2-related factor 2 (NRF2) were evaluated.
    Results: In saline patient veins, histological analysis revealed a limited luminal layer, suggesting a loss of endothelial cells (ECs). Immunofluorescent staining of EC markers vascular endothelial cadherin (VE-cadherin) and endothelial nitric oxide identified a significant improvement in EC coverage in the blood versus saline groups. Although both treatment groups expressed 4HNE to similar levels, EC blood samples expressed higher levels of NRF2.
    Conclusion: Our data indicate that use of heparinized patient blood helps preserve the endothelium and promotes vein graft health. This has the potential to improve long-term outcomes in patients.
    MeSH term(s) Humans ; Saphenous Vein/pathology ; Endothelial Cells ; NF-E2-Related Factor 2 ; Endothelium, Vascular/pathology ; Coronary Artery Bypass/adverse effects
    Chemical Substances NF-E2-Related Factor 2
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1105259-4
    ISSN 1423-0135 ; 1018-1172
    ISSN (online) 1423-0135
    ISSN 1018-1172
    DOI 10.1159/000535843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 513: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: 'Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction.

    Johnstone, Scott R / Isakson, Brant E

    Heart (British Cardiac Society)

    2018  Volume 104, Issue 19, Page(s) 1557–1558

    MeSH term(s) Dipeptides ; Humans ; Myocardial Infarction ; Percutaneous Coronary Intervention ; ST Elevation Myocardial Infarction
    Chemical Substances Dipeptides ; danegaptide (PA0Y7735AT)
    Language English
    Publishing date 2018-03-30
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2018-313084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.40: Show issues Location:
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  8. Article ; Online: Going against the flow: the connexin connection in hypertension.

    Johnstone, Scott R

    Hypertension (Dallas, Tex. : 1979)

    2014  Volume 65, Issue 3, Page(s) 502–504

    MeSH term(s) Animals ; Connexins/deficiency ; Endothelium, Vascular/metabolism ; Hypertension/etiology ; Hypertension/physiopathology ; Male ; Physical Conditioning, Animal/adverse effects ; Gap Junction alpha-5 Protein
    Chemical Substances Connexins
    Language English
    Publishing date 2014-12-29
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.114.04707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1488: Show issues Location:
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  9. Article ; Online: Selective Chromium(VI) Trapping by an Acetate-Releasing Coordination Polymer.

    Conour, Cambell S / Droege, Daniel G / Ehlke, Beatriz / Johnstone, Timothy C / Oliver, Scott R J

    Inorganic chemistry

    2022  

    Abstract: We report the high-capacity and selective uptake of Cr(VI) from water using the coordination polymer silver bipyridine acetate (SBA, [Ag(4,4'-bipy)][ ... ...

    Abstract We report the high-capacity and selective uptake of Cr(VI) from water using the coordination polymer silver bipyridine acetate (SBA, [Ag(4,4'-bipy)][CH
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c03110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Changing Radiotherapy Paradigms in Penile Cancer.

    Johnstone, Peter A S / Spiess, Philippe E / Sedor, Geoff / Grass, G Daniel / Yamoah, Kosj / Scott, Jacob G / Torres-Roca, Javier F

    European urology open science

    2022  Volume 36, Page(s) 47–48

    Abstract: Radiation therapy (RT) has not been prominent in the treatment of penile cancer because of poorly reproducible results when used in the adjuvant setting. A genomic signature has recently been described that assays radiosensitivity of tumors and informs ... ...

    Abstract Radiation therapy (RT) has not been prominent in the treatment of penile cancer because of poorly reproducible results when used in the adjuvant setting. A genomic signature has recently been described that assays radiosensitivity of tumors and informs radiotherapy doses in these cases. Clinical validation in more than 1600 patients demonstrated associations with both overall survival and time to first recurrence. In addition, the signature predicted and quantified the therapeutic benefit of RT for each individual patient. Since penile cancer patients were not part of this analysis, we applied the model to patients with primary and nodal penile cancer tissue and clinical outcomes.
    Language English
    Publishing date 2022-01-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-1683
    ISSN (online) 2666-1683
    DOI 10.1016/j.euros.2021.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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