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Article ; Online: Large Thoracic Lymphadenopathy and Pulmonary Nodules in Young Man.

Rudnay, Maroš / Blichárová, Alžbeta / Křupka, Michal / Paraničová, Ivana / Pobeha, Pavol / Rjašková, Gabriela / Lehotská, Viera

Chest

2022 Volume 161, Issue 3, Page(s) e169–e173

Abstract: Case presentation: A 33-year-old man with obesity, systemic arterial hypertension, and psoriasis who had been treated previously with little success by a pulmonologist for chronic unproductive irritant cough came to the outpatient pulmonary department ... ...

Abstract	Case presentation: A 33-year-old man with obesity, systemic arterial hypertension, and psoriasis who had been treated previously with little success by a pulmonologist for chronic unproductive irritant cough came to the outpatient pulmonary department because of profuse cough and short syncope (probably cough-induced). Chest radiography revealed widened mediastinum with lobular, polycyclic contours that was suspected to be a large mediastinal lymphadenopathy or mediastinal mass.
MeSH term(s)	Adult ; Cough/etiology ; Humans ; Lung ; Lymphadenopathy/diagnostic imaging ; Lymphadenopathy/etiology ; Male ; Mediastinal Diseases/complications ; Mediastinum ; Multiple Pulmonary Nodules/complications ; Multiple Pulmonary Nodules/diagnostic imaging ; Radiography, Thoracic
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.10.008
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Article ; Online: Antigenicity and immunogenicity of different morphological forms of Borrelia burgdorferi sensu lato spirochetes.

Sloupenska, Kristyna / Koubkova, Barbora / Horak, Pavel / Dolezilkova, Jana / Hutyrova, Beata / Racansky, Mojmir / Miklusova, Martina / Mares, Jan / Raska, Milan / Krupka, Michal

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4014

Abstract: Borrelia burgdorferi sensu lato is a species complex of pleomorphic spirochetes, including species that cause Lyme disease (LD) in humans. In addition to classic spiral forms, these bacteria are capable of creating morphological forms referred to as ... ...

Abstract	Borrelia burgdorferi sensu lato is a species complex of pleomorphic spirochetes, including species that cause Lyme disease (LD) in humans. In addition to classic spiral forms, these bacteria are capable of creating morphological forms referred to as round bodies and aggregates. The subject of discussion is their possible contribution to the persistence of infection or post-infection symptoms in LD. This study investigates the immunological properties of these forms by monitoring reactivity with early (n = 30) and late stage (n = 30) LD patient sera and evaluating the immune response induced by vaccination of mice. In patient sera, we found a quantitative difference in reactivity with individual morphotypes, when aggregates were recognized most intensively, but the difference was statistically significant in only half of the tested strains. In post-vaccination mouse sera, we observed a statistically significant higher reactivity with antigens p83 and p25 (OspC) in mice vaccinated with aggregates compared to mice vaccinated with spiral forms. The importance of the particulate nature of the antigen for the induction of a Th1-directed response has also been demonstrated. In any of morphological forms, the possibility of inducing antibodies cross-reacting with human nuclear and myositis specific/associated autoantigens was not confirmed by vaccination of mice.
MeSH term(s)	Humans ; Animals ; Mice ; Borrelia burgdorferi ; Borrelia burgdorferi Group ; Lyme Disease/microbiology ; Antigens, Bacterial
Chemical Substances	Antigens, Bacterial
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54505-y
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Article ; Online: Effect of Contact Conformity on Grease Lubrication

Michal Okal / David Kostal / Petr Sperka / Ivan Krupka / Martin Hartl

Lubricants, Vol 10, Iss 289, p

2022 Volume 289

Abstract: This work focused on the experimental study of grease lubrication mechanisms around contacts in radial ball bearing 6314. The main objective of this work was to show the influence of conformities and their impact on grease lubrication in ball bearings. ... ...

Abstract	This work focused on the experimental study of grease lubrication mechanisms around contacts in radial ball bearing 6314. The main objective of this work was to show the influence of conformities and their impact on grease lubrication in ball bearings. For the experiments, a tribometer of ball-on-ring configuration was used and fluorescence microscopy was chosen as the observation method. The results showed that, under starvation conditions, a conformity of 0.52 at velocities around 2 m/s produces a 50% thicker lubricating film than a conformity of 0.58. The available amount of lubricant around the contact area for conformity 0.52 was approximately three times less than that for conformity 0.58, and the same ratio was observed for the amount of lubricant on the rolling track. Experiments show that a realistic tribometer geometry allows a more accurate experimental study of the lubrication mechanisms of greases in ball bearings.
Keywords	grease lubrication ; ball bearing ; starvation ; replenishment ; Science ; Q
Subject code	670
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Concurrent Infection of the Human Brain with Multiple

Golovchenko, Maryna / Opelka, Jakub / Vancova, Marie / Sehadova, Hana / Kralikova, Veronika / Dobias, Martin / Raska, Milan / Krupka, Michal / Sloupenska, Kristyna / Rudenko, Natalie

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune ... ...

Abstract	Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune suppression, induction of immune tolerance, phase and antigenic variation, intracellular seclusion, changing of morphological and physiological state in varying environments, formation of biofilms and persistent forms, and, importantly, incursion into immune-privileged sites such as the brain. Invasion of immune-privileged sites allows the spirochetes to not only escape from the host immune system but can also reduce the efficacy of antibiotic therapy. Here we present a case of the detection of spirochetal DNA in multiple loci in a LD patient's post-mortem brain. The presence of co-infection with
MeSH term(s)	Humans ; Borrelia/genetics ; Borrelia burgdorferi/genetics ; Borrelia burgdorferi Group/genetics ; Brain ; Lyme Disease
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242316906
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Article ; Online: Comprehensive Empirical Model of Substitution-Influence on Hydrogen Bonding in Aromatic Schiff Bases.

Krupka, Katarzyna M / Pocheć, Michał / Panek, Jarosław J / Jezierska, Aneta

International journal of molecular sciences

2022 Volume 23, Issue 20

Abstract: In this work, over 500 structures of tri-ring aromatic Schiff bases with different substitution patterns were investigated to develop a unified description of the substituent effect on the intramolecular hydrogen bridge. Both proximal and distal effects ... ...

Abstract	In this work, over 500 structures of tri-ring aromatic Schiff bases with different substitution patterns were investigated to develop a unified description of the substituent effect on the intramolecular hydrogen bridge. Both proximal and distal effects were examined using Density Functional Theory (DFT) in the gas phase and with solvent reaction field (Polarizable Continuum Model (PCM) and water as the solvent). In order to investigate and characterize the non-covalent interactions, a topological analysis was performed using the Quantum Theory of Atoms In Molecules (QTAIM) theory and Non-Covalent Interactions (NCI) index. The obtained results were summarized as the generalized, empirical model of the composite substituent effect, assessed using an additional group of simple ring-based Schiff bases. The composite substituent effect has been divided into separate increments describing the different interactions of the hydrogen bridge and the substituent: the classical substituent effect, involving resonance and induction mediated through the ring, steric increment based on substituent proximity to the bridge elements, and distal increment, derived from substitution on the distal ring.
MeSH term(s)	Hydrogen Bonding ; Schiff Bases/chemistry ; Models, Molecular ; Quantum Theory ; Solvents ; Hydrogen ; Water
Chemical Substances	Schiff Bases ; Solvents ; Hydrogen (7YNJ3PO35Z) ; Water (059QF0KO0R)
Language	English
Publishing date	2022-10-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232012439
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Article ; Online: Concurrent Infection of the Human Brain with Multiple Borrelia Species

Maryna Golovchenko / Jakub Opelka / Marie Vancova / Hana Sehadova / Veronika Kralikova / Martin Dobias / Milan Raska / Michal Krupka / Kristyna Sloupenska / Natalie Rudenko

International Journal of Molecular Sciences, Vol 24, Iss 23, p

2023 Volume 16906

Abstract	Lyme disease (LD) spirochetes are well known to be able to disseminate into the tissues of infected hosts, including humans. The diverse strategies used by spirochetes to avoid the host immune system and persist in the host include active immune suppression, induction of immune tolerance, phase and antigenic variation, intracellular seclusion, changing of morphological and physiological state in varying environments, formation of biofilms and persistent forms, and, importantly, incursion into immune-privileged sites such as the brain. Invasion of immune-privileged sites allows the spirochetes to not only escape from the host immune system but can also reduce the efficacy of antibiotic therapy. Here we present a case of the detection of spirochetal DNA in multiple loci in a LD patient’s post-mortem brain. The presence of co-infection with Borrelia burgdorferi sensu stricto and Borrelia garinii in this LD patient’s brain was confirmed by PCR. Even though both spirochete species were simultaneously present in human brain tissue, the brain regions where the two species were detected were different and non-overlapping. The presence of atypical spirochete morphology was noted by immunohistochemistry of the brain samples. Atypical morphology was also found in the tissues of experimentally infected mice, which were used as a control.
Keywords	Borrelia burgdorferi ; Borrelia garinii ; co-infection ; human brain ; immunohistochemistry ; Lyme disease ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Crucial correction of the Faix method for the determination of carbonyls in pyrolysis and hydrothermal liquefaction bio-oils with high nitrogen content

Šiman, Michal / Krupka, Vojtěch / Kejla, Lukáš / Straka, Petr / Schulzke, Tim / dos Passos, Juliano Souza / Biller, Patrick / Auersvald, Miloš

Journal of Analytical and Applied Pyrolysis. 2023 Aug., v. 173 p.106086-

2023

Abstract: Accurate and reliable determination of carbonyl content in bio-oils from pyrolysis and hydrothermal liquefaction (HTL) of biomass is crucial not only for estimating the storage stability of the sample but also for creating an adequate design of the ... ...

Abstract	Accurate and reliable determination of carbonyl content in bio-oils from pyrolysis and hydrothermal liquefaction (HTL) of biomass is crucial not only for estimating the storage stability of the sample but also for creating an adequate design of the hydrotreatment process allowing long-term operation. The composition of bio-oils from various feedstocks can, however, significantly differ from woody bio-oils, which were utilized to develop the Faix method, the most frequently used for carbonyl determination. In this study, we present a limitation of this method when used for the analysis of bio-oils prepared from protein-rich biomass. These bio-oils are known to have a high nitrogen content, which can be present in the form of possibly interfering compounds. In this study, nitrogen interferences were identified, and a correction step mitigating the underestimation of carbonyl content was introduced. This novel approach was tested for 13 crude bio-oils prepared by pyrolysis or HTL from 10 different feedstocks with a wide range of nitrogen content. Besides crude bio-oils, five hydrotreated HTL oils from sewage sludge were also analyzed. For bio-oils or hydrotreated products with increased nitrogen content but containing less than 0.5 mmol/g of carbonyls, without the correction step, the method can provide zero and in extreme cases even negative values. Statistical analysis of results showed that the introduction of the correction step can be crucial for bio-oils containing more than 2 wt% of nitrogen and especially hydrotreated bio-oils from protein-rich biomass.
Keywords	biofuels ; biomass ; feedstocks ; hydrothermal liquefaction ; nitrogen ; nitrogen content ; pyrolysis ; sewage sludge ; statistical analysis ; storage quality ; Bio-oils ; Hydrotreating ; Carbonyl content ; Nitrogen compounds
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ISSN	0165-2370
DOI	10.1016/j.jaap.2023.106086
Database	NAL-Catalogue (AGRICOLA)

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Article: Reactive Oxygen Species Imaging in U937 Cells.

Prasad, Ankush / Sedlářová, Michaela / Balukova, Anastasiia / Ovsii, Alina / Rác, Marek / Křupka, Michal / Kasai, Shigenobu / Pospíšil, Pavel

Frontiers in physiology

2020 Volume 11, Page(s) 552569

Abstract: The U937 cell culture is a pro-monocytic, human histiocytic lymphoma cell line. These monocytes can differentiate into either macrophages or dendritic cells (antigen-presenting cells) depending on the initiators. The U937 cells activated in the presence ... ...

Abstract	The U937 cell culture is a pro-monocytic, human histiocytic lymphoma cell line. These monocytes can differentiate into either macrophages or dendritic cells (antigen-presenting cells) depending on the initiators. The U937 cells activated in the presence of phorbol 12-myristate 13-acetate (PMA) change their morphology into macrophage-like cells creating pseudopodia and adhering generously. Macrophages are known to produce reactive oxygen species (ROS) mostly during phagocytosis of foreign particles, an important non-specific immune response. Recently, we have focused on the role of hydroxyl radical (HO
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2020.552569
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Article ; Online: An Analysis of the Effects of In Vitro Photodynamic Therapy on Prostate Cancer Tissue by Histopathological Examination and Magnetic Resonance Imaging.

Aebisher, David / Osuchowski, Michał / Bartusik-Aebisher, Dorota / Krupka-Olek, Magdalena / Dynarowicz, Klaudia / Kawczyk-Krupka, Aleksandra

International journal of molecular sciences

2022 Volume 23, Issue 19

Abstract: Prostate cancer can significantly shorten the lifetime of a patient, even if he is diagnosed at an early stage. The development of minimally-invasive focal therapies such as photodynamic therapy to reduce the number of neoplastic cells while sparing ... ...

Abstract	Prostate cancer can significantly shorten the lifetime of a patient, even if he is diagnosed at an early stage. The development of minimally-invasive focal therapies such as photodynamic therapy to reduce the number of neoplastic cells while sparing delicate structures is extremely advantageous for treating prostate cancer. This study investigates the effect of photodynamic therapy performed in prostate tissue samples in vitro, using quantitative magnetic resonance imaging and histopathological analysis. Prostate tissue samples were treated with oxygenated solutions of Rose Bengal (RB) or protoporphyrin IX disodium salt (PpIX), illuminated with visible light, and then analyzed for changes in morphology by microscopy and by measurement of spin-lattice and spin-spin relaxation times at 1.5 Tesla. In the treated prostate tissue samples, histopathological images revealed chromatin condensation and swelling of the stroma, and in some cases, thrombotic necrosis and swelling of the stroma accompanied by pyknotic nuclei occurred. Several samples had protein fragments in the stroma. Magnetic resonance imaging of the treated prostate tissue samples revealed differences in the spin-lattice and spin-spin relaxation times prior to and post photodynamic action.
MeSH term(s)	Chromatin ; Humans ; Magnetic Resonance Imaging ; Male ; Photochemotherapy/methods ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/drug therapy ; Protoporphyrins/therapeutic use ; Rose Bengal/pharmacology
Chemical Substances	Chromatin ; Photosensitizing Agents ; Protoporphyrins ; Rose Bengal (1ZPG1ELY14)
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231911354
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Article: Photodynamic Therapy-Adjunctive Therapy in the Treatment of Prostate Cancer.

Osuchowski, Michał / Aebisher, David / Bartusik-Aebisher, Dorota / Krupka-Olek, Magdalena / Dynarowicz, Klaudia / Przygoda, Maria / Kawczyk-Krupka, Aleksandra

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: The alarming increase in the number of advanced-stage prostate cancer cases with poor prognosis has led to a search for innovative methods of treatment. In response to the need for implementation of new and innovative methods of cancer tissue therapy, we ...

Abstract	The alarming increase in the number of advanced-stage prostate cancer cases with poor prognosis has led to a search for innovative methods of treatment. In response to the need for implementation of new and innovative methods of cancer tissue therapy, we studied photodynamic action in excised prostate tissue in vitro as a model for photodynamic therapy. To ascertain the effects of photodynamic action in prostate tissue, Rose Bengal (0.01 to 0.05 mM) was used as a photosensitizer in the presence of oxygen and light to generate singlet oxygen in tissues in vitro. Five preset concentrations of Rose Bengal were chosen and injected into prostate tissue samples (60 samples with 12 replications for each RB concentration) that were subsequently exposed to 532 nm light. The effects of irradiation of the Rose Bengal infused tissue samples were determined by histopathological analysis. Histopathological examination of prostate samples subjected to photodynamic action revealed numerous changes in the morphology of the neoplastic cells and the surrounding tissues. We conclude that the morphological changes observed in the prostate cancer tissues were a result of the photogeneration of cytotoxic singlet oxygen. The tissue damage observed post photodynamic action offers an incentive for continued in vitro investigations and future in vivo clinical trials.
Language	English
Publishing date	2022-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051113
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