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  1. Article ; Online: Knowledge and vaccination practices among family physicians in northeastern France regarding tick-borne encephalitis virus.

    Dollat, Marie / Bellanger, Anne-Pauline / Millon, Laurence / Chirouze, Catherine / Lepiller, Quentin / Marguet, Philippe

    Ticks and tick-borne diseases

    2021  Volume 12, Issue 5, Page(s) 101774

    Abstract: Tick-borne encephalitis (TBE) cases have been emerging in Europe. The Franche-Comte area, in northeastern France, borders Switzerland, but the two countries differ in their approach to TBE surveillance and prevention. Because family physicians (FPs) are ... ...

    Abstract Tick-borne encephalitis (TBE) cases have been emerging in Europe. The Franche-Comte area, in northeastern France, borders Switzerland, but the two countries differ in their approach to TBE surveillance and prevention. Because family physicians (FPs) are in direct contact with the local population, at-risk of infected tick bites, they need to be well aware of TBE epidemiology and management. An observational survey was performed in 2019 in order to investigate Franche-Comte physicians' knowledge and vaccination practices with regard to TBE. Standardized online questionnaires were sent to a list of FPs practicing in Franche-Comte. The questionnaires included socio-demographic details, questions about TBE knowledge, symptomatology and vaccination. The response rate was 14.7%. FPs practicing in rural areas reported a significantly higher frequency of consultations for tick bites. While 81% of FPs indicated that they had some knowledge about TBE, only 20% were at ease with its clinical symptomatology. Thirty-one % of the FP participants performed TBE vaccinations. A general lack of knowledge about TBE and its clinical symptoms was observed in this survey. FPs play an essential role in screening and preventing TBE, especially those practicing in rural areas and in areas bordering Switzerland.
    MeSH term(s) Clinical Competence/statistics & numerical data ; Encephalitis Viruses, Tick-Borne ; Encephalitis, Tick-Borne/psychology ; France ; Immunization Programs ; Physicians, Family/statistics & numerical data ; Surveys and Questionnaires ; Vaccination/psychology
    Language English
    Publishing date 2021-06-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2021.101774
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  2. Article ; Online: Moving the Dial on Airway Inflammation in Response to Trikafta in Adolescents with Cystic Fibrosis.

    Lepissier, Agathe / Bonnel, Anne Sophie / Wizla, Nathalie / Weiss, Laurence / Mittaine, Marie / Bessaci, Katia / Kerem, Eitan / Houdouin, Véronique / Reix, Philippe / Marguet, Christophe / Sermet-Gaudelus, Isabelle

    American journal of respiratory and critical care medicine

    2023  Volume 207, Issue 6, Page(s) 792–795

    MeSH term(s) Adolescent ; Humans ; Cystic Fibrosis ; Respiratory System ; Aminophenols ; Inflammation ; Cystic Fibrosis Transmembrane Conductance Regulator
    Chemical Substances elexacaftor, ivacaftor, tezacaftor drug combination ; Aminophenols ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202210-1938LE
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  3. Article ; Online: COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?

    Lejeune, Stéphanie / Bouazza, Naïm / Nicaise, Pascale Roland / Jolaine, Valérie / Roditis, Léa / Marguet, Christophe / Amat, Flore / Berger, Patrick / Fayon, Michael / Dubus, Jean-Christophe / Valois, Sophie / Reix, Philippe / Pellan, Mathieu / Brouard, Jacques / Chiron, Raphael / Giovannini-Chami, Lisa / de Blic, Jacques / Deschildre, Antoine / Lezmi, Guillaume

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2024  Volume 35, Issue 3, Page(s) e14112

    Abstract: Background: It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether ... ...

    Abstract Background: It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with non-severe recurrent wheeze (NSRW)/non-severe asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA.
    Methods: IgE to 112 components (c-sIgE) (ImmunoCAP® ISAC) were analyzed in 125 preschools (3-6 years) and 170 school-age children (7-12 years). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive c-sIgE.
    Results: We observed c-sIgE sensitization in 51% of preschool and 75% of school-age children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p < .01). Sensitization to non-specific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p < .01) and associated with an FEV1/FVC < -1.64 z-score. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by "few sensitizations, mainly to HDM." One cluster (n = 4) with "multiple sensitizations, mainly to grass pollen, HDM, PR-10, and nsLTP" was associated with SA in school-age children.
    Conclusions: Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgE- and non-IgE-mediated mechanisms.
    MeSH term(s) Child ; Child, Preschool ; Animals ; Humans ; Allergens ; Immunoglobulin E ; Asthma/diagnosis ; Asthma/epidemiology ; Pyroglyphidae ; Dermatophagoides pteronyssinus ; Respiratory Sounds
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.14112
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  4. Article ; Online: Prenatal Alcohol Exposure Impairs the Placenta-Cortex Transcriptomic Signature, Leading to Dysregulation of Angiogenic Pathways.

    Sautreuil, Camille / Lecointre, Maryline / Derambure, Céline / Brasse-Lagnel, Carole / Leroux, Philippe / Laquerrière, Annie / Nicolas, Gaël / Gil, Sophie / Savage, Daniel D / Marret, Stéphane / Marguet, Florent / Falluel-Morel, Anthony / Gonzalez, Bruno J

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: Although alcohol consumption during pregnancy is a major cause of behavioral and learning disabilities, most FASD infants are late- or even misdiagnosed due to clinician's difficulties achieving early detection of alcohol-induced neurodevelopmental ... ...

    Abstract Although alcohol consumption during pregnancy is a major cause of behavioral and learning disabilities, most FASD infants are late- or even misdiagnosed due to clinician's difficulties achieving early detection of alcohol-induced neurodevelopmental impairments. Neuroplacentology has emerged as a new field of research focusing on the role of the placenta in fetal brain development. Several studies have reported that prenatal alcohol exposure (PAE) dysregulates a functional placenta-cortex axis, which is involved in the control of angiogenesis and leads to neurovascular-related defects. However, these studies were focused on PlGF, a pro-angiogenic factor. The aim of the present study is to provide the first transcriptomic "placenta-cortex" signature of the effects of PAE on fetal angiogenesis. Whole mouse genome microarrays of paired placentas and cortices were performed to establish the transcriptomic inter-organ "placenta-cortex" signature in control and PAE groups at gestational day 20. Genespring comparison of the control and PAE signatures revealed that 895 and 1501 genes were only detected in one of two placenta-cortex expression profiles, respectively. Gene ontology analysis indicated that 107 of these genes were associated with vascular development, and String protein-protein interaction analysis showed that they were associated with three functional clusters. PANTHER functional classification analysis indicated that "intercellular communication" was a significantly enriched biological process, and 27 genes were encoded for neuroactive ligand/receptors interactors. Protein validation experiments involving Western blot for one ligand-receptor couple (Agt/AGTR1/2) confirmed the transcriptomic data, and Pearson statistical analysis of paired placentas and fetal cortices revealed a negative correlation between placental Atg and cortical AGTR1, which was significantly impacted by PAE. In humans, a comparison of a 38WG control placenta with a 36WG alcohol-exposed placenta revealed low Agt immunolabeling in the syncytiotrophoblast layer of the alcohol case. In conclusion, this study establishes the first transcriptomic placenta-cortex signature of a developing mouse. The data show that PAE markedly unbalances this inter-organ signature; in particular, several ligands and/or receptors involved in the control of angiogenesis. These data support that PAE modifies the existing communication between the two organs and opens new research avenues regarding the impact of placental dysfunction on the neurovascular development of fetuses. Such a signature would present a clinical value for early diagnosis of brain defects in FASD.
    MeSH term(s) Pregnancy ; Infant ; Female ; Humans ; Animals ; Mice ; Transcriptome ; Fetal Alcohol Spectrum Disorders/genetics ; Ligands ; Placenta ; Prenatal Exposure Delayed Effects/genetics
    Chemical Substances Ligands
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713484
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  5. Article: Knowledge and vaccination practices among family physicians in northeastern France regarding tick-borne encephalitis virus

    Dollat, Marie / Bellanger, Anne-Pauline / Millon, Laurence / Chirouze, Catherine / Lepiller, Quentin / Marguet, Philippe

    Ticks and tick-borne diseases. 2021 Sept., v. 12, no. 5

    2021  

    Abstract: Tick-borne encephalitis (TBE) cases have been emerging in Europe. The Franche-Comte area, in northeastern France, borders Switzerland, but the two countries differ in their approach to TBE surveillance and prevention. Because family physicians (FPs) are ... ...

    Abstract Tick-borne encephalitis (TBE) cases have been emerging in Europe. The Franche-Comte area, in northeastern France, borders Switzerland, but the two countries differ in their approach to TBE surveillance and prevention. Because family physicians (FPs) are in direct contact with the local population, at-risk of infected tick bites, they need to be well aware of TBE epidemiology and management. An observational survey was performed in 2019 in order to investigate Franche-Comte physicians’ knowledge and vaccination practices with regard to TBE. Standardized online questionnaires were sent to a list of FPs practicing in Franche-Comte. The questionnaires included socio-demographic details, questions about TBE knowledge, symptomatology and vaccination. The response rate was 14.7%. FPs practicing in rural areas reported a significantly higher frequency of consultations for tick bites. While 81% of FPs indicated that they had some knowledge about TBE, only 20% were at ease with its clinical symptomatology. Thirty-one % of the FP participants performed TBE vaccinations. A general lack of knowledge about TBE and its clinical symptoms was observed in this survey. FPs play an essential role in screening and preventing TBE, especially those practicing in rural areas and in areas bordering Switzerland.
    Keywords Tick-borne encephalitis virus ; direct contact ; monitoring ; surveys ; tick-borne encephalitis ; ticks ; vaccination ; France ; Switzerland
    Language English
    Dates of publication 2021-09
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2021.101774
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: A survey investigating the current practice of French health professionals regarding infection risk after monkey bites.

    Gauthier, Pauline / Bellanger, Anne-Pauline / Bozon, Fabienne / Lepiller, Quentin / Chirouze, Catherine / Marguet, Philippe

    Zoonoses and public health

    2019  Volume 67, Issue 2, Page(s) 193–197

    Abstract: International tourism is steadily increasing, with 15% of travellers reporting health problems when they come back. Animal bites represent 2% of consulting causes, of which 20% are due to monkey bites. The Monkey B virus (Macacine alphaherpesvirus 1) is ... ...

    Abstract International tourism is steadily increasing, with 15% of travellers reporting health problems when they come back. Animal bites represent 2% of consulting causes, of which 20% are due to monkey bites. The Monkey B virus (Macacine alphaherpesvirus 1) is an alphaherpesvirus (Herpesviridae, genus Simplexvirus) enzootic in macaques (Genus Macaca). Zoonotic infections with the Monkey B virus following exposure to macaques are exceptionally rare, but can cause fatal encephalomyelitis in humans. An observational survey was undertaken in 2018 to assess the practice of French health professionals regarding infection risk after monkey bites. French health professionals practicing in vaccination and rabies centres were specifically targeted for this study. Standardized questionnaires were sent by email to a sample of French health professionals. They were asked to participate on a voluntary and anonymous basis. The questionnaires requested epidemiological details and included multiple-choice questions about the infection management of monkey bites. The response rate was 33.5%. The frequency of monkey bites in 2017 was variable with a minority of centres managing more than 6 per year (12%), 46% managing 1-5 monkey bites and 42% none. Most of the monkey bites were described as occurring in South Asia at tourist sites, on naked upper limbs, shortly after the travellers arrived at their destination. Tetanus status verification, rabies post-exposure prophylaxis and antibiotic therapy were said to be prescribed in most cases. Knowledge about the Monkey B virus was reported as scarce for 38% of the participants. The number of monkey bites managed per year per centre varied greatly but practices regarding infectious risk after monkey bites were generally homogeneous. The risk of Monkey B virus transmission did not readily come to mind in the differential diagnosis of infection risk for many French health professionals.
    MeSH term(s) Adult ; Animals ; Bites and Stings/complications ; Bites and Stings/prevention & control ; Communicable Diseases/transmission ; Data Collection ; Female ; France ; Haplorhini ; Health Knowledge, Attitudes, Practice ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/veterinary ; Herpesviridae Infections/virology ; Herpesvirus 1, Cercopithecine ; Humans ; Male ; Risk Factors ; Surveys and Questionnaires ; Travel ; Vaccination
    Language English
    Publishing date 2019-12-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2271118-1
    ISSN 1863-2378 ; 1863-1959
    ISSN (online) 1863-2378
    ISSN 1863-1959
    DOI 10.1111/zph.12665
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  7. Article ; Online: Profiling the response to lumacaftor-ivacaftor in children with cystic between fibrosis and new insight from a French-Italian real-life cohort.

    Cornet, Matthieu / Robin, Geneviève / Ciciriello, Fabiana / Bihouee, Tiphaine / Marguet, Christophe / Roy, Valérie / Lebourgeois, Muriel / Chedevergne, Frédérique / Bonnel, Anne Sophie / Kelly, Mairead / Reix, Philippe / Lucidi, Vincenzina / Stoven, Véronique / Sermet-Gaudelus, Isabelle

    Pediatric pulmonology

    2022  Volume 57, Issue 12, Page(s) 2992–2999

    Abstract: Introduction: Clinical trials for CFTR modulators consider mean changes of clinical status at the cohort level, and thus fail to assess the heterogeneity of the response. We aimed to study the different response profiles to lumacaftor-ivacaftor ... ...

    Abstract Introduction: Clinical trials for CFTR modulators consider mean changes of clinical status at the cohort level, and thus fail to assess the heterogeneity of the response. We aimed to study the different response profiles to lumacaftor-ivacaftor according to age in children with cystic fibrosis (CF).
    Methods: A mathematical framework, including principal component analysis, data clustering, and data completion, was applied to a multicenter cohort of 112 children aged 6-18 years, treated with lumacaftor-ivacaftor. Studied parameters at baseline and 6 months included body mass index (BMI), number of days of antibiotics (ATB), Sweat test (ST), forced expiratory volume in 1 s expressed in percentage predicted (ppFEV
    Results: Change in ppFEV
    Conclusions: Change in ppFEV
    MeSH term(s) Child ; Humans ; Adolescent ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Aminophenols/therapeutic use ; Aminophenols/pharmacology ; Benzodioxoles/therapeutic use ; Benzodioxoles/pharmacology ; Aminopyridines/therapeutic use ; Aminopyridines/pharmacology ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis/complications ; Forced Expiratory Volume ; Drug Combinations ; Anti-Bacterial Agents/therapeutic use ; Fibrosis ; Mutation
    Chemical Substances ivacaftor (1Y740ILL1Z) ; lumacaftor (EGP8L81APK) ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Aminophenols ; Benzodioxoles ; Aminopyridines ; Drug Combinations ; Anti-Bacterial Agents
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26123
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2143: Show issues Location:
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  8. Article ; Online: Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy.

    Bouazza, Naïm / Urien, Saïk / Foissac, Frantz / Choupeaux, Laure / Lui, Gabrielle / Froelicher Bournaud, Léo / Rouillon, Steeve / Zheng, Yi / Bardin, Emmanuelle / Stremler, Nathalie / Bessaci, Katia / Bihouee, Tiphaine / Coirier-Duet, Emmanuelle / Marguet, Christophe / Deneuville, Eric / Laurans, Muriel / Reix, Philippe / Gerardin, Michèle / Mittaine, Marie /
    Epaud, Ralph / Thumerelle, Caroline / Weiss, Laurence / Berthaud, Romain / Semeraro, Michaela / Treluyer, Jean-Marc / Benaboud, Sihem / Sermet-Gaudelus, Isabelle

    Clinical pharmacokinetics

    2024  Volume 63, Issue 3, Page(s) 333–342

    Abstract: Background: A major breakthrough in cystic fibrosis (CF) therapy was achievedAQ1 with CFTR modulators. The lumacaftor/ivacaftor combination is indicated for the treatment of CF in pediatric patients above 6 years old. Pharmacokinetic (PK) studies of ... ...

    Abstract Background: A major breakthrough in cystic fibrosis (CF) therapy was achievedAQ1 with CFTR modulators. The lumacaftor/ivacaftor combination is indicated for the treatment of CF in pediatric patients above 6 years old. Pharmacokinetic (PK) studies of lumacaftor/ivacaftor in these vulnerable pediatric populations are AQ2crucial to optimize treatment protocols.
    Objectives and methods: The objectives of this study were to describe the population PK (PPK) of lumacaftor and ivacaftor in children with CF, and to identify factors associated with interindividual variability. The association between drug exposure and clinical response was also investigated.
    Results: A total of 75 children were included in this PPK study, with 191 concentrations available for each compound and known metabolites (lumacaftor, ivacaftor, ivacaftor-M1, and ivacaftor-M6). PPK analysis was performed using Monolix software. A large interindividual variability was observed. The main sources of interpatient variability identified were patient bodyweight and hepatic function (aspartate aminotransferase). Forced expiratory volume in the first second (FEV1) was statistically associated with the level of exposure to ivacaftor after 48 weeks of treatment.
    Conclusions: This study is the first analysis of lumacaftor/ivacaftor PPK in children with CF. These data suggest that dose adjustment is required after identifying variability factors to optimize efficacy. The use of therapeutic drug monitoring as a basis for dose adjustment in children with CF may be useful.
    MeSH term(s) Humans ; Child ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/therapeutic use ; Drug Combinations ; Aminophenols/therapeutic use ; Aminopyridines/therapeutic use ; Forced Expiratory Volume ; Quinolones ; Benzodioxoles
    Chemical Substances ivacaftor (1Y740ILL1Z) ; lumacaftor (EGP8L81APK) ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Drug Combinations ; Aminophenols ; Aminopyridines ; Quinolones ; Benzodioxoles
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197627-8
    ISSN 1179-1926 ; 0312-5963
    ISSN (online) 1179-1926
    ISSN 0312-5963
    DOI 10.1007/s40262-023-01342-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1246: Show issues Location:
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  9. Article ; Online: Cumulative Incidence and Risk Factors for Severe COVID-19 in French People with Cystic Fibrosis.

    Corvol, Harriet / de Miranda, Sandra / Dehillotte, Clémence / Lemonnier, Lydie / Chiron, Raphael / Danner-Boucher, Isabelle / Hamidfar, Rebecca / Houdouin, Véronique / Macey, Julie / Marguet, Christophe / Murris-Espin, Marlène / Reynaud, Quitterie / Reix, Philippe / Gaubert, Martine Reynaud / Kemgang, Astrid / Burgel, Pierre-Régis

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are closely monitored in people with cystic fibrosis (pwCF), with a special emphasis on severe cases. Previous studies used hospitalization rates as proxy for severity.!# ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are closely monitored in people with cystic fibrosis (pwCF), with a special emphasis on severe cases. Previous studies used hospitalization rates as proxy for severity.
    Methods: We evaluated data from coronavirus disease 2019 (COVID-19) cases diagnosed in French pwCF followed in one of the 47 French CF center over the first year of the pandemic.
    Objective: criteria were applied for defining severity (e.g., respiratory failure and/or death). Data were compared to those from all French pwCF using the French CF Registry.
    Results: As of April 30, 2021, 223 pwCF were diagnosed with COVID-19, with higher risks in adults (≥18 years, odds ratio [OR] = 2.52, 95% confidence interval [CI] = 1.82-3.48) and post-transplant individuals (OR = 2.68, 95% CI = 1.98-3.63). Sixty (26.9%) patients were hospitalized, with an increased risk in post-transplant individuals (OR = 4.74, 95% CI = 2.49-9.02). In 34 (15%) cases, COVID-19 was considered severe; 28/60 (46.7%) hospitalizations occurred in patients without objective criteria of severity. Severe cases occurred mostly in adults (85.3%) and post-transplant pwCF (61.8%, OR = 6.02, 95% CI = 2.77-13.06). In non-transplanted pwCF, risk factors for severity included low lung function (median ppFEV1 54.6% vs. 75.1%, OR = 1.04, 95% CI = 1.01-1.08) and CF-associated diabetes (OR = 3.26, 95% CI = 1.02-10.4). While most cases recovered without sequelae (n = 204, 91.5%), 16 (13%) were followed for possible sequelae, and three post-transplant females died.
    Conclusions: Severe COVID-19 cases occurred infrequently during the first year of the pandemic in French pwCF. Non-transplanted adults with severe respiratory disease or diabetes and post-transplant individuals were at risk for severe COVID-19. Thus, specific preventive measures should be proposed.
    Language English
    Publishing date 2022-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac333
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  10. Article: Chest physiotherapy enhances detection of

    Marguet, Christophe / Houdouin, Véronique / Pin, Isabelle / Reix, Philippe / Huet, Frédéric / Mittaine, Marie / Ramel, Sophie / Wizla-Derambure, Nathalie / Abely, Michel / Dalphin, Marie-Laure / Fayon, Michael / Bihouée, Tiphaine / Le Bourgeois, Muriel / Deneuville, Eric / Corvol, Harriet / Laurans, Muriel / Couderc, Laure / Leroux, Evelyne / Lémée, Ludovic

    ERJ open research

    2021  Volume 7, Issue 1

    Abstract: Lung damage in cystic fibrosis (CF) is strongly associated with lower airway infections. Early treatment ... ...

    Abstract Lung damage in cystic fibrosis (CF) is strongly associated with lower airway infections. Early treatment of
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00513-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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