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Article ; Online: Gut microbiota gestalt.

Melamed, Jonathan / LeBlanc, Gabrielle / Constantinides, Michael G

2022 Volume 30, Issue 7, Page(s) 899–901

Abstract: The pathogenicity of disease-associated microbes varies widely between individuals. In this issue of Cell Host & Microbe, Rice et al. demonstrate that interactions between intestinal commensals reciprocally modulate the host immune response to each ... ...

Abstract	The pathogenicity of disease-associated microbes varies widely between individuals. In this issue of Cell Host & Microbe, Rice et al. demonstrate that interactions between intestinal commensals reciprocally modulate the host immune response to each microbe, ameliorating the inflammation caused by one and dampening antibody responses to the other.
MeSH term(s)	Gastrointestinal Microbiome/physiology ; Humans ; Inflammation ; Intestines ; Symbiosis
Language	English
Publishing date	2022-06-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2022.06.009
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Zs.A 6578: Show issues

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Article ; Online: The role of unconventional T cells in maintaining tissue homeostasis.

LeBlanc, Gabrielle / Kreissl, Felix K / Melamed, Jonathan / Sobel, Adam L / Constantinides, Michael G

Seminars in immunology

2022 Volume 61-64, Page(s) 101656

Language	English
Publishing date	2022-10-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2022.101656
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Zs.A 2843: Show issues

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Article: COVID-19-Associated Middle Ear Myoclonus in a 10-Year-Old Male.

LeBlanc, Gabrielle / Blanco, Patricia

Cureus

2022 Volume 14, Issue 4, Page(s) e24550

Abstract: Middle ear myoclonus is a rare condition attributed to abnormal, repetitive contractions of the middle ear muscles including the tensor tympani and/or stapedius muscles. This condition generates objective tinnitus that is characterized by a "clicking" ... ...

Abstract	Middle ear myoclonus is a rare condition attributed to abnormal, repetitive contractions of the middle ear muscles including the tensor tympani and/or stapedius muscles. This condition generates objective tinnitus that is characterized by a "clicking" noise that is audible to both the patient and an outside observer. No specific pathophysiologic process has been identified as the cause of middle ear myoclonus, making its diagnosis and treatment challenging. In this report, we present a presumptive case of COVID-19-associated middle ear myoclonus in a 10-year-old male.
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.24550
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Article ; Online: Cell therapy rescues aging-induced beta-1 adrenergic receptor and GRK2 dysfunction in the coronary microcirculation.

Rowe, Gabrielle / Tracy, Evan / Beare, Jason E / LeBlanc, Amanda J

GeroScience

2021 Volume 44, Issue 1, Page(s) 329–348

Abstract: ... adrenergic signaling cascade, G-protein receptor kinase 2 (GRK2) and G-alpha inhibitory (Gαi) proteins, back ...

Abstract	Our past study showed that coronary arterioles isolated from adipose-derived stromal vascular fraction (SVF)-treated rats showed amelioration of the age-related decrease in vasodilation to beta-adrenergic receptor (β-AR) agonist and improved β-AR-dependent coronary flow and microvascular function in a model of advanced age. We hypothesized that intravenously (i.v.) injected SVF improves coronary microvascular function in aged rats by re-establishing the equilibrium of the negative regulators of the internal adrenergic signaling cascade, G-protein receptor kinase 2 (GRK2) and G-alpha inhibitory (Gαi) proteins, back to youthful levels. Female Fischer-344 rats aged young (3 months, n = 24), old (24 months, n = 26), and old animals that received 1 × 10
MeSH term(s)	Aging/pathology ; Animals ; Cell- and Tissue-Based Therapy ; Coronary Circulation ; Female ; G-Protein-Coupled Receptor Kinase 2/physiology ; Microcirculation ; Rats ; Receptors, Adrenergic, beta-1/physiology ; Vasodilation
Chemical Substances	Receptors, Adrenergic, beta-1 ; Grk2 protein, rat (EC 2.7.11.15) ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16)
Language	English
Publishing date	2021-10-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-021-00455-6
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Zs.A 1502: Show issues

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Article ; Online: IgG4-associated autoimmune hepatitis and cholangitis: A relatively novel entity to consider in cases of seronegative autoimmune hepatitis.

Jutras, Gabrielle / Wong, Philip / Ferreira, José / Leblanc, Jean-Frederic

Canadian liver journal

2021 Volume 4, Issue 2, Page(s) 99–103

Abstract: ... hepatitis and autoimmune liver diseases was negative. An elevated immunoglobulin G (IgG) level suggested ...

Abstract	A 49-year-old woman with no inflammatory bowel disease history presented to our clinic with abnormal liver function tests and right upper quadrant abdominal pain. Blood tests revealed a mixed pattern of liver injury. Abdominal magnetic resonance imaging demonstrated hepatomegaly with periportal edema and hyper-enhancing bile ducts without any sign of biliary obstruction or stricturing. Screening for viral hepatitis and autoimmune liver diseases was negative. An elevated immunoglobulin G (IgG) level suggested the possibility of autoimmune hepatitis (AIH), and a biopsy confirmed the presence of severe interface hepatitis with necrotic areas and focal lymphoid nodular formation. IgG4 staining revealed marked IgG4-positive plasma cell infiltration. A diagnosis of IgG4-associated seronegative AIH was made, and the patient was started on prednisone and azathioprine, with rapid resolution of the enzyme abnormalities. This clinical vignette highlights the potential challenges in establishing a diagnosis of IgG4-associated AIH and cholangitis, as demonstrated by the importance of confirmatory histopathology. Clinicians should maintain a high index of suspicion when confronted with a mixed pattern of liver injury with elevated immunoglobulins but seronegative autoimmune markers.
Language	English
Publishing date	2021-04-29
Publishing country	Canada
Document type	Case Reports
ISSN	2561-4444
ISSN (online)	2561-4444
DOI	10.3138/canlivj-2020-0023
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Article ; Online: State of the field: cellular and exosomal therapeutic approaches in vascular regeneration.

Tracy, Evan Paul / Stielberg, Virginia / Rowe, Gabrielle / Benson, Daniel / Nunes, Sara S / Hoying, James B / Murfee, Walter Lee / LeBlanc, Amanda Jo

American journal of physiology. Heart and circulatory physiology

2022 Volume 322, Issue 4, Page(s) H647–H680

Abstract: ... focused on cellular therapies and cell-free therapies (e.g., exosomes) that can tackle the multifaceted ...

Abstract	Pathologies of the vasculature including the microvasculature are often complex in nature, leading to loss of physiological homeostatic regulation of patency and adequate perfusion to match tissue metabolic demands. Microvascular dysfunction is a key underlying element in the majority of pathologies of failing organs and tissues. Contributing pathological factors to this dysfunction include oxidative stress, mitochondrial dysfunction, endoplasmic reticular (ER) stress, endothelial dysfunction, loss of angiogenic potential and vascular density, and greater senescence and apoptosis. In many clinical settings, current pharmacologic strategies use a single or narrow targeted approach to address symptoms of pathology rather than a comprehensive and multifaceted approach to address their root cause. To address this, efforts have been heavily focused on cellular therapies and cell-free therapies (e.g., exosomes) that can tackle the multifaceted etiology of vascular and microvascular dysfunction. In this review, we discuss
MeSH term(s)	Animals ; Endothelium, Vascular/metabolism ; Microvessels ; Oxidative Stress ; Regeneration ; Vascular Diseases/metabolism
Language	English
Publishing date	2022-02-18
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00674.2021
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Uc I Zs.89: Show issues

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Article ; Online: Cell therapy-induced recovery of dysfunctional microvasculature.

Tracy, Evan Paul / Rowe, Gabrielle / LeBlanc, Amanda J

Aging

2022 Volume 14, Issue 13, Page(s) 5296–5298

MeSH term(s)	Adipose Tissue ; Cell- and Tissue-Based Therapy ; Microvessels ; Stromal Cells
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204183
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Article ; Online: Latent pathway-based Bayesian models to identify intervenable factors of racial disparities in breast cancer stage at diagnosis.

Lee, Inkoo / Luo, Yi / Carretta, Henry / LeBlanc, Gabrielle / Sinha, Debajyoti / Rust, George

Cancer causes & control : CCC

2023 Volume 35, Issue 2, Page(s) 253–263

Abstract: Purpose: We built Bayesian Network (BN) models to explain roles of different patient-specific factors affecting racial differences in breast cancer stage at diagnosis, and to identify healthcare related factors that can be intervened to reduce racial ... ...

Abstract	Purpose: We built Bayesian Network (BN) models to explain roles of different patient-specific factors affecting racial differences in breast cancer stage at diagnosis, and to identify healthcare related factors that can be intervened to reduce racial health disparities. Methods: We studied women age 67-74 with initial diagnosis of breast cancer during 2006-2014 in the National Cancer Institute's SEER-Medicare dataset. Our models included four measured variables (tumor grade, hormone receptor status, screening utilization and biopsy delay) expressed through two latent pathways-a tumor biology path, and health-care access/utilization path. We used various Bayesian model assessment tools to evaluate these two latent pathways as well as each of the four measured variables in explaining racial disparities in stage-at-diagnosis. Results: Among 3,010 Black non-Hispanic (NH) and 30,310 White NH breast cancer patients, respectively 70.2% vs 76.9% were initially diagnosed at local stage, 25.3% vs 20.3% with regional stage, and 4.56% vs 2.80% with distant stage-at-diagnosis. Overall, BN performed approximately 4.7 times better than Classification And Regression Tree (CART) (Breiman L, Friedman JH, Stone CJ, Olshen RA. Classification and regression trees. CRC press; 1984) in predicting stage-at-diagnosis. The utilization of screening mammography is the most prominent contributor to the accuracy of the BN model. Hormone receptor (HR) status and tumor grade are useful for explaining racial disparity in stage-at diagnosis, while log-delay in biopsy impeded good prediction. Conclusions: Mammography utilization had a significant effect on racial differences in breast cancer stage-at-diagnosis, while tumor biology factors had less impact. Biopsy delay also aided in predicting local and regional stages-at-diagnosis for Black NH women but not for white NH women.
MeSH term(s)	Humans ; Female ; Aged ; United States/epidemiology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Mammography ; Bayes Theorem ; Medicare ; Early Detection of Cancer ; Healthcare Disparities ; Hormones
Chemical Substances	Hormones
Language	English
Publishing date	2023-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-023-01785-w
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Zs.A 3375: Show issues

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Article ; Online: The use of indocyanine green (ICYG) angiography intraoperatively to evaluate gastric conduit perfusion during esophagectomy: does it impact surgical decision-making?

LeBlanc, Gabrielle / Takahashi, Caitlin / Huston, Jamie / Shridhar, Ravi / Meredith, Kenneth

Surgical endoscopy

2023 Volume 37, Issue 11, Page(s) 8720–8727

Abstract: Background: Ischemia is known to be a major contributor for anastomotic leaks and indocyanine green (ICYG) fluorescence angiography has been utilized to assess perfusion. Experienced esophageal surgeons have clinically assessed the gastric conduit with ... ...

Abstract	Background: Ischemia is known to be a major contributor for anastomotic leaks and indocyanine green (ICYG) fluorescence angiography has been utilized to assess perfusion. Experienced esophageal surgeons have clinically assessed the gastric conduit with acceptable outcomes for years. We sought to examine the impact of ICYG in a surgeon's decision-making during esophagectomy. Methods: We queried a prospectively maintained database to identify patients who underwent robotic esophagectomy. Time to initial perfusion, time to maximum perfusion, and residual ischemia were measured and used as a guide to resection of residual stomach. During esophagectomy the surgeon identified the anticipated line of ischemic demarcation (LOD) prior to ICYG injection. The distance between the surgeon's LOD and ICYG LOD was measured. Results: We identified 312 patients who underwent robotic esophagectomy, 251 without ICYG and 61 with ICGY. There were no differences in age, sex, race, body mass index, histology, stage, or neoadjuvant therapy use between groups. The incidence of anastomotic leak did not differ between groups (non-ICYG, 5.2% vs. ICYG, 6.6%), p = 0.67. The initial perfusion time was ≥ 10 s and max perfusion was > 25 s in all the patients in the ICYG that developed anastomotic leaks. All patients were noted to have at least 1 cm of residual gastric ischemia. Fifteen patients underwent independent surgeon evaluation of the ischemic LOD prior to ICYG. Differential distances were noted in 12 (80%) patients with a mean distance between surgical line of demarcation and ICYG LOD of 0.77 cm. Conclusion: While the implementation of ICYG during esophagectomy demonstrates no significant improvements in anastomotic leak rates compared to historical controls, surgeon's decision-making is impacted in 80% of cases resulting in additional resection of the gastric conduit. Elevated times to initial perfusion and maximum perfusion were associated with increased gastric ischemia and anastomotic leaks.
MeSH term(s)	Humans ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Anastomotic Leak/surgery ; Indocyanine Green ; Esophagectomy/methods ; Anastomosis, Surgical/methods ; Stomach/surgery ; Fluorescein Angiography/methods ; Perfusion ; Ischemia/etiology ; Ischemia/surgery ; Esophageal Neoplasms/surgery
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-08-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10258-9
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Zs.A 2214: Show issues

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Article ; Online: Principles of reproducible metabolite profiling of enriched lymphocytes in tumors and ascites from human ovarian cancer.

Kilgour, Marisa K / MacPherson, Sarah / Zacharias, Lauren G / LeBlanc, Jodi / Babinszky, Sindy / Kowalchuk, Gabrielle / Parks, Scott / Sheldon, Ryan D / Jones, Russell G / DeBerardinis, Ralph J / Hamilton, Phineas T / Watson, Peter H / Lum, Julian J

Nature protocols

2022 Volume 17, Issue 11, Page(s) 2668–2698

Abstract: Identifying metabolites and delineating their immune-regulatory contribution in the tumor microenvironment is an area of intense study. Interrogating metabolites and metabolic networks among immune cell subsets and host cells from resected tissues and ... ...

Abstract	Identifying metabolites and delineating their immune-regulatory contribution in the tumor microenvironment is an area of intense study. Interrogating metabolites and metabolic networks among immune cell subsets and host cells from resected tissues and fluids of human patients presents a major challenge, owing to the specialized handling of samples for downstream metabolomics. To address this, we first outline the importance of collaborating with a biobank for coordinating and streamlining workflow for point of care, sample collection, processing and cryopreservation. After specimen collection, we describe our 60-min rapid bead-based cellular enrichment method that supports metabolite analysis between T cells and tumor cells by mass spectrometry. We also describe how the metabolic data can be complemented with metabolic profiling by flow cytometry. This protocol can serve as a foundation for interrogating the metabolism of cell subsets from primary human ovarian cancer.
MeSH term(s)	Humans ; Female ; Ascites/pathology ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Metabolomics/methods ; Tumor Microenvironment ; Lymphocytes/metabolism
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2244966-8
ISSN	1750-2799 ; 1754-2189
ISSN (online)	1750-2799
ISSN	1754-2189
DOI	10.1038/s41596-022-00729-z
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