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Article ; Online: Community pharmacists require additional support to develop capacity in delivering alcohol-related health information to older adults.

Dare, Julie / Wilkinson, Celia / Garlepp, Michael / Lo, Johnny / Allsop, Steve

The International journal of pharmacy practice

2017 Volume 25, Issue 4, Page(s) 301–310

Abstract: Objectives: This qualitative study explored the barriers and enablers influencing Western Australian (WA) community pharmacists' knowledge, confidence, willingness and practice in engaging older clients (>60 years) in alcohol-related health discussions.! ...

Abstract	Objectives: This qualitative study explored the barriers and enablers influencing Western Australian (WA) community pharmacists' knowledge, confidence, willingness and practice in engaging older clients (>60 years) in alcohol-related health discussions. Methods: Two focus groups were conducted with a total of 14 community pharmacists who had previously completed a formative quantitative survey (n = 63), and indicated willingness to participate in a follow-up focus group. Focus group questions, informed by the survey results, explored participants' perceptions about barriers and enablers to delivering health information and advice about alcohol to older clients (60+ years). Shaw and colleagues' theoretical framework was used to understand barriers and enablers in relation to role legitimacy, role adequacy and role support. Key findings: Participants acknowledged that providing health information about alcohol to older clients is a legitimate part of a community pharmacist's role, and most were confident performing this role in situations perceived as core to their professional practice, such as while dispensing medicines. However, many participants identified limited knowledge, skills and confidence in assisting older clients who may have alcohol issues, beyond advising them on medication and alcohol use. Structural barriers such as time and financial barriers were also identified. Conclusion: Routine professional practice including dispensing medicine and home medicine reviews may provide valuable opportunities to engage older clients in alcohol-related discussions. However, limited knowledge concerning appropriate strategies to assist older clients reduce their alcohol consumption, coupled with limited skills and confidence among community pharmacists in raising sensitive alcohol-related issues with clients, suggest the need for specific alcohol-related training and support.
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1087040-4
ISSN	2042-7174 ; 0961-7671
ISSN (online)	2042-7174
ISSN	0961-7671
DOI	10.1111/ijpp.12319
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Zs.A 3320: Show issues

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Article ; Online: Behavioral responses of Australian fur seals (Arctocephalus pusillus doriferus) to environmental variations

Garlepp, L. / Logan, M. / Kirkwood, R.J.

Marine Mammal Science

2014 Volume 30, Issue 3

Abstract: Observing how pinnipeds respond to variations in climatic and oceanographic conditions informs marine managers on factors that could limit their range, foraging ability and breeding success. Here, we examine how Australian fur seals (Arctocephalus ... ...

Abstract	Observing how pinnipeds respond to variations in climatic and oceanographic conditions informs marine managers on factors that could limit their range, foraging ability and breeding success. Here, we examine how Australian fur seals (Arctocephalus pusillus doriferus) at Seal Rocks, Victoria, Australia, responded to normal climatic conditions from August 2009 to January 2010, which included their Austral spring-summer breeding period, to investigate their tolerances to a range of environmental stimuli. Seal numbers ashore and a range of climatic variables were collected hourly during daylight periods and compared using Generalized Additive Mixed Models (GAMMs). Air temperature was the most consistent predictor of haul-out behavior, with seal numbers ashore declining as air temperature increased (effect size -50%, edf 1.00, P <0.001). Increased wave height (effect size 74%, edf 1.00, P <0.001) and wind speed (effect size 79%, edf 1.00, P <0.001) were associated with increased seal numbers ashore. Potentially, higher air temperatures reduce the seals tolerance to remain out of the water, while high wind/wave action increases at-sea metabolic costs. These results demonstrate how changes in climate could alter a seal's ability to remain ashore, to rest or breed, and its ability to forage effectively, thus driving changes in population status and range.
Keywords	colony ; habitat use ; harbor seals ; haul-out ; island ; patterns ; population ; pup production ; thermoregulation ; wollebaeki
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2218018-7
ISSN	1748-7692 ; 0824-0469
ISSN (online)	1748-7692
ISSN	0824-0469
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Genetics of the idiopathic inflammatory myopathies.

Garlepp, M J

Current opinion in rheumatology

1996 Volume 8, Issue 6, Page(s) 514–520

Abstract: Genetic predisposition to development of the idiopathic inflammatory myopathies is probably multifactorial. Major histocompatibility complex associations with these diseases provide the strongest evidence for a genetic component. In Caucasoids, ... ...

Abstract	Genetic predisposition to development of the idiopathic inflammatory myopathies is probably multifactorial. Major histocompatibility complex associations with these diseases provide the strongest evidence for a genetic component. In Caucasoids, haplotypes marked by B8/DR3 are associated with each of the clinical subgroups, except mixed connective tissue disease (DR4). The strongest associations are with inclusion body myositis, polymyositis in the presence of anti-Jo-1, and with antibodies to PM-Scl in overlap syndromes. The underlying mechanisms of these associations are probably different. Unique major histocompatibility complex associations are seen with other myositis-associated autoantibodies. The association can vary between racial groups as can the type of autoantibody produced within a disease subgroup, perhaps reflecting different T cell receptor repertoires or different inducing agents. The mapping of a gene for one form of hereditary inclusion body myositis to chromosome 9p1-q1 provides a lead for the investigation of sporadic inclusion body myositis, as does the expanding knowledge of genetic factors in Alzheimer's disease. The demonstration of deletions of mitochondrial DNA in the muscle of patients with inclusion body myositis raises the question of their role in the pathogenesis of the disease.
MeSH term(s)	Autoantibodies/immunology ; DNA, Mitochondrial ; Genes, Immunoglobulin ; Genotype ; HLA Antigens/genetics ; HLA Antigens/immunology ; Humans ; Inclusion Bodies ; Major Histocompatibility Complex/genetics ; Major Histocompatibility Complex/immunology ; Mixed Connective Tissue Disease ; Myositis/genetics ; Myositis/immunology ; Phenotype ; Receptors, Antigen, T-Cell/genetics
Chemical Substances	Autoantibodies ; DNA, Mitochondrial ; HLA Antigens ; Receptors, Antigen, T-Cell
Language	English
Publishing date	1996-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1045317-9
ISSN	1531-6963 ; 1040-8711
ISSN (online)	1531-6963
ISSN	1040-8711
DOI	10.1097/00002281-199611000-00004
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Zs.A 3028: Show issues

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Article: Immunogenetics of inflammatory myopathies.

Garlepp, M J

Bailliere's clinical neurology

1993 Volume 2, Issue 3, Page(s) 579–597

Abstract: The genes most commonly considered when investigating immunogenetic associations with autoimmune diseases, including inflammatory muscle disease (IMD), are those encoded in the major histocompatibility complex (MHC), the T-cell receptor (TCR) genes and ... ...

Abstract	The genes most commonly considered when investigating immunogenetic associations with autoimmune diseases, including inflammatory muscle disease (IMD), are those encoded in the major histocompatibility complex (MHC), the T-cell receptor (TCR) genes and the immunoglobulin genes. In caucasoids HLA DR3 is associated with adult polymyositis (PM) and juvenile dermatomyositis (JDM) and is probably increased in frequency in adult DM. In inclusion body myositis (IBM) DR3 and DR1 have been separately reported to be increased but few patients have been analysed. The DR3 in IMD is almost always present on the ancestral haplotype marked by HLA-B8, C4AQ0 and DR3 and presumably accounts for the association with C4AQ0 which has been reported in some subgroups of IMD. In other races the associations are less clear although DR6 may be increased in blacks with PM. In PM, DR3 is strongly associated with the presence of antibodies to histidyl tRNA synthetase (Jo-1). DR52 is even more strongly associated with the presence of this autoantibody and this association can be demonstrated in black and white patients. It is unlikely that DR3 is associated with autoantibodies to other aminoacyl-tRNA synthetases or signal recognition proteins although fewer cases have been reported and racial differences may exist. Antibodies to the Pm-Scl antigen are also associated with DR3 while autoantibodies to Mi-2 may be associated with DR53. In caucasoids DR4 was increased in D-penicillamine induced IMD but again there may be inter-racial differences. Amongst caucasoids with mixed connective tissue disease (MCTD) there is an increased frequency of DR4 and this allele is associated with the development of antibodies to ribonucleoprotein (RNP). In other races the data are minimal. Very few investigations of associations between TCR polymorphisms or immunoglobulin allotypes and IMD have been reported. The phenotype Gm 3;5 has been associated with PM in caucasoids and may interact with DR3 in predisposing to disease. The Gm phenotype 1,3;5,21 has been associated with MCTD and with the development of anti-RNP, with or without MCTD, in caucasoids. Multiple genetic factors are likely to determine the development of IMD and the particular combination of alleles at predisposing loci may differ between races and according to the inducing agent. Furthermore, the predisposing genetic factors may vary between subgroups of IMD.
MeSH term(s)	Autoantibodies/biosynthesis ; Complement System Proteins/deficiency ; Humans ; Myositis/chemically induced ; Myositis/genetics ; Myositis/immunology ; Penicillamine/adverse effects
Chemical Substances	Autoantibodies ; Complement System Proteins (9007-36-7) ; Penicillamine (GNN1DV99GX)
Language	English
Publishing date	1993-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1181242-4
ISSN	0961-0421
ISSN	0961-0421
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Article: Genetics of inclusion-body myositis.

Needham, M / Mastaglia, F L / Garlepp, M J

Muscle & nerve

2007 Volume 35, Issue 5, Page(s) 549–561

Abstract: Sporadic inclusion-body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet-unknown way to cause ... ...

Abstract	Sporadic inclusion-body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet-unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion-body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion-body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM.
MeSH term(s)	Female ; Genetic Predisposition to Disease ; Humans ; Major Histocompatibility Complex ; Male ; Middle Aged ; Myositis, Inclusion Body/classification ; Myositis, Inclusion Body/genetics ; Proteins/genetics
Chemical Substances	Proteins
Language	English
Publishing date	2007-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	438353-9
ISSN	1097-4598 ; 0148-639X
ISSN (online)	1097-4598
ISSN	0148-639X
DOI	10.1002/mus.20766
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Zs.A 1449: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 551: Show issues

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Article: Autoantibodies in inflammatory myopathies.

Garlepp, M J / Mastaglia, F L

The American journal of the medical sciences

2000 Volume 319, Issue 4, Page(s) 227–233

MeSH term(s)	Autoantibodies/blood ; Autoantibodies/genetics ; Autoantibodies/metabolism ; Dermatomyositis/immunology ; Diagnosis, Differential ; Humans ; Myositis/classification ; Myositis/diagnosis ; Myositis/genetics ; Myositis/immunology ; Myositis, Inclusion Body/immunology ; Polymyositis/immunology
Chemical Substances	Autoantibodies
Language	English
Publishing date	2000-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1097/00000441-200004000-00005
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Article: Apolipoprotein E and inclusion body myositis.

Garlepp, M J / Mastaglia, F L

Annals of neurology

1996 Volume 40, Issue 6, Page(s) 826–828

MeSH term(s)	Apolipoproteins E/metabolism ; Humans ; Myositis, Inclusion Body/metabolism ; Myositis, Inclusion Body/pathology
Chemical Substances	Apolipoproteins E
Language	English
Publishing date	1996-12
Publishing country	United States
Document type	Editorial
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.410400603
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Zs.MO 478: Show issues

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Article: Inclusion body myositis.

Garlepp, M J / Mastaglia, F L

Journal of neurology, neurosurgery, and psychiatry

1996 Volume 60, Issue 3, Page(s) 251–255

MeSH term(s)	Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Humans ; Myositis, Inclusion Body/genetics ; Myositis, Inclusion Body/immunology ; Myositis, Inclusion Body/pathology ; T-Lymphocytes/immunology
Language	English
Publishing date	1996-03
Publishing country	England
Document type	Editorial ; Review
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp.60.3.251
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Ui II Zs.93: Show issues

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Article: Biological and immunological aspects of malignant mesothelioma.

Garlepp, M J / Leong, C C

The European respiratory journal

1995 Volume 8, Issue 4, Page(s) 643–650

Abstract: Malignant mesothelioma (MM) is an aggressive tumour, which is strongly associated with previous asbestos exposure and is resistant to all conventional anticancer therapies. An understanding of the biological properties of MM may provide insights into ... ...

Abstract	Malignant mesothelioma (MM) is an aggressive tumour, which is strongly associated with previous asbestos exposure and is resistant to all conventional anticancer therapies. An understanding of the biological properties of MM may provide insights into useful therapeutic strategies, and MM cell lines and animal models have been major contributors to our current knowledge of this tumour. Although karyotypic abnormalities are frequent, there is no clear evidence of a mesothelioma-specific chromosomal aberration. Similarly, there is no evidence of activation or over-expression of a known oncogene, or of the inactivation of currently identified tumour suppressor genes. A number of growth factors, including platelet derived growth factors A and B (PDGF-A and -B), insulin-like growth factor I and transforming growth factor-beta (TGF-beta), and some of their receptors, have been reported to be expressed by MM cells, and each has the potential to play a role as a growth stimulant for MM or to modify immune responses to the tumour. Some data support an autocrine role for PDGF-A. MM cell lines are susceptible to lysis by a variety of immune effector cells, and their growth can often be inhibited by cytokines. The possibility of stimulating an immune response to MM by genetic manipulation of the tumour cells has been investigated using a murine model. The data so far suggest that transfection of allogeneic class I major histocompatibility complex genes or syngeneic class II genes alone is unlikely to induce protective immunity.(ABSTRACT TRUNCATED AT 250 WORDS)
MeSH term(s)	Animals ; Asbestos/adverse effects ; Gene Transfer Techniques ; Genes, Tumor Suppressor ; Growth Substances/metabolism ; Humans ; Lymphocyte Activation ; Mesothelioma/genetics ; Mesothelioma/immunology ; Oncogenes ; Peritoneal Neoplasms/genetics ; Peritoneal Neoplasms/immunology ; Pleural Neoplasms/genetics ; Pleural Neoplasms/immunology ; T-Lymphocytes ; Transfection ; Tumor Cells, Cultured
Chemical Substances	Growth Substances ; Asbestos (1332-21-4)
Language	English
Publishing date	1995-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
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Zs.A 2322: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 292: Show issues

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Article: T cell receptor haplotypes in families of patients with insulin-dependent diabetes mellitus.

Kelly, H / Garlepp, M J

Clinical and experimental immunology

1993 Volume 91, Issue 2, Page(s) 226–231

Abstract: The frequencies of Bgl 11 and BamH1 restriction fragment length polymorphisms (RFLP) of C beta, V beta 8, V beta 11 and V beta 7.2 have been defined in a healthy Australian population. Linkage disequilibrium between alleles of the T cell receptor (TCR) V ...

Abstract	The frequencies of Bgl 11 and BamH1 restriction fragment length polymorphisms (RFLP) of C beta, V beta 8, V beta 11 and V beta 7.2 have been defined in a healthy Australian population. Linkage disequilibrium between alleles of the T cell receptor (TCR) V beta 8 and V beta 11 gene segments has been confirmed. We have also confirmed the lack of linkage disequilibrium between either of these loci and alleles at C beta or V beta 7.2. Using RFLPs at V beta 11 and V beta 8 loci TCR beta haplotypes have been identified in five families in which the probands have insulin-dependent diabetes mellitus (IDDM). An extremely rare haplotype, marked by the higher molecular weight BamH1 allele (H, H) at each of V beta 11 and V beta 8, was found in the DR4+ DR3- probands of two families (P = 0.004). In three families in which the probands had DR3, the more common TCR haplotype LH (V beta 11, V beta 8) was found. Taken together, these data confirm that linkage disequilibrium does exist in the TCR beta locus, at least in some regions, and suggest that detailed analysis of the relationship between TCR V beta haplotypes and HLA is warranted since these RFLPs may be markers for important allelic V gene sequence variations.
MeSH term(s)	Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/immunology ; Female ; Haplotypes ; Humans ; Linkage Disequilibrium ; Major Histocompatibility Complex ; Male ; Polymorphism, Restriction Fragment Length ; Receptors, Antigen, T-Cell, alpha-beta/genetics
Chemical Substances	Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	1993-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/j.1365-2249.1993.tb05887.x
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