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Article: A Partial C

Lin, HsiangChun / Arrivault, Stéphanie / Coe, Robert A / Karki, Shanta / Covshoff, Sarah / Bagunu, Efren / Lunn, John E / Stitt, Mark / Furbank, Robert T / Hibberd, Julian M / Quick, William Paul

Frontiers in plant science

2020 Volume 11, Page(s) 564463

Abstract: Introduction of a C ...

Abstract	Introduction of a C
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.564463
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Article ; Online: Installation of C

Ermakova, Maria / Arrivault, Stéphanie / Giuliani, Rita / Danila, Florence / Alonso-Cantabrana, Hugo / Vlad, Daniela / Ishihara, Hirofumi / Feil, Regina / Guenther, Manuela / Borghi, Gian Luca / Covshoff, Sarah / Ludwig, Martha / Cousins, Asaph B / Langdale, Jane A / Kelly, Steven / Lunn, John E / Stitt, Mark / von Caemmerer, Susanne / Furbank, Robert T

Plant biotechnology journal

2020 Volume 19, Issue 3, Page(s) 575–588

Abstract: Introduction of a C ...

Abstract	Introduction of a C
MeSH term(s)	Malate Dehydrogenase/genetics ; Malate Dehydrogenase/metabolism ; Oryza/genetics ; Oryza/metabolism ; Phosphoenolpyruvate Carboxylase/genetics ; Phosphoenolpyruvate Carboxylase/metabolism ; Photosynthesis ; Pyruvate, Orthophosphate Dikinase/genetics ; Pyruvate, Orthophosphate Dikinase/metabolism ; Zea mays/metabolism
Chemical Substances	Malate Dehydrogenase (EC 1.1.1.37) ; Pyruvate, Orthophosphate Dikinase (EC 2.7.9.1) ; Phosphoenolpyruvate Carboxylase (EC 4.1.1.31)
Language	English
Publishing date	2020-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.13487
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Article ; Online: Spliceosomal complex components are critical for adjusting the C:N balance during high-light acclimation.

Araguirang, Gali Estopare / Venn, Benedikt / Kelber, Nadja-Magdalena / Feil, Regina / Lunn, John / Kleine, Tatjana / Leister, Dario / Mühlhaus, Timo / Richter, Andreas S

The Plant journal : for cell and molecular biology

2024

Abstract: Plant acclimation to an ever-changing environment is decisive for growth, reproduction, and survival. Light availability limits biomass production on both ends of the intensity spectrum. Therefore, the adjustment of plant metabolism is central to high- ... ...

Abstract	Plant acclimation to an ever-changing environment is decisive for growth, reproduction, and survival. Light availability limits biomass production on both ends of the intensity spectrum. Therefore, the adjustment of plant metabolism is central to high-light (HL) acclimation, and the accumulation of photoprotective anthocyanins is commonly observed. However, mechanisms and factors regulating the HL acclimation response are less clear. Two Arabidopsis mutants of spliceosome components exhibiting a pronounced anthocyanin overaccumulation in HL were isolated from a forward genetic screen for new factors crucial for plant acclimation. Time-resolved physiological, transcriptome, and metabolome analysis revealed a vital function of the spliceosome components for rapidly adjusting gene expression and metabolism. Deficiency of INCREASED LEVEL OF POLYPLOIDY1 (ILP1), NTC-RELATED PROTEIN1 (NTR1), and PLEIOTROPIC REGULATORY LOCUS1 (PRL1) resulted in a marked overaccumulation of carbohydrates and strongly diminished amino acid biosynthesis in HL. While not generally limited in N-assimilation, ilp1, ntr1, and prl1 showed higher glutamate levels and reduced amino acid biosynthesis in HL. The comprehensive analysis reveals a function of the spliceosome components in the conditional regulation of the carbon:nitrogen balance and the accumulation of anthocyanins during HL acclimation. The importance of gene expression, metabolic regulation, and re-direction of carbon towards anthocyanin biosynthesis for HL acclimation are discussed.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16751
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Article ; Online: Preliminary Evaluation of Stability Data for Dolutegravir-Containing Triple Active Formulations Intended for PEPFAR. Degradation of Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide as the Limiting Factor.

Lunn, George

Journal of pharmaceutical sciences

2023 Volume 112, Issue 6, Page(s) 1733–1739

Abstract: ... Bottles are stored at 30 °C/75% RH and opened for about 1 min a day. Water content increased significantly ...

Abstract	FDA reviews applications that are filed under the PEPFAR program to ensure that these products are manufactured to FDA's stringent requirements. Dolutegravir is a comparatively recent molecular entity that represents an advance over previous products. The stability behaviors of tablets that contain dolutegravir, lamivudine, and tenofovir disoproxil fumarate and tablets that contain dolutegravir, emtricitabine and tenofovir alafenamide were surveyed and it was found that tenofovir-related degradants increase the most and are the parameters most likely to result in product failure. A desiccant is advantageous and this desiccant should remain in the bottle after it has been opened. In-use studies simulate consumer use. Bottles are stored at 30 °C/75% RH and opened for about 1 min a day. Water content increased significantly and the rate of degradation was faster than the degradation rate observed during long-term storage. The data predict that most formulations containing TDF will stay within specification over 4 years of long-term storage followed by dispensing one tablet per day. With the current data it appears that some TAF-containing formulations may fail under similar conditions. However, the data are limited and preliminary and it is possible that the situation may improve as more stability data are acquired.
MeSH term(s)	Humans ; Tenofovir ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; Hygroscopic Agents/therapeutic use ; Adenine ; Tablets ; Alanine
Chemical Substances	Tenofovir (99YXE507IL) ; dolutegravir (DKO1W9H7M1) ; Anti-HIV Agents ; Hygroscopic Agents ; Adenine (JAC85A2161) ; Tablets ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3151-3
ISSN	1520-6017 ; 0022-3549
ISSN (online)	1520-6017
ISSN	0022-3549
DOI	10.1016/j.xphs.2023.01.018
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Article ; Online: c-Jun expression in human neuropathies: a pilot study.

Hutton, Elspeth J / Carty, Lucy / Laurá, Matilde / Houlden, Henry / Lunn, Michael P T / Brandner, Sebastian / Mirsky, Rhona / Jessen, Kristjan / Reilly, Mary M

Journal of the peripheral nervous system : JPNS

2011 Volume 16, Issue 4, Page(s) 295–303

Abstract: ... axonal regrowth. Animal studies have shown that the transcription factor c-Jun is upregulated ... whether c-Jun is also upregulated in human neuropathies. We examined c-Jun expression in normal and diseased ... c-Jun is rarely expressed in normal nerves, it is expressed in Schwann cell nuclei of pathological ...

Abstract	Schwann cell dedifferentiation following nerve injury is important to permit neural survival and axonal regrowth. Animal studies have shown that the transcription factor c-Jun is upregulated in Schwann cells of injured and pathological nerves where it acts as an important regulator of Schwann cell plasticity, promoting dedifferentiation and demyelination. This pilot immunohistochemical study investigates whether c-Jun is also upregulated in human neuropathies. We examined c-Jun expression in normal and diseased human nerves, as well as in dermal myelinated nerve fibres. Our findings show that although as predicted c-Jun is rarely expressed in normal nerves, it is expressed in Schwann cell nuclei of pathological nerves as predicted by animal studies. Pathological dermal myelinated nerve fibres also show clear nuclear c-Jun expression. Further studies of c-Jun expression will help clarify its role in human neuropathies.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Immunohistochemistry ; Infant ; Male ; Middle Aged ; Nerve Fibers, Myelinated/metabolism ; Nerve Fibers, Myelinated/pathology ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/pathology ; Pilot Projects ; Proto-Oncogene Proteins c-jun/analysis ; Proto-Oncogene Proteins c-jun/biosynthesis ; Schwann Cells/metabolism ; Skin/innervation ; Skin/metabolism ; Young Adult
Chemical Substances	Proto-Oncogene Proteins c-jun
Language	English
Publishing date	2011-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1364009-4
ISSN	1529-8027 ; 1085-9489
ISSN (online)	1529-8027
ISSN	1085-9489
DOI	10.1111/j.1529-8027.2011.00360.x
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Article ; Online: Gene families and evolution of trehalose metabolism in plants.

Lunn, John E

Functional plant biology : FPB

2020 Volume 34, Issue 6, Page(s) 550–563

Abstract: ... of the Brassicaceae family. The class II TPS genes encode TPS-like proteins with a C-terminal TPP-like domain ...

Abstract	The genomes of Arabidopsis thaliana L., rice (Oryza sativa L.) and poplar (Populus trichocarpa Torr. & A.Gray) contain large families of genes encoding trehalose-phosphate synthase (TPS) and trehalose-phosphatase (TPP). The class I subfamily of TPS genes encodes catalytically active TPS enzymes, and is represented by only one or two genes in most species. A. thaliana is atypical in having four class I TPS genes, three of which (AtTPS2-4) encode unusual short isoforms of TPS that appear to be found only in members of the Brassicaceae family. The class II TPS genes encode TPS-like proteins with a C-terminal TPP-like domain, but there is no experimental evidence that they have any enzymatic activity and their function is unknown. Both classes of TPS gene are represented in the genomes of chlorophyte algae (Ostreococcus species) and non-flowering plants [Physcomitrella patens (Hedw.) Bruch & Schimp.(B.S.G.) and Selaginella moellendorffii (Hieron. in Engl. & Prantl.)]. This survey shows that the gene families encoding the enzymes of trehalose metabolism are very ancient, pre-dating the divergence of the streptophyte and chlorophyte lineages. It also provides a frame of reference for future studies to elucidate the function of trehalose metabolism in plants.
Language	English
Publishing date	2020-07-21
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP06315
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Article ; Online: Hydroxyapatite coatings on cement paste as barriers against radiological contamination.

Cumberland, Susan A / Hamilton, Andrea / Renshaw, Joanna C / Tierney, Kieran M / Lunn, Rebecca J

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11136

Abstract: A novel method for precipitating hydroxyapatite (HAp) onto cement paste is investigated for protecting concrete infrastructure from radiological contamination. Legacy nuclear sites contain large volumes of contaminated concrete and are expensive and ... ...

Abstract	A novel method for precipitating hydroxyapatite (HAp) onto cement paste is investigated for protecting concrete infrastructure from radiological contamination. Legacy nuclear sites contain large volumes of contaminated concrete and are expensive and dangerous to decommission. One solution is to 'design for decommissioning' by confining contaminants to a thin layer. Current layering methods, including paints or films, offer poor durability over plant lifespans. Here, we present a mineral-HAp-coated cement, which innovatively serves as a barrier layer to radioactive contaminants (e.g. Sr, U). HAp is shown to directly mineralise onto a cement paste block in a layer several microns thick via a two-step process: first, applying a silica-based scaffold onto a cement paste block; and second, soaking the resulting block in a PO
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37822-6
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Article ; Online: Direct and indirect responses of the Arabidopsis transcriptome to an induced increase in trehalose 6-phosphate.

Avidan, Omri / Martins, Marina C M / Feil, Regina / Lohse, Marc / Giorgi, Federico M / Schlereth, Armin / Lunn, John E / Stitt, Mark

Plant physiology

2024

Abstract: ... pointing toward Tre6P interacting with other C-signaling pathways. Additionally, elevated Tre6P modified ...

Abstract	Trehalose 6-phosphate (Tre6P) is an essential signal metabolite that regulates the level of sucrose, linking growth and development to the metabolic status. We hypothesized that Tre6P plays a role in mediating the regulation of gene expression by sucrose. To test this, we performed transcriptomic profiling on Arabidopsis (Arabidopsis thaliana) plants that expressed a bacterial TREHALOSE 6-PHOSPHATE SYNTHASE (TPS) under the control of an ethanol-inducible promoter. Induction led to a 4-fold rise in Tre6P levels, a concomitant decrease in sucrose, significant changes (FDR ≤ 0.05) of over 13,000 transcripts, and two-fold or larger changes of over 5000 transcripts. Comparison with nine published responses to sugar availability allowed some of these changes to be linked to the rise in Tre6P, while others were probably due to lower sucrose or other indirect effects. Changes linked to Tre6P included repression of photosynthesis-related gene expression and induction of many growth-related processes including ribosome biogenesis. About 500 starvation-related genes are known to be induced by SUCROSE-NON-FERMENTING-1-RELATED KINASE 1 (SnRK1). They were largely repressed by Tre6P in a manner consistent with SnRK1 inhibition by Tre6P. SnRK1 also represses many genes that are involved in biosynthesis and growth. These responded to Tre6P in a more complex manner, pointing toward Tre6P interacting with other C-signaling pathways. Additionally, elevated Tre6P modified the expression of genes encoding regulatory subunits of the SnRK1 complex and TPS class II and FCS-LIKE ZINC FINGER proteins that are thought to modulate SnRK1 function and genes involved in circadian, TARGET OF RAPAMYCIN-, light, abscisic acid, and other hormone signaling.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1093/plphys/kiae196
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Article ; Online: Updated ACVIM consensus statement on equine herpesvirus-1.

Lunn, David P / Burgess, Brandy A / Dorman, David C / Goehring, Lutz S / Gross, Peggy / Osterrieder, Klaus / Pusterla, Nicola / Soboll Hussey, Gisela

Journal of veterinary internal medicine

2024

Abstract: Equine herpesvirus-1 (EHV-1) is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). The previous consensus statement was ... ...

Abstract	Equine herpesvirus-1 (EHV-1) is a highly prevalent and frequently pathogenic infection of equids. The most serious clinical consequences of infection are abortion and equine herpesvirus myeloencephalopathy (EHM). The previous consensus statement was published in 2009 and considered pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment. A recent survey of American College of Veterinary Internal Medicine large animal diplomates identified the need for a revision to this original consensus statement. This updated consensus statement is underpinned by 4 systematic reviews that addressed key questions concerning vaccination, pharmaceutical treatment, pathogenesis, and diagnostic testing. Evidence for successful vaccination against, or effective treatment of EHV-1 infection was limited, and improvements in experimental design and reporting of results are needed in future studies of this important disease. This consensus statement also updates the topics considered previously in 2009.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.17047
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Article: The Evolution of Scientific Visualisations: A Case Study Approach to Big Data for Varied Audiences.

Lunn, Andrew J / Shaw, Vivien / Winder, Isabelle C

Advances in experimental medicine and biology

2022 Volume 1388, Page(s) 51–84

Abstract: Visual representations of complex data are a cornerstone of how scientific information is shared. By taking large quantities of data and creating accessible visualisations that show relationships, patterns, outliers, and conclusions, important research ... ...

Abstract	Visual representations of complex data are a cornerstone of how scientific information is shared. By taking large quantities of data and creating accessible visualisations that show relationships, patterns, outliers, and conclusions, important research can be communicated effectively to any audience. The nature of animal cognition is heavily debated with no consensus on what constitutes animal intelligence. Over the last half-century, the methods used to define intelligence have evolved to incorporate larger datasets and more complex theories-moving from relatively simple comparisons of brain mass and body mass to explorations of brain composition and how neuron count changes between specific groups of animals. The primary aim of this chapter is therefore to explore how visualisation choice influences the accessibility of complex scientific information, using animal cognition as a case study. As the datasets concerned with animal intelligence have increased in both size and complexity, have the visualisations that accompany them evolved as well? We first investigate how the basic presentation of visualisations (figure legends, inclusion of statistics, use of colour, etc.) has changed, before discussing alternative approaches that might improve communication with both scientific and general audiences. By building upon the types of visualisation techniques that everyone is taught at school (bar charts, XY scatter plots, pie charts, etc.), we show how small changes can improve our communication with both scientific and general audiences. We suggest that there is no single right way to visualise data, but careful consideration of the audience and the specific message can help, even where communications are constrained by time, technology, or medium.
MeSH term(s)	Animals ; Big Data ; Brain ; Cognition/physiology
Language	English
Publishing date	2022-09-14
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-031-10889-1_3
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