Article ; Online: NMR-based metabolomics approach to study the effects of Wu-Zi-Yan-Zong-Wan on triptolide-induced oligospermia in rats.
2020 Volume 265, Page(s) 113192
Abstract: Ethnopharmacological relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a commonly used Chinese medicinal ...
| Abstract | Ethnopharmacological relevance: Wu-Zi-Yan-Zong-Wan (WZYZW) is a commonly used Chinese medicinal recipe for oligozoospermia. Oligozoospermia is a common disease that harms human fertility, there is no effective therapeutic medicine at present. However, the underlying pharmacological mechanism remains unclear. Methods: Oligozoospermia rats model induced by Tripterygium glycosides (TG) was established to inspect the efficiency of WZYZW in the treatment of oligozoospermia by traditional pharmacodynamics combined with NMR-based metabolomics. Multivariate statistics were used to extracted the underlying biomarkers and metabolic pathways of WZYZW in the treatment of oligozoospermia. Results: The results showed that TG disturbed many metabolites and metabolic pathways such as oxidative stress (choline, O-phosphocholine, betaine and ascorbate), energy metabolism in mitochondria (glucose, lactate, succinate, fumarate, 3-hydroxybutyrate and alanine), mitochondrial apoptosis markers (Bax and Bcl-2) and amino acids metabolisms (arginine, branched-chain amino acids, taurine and myo-inositol). Conclusions: WZYZW could significantly reverse the disturbed metabolites to their normal status by their abilities of anti-oxidation, anti-apoptosis, balancing the osmotic pressure regulatory molecules and regulating the amino acids metabolism. This study provides pharmacological basis and guidance for the clinical usage of WZYZW. |
|---|---|
| MeSH term(s) | Amino Acids/metabolism ; Animals ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Biomarkers/metabolism ; Diterpenes ; Drugs, Chinese Herbal/pharmacology ; Epoxy Compounds ; Magnetic Resonance Spectroscopy ; Male ; Metabolomics ; Oligospermia/drug therapy ; Oligospermia/metabolism ; Osmotic Pressure/drug effects ; Oxidative Stress/drug effects ; Phenanthrenes ; Rats ; Rats, Sprague-Dawley |
| Chemical Substances | Amino Acids ; Antioxidants ; Biomarkers ; Diterpenes ; Drugs, Chinese Herbal ; Epoxy Compounds ; Phenanthrenes ; triptolide (19ALD1S53J) |
| Language | English |
| Publishing date | 2020-09-02 |
| Publishing country | Ireland |
| Document type | Journal Article |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2020.113192 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1494: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.