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  1. Article ; Online: A cross-sectional study of knowledge, attitude, behaviour and preventive measures for COVID-19 infection in Lebanon.

    Sakr, Fouad / Maalouf, Anna / Msallem, Elissa / Issa, Aline / Nehme, Jessica / Hoteit, Maha / Hleyhel, Mira / Salameh, Pascale

    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

    2023  Volume 29, Issue 4, Page(s) 295–301

    Abstract: Background: The World Health Organization has often reiterated its recommendations for the prevention of COVID-19, however, the success of these measures largely depends on public knowledge and attitudes.: Aims: This study assessed the relationship ... ...

    Abstract Background: The World Health Organization has often reiterated its recommendations for the prevention of COVID-19, however, the success of these measures largely depends on public knowledge and attitudes.
    Aims: This study assessed the relationship between knowledge, attitude, behaviour and preventive measures for COVID-19 infection in a Lebanese population.
    Methods: This cross-sectional study was conducted between September and October 2020 using the snowball sampling technique and an online self-administered questionnaire. The questionnaire had 4 parts targeting sociodemographic characteristics; medical history; knowledge, attitude and practices (preventive measures and behaviours related to COVID-19); and mental health variables such as psychological distress. Two models were derived using multivariable binomial logistic regression to optimize the picture of COVID-19 correlates.
    Results: Our sample comprised 1119 adults. Being older, female, a regular alcohol consumer, waterpipe smoker, having low level of education, low family income, and having contact with a COVID-19 patient correlated with increased odds of ever having been diagnosed with COVID-19. Participants who had ever been diagnosed with COVID-19 had a significantly better knowledge and a higher risky practice scale [adjusted odds ratio (ORa) = 1.49; 95% CI 1.27-1.74; P < 0.001; and ORa = 1.04; 95% CI 1.01-1.08; P = 0.024, respectively].
    Conclusion: The most important predictors of COVID-19 infection appear to be generally well-known among the general population, however, their knowledge and adherence to preventive measures should be continuously re-evaluated. This study highlights the need for greater awareness to improve precautionary behaviours among the public.
    MeSH term(s) Adult ; Humans ; Female ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Lebanon/epidemiology ; Health Knowledge, Attitudes, Practice ; Surveys and Questionnaires
    Language English
    Publishing date 2023-04-27
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1291071-5
    ISSN 1687-1634 ; 1020-3397
    ISSN (online) 1687-1634
    ISSN 1020-3397
    DOI 10.26729/emhj.23.038
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  2. Journal ; Article ; Online: A cross-sectional study of knowledge, attitude, behaviour and preventive measures for COVID-19 infection in Lebanon

    Fouad Sakr / Anna Maalouf / Elissa Msallem / Aline Issa / Jessica Nehme / Maha Hoteit / Mira Hleyhel / Pascale Salameh

    2023  

    Abstract: Background: The World Health Organization has often reiterated its recommendations for the prevention of COVID-19, however, the success of these measures largely depends on public knowledge and attitudes. Aims: This study assessed the relationship ... ...

    Abstract Background: The World Health Organization has often reiterated its recommendations for the prevention of COVID-19, however, the success of these measures largely depends on public knowledge and attitudes. Aims: This study assessed the relationship between knowledge, attitude, behaviour and preventive measures for COVID-19 infection in a Lebanese population. Methods: This cross-sectional study was conducted between September and October 2020 using the snowball sampling technique and an online self-administered questionnaire. The questionnaire had 4 parts targeting sociodemographic characteristics; medical history; knowledge, attitude and practices (preventive measures and behaviours related to COVID-19); and mental health variables such as psychological distress. Two models were derived using multivariable binomial logistic regression to optimize the picture of COVID-19 correlates. Results: Our sample comprised 1119 adults. Being older, female, a regular alcohol consumer, waterpipe smoker, having low level of education, low family income, and having contact with a COVID-19 patient correlated with increased odds of ever having been diagnosed with COVID-19. Participants who had ever been diagnosed with COVID-19 had a significantly better knowledge and a higher risky practice scale [adjusted odds ratio (ORa) = 1.49; 95% CI 1.27–1.74; P < 0.001; and ORa = 1.04; 95% CI 1.01–1.08; P = 0.024, respectively]. Conclusion: The most important predictors of COVID-19 infection appear to be generally well-known among the general population, however, their knowledge and adherence to preventive measures should be continuously re-evaluated. This study highlights the need for greater awareness to improve precautionary behaviours among the public.

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    Keywords Coronavirus Disease (COVID-19) ; COVID-19 ; Cross-Sectional Studies ; Health Knowledge ; Attitudes ; Practice ; Lebanon ; Surveys and Questionnaires ; Disease Outbreaks ; Betacoronavirus ; epidemiology ; prevention and control
    Language English
    Publisher World Health Organization. Regional Office for the Eastern Mediterranean
    Document type Journal ; Article ; Online
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  3. Article ; Online: Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase.

    Al-Choboq, Joëlle / Ferlazzo, Mélanie L / Sonzogni, Laurène / Granzotto, Adeline / El-Nachef, Laura / Maalouf, Mira / Berthel, Elise / Foray, Nicolas

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Usher syndrome (USH) is a rare autosomal recessive disease characterized by the combination of hearing loss, visual impairment due to retinitis pigmentosa, and in some cases vestibular dysfunctions. Studies published in the 1980s reported that USH is ... ...

    Abstract Usher syndrome (USH) is a rare autosomal recessive disease characterized by the combination of hearing loss, visual impairment due to retinitis pigmentosa, and in some cases vestibular dysfunctions. Studies published in the 1980s reported that USH is associated with cellular radiosensitivity. However, the molecular basis of this particular phenotype has not yet been documented. The aim of this study was therefore to document the radiosensitivity of USH1-a subset of USH-by examining the radiation-induced nucleo-shuttling of ATM (RIANS), as well as the functionality of the repair and signaling pathways of the DNA double-strand breaks (DSBs) in three skin fibroblasts derived from USH1 patients. The clonogenic cell survival, the micronuclei, the nuclear foci formed by the phosphorylated forms of the X variant of the H2A histone (ɣH2AX), the phosphorylated forms of the ATM protein (pATM), and the meiotic recombination 11 nuclease (MRE11) were used as cellular and molecular endpoints. The interaction between the ATM and USH1 proteins was also examined by proximity ligation assay. The results showed that USH1 fibroblasts were associated with moderate but significant radiosensitivity, high yield of micronuclei, and impaired DSB recognition but normal DSB repair, likely caused by a delayed RIANS, suggesting a possible sequestration of ATM by some USH1 proteins overexpressed in the cytoplasm. To our knowledge, this report is the first radiobiological characterization of cells from USH1 patients at both molecular and cellular scales.
    MeSH term(s) Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Clone Cells ; Diphosphonates/pharmacology ; Fibroblasts/drug effects ; Fibroblasts/pathology ; Fibroblasts/radiation effects ; Histones/metabolism ; Humans ; Kinetics ; MRE11 Homologue Protein/metabolism ; Micronuclei, Chromosome-Defective/radiation effects ; Models, Biological ; Phosphorylation/drug effects ; Phosphorylation/radiation effects ; Radiation Tolerance/drug effects ; Radiation Tolerance/genetics ; Radiation Tolerance/radiation effects ; Subcellular Fractions/drug effects ; Subcellular Fractions/metabolism ; Subcellular Fractions/radiation effects ; Usher Syndromes/enzymology ; Usher Syndromes/genetics
    Chemical Substances Diphosphonates ; H2AX protein, human ; Histones ; MRE11 protein, human ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; MRE11 Homologue Protein (EC 3.1.-)
    Language English
    Publishing date 2022-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031570
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  4. Article ; Online: Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity

    Joëlle Al-Choboq / Mélanie L. Ferlazzo / Laurène Sonzogni / Adeline Granzotto / Laura El-Nachef / Mira Maalouf / Elise Berthel / Nicolas Foray

    International Journal of Molecular Sciences, Vol 23, Iss 1570, p

    Influence of the ATM Protein Kinase

    2022  Volume 1570

    Abstract: Usher syndrome (USH) is a rare autosomal recessive disease characterized by the combination of hearing loss, visual impairment due to retinitis pigmentosa, and in some cases vestibular dysfunctions. Studies published in the 1980s reported that USH is ... ...

    Abstract Usher syndrome (USH) is a rare autosomal recessive disease characterized by the combination of hearing loss, visual impairment due to retinitis pigmentosa, and in some cases vestibular dysfunctions. Studies published in the 1980s reported that USH is associated with cellular radiosensitivity. However, the molecular basis of this particular phenotype has not yet been documented. The aim of this study was therefore to document the radiosensitivity of USH1—a subset of USH—by examining the radiation-induced nucleo-shuttling of ATM (RIANS), as well as the functionality of the repair and signaling pathways of the DNA double-strand breaks (DSBs) in three skin fibroblasts derived from USH1 patients. The clonogenic cell survival, the micronuclei, the nuclear foci formed by the phosphorylated forms of the X variant of the H2A histone (ɣH2AX), the phosphorylated forms of the ATM protein (pATM), and the meiotic recombination 11 nuclease (MRE11) were used as cellular and molecular endpoints. The interaction between the ATM and USH1 proteins was also examined by proximity ligation assay. The results showed that USH1 fibroblasts were associated with moderate but significant radiosensitivity, high yield of micronuclei, and impaired DSB recognition but normal DSB repair, likely caused by a delayed RIANS, suggesting a possible sequestration of ATM by some USH1 proteins overexpressed in the cytoplasm. To our knowledge, this report is the first radiobiological characterization of cells from USH1 patients at both molecular and cellular scales.
    Keywords Usher syndrome ; radiosensitivity ; DNA double-strand breaks ; ATM ; ionizing radiation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms

    Azzi, Joyce / Waked, Anthony / Bou-Gharios, Jolie / Al Choboq, Joelle / Geara, Fady / Bodgi, Larry / Maalouf, Mira

    Nutrition and Cancer. 2022 July 3, v. 74, no. 6 p.2207-2221

    2022  

    Abstract: Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood. ... ...

    Abstract Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood. Here, the In Vitro response of UM-UC5 and UM-UC6 bladder cell lines to curcumin and radiation treatments was evaluated. The effect of curcumin on the DNA double-strand breaks repair system after treatment with ionizing radiation (2 Gy) was determined by immunofluorescence. Cell viability, proliferation, and survival were performed using trypan blue, MTT, clonogenic, and sphere-forming assays. The migratory ability of both cells was assessed by wound healing. We showed that curcumin treatment increased the radiosensitivity by modifying the DNA double-strand breaks repair kinetics of the most radioresistant cells UM-UC6 without affecting the radiosensitive UM-UC5. Moreover, UM-UC6 cell survival and proliferation was significantly decreased after the combination of curcumin with radiation. Bladder cell migration was also inhibited considerably. Curcumin was also shown to reduce the number and the volume of bladder cancer spheres of both cell lines. This study revealed that curcumin was able to radiosensitize resistant bladder cell line without affecting the sensitive one with minimal side effects through enhancing DNA damage signaling and repair pathway.
    Keywords DNA damage ; DNA repair ; bladder ; cell lines ; cell movement ; cell viability ; curcumin ; fluorescent antibody technique ; humans ; migratory behavior ; neoplasm cells ; nutrition ; polyphenols ; radiation resistance ; urinary bladder neoplasms
    Language English
    Dates of publication 2022-0703
    Size p. 2207-2221.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2021.1985534
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Molecular and Cellular Responses to Ionization Radiation in Untransformed Fibroblasts from the Rothmund–Thomson Syndrome

    Joëlle Al-Choboq / Myriam Nehal / Laurène Sonzogni / Adeline Granzotto / Laura El Nachef / Juliette Restier-Verlet / Mira Maalouf / Elise Berthel / Bernard Aral / Nadège Corradini / Michel Bourguignon / Nicolas Foray

    Radiation, Vol 3, Iss 2, Pp 21-

    Influence of the Nucleo-Shuttling of the ATM Protein Kinase

    2023  Volume 38

    Abstract: The Rothmund–Thomson syndrome (RTS) is a rare autosomal recessive disease associated with poikiloderma, telangiectasias, sun-sensitive rash, hair growth problems, juvenile cataracts and, for a subset of some RTS patients, a high risk of cancer, ... ...

    Abstract The Rothmund–Thomson syndrome (RTS) is a rare autosomal recessive disease associated with poikiloderma, telangiectasias, sun-sensitive rash, hair growth problems, juvenile cataracts and, for a subset of some RTS patients, a high risk of cancer, especially osteosarcoma. Most of the RTS cases are caused by biallelic mutations of the RECQL4 gene, coding for the RECQL4 DNA helicase that belongs to the RecQ family. Cellular and post-radiotherapy radiosensitivity was reported in RTS cells and patients since the 1980s. However, the molecular basis of this particular phenotype has not been documented to reliably link the biological and clinical responses to the ionizing radiation (IR) of cells from RTS patients. The aim of this study was therefore to document the specificities of the radiosensitivity associated with RTS by examining the radiation-induced nucleo-shuttling of ATM (RIANS) and the recognition and repair of the DNA double-strand breaks (DSB) in three skin fibroblasts cell lines derived from RTS patients and two derived from RTS patients’ parents. The results showed that the RTS fibroblasts tested were associated with moderate but significant radiosensitivity, a high yield of micronuclei, and impaired DSB recognition but normal DSB repair at 24 h likely caused by a delayed RIANS, supported by the sequestration of ATM by some RTS proteins overexpressed in the cytoplasm. To our knowledge, this report is the first radiobiological characterization of cells from RTS patients at both molecular and cellular scales.
    Keywords Rothmund–Thomson syndrome ; radiosensitivity ; DNA double-strand breaks ; ATM ; ionizing radiation ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  7. Article ; Online: Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms.

    Azzi, Joyce / Waked, Anthony / Bou-Gharios, Jolie / Al Choboq, Joelle / Geara, Fady / Bodgi, Larry / Maalouf, Mira

    Nutrition and cancer

    2021  Volume 74, Issue 6, Page(s) 2207–2221

    Abstract: Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood. ... ...

    Abstract Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood. Here, the In Vitro response of UM-UC5 and UM-UC6 bladder cell lines to curcumin and radiation treatments was evaluated. The effect of curcumin on the DNA double-strand breaks repair system after treatment with ionizing radiation (2 Gy) was determined by immunofluorescence. Cell viability, proliferation, and survival were performed using trypan blue, MTT, clonogenic, and sphere-forming assays. The migratory ability of both cells was assessed by wound healing. We showed that curcumin treatment increased the radiosensitivity by modifying the DNA double-strand breaks repair kinetics of the most radioresistant cells UM-UC6 without affecting the radiosensitive UM-UC5. Moreover, UM-UC6 cell survival and proliferation was significantly decreased after the combination of curcumin with radiation. Bladder cell migration was also inhibited considerably. Curcumin was also shown to reduce the number and the volume of bladder cancer spheres of both cell lines. This study revealed that curcumin was able to radiosensitize resistant bladder cell line without affecting the sensitive one with minimal side effects through enhancing DNA damage signaling and repair pathway.
    MeSH term(s) Cell Line ; Cell Line, Tumor ; Cell Survival ; Curcumin/pharmacology ; DNA/genetics ; DNA/pharmacology ; DNA/radiation effects ; DNA Damage ; DNA Repair ; Humans ; Radiation-Sensitizing Agents/pharmacology ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Radiation-Sensitizing Agents ; DNA (9007-49-2) ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2021.1985534
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  8. Article ; Online: Biological effects of space radiation on human cells: history, advances and outcomes.

    Maalouf, Mira / Durante, Marco / Foray, Nicolas

    Journal of radiation research

    2011  Volume 52, Issue 2, Page(s) 126–146

    Abstract: Exposure to radiation is one of the main concerns for space exploration by humans. By focusing deliberately on the works performed on human cells, we endeavored to review, decade by decade, the technological developments and conceptual advances of space ... ...

    Abstract Exposure to radiation is one of the main concerns for space exploration by humans. By focusing deliberately on the works performed on human cells, we endeavored to review, decade by decade, the technological developments and conceptual advances of space radiation biology. Despite considerable efforts, the cancer and the toxicity risks remain to be quantified: 1) the nature and the frequency of secondary heavy ions need to be better characterized in order to estimate their contribution to the dose and to the final biological response; 2) the diversity of radiation history of each astronaut and the impact of individual susceptibility make very difficult any epidemiological analysis for estimating hazards specifically due to space radiation exposure. 3) Cytogenetic data undoubtedly revealed that space radiation exposure produce significant damage in cells. However, our knowledge of the basic mechanisms specific to low-dose, to repeated doses and to adaptive response is still poor. The application of new radiobiological techniques, like immunofluorescence, and the use of human tissue models different from blood, like skin fibroblasts, may help in clarifying all the above items.
    MeSH term(s) Astronauts ; Cosmic Radiation ; Cytogenetics ; DNA Damage ; Fibroblasts/radiation effects ; Heavy Ions ; History, 20th Century ; History, 21st Century ; Humans ; Microscopy, Fluorescence/methods ; Radiation Dosage ; Radiobiology/history ; Relative Biological Effectiveness ; Space Flight/history
    Language English
    Publishing date 2011-03-24
    Publishing country England
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 603983-2
    ISSN 1349-9157 ; 0449-3060
    ISSN (online) 1349-9157
    ISSN 0449-3060
    DOI 10.1269/jrr.10128
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  9. Article ; Online: Influence of Linear Energy Transfer on the Nucleo-shuttling of the ATM Protein: A Novel Biological Interpretation Relevant for Particles and Radiation.

    Maalouf, Mira / Granzotto, Adeline / Devic, Clément / Bodgi, Larry / Ferlazzo, Mélanie / Peaucelle, Christophe / Bajard, Marcel / Giraud, Jean-Yves / Balosso, Jacques / Hérault, Joël / Biston, Marie-Claude / Malet, Claude / Foray, Nicolas

    International journal of radiation oncology, biology, physics

    2018  Volume 103, Issue 3, Page(s) 709–718

    Abstract: Purpose: Linear energy transfer (LET) plays an important role in radiation response. Recently, the radiation-induced nucleo-shuttling of ATM from cytoplasm to the nucleus was shown to be a major event of the radiation response that permits a normal DNA ... ...

    Abstract Purpose: Linear energy transfer (LET) plays an important role in radiation response. Recently, the radiation-induced nucleo-shuttling of ATM from cytoplasm to the nucleus was shown to be a major event of the radiation response that permits a normal DNA double-strand break (DSB) recognition and repair. Here, we aimed to verify the relevance of the ATM nucleo-shuttling model for high-LET particles and various radiation types.
    Methods and materials: ATM- and H2AX-immunofluorescence was used to assess the number of recognized and unrepaired DSB in quiescent fibroblast cell lines exposed to x-rays, γ-rays, 9- and 12-MeV electrons, 3- and 65-MeV protons and 75-MeV/u carbon ions.
    Results: The rate of radiation-induced ATM nucleo-shuttling was found to be specific to each radiation type tested. By increasing the permeability of the nuclear membrane with statin and bisphosphonates, 2 fibroblast cell lines exposed to high-LET particles were shown to be protected by an accelerated ATM nucleo-shuttling.
    Conclusions: Our findings are in agreement with the conclusion that LET and the radiation/particle type influence the formation of ATM monomers in cytoplasm that are required for DSB recognition. A striking analogy was established between the DSB repair kinetics of radioresistant cells exposed to high-LET particles and that of several radiosensitive cells exposed to low-LET radiation. Our data show that the nucleo-shuttling of ATM provides crucial elements to predict radiation response in human quiescent cells, whatever the LET value and their radiosensitivity.
    MeSH term(s) Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Carbon/chemistry ; Cell Line ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Survival ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA Repair ; Fibroblasts/radiation effects ; Gamma Rays ; Histones/metabolism ; Humans ; Ions ; Kinetics ; Linear Energy Transfer ; Microscopy, Fluorescence ; Permeability ; Protons ; Radiation Tolerance ; Radiometry
    Chemical Substances H2AX protein, human ; Histones ; Ions ; Protons ; Carbon (7440-44-0) ; ATM protein, human (EC 2.7.11.1) ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2018.10.011
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  10. Article ; Online: Individual susceptibility to radiosensitivity and to genomic instability: its impact on low-dose phenomena.

    Granzotto, Adeline / Devic, Clément / Viau, Muriel / Maalouf, Mira / Joubert, Aurélie / Massart, Catherine / Thomas, Charles / Foray, Nicolas

    Health physics

    2011  Volume 100, Issue 3, Page(s) 282

    MeSH term(s) Animals ; Cells/radiation effects ; DNA Damage/radiation effects ; DNA Repair ; Dose-Response Relationship, Radiation ; Genomic Instability/radiation effects ; Humans ; Mammals ; Models, Theoretical ; Radiation, Ionizing ; Rodentia
    Language English
    Publishing date 2011-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2406-5
    ISSN 1538-5159 ; 0017-9078
    ISSN (online) 1538-5159
    ISSN 0017-9078
    DOI 10.1097/hp.0b013e318204ec04
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