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  1. Article ; Online: Progress for patients with melanoma brain metastases.

    Sperduto, Paul W / Salama, April K S / Anders, Carey

    Neuro-oncology

    2023  Volume 25, Issue 7, Page(s) 1321–1322

    MeSH term(s) Humans ; Melanoma/pathology ; Brain Neoplasms/pathology
    Language English
    Publishing date 2023-03-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noad050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5307: Show issues Location:
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  2. Article ; Online: Screening brain MRI in inflammatory breast cancer: Is it time?

    Dhakal, Ajay / Anders, Carey K

    Cancer

    2022  Volume 128, Issue 23, Page(s) 4055–4057

    MeSH term(s) Humans ; Female ; Inflammatory Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer ; Breast Neoplasms/diagnostic imaging ; Mass Screening ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Mammography ; Breast/diagnostic imaging
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.34442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.146: Show issues Location:
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  3. Article ; Online: Management of Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: ASCO Guideline Update Q and A.

    Ramakrishna, Naren / Anders, Carey K / Temin, Sarah

    JCO oncology practice

    2022  Volume 18, Issue 11, Page(s) 756–758

    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Receptor, ErbB-2/metabolism ; Brain Neoplasms/therapy ; Breast
    Chemical Substances ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7198: Show issues Location:
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  4. Article ; Online: Nivolumab plus ipilimumab in melanoma brain metastases - Authors' reply.

    Tawbi, Hussein A / Eroglu, Zeynep / Anders, Carey K / Margolin, Kim A

    The Lancet. Oncology

    2022  Volume 23, Issue 2, Page(s) e54

    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(22)00033-X
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    Zs.MO 460: Show issues

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  5. Article ; Online: Triple Negative Breast Cancer and Brain Metastases.

    Bansal, Rani / Van Swearingen, Amanda E D / Anders, Carey K

    Clinical breast cancer

    2023  Volume 23, Issue 8, Page(s) 825–831

    Abstract: The treatment of metastatic breast cancer (MBC) has improved over the past decade, however prognosis continues to be mitigated by the fact that about 1 in 5 patients with MBC will develop brain metastases (BrM) during their metastatic disease course. 1 ... ...

    Abstract The treatment of metastatic breast cancer (MBC) has improved over the past decade, however prognosis continues to be mitigated by the fact that about 1 in 5 patients with MBC will develop brain metastases (BrM) during their metastatic disease course. 1 This number is even higher for patients with triple-negative breast cancer (TNBC), with studies showing as high as 40% of patients developing BrM. 2, 3 Studies have shown that TNBC portends a worse survival after a diagnosis of BrM compared with non-TNBC subtypes. 4 Given the unique location and biologic properties of BrM, treatment options have historically been limited. Challenges to the treatment of TNBC BrM include a lack of targeted therapies and difficulties in delivery of drug to the brain past the blood-brain barrier (BBB). Herein, we will review the advances in local and systemic therapies to most effectively treat patients with TNBC BrM, including therapies on the horizon currently in clinical trials.
    MeSH term(s) Humans ; Female ; Triple Negative Breast Neoplasms/pathology ; Breast Neoplasms/pathology ; Prognosis ; Disease Progression ; Brain Neoplasms/therapy ; Brain Neoplasms/secondary
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2106734-X
    ISSN 1938-0666 ; 1526-8209
    ISSN (online) 1938-0666
    ISSN 1526-8209
    DOI 10.1016/j.clbc.2023.07.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5800: Show issues Location:
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    Zs.MO 498: Show issues

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  6. Article ; Online: Available Systemic Treatments and Emerging Therapies for Breast Cancer Brain Metastases.

    Rader, Ryan K / Anders, Carey K / Lin, Nancy U / Sammons, Sarah L

    Current treatment options in oncology

    2023  Volume 24, Issue 6, Page(s) 611–627

    Abstract: Opinion statement: In 2023, breast cancer brain metastases (BCBrM) remain a major clinical challenge gaining well-deserved attention. Historically managed with local therapies alone, systemic therapies including small molecule inhibitors and antibody- ... ...

    Abstract Opinion statement: In 2023, breast cancer brain metastases (BCBrM) remain a major clinical challenge gaining well-deserved attention. Historically managed with local therapies alone, systemic therapies including small molecule inhibitors and antibody-drug conjugates (ADCs) have shown unprecedented activity in recent trials including patients with brain metastases. These advancements stem from efforts to include patients with stable and active BCBrM in early- and late-phase trial design. Tucatinib added to trastuzumab and capecitabine improves intracranial and extracranial progression-free survival and overall survival in stable and active human epidermal growth factor receptor 2 (HER2+)-positive brain metastases. Trastuzumab deruxtecan (T-DXd) has both shown impressive intracranial activity in stable and active HER2+ BCBrMs challenging historical thinking of ADCs' inability to penetrate the central nervous system (CNS). T-DXd has shown potent activity in HER2-low (immunohistochemistry scores of 1+ or 2+, non-amplified by fluorescence in situ hybridization) metastatic breast cancer and will be studied in HER2-low BCBrM as well. Novel endocrine therapies including oral selective estrogen downregulators (SERDs) and complete estrogen receptor antagonists (CERANs) are being studied in hormone receptor-positive BCBrM clinical trials due to robust intracranial activity in preclinical models. Triple-negative breast cancer (TNBC) brain metastases continue to portend the worst prognosis of all subtypes. Clinical trials leading to the approval of immune checkpoint inhibitors have enrolled few BCBrM patients leading to a lack of understanding of immunotherapies contribution in this subgroup. Data surrounding the use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in patients with germline BRCA mutation carriers with CNS disease is hopeful. ADCs including those targeting low-level HER2 expression and TROP2 are under active investigation in triple-negative BCBrMs.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/pathology ; In Situ Hybridization, Fluorescence ; Trastuzumab ; Receptor, ErbB-2 ; Brain Neoplasms/drug therapy ; Capecitabine ; Prognosis ; Triple Negative Breast Neoplasms/drug therapy
    Chemical Substances Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Capecitabine (6804DJ8Z9U)
    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-023-01086-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5523: Show issues Location:
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  7. Article: Editorial: It takes a village: The expanding multi-disciplinary approach to brain metastasis.

    Fecci, Peter E / Rao, Ganesh / Brastianos, Priscilla K / Dunn, Gavin P / Anders, Carey K

    Frontiers in oncology

    2022  Volume 12, Page(s) 1054490

    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1054490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Management of brain metastases in breast cancer.

    Anders, Carey K

    Clinical advances in hematology & oncology : H&O

    2016  Volume 14, Issue 9, Page(s) 686–688

    MeSH term(s) Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Breast Neoplasms/pathology ; Female ; Humans ; Prognosis
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6505: Show issues Location:
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  9. Article ; Online: Unique genomic alterations in the circulating tumor DNA of patients with solid tumors brain metastases.

    Alder, Laura / Broadwater, Gloria / Green, Michelle / Van Swearingen, Amanda E D / Lipp, Eric S / Clarke, Jeffrey Melson / Anders, Carey K / Sammons, Sarah

    Neuro-oncology advances

    2024  Volume 6, Issue 1, Page(s) vdae052

    Abstract: Background: Although serum circulating tumor DNA (ctDNA) is routine, data from patients with brain metastases (BrMs) is limited. We assessed genomic alterations in ctDNA from patients with solid tumor BrMs in 3 groups: Isolated BrMs with stable ... ...

    Abstract Background: Although serum circulating tumor DNA (ctDNA) is routine, data from patients with brain metastases (BrMs) is limited. We assessed genomic alterations in ctDNA from patients with solid tumor BrMs in 3 groups: Isolated BrMs with stable extracranial disease (iCNS), concurrent brain and extracranial progression (cCNS), and extracranial progression with no active BrMs (eCNS). We also compared ctDNA alterations between patients with and without BrMs.
    Methods: Patients with a Guardant360 ctDNA profile with (
    Results: Among the 253 patients with BrMs: 29 (12%) had iCNS, 160 (63%) cCNS, and 64 (25%) eCNS. Breast (BC; 12.0%) and non-small cell lung cancer (NSCLC; 76.4%) were the most common tumor types.
    Conclusions: This study illustrates the feasibility of detecting alterations from ctDNA among patients with BrMs. A higher frequency of actionable mutations was observed in ctDNA in patients with BrMs. Additional studies comparing ctDNA and alterations in BrMs tissue are needed to determine if ctDNA can be considered a surrogate to support treatment decisions.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdae052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Special issue: advances in the multimodality management of brain metastases and ongoing approaches to further improve their treatment.

    Zuccato, Jeffrey A / Zadeh, Gelareh / Anders, Carey K / Shultz, David B / Brastianos, Priscilla K

    Neuro-oncology advances

    2021  Volume 3, Issue Suppl 5, Page(s) v1–v3

    Language English
    Publishing date 2021-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdab157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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