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Article: Association between the Co-administration of Histamine H

2022 Volume 13, Issue 10, Page(s) 3073–3083

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-08-08
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.73385
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Article ; Online: Impact of multiple H/D replacements on the physicochemical properties of flurbiprofen.

RSC medicinal chemistry

2023 Volume 14, Issue 12, Page(s) 2583–2592

Abstract: Although deuterium incorporation into pharmaceutical drugs is an attractive way to expand drug modalities, their physicochemical properties have not been sufficiently examined. This study focuses on examining the changes in physicochemical properties ... ...

Abstract	Although deuterium incorporation into pharmaceutical drugs is an attractive way to expand drug modalities, their physicochemical properties have not been sufficiently examined. This study focuses on examining the changes in physicochemical properties between flurbiprofen (FP) and flurbiprofen-
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Journal Article
ISSN	2632-8682
ISSN (online)	2632-8682
DOI	10.1039/d3md00357d
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Article ; Online: Cell surface ATP synthase-released H

Arai, Nariaki / Kajihara, Ryo / Takasaka, Mieko / Amari, Kei / Kuneshita, Norika / Maejima, Daisuke / Watanabe-Asaka, Tomomi / Hayashi, Moyuru / Yokoyama, Yumiko / Kaidoh, Maki / Kawai, Yoshiko / Ohhashi, Toshio

Pflugers Archiv : European journal of physiology

2023 Volume 475, Issue 8, Page(s) 945–960

Abstract: ... jejunum released ATP and carbon dioxide depended with H ...

Abstract	Proper food intake is important for maintaining good health in humans. Chocolate is known to exert anti-inflammatory effects; however, the mechanisms remain unclear. In this study, we aimed to investigate the effects of cocoa butter intake on gut immunity in rats and rabbits. Cocoa butter intake increased the lymph flow, cell density, and IL-1β, IL-6 and IL-10 levels in mesenteric lymph. Clodronate, a macrophage depletion compound, significantly enhanced the release of all cytokines. The immunoreactivities of macrophage markers CD68 and F4/80 in the jejunal villi were significantly decreased with clodronate. Piceatannol, a selective cell surface ATP synthase inhibitor significantly reduced the cocoa butter intake-mediated releases of IL-1β, IL-6 and IL-10. The immunoreactivities of cell surface ATP synthase were observed in rat jejunal villi. Shear stress stimulation on the myofibroblast cells isolated from rat jejunum released ATP and carbon dioxide depended with H
MeSH term(s)	Animals ; Rats ; Rabbits ; Dietary Fats/administration & dosage ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/metabolism ; Chocolate ; Male ; Rats, Sprague-Dawley ; Lymph/metabolism ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Interleukin-10/metabolism ; Clodronic Acid ; Jejunum/metabolism ; Shear Strength ; Adenosine Triphosphate/metabolism ; Carbon Dioxide/metabolism ; Cells, Cultured ; Proton-Translocating ATPases/antagonists & inhibitors ; Proton-Translocating ATPases/metabolism
Chemical Substances	cocoa butter (512OYT1CRR) ; Dietary Fats ; Interleukin-1beta ; Interleukin-6 ; Interleukin-10 (130068-27-8) ; Clodronic Acid (0813BZ6866) ; Adenosine Triphosphate (8L70Q75FXE) ; Carbon Dioxide (142M471B3J) ; 3,3',4,5'-tetrahydroxystilbene (6KS3LS0D4F) ; Proton-Translocating ATPases (EC 3.6.3.14)
Language	English
Publishing date	2023-06-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6380-0
ISSN	1432-2013 ; 0031-6768
ISSN (online)	1432-2013
ISSN	0031-6768
DOI	10.1007/s00424-023-02822-y
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Article ; Online: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.

Xu, Hanbing / Miyajima, Masakazu / Nakajima, Madoka / Ogino, Ikuko / Kawamura, Kaito / Akiba, Chihiro / Kamohara, Chihiro / Sakamoto, Koichiro / Karagiozov, Kostadin / Nakamura, Eri / Tada, Nobuhiro / Arai, Hajime / Kondo, Akihide

Fluids and barriers of the CNS

2022 Volume 19, Issue 1, Page(s) 39

Abstract: ... potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most ... on non-hydrocephalic and hydrocephalic H-Tx rats was used to identify causative genes of hydrocephalus ... Results: CGH array revealed a copy number loss in chromosome 16p16 region in hydrocephalic H-Tx rats ...

Abstract	Background: Congenital hydrocephalus occurs with some inheritable characteristics, but the mechanisms of its development remain poorly understood. Animal models provide the opportunity to identify potential genetic causes in this condition. The Hydrocephalus-Texas (H-Tx) rat strain is one of the most studied animal models for investigating the causative genetic alterations and analyzing downstream pathogenetic mechanisms of congenital hydrocephalus. Methods: Comparative genomic hybridization (CGH) array on non-hydrocephalic and hydrocephalic H-Tx rats was used to identify causative genes of hydrocephalus. Targeted gene knockout mice were generated by CRISPR/Cas9 to study the role of this gene in hydrocephalus. Results: CGH array revealed a copy number loss in chromosome 16p16 region in hydrocephalic H-Tx rats at 18 days gestation, encompassing the protein tyrosine phosphatase non-receptor type 20 (Ptpn20), a non-receptor tyrosine phosphatase, without change in most non-hydrocephalic H-Tx rats. Ptpn20-knockout (Ptpn20 Conclusions: This study determined the chromosomal location of the hydrocephalus-associated Ptpn20 gene in hydrocephalic H-Tx rats. The high level of pNKCC1 mediated by Ptpn20 deletion in CP epithelium may cause overproduction of cerebrospinal fluid and contribute to the formation of hydrocephalus in Ptpn20
MeSH term(s)	Animals ; Choroid Plexus/metabolism ; Comparative Genomic Hybridization ; Hydrocephalus/cerebrospinal fluid ; Mice ; Phosphoric Monoester Hydrolases/metabolism ; Phosphorylation ; Rats ; Solute Carrier Family 12, Member 2/genetics ; Solute Carrier Family 12, Member 2/metabolism ; Texas
Chemical Substances	Slc12a2 protein, rat ; Solute Carrier Family 12, Member 2 ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
Language	English
Publishing date	2022-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2595406-4
ISSN	2045-8118 ; 2045-8118
ISSN (online)	2045-8118
ISSN	2045-8118
DOI	10.1186/s12987-022-00341-z
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Article ; Online: Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450.

Iizaka, Yohei / Arai, Ryusei / Takahashi, Akari / Ito, Mikino / Sakai, Miho / Fukumoto, Atsushi / Sherman, David H / Anzai, Yojiro

Journal of industrial microbiology & biotechnology

2021 Volume 49, Issue 1

Abstract: MycG is a multifunctional P450 monooxygenase that catalyzes sequential hydroxylation and epoxidation or a single epoxidation in mycinamicin biosynthesis. In the mycinamicin-producing strain Micromonospora griseorubida A11725, very low-level accumulation ... ...

Abstract	MycG is a multifunctional P450 monooxygenase that catalyzes sequential hydroxylation and epoxidation or a single epoxidation in mycinamicin biosynthesis. In the mycinamicin-producing strain Micromonospora griseorubida A11725, very low-level accumulation of mycinamicin V generated by the initial C-14 allylic hydroxylation of MycG is observed due to its subsequent epoxidation to generate mycinamicin II, the terminal metabolite in this pathway. Herein, we investigated whether MycG can be engineered for production of the mycinamicin II intermediate as the predominant metabolite. Thus, mycG was subject to random mutagenesis and screening was conducted in Escherichia coli whole-cell assays. This enabled efficient identification of amino acid residues involved in reaction profile alterations, which included MycG R111Q/V358L, W44R, and V135G/E355K with enhanced monohydroxylation to accumulate mycinamicin V. The MycG V135G/E355K mutant generated 40-fold higher levels of mycinamicin V compared to wild-type M. griseorubida A11725. In addition, the E355K mutation showed improved ability to catalyze sequential hydroxylation and epoxidation with minimal mono-epoxidation product mycinamicin I compared to the wild-type enzyme. These approaches demonstrate the ability to selectively coordinate the catalytic activity of multifunctional P450s and efficiently produce the desired compounds.
MeSH term(s)	Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Hydroxylation ; Macrolides ; Oxidation-Reduction ; Peptide Biosynthesis
Chemical Substances	Macrolides ; Cytochrome P-450 Enzyme System (9035-51-2)
Language	English
Publishing date	2021-09-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1482484-X
ISSN	1476-5535 ; 1367-5435
ISSN (online)	1476-5535
ISSN	1367-5435
DOI	10.1093/jimb/kuab069
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Article ; Online: New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B

Yang, Lifeng / Kirikoshi, Jyunichi / Sato, Daiki / Takasugi, Mikako / Hishida, Atsuyuki / Hayashi, Shigeki / Kawahara, Nobuo / Mizukami, Megumi / Wu, Maoyu / Yamagishi, Takashi / Arai, Hirofumi

Journal of natural medicines

2020 Volume 75, Issue 1, Page(s) 28–36

Abstract: Yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica ... Oliv.) H.Ohashi) is a legume plant that the Ainu people eat as a traditional food ...

Abstract	Yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) is a legume plant that the Ainu people eat as a traditional food, although the bioactive ingredients other than vitamins have not been studied. In this study, the structures of yabumame isoflavone glucosides were determined and their effect on leukotriene (LT) B
MeSH term(s)	Fabaceae/chemistry ; Glucosides/chemistry ; Isoflavones/chemistry ; Leukotriene B4/metabolism ; Mast Cells/metabolism
Chemical Substances	Glucosides ; Isoflavones ; Leukotriene B4 (1HGW4DR56D)
Language	English
Publishing date	2020-08-16
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2227540-X
ISSN	1861-0293 ; 1340-3443
ISSN (online)	1861-0293
ISSN	1340-3443
DOI	10.1007/s11418-020-01439-0
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Article ; Online: Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody.

Miyanabe, Kazuhiro / Akiba, Hiroki / Kuroda, Daisuke / Nakakido, Makoto / Kusano-Arai, Osamu / Iwanari, Hiroko / Hamakubo, Takao / Caaveiro, Jose M M / Tsumoto, Kouhei

Journal of biochemistry

2018 Volume 164, Issue 1, Page(s) 65–76

Abstract: ... In particular, intermolecular H-bonds have been recognized as key stabilizing forces in antibody-antigen ... of intramolecular H-bonds is far less clear and not universally acknowledged. Herein, we have carried out ... a molecular-level study to dissect the contribution of intramolecular H-bonds in a flexible peptide ...

Abstract	Molecular recognition is a fundamental event at the core of essentially every biological process. In particular, intermolecular H-bonds have been recognized as key stabilizing forces in antibody-antigen interactions resulting in exquisite specificity and high affinity. Although equally abundant, the role of intramolecular H-bonds is far less clear and not universally acknowledged. Herein, we have carried out a molecular-level study to dissect the contribution of intramolecular H-bonds in a flexible peptide for the recognition by an antibody. We show that intramolecular H-bonds may have a profound, multifaceted and favorable effect on the binding affinity by up to 2 kcal mol-1 of free energy. Collectively, our results suggest that antibodies are fine tuned to recognize transiently stabilized structures of flexible peptides in solution, for which intramolecular H-bonds play a key role.
MeSH term(s)	Antibodies/chemistry ; Antigen-Antibody Reactions ; Calorimetry ; Hydrogen Bonding ; Models, Molecular ; Peptides/chemistry ; Peptides/isolation & purification ; Protein Refolding
Chemical Substances	Antibodies ; Peptides
Language	English
Publishing date	2018-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvy032
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Article ; Online: Investigation of ratio of carbon to hydrogen (C/H ratio) in agricultural plants for further estimation of their productivity of organically bound tritium.

Satoh, Yuhi / Imada, Shogo / Tani, Takashi / Ishimine, Akinobu / Arai, Ryuji

Journal of environmental radioactivity

2022 Volume 246, Page(s) 106845

Abstract: The carbon to hydrogen ratio (C/H ratio, w/w) in plants is a key factor in estimating the amount ... estimation associated with the C/H ratio is an essential parameter of the estimation model of productivity ... plants, temporal changes in the C/H ratio of six plant species (Japanese radish, cabbage, orchard grass ...

Abstract	The carbon to hydrogen ratio (C/H ratio, w/w) in plants is a key factor in estimating the amount of hydrogen in the photosynthetic product. The amount of hydrogen calculated from photosynthetic model estimation associated with the C/H ratio is an essential parameter of the estimation model of productivity of organically bound tritium (OBT) by plants. To propose a sophisticated estimation model of OBT by agricultural plants, temporal changes in the C/H ratio of six plant species (Japanese radish, cabbage, orchard grass, paddy field rice, apple, and radish) during their cultivation were investigated for each plant part. The C/H ratio in the plants cultivated in the field and growth chamber generally exceeded 6, which is the value for the primary photosynthetic monosaccharides, such as glucose and fructose (both chemical formulae, C
MeSH term(s)	Carbon ; Hydrogen ; Plants/metabolism ; Radiation Monitoring ; Tritium/analysis
Chemical Substances	Tritium (10028-17-8) ; Carbon (7440-44-0) ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1483112-0
ISSN	1879-1700 ; 0265-931X
ISSN (online)	1879-1700
ISSN	0265-931X
DOI	10.1016/j.jenvrad.2022.106845
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Article: Complement Factor H Is an Early Predictive Biomarker of the Therapeutic Efficacy of Sublingual Immunotherapy for Japanese Cedar Pollinosis.

Yoneda, Riyo / Iinuma, Tomohisa / Sakurai, Daiju / Kurita, Junya / Arai, Tomoyuki / Sonobe, Yuri / Yonekura, Syuji / Okamoto, Yoshitaka / Hanazawa, Toyoyuki

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: ... factor H was upregulated in the good response group and downregulated in the poor response group ... Complement factor H may be a useful biomarker for predicting the efficacy of sublingual immunotherapy ...

Abstract	Sublingual immunotherapy for Japanese cedar pollinosis can improve the symptoms of allergic rhinitis and modify its natural course. However, sublingual immunotherapy requires a long treatment period and some patients do not respond to treatment. In this study, we aimed to identify biomarkers that could predict the efficacy of sublingual immunotherapy at an early stage. In this study, 40 patients from phase III trials were recruited and divided into good and poor response groups. Using peripheral blood mononuclear cells from before and two months after the start of medication, microarray, discriminant analysis, and real-time polymerase chain reaction were performed to extract candidate genes that could be biomarkers. Furthermore, these genes were validated in 30 patients in general clinical practice. Complement factor H was upregulated in the good response group and downregulated in the poor response group. Complement factor H may be a useful biomarker for predicting the efficacy of sublingual immunotherapy for Japanese cedar pollinosis at early time points after treatment initiation.
Language	English
Publishing date	2022-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11111280
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Article: Availability of 24-h urine collection method on dietary phosphorus intake estimation.

Sakuma, Masae / Morimoto, Yuuka / Suzuki, Yukie / Suzuki, Akitsu / Noda, Saaya / Nishino, Kanaho / Ando, Sakiko / Ishikawa, Makoto / Arai, Hidekazu

Journal of clinical biochemistry and nutrition

2016 Volume 60, Issue 2, Page(s) 125–129

Abstract: ... of this study was to evaluate the 24-h urine collection method for estimation of phosphate intake in healthy ... subjects consumed test meals, 24-h urine collection was performed, and blood samples were obtained ... supplementation. Our results indicate that estimation of dietary phosphorus intake with the 24-h urine collection ...

Abstract	Accurate assessment of dietary phosphorus intake is necessary to prevent hyperphosphatemia. The aim of this study was to evaluate the 24-h urine collection method for estimation of phosphate intake in healthy males. Two experiments, a 1-day and a 5-day loading test, were performed. After an overnight fast, subjects consumed test meals, 24-h urine collection was performed, and blood samples were obtained. In the 5-day loading test, a phosphorus supplement was orally administered on day 3. The association between the phosphorus content of test meals and urinary excretion, anthropometric indices, and blood biomarkers was analyzed to develop a more precise formula for estimating phosphorus intake. In the 1-day loading test, the standard deviation of predictive phosphorus intake, based on multiple linear regression analysis, was less than that for the phosphorus absorption rate. In the 5-day loading test, urinary phosphorus excretion was similar on days 2, 4 and 5, but was significantly higher on day 3 after phosphorus supplementation. Our results indicate that estimation of dietary phosphorus intake with the 24-h urine collection method, using the amount of phosphorus and urea nitrogen excretion, may increase the precision of short-term monitoring.
Language	English
Publishing date	2016-12-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632945-7
ISSN	1880-5086 ; 0912-0009
ISSN (online)	1880-5086
ISSN	0912-0009
DOI	10.3164/jcbn.16-50
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