Article ; Online: Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy.
2020 Volume 166, Page(s) 107935
Abstract: Neuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Intraplantar formalin injection produces local necrosis over a two-week period and has been used to model neuropathy in rats. To determine ... ...
Abstract | Neuropathy is major source of chronic pain that can be caused by mechanically or chemically induced nerve injury. Intraplantar formalin injection produces local necrosis over a two-week period and has been used to model neuropathy in rats. To determine whether neuropathy alters dopamine (DA) receptor responsiveness in mesolimbic brain regions, we examined dopamine D |
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MeSH term(s) | Animals ; Conditioning, Operant/drug effects ; Conditioning, Operant/physiology ; Disease Models, Animal ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Formaldehyde/toxicity ; Male ; Neuralgia/chemically induced ; Neuralgia/metabolism ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/antagonists & inhibitors ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/agonists ; Receptors, Dopamine D2/metabolism ; Signal Transduction/drug effects ; Signal Transduction/physiology |
Chemical Substances | DRD2 protein, rat ; Dopamine Agonists ; Dopamine Antagonists ; Drd1 protein, rat ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Formaldehyde (1HG84L3525) |
Language | English |
Publishing date | 2020-01-07 |
Publishing country | England |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ZDB-ID | 218272-5 |
ISSN | 1873-7064 ; 0028-3908 |
ISSN (online) | 1873-7064 |
ISSN | 0028-3908 |
DOI | 10.1016/j.neuropharm.2020.107935 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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