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Article ; Online: Reply from Authors re: Xue-Ru Wu. Attention to Detail by Single-cell sequencing. Eur Urol 2017;71:13-4.

Yang, Zhao / Wu, Song / Cai, Zhiming / Li, Chong

2017 Volume 71, Issue 1, Page(s) 15–16

Language	English
Publishing date	2017-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.11.003
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Attention to Detail by Single-cell Sequencing.

Wu, Xue-Ru

European urology

2017 Volume 71, Issue 1, Page(s) 13–14

Language	English
Publishing date	2017-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.09.005
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article: [Analysis of Carbon Emissions and Influencing Factors in China Based on City Scale].

Wu, Jian-Sheng / Jin, Xue-Ru / Wang, Han / Feng, Zhe / Zhang, Dan-Ni / Li, Xue-Chen

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 5, Page(s) 2974–2982

Abstract: Assessing regional carbon emissions and their relationship with socio-economic conditions is very important for developing strategies for carbon emission reduction. This study explored the impact of the proportion of non-fossil energy, the land ... ...

Abstract	Assessing regional carbon emissions and their relationship with socio-economic conditions is very important for developing strategies for carbon emission reduction. This study explored the impact of the proportion of non-fossil energy, the land development degree, the urbanization rate of permanent residents, the proportion of secondary industry, per capita GDP, and per capita construction land area on per capita CO
Language	Chinese
Publishing date	2023-05-13
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202205326
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Article ; Online: Assembly of a Heterotrimetallic Zn

Zeng, Min / Zhou, Ze-Yang / Wu, Xue-Ru / Liu, Cai-Ming / Kou, Hui-Zhong

Inorganic chemistry

2022 Volume 61, Issue 36, Page(s) 14275–14281

Abstract: Rational selection of metal ions and organic ligands to synthesize metal-organic complexes (MOCs) is necessary for constructing multifunctional materials. Herein, we have obtained a novel heterotrimetallic ... ...

Abstract	Rational selection of metal ions and organic ligands to synthesize metal-organic complexes (MOCs) is necessary for constructing multifunctional materials. Herein, we have obtained a novel heterotrimetallic Zn
Language	English
Publishing date	2022-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c01822
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Article ; Online: Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall's plaques.

Wu, Xue-Ru

Urolithiasis

2014 Volume 43 Suppl 1, Page(s) 65–76

Abstract: Genetically engineered mouse models (GEMMs) have been highly instrumental in elucidating gene functions and molecular pathogenesis of human diseases, although their use in studying kidney stone formation or nephrolithiasis remains relatively limited. ... ...

Abstract	Genetically engineered mouse models (GEMMs) have been highly instrumental in elucidating gene functions and molecular pathogenesis of human diseases, although their use in studying kidney stone formation or nephrolithiasis remains relatively limited. This review intends to provide an overview of several knockout mouse models that develop interstitial calcinosis in the renal papillae. Included herein are mice deficient for Tamm-Horsfall protein (THP; also named uromodulin), osteopontin (OPN), both THP and OPN, Na(+)-phosphate cotransporter Type II (Npt2a) and Na(+)/H(+) exchanger regulatory factor (NHERF-1). The baseline information of each protein is summarized, along with key morphological features of the interstitial calcium deposits in mice lacking these proteins. Attempts are made to correlate the papillary interstitial deposits found in GEMMs with Randall's plaques, the latter considered precursors of idiopathic calcium stones in patients. The pathophysiology that underlies the renal calcinosis in the knockout mice is also discussed wherever information is available. Not all the knockout models are allocated equal space because some are more extensively characterized than others. Despite the inroads already made, the exact physiological underpinning, origin, evolution and fate of the papillary interstitial calcinosis in the GEMMs remain incompletely defined. Greater investigative efforts are warranted to pin down the precise role of the papillary interstitial calcinosis in nephrolithiasis using the existing models. Additionally, more sophisticated, second-generation GEMMs that allow gene inactivation in a time-controlled manner and "compound mice" that bear several genetic alterations are urgently needed, in light of mounting evidence that nephrolithiasis is a multifactorial, multi-stage and polygenic disease.
MeSH term(s)	Animals ; Calcinosis/genetics ; Disease Models, Animal ; Kidney Diseases/genetics ; Kidney Medulla ; Mice/genetics ; Mice, Knockout ; Osteopontin/genetics ; Phosphoproteins/genetics ; Sodium-Hydrogen Exchangers/genetics ; Sodium-Phosphate Cotransporter Proteins, Type II/genetics ; Uromodulin/genetics
Chemical Substances	Phosphoproteins ; Sodium-Hydrogen Exchangers ; Sodium-Phosphate Cotransporter Proteins, Type II ; Umod protein, mouse ; Uromodulin ; sodium-hydrogen exchanger regulatory factor ; Osteopontin (106441-73-0)
Language	English
Publishing date	2014-08-06
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-014-0699-3
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Zs.A 928: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Urothelium-Specific Expression of Mutationally Activated Pik3ca Initiates Early Lesions of Noninvasive Bladder Cancer.

Shuman, Lauren / Pham, Jonathan / Wildermuth, Thomas / Wu, Xue-Ru / Walter, Vonn / Warrick, Joshua I / DeGraff, David J

The American journal of pathology

2023 Volume 193, Issue 12, Page(s) 2133–2143

Abstract: Although approximately 70% of bladder cancers are noninvasive and have high recurrence rates, early-stage disease is understudied. The lack of models to validate the contribution of molecular drivers of bladder tumorigenesis is a significant issue. ... ...

Abstract	Although approximately 70% of bladder cancers are noninvasive and have high recurrence rates, early-stage disease is understudied. The lack of models to validate the contribution of molecular drivers of bladder tumorigenesis is a significant issue. Although mutations in PIK3CA are frequent in human bladder cancer, an in vivo model for understanding their contribution to bladder tumorigenesis is unavailable. Therefore, a Upk2-Cre/Pik3ca
MeSH term(s)	Animals ; Humans ; Mice ; Carcinogenesis/genetics ; Class I Phosphatidylinositol 3-Kinases/genetics ; Mutation ; Proto-Oncogene Proteins c-akt/metabolism ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Urothelium/metabolism
Chemical Substances	Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Pik3ca protein, mouse (EC 2.7.1.137)
Language	English
Publishing date	2023-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2023.07.001
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Ud II Zs.76: Show issues

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Article ; Online: Kavalactone Kawain Impedes Urothelial Tumorigenesis in UPII-Mutant Ha-Ras Mice via Inhibition of mTOR Signaling and Alteration of Cancer Metabolism.

Liu, Zhongbo / Song, Liankun / Xie, Jun / Wu, Xue-Ru / Gin, Greg E / Wang, Beverly / Uchio, Edward / Zi, Xiaolin

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 4

Abstract: UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, ...

Abstract	UPII-mutant Ha-ras transgenic mice develop urothelial hyperplasia and low-grade papillary carcinoma, which mimics human non-muscle invasive bladder cancer (NMIBC). We investigated the effects and mechanisms of kawain, a main kavalactone in the kava plant, on oncogenic Ha-ras-driven urothelial carcinoma in these mice. The mice were fed at six weeks of age with vehicle control or kawain (6 g/kg) formulated food for approximately five months. Seventy-eight percent of the mice or more fed with kawain food survived more than six months of age, whereas only 32% control food-fed male mice survived, (
MeSH term(s)	Animals ; Mice ; Carcinoma, Transitional Cell ; Cell Transformation, Neoplastic ; Mice, Transgenic ; TOR Serine-Threonine Kinases ; Urinary Bladder Neoplasms/pathology
Chemical Substances	kavain (W1ES06373M) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28041666
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Zs.MO 81: Show issues

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Article ; Online: Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer's disease diagnosis and differential diagnosis.

Guo, Zhen / Tian, Chen / Shi, Yang / Song, Xue-Ru / Yin, Wei / Tao, Qing-Qing / Liu, Jie / Peng, Guo-Ping / Wu, Zhi-Ying / Wang, Yan-Jiang / Zhang, Zhen-Xin / Zhang, Jing

Acta neuropathologica communications

2024 Volume 12, Issue 1, Page(s) 38

Abstract: Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer's disease (AD). The study began with searching for novel blood-based neuronal extracellular vesicles (EVs) that are more enriched in the brain regions ...

Abstract	Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer's disease (AD). The study began with searching for novel blood-based neuronal extracellular vesicles (EVs) that are more enriched in the brain regions vulnerable to AD development and progression. With extensive proteomic profiling, GABRD and GPR162 were identified as novel brain regionally enriched plasma EVs markers. The performance of GABRD and GPR162, along with the AD molecule pTau217, was tested using the self-developed and optimized nanoflow cytometry-based technology, which not only detected the positive ratio of EVs but also concurrently presented the corresponding particle size of the EVs, in discovery (n = 310) and validation (n = 213) cohorts. Plasma GABRD
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Diagnosis, Differential ; NAD ; Proteomics ; Extracellular Vesicles
Chemical Substances	NAD (0U46U6E8UK)
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-024-01727-w
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Article ; Online: Structural or functional defects of PTEN in urothelial cells lacking P53 drive basal/squamous-subtype muscle-invasive bladder cancer.

He, Feng / Zhang, Fenglin / Liao, Yi / Tang, Moon-Shong / Wu, Xue-Ru

Cancer letters

2022 Volume 550, Page(s) 215924

Abstract: Muscle-invasive bladder cancer (MIBC) exhibits strong inter- and intra-tumor heterogeneity that affects biological behaviors, therapeutic responses, and prognoses. Mutations that activate RTK-RAS-PI3K and inactivate P19-P53-P21 coexist in 60-70% of MIBC. ...

Abstract	Muscle-invasive bladder cancer (MIBC) exhibits strong inter- and intra-tumor heterogeneity that affects biological behaviors, therapeutic responses, and prognoses. Mutations that activate RTK-RAS-PI3K and inactivate P19-P53-P21 coexist in 60-70% of MIBC. By time-controlled ablation of Tp53 and Pten, singly or combined, in adult mouse urothelium, we found that Tp53 loss alone produced no abnormality. While Pten loss elicited hyperplasia, it synergized with Tp53 loss to trigger 100% penetrant MIBC that exhibited basal/squamous features that resembled its human counterpart. Furthermore, PTEN was inactivated in human MIBC cell lines and specimens primarily by hyperphosphorylation of the C-terminus. Mutated or tailless PTEN incapable of C-terminal phosphorylation demonstrated increased inhibition of proliferation and invasion than full-length PTEN in cultured MIBC cells. In xenograft and transgenic mice, tailless PTEN, but not full-length PTEN, prevented further growth in established tumors. Collectively, deficiencies of both PTEN and P53 drive basal/squamous subtype MIBC. PTEN is inactivated by C-terminal hyperphosphorylation, and this modification may serve as a biomarker for subtyping MIBC and predicting tumor progression. Tailless PTEN is a potential molecular therapeutic for tumors, such as bladder cancer (BC), that can be readily accessed.
MeSH term(s)	Adult ; Animals ; Carcinoma, Squamous Cell/genetics ; Humans ; Mice ; Muscles/metabolism ; Muscles/pathology ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Tumor Suppressor Protein p53/genetics ; Urinary Bladder Neoplasms/pathology
Chemical Substances	Tumor Suppressor Protein p53 ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2022-10-03
Publishing country	Ireland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2022.215924
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Zs.A 1177: Show issues

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Article: Effect of PCI on ophthalmic artery hemodynamics in patients with acute coronary syndrome.

Liu, Wen-Long / Wu, Lan-Ting / Wang, Jia-Lin / Sun, Jiao / Cheng, Xue-Ru / Zhou, Zhuo-Hua / Guan, Jia-Xin / Wang, Yan-Ling / Meng, Zhao-Yang

Frontiers in medicine

2024 Volume 11, Page(s) 1367900

Abstract: Purpose: We aimed to explore the effects of percutaneous coronary intervention (PCI) on the ophthalmic artery (OA) hemodynamics in patients with acute coronary syndrome (ACS).: Methods: A total of 73 participants (Group0: healthy controls, Group1: ... ...

Abstract	Purpose: We aimed to explore the effects of percutaneous coronary intervention (PCI) on the ophthalmic artery (OA) hemodynamics in patients with acute coronary syndrome (ACS). Methods: A total of 73 participants (Group0: healthy controls, Group1: Patients with ACS underwent PCI < 3 months, Group2: Patients with ACS underwent PCI ≥ 3 months) were enrolled. Computed tomographic angiography images were used to construct three-dimensional models of participants' OAs. Numerical simulations based on computational fluid dynamics were used to acquire hemodynamic parameters. Results: The angle between the OA and internal carotid artery in Group2 was significantly larger compared with Group0 and Group1 ( Conclusions: The OA blood flow velocity of patients with ACS after PCI initially slowed down, which increased the risk of plaque formation, and then showed an increasing trend. There was a correlation between OA hemodynamic parameters and clinical indexes related to cardiac stress. Ischemia-reperfusion injury and changes in blood flow status after PCI may affect OA morphology and hemodynamics, leading to ocular lesions. Trial registration: ChiCTR2100050428.
Language	English
Publishing date	2024-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2024.1367900
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