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  1. Article: Full-length transcriptome reveals the pivotal role of ABA and ethylene in the cold stress response of

    Qian, Lihua / Yin, Shuya / Lu, Na / Yue, Erkui / Yan, Jianli

    Frontiers in plant science

    2024  Volume 15, Page(s) 1285879

    Abstract: Tetrastigma ... ...

    Abstract Tetrastigma hemsleyanum
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1285879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical prediction models for the early diagnosis of obstructive sleep apnea in stroke patients: a systematic review.

    Yang, Hualu / Lu, Shuya / Yang, Lin

    Systematic reviews

    2024  Volume 13, Issue 1, Page(s) 38

    Abstract: Background: Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repetitive cessation or reduction in airflow during sleep. Stroke patients have a higher risk of OSA, which can worsen their cognitive and functional disabilities, ... ...

    Abstract Background: Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repetitive cessation or reduction in airflow during sleep. Stroke patients have a higher risk of OSA, which can worsen their cognitive and functional disabilities, prolong their hospitalization, and increase their mortality rates.
    Methods: We conducted a comprehensive literature search in the databases of PubMed, CINAHL, Embase, PsycINFO, Cochrane Library, and CNKI, using a combination of keywords and MeSH words in both English and Chinese. Studies published up to March 1, 2022, which reported the development and/or validation of clinical prediction models for OSA diagnosis in stroke patients.
    Results: We identified 11 studies that met our inclusion criteria. Most of the studies used logistic regression models and machine learning approaches to predict the incidence of OSA in stroke patients. The most frequently selected predictors included body mass index, sex, neck circumference, snoring, and blood pressure. However, the predictive performance of these models ranged from poor to moderate, with the area under the receiver operating characteristic curve varying from 0.55 to 0.82. All the studies have a high overall risk of bias, mainly due to the small sample size and lack of external validation.
    Conclusion: Although clinical prediction models have shown the potential for diagnosing OSA in stroke patients, their limited accuracy and high risk of bias restrict their implications. Future studies should focus on developing advanced algorithms that incorporate more predictors from larger and representative samples and externally validating their performance to enhance their clinical applicability and accuracy.
    MeSH term(s) Humans ; Models, Statistical ; Prognosis ; Early Diagnosis ; Sleep Apnea, Obstructive/diagnosis ; Sleep
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-024-02449-9
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  3. Article: Investigating the relationship between online information seeking and translation performance among translation students: The mediating role of translation self-efficacy.

    Lu, Sha / Xiangling, Wang / Shuya, Ma

    Frontiers in psychology

    2022  Volume 13, Page(s) 944265

    Abstract: The widespread use of online information resources by translation students has motivated an increasing number of researchers to investigate the relationship between online information seeking and translation performance. However, these studies mainly ... ...

    Abstract The widespread use of online information resources by translation students has motivated an increasing number of researchers to investigate the relationship between online information seeking and translation performance. However, these studies mainly address the direct effect of online information seeking on translation performance, thus failing to explore and identify the internal psychological mechanisms. This study, therefore, explores the mediating role of translation self-efficacy in the relationship between online information seeking and translation performance. A total of 314 translation students in China completed questionnaires on online information seeking and translation self-efficacy, and translation performance was measured by assessing the quality of a translation task given to them. Results showed that translation self-efficacy partially mediated the association between online information seeking and students' translation performance. These findings can contribute to our understanding of the role that translation self-efficacy plays in information seeking behaviors and the emotional states of translation students in translator training.
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.944265
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  4. Article ; Online: Topological structures of DNA octahedrons determined by the number of ssDNA strands.

    Lu, Yufan / Guo, Xingmin / Liu, Shuya

    Journal of molecular graphics & modelling

    2023  Volume 126, Page(s) 108657

    Abstract: How to control the nontrivial topological structures of DNA nanocages by the number of ssDNA strands is a fundamental problem for polyhedra assembly. In this paper, oriented octahedral links have been established as topological structure models to ... ...

    Abstract How to control the nontrivial topological structures of DNA nanocages by the number of ssDNA strands is a fundamental problem for polyhedra assembly. In this paper, oriented octahedral links have been established as topological structure models to characterize DNA octahedrons with double helix edges assembled from one or more ssDNA strands. Here a program "Octa-links" has been developed in Python language to give all octahedral links and their components (number). There are 1566 types of octahedral links generated by considering all orientations calculated and the allowable tangle types on each edge. Note that all same orientations and links have been excluded by introducing 24 symmetric operations of octahedra. Furthermore, a new algorithm is proposed to give each component of each octahedral link as a series of vertex arcs, obtaining that the component number of all links fills the integer interval [1, 8]. Hence our program designed according to this algorithm paves an effective approach to calculate the component number of polyhedral links, making up the gap in the computer program on this aspect. Also, our work provides a complete list of topological structures with different component number for new DNA octahedrons assembled by adjusting the number of ssDNA strands.
    MeSH term(s) Nucleic Acid Conformation ; DNA, Single-Stranded ; DNA/chemistry ; Algorithms ; Software
    Chemical Substances DNA, Single-Stranded ; DNA (9007-49-2)
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1396450-1
    ISSN 1873-4243 ; 1093-3263
    ISSN (online) 1873-4243
    ISSN 1093-3263
    DOI 10.1016/j.jmgm.2023.108657
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3491: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Tailam paramyxovirus C protein inhibits viral replication.

    Zhou, Lu / Kang, Haixian / Xu, Shuya / Chen, Jinbi / Wang, Xianyang / Long, Haishang / Li, Geng / Xu, Pei / He, Biao

    Journal of virology

    2024  Volume 98, Issue 1, Page(s) e0165423

    Abstract: Jeilongviruses are emerging single-stranded negative-sense RNA viruses in the Paramyxoviridae family. Tailam paramyxovirus (TlmPV) is ... ...

    Abstract Jeilongviruses are emerging single-stranded negative-sense RNA viruses in the Paramyxoviridae family. Tailam paramyxovirus (TlmPV) is a
    MeSH term(s) Paramyxovirinae/genetics ; Paramyxovirinae/physiology ; RNA, Viral/genetics ; Viral Proteins/genetics ; Virus Replication ; Animals ; Cricetinae ; Cell Line
    Chemical Substances RNA, Viral ; Viral Proteins
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01654-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
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  6. Article ; Online: Controlled Growth of Metal Atom Arrays on Graphdiyne for Seawater Oxidation.

    Qi, Lu / Gao, Yaqi / Gao, Yang / Zheng, Zhiqiang / Luan, Xiaoyu / Zhao, Shuya / Chen, Zhaoyang / Liu, Huimin / Xue, Yurui / Li, Yuliang

    Journal of the American Chemical Society

    2024  Volume 146, Issue 8, Page(s) 5669–5677

    Abstract: Advanced atomic-level heterointerface engineering provides a promising method for the preparation of next-generation catalysts. Traditional carbon-based heterointerface catalytic performance rely heavily on the undetermined defects in complex and ... ...

    Abstract Advanced atomic-level heterointerface engineering provides a promising method for the preparation of next-generation catalysts. Traditional carbon-based heterointerface catalytic performance rely heavily on the undetermined defects in complex and demanding preparation processes, rendering it impossible to control the catalytic performance. Here, we present a general method for the controlled growth of metal atom arrays on graphdiyne (GDY/IrCuO
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14742
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  7. Article ; Online: Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial.

    Li, Shuya / Gu, Hong-Qiu / Dai, Hongguo / Lu, Guozhi / Wang, Yongjun

    Stroke and vascular neurology

    2024  

    Abstract: Background and purpose: Reteplase is the third generation of alternative thrombolytic agent. We hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among eligible patients with acute ischaemic ...

    Abstract Background and purpose: Reteplase is the third generation of alternative thrombolytic agent. We hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among eligible patients with acute ischaemic stroke.
    Methods and design: Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE) trial is a multicentre, prospective, randomised, open-label, blinded endpoint (PROBE), controlled phase 3 non-inferiority trial. A total of 1412 eligible patients will be randomly assigned to receive either reteplase at a dose of 18 mg+ 18 mg or alteplase 0.9 mg/kg at a ratio of 1:1. An independent data monitoring committee will review the trail's progress and safety data.
    Study outcomes: The primary efficacy outcome of this study is proportion of individuals attaining an excellent functional outcome, defined as modified Rankin Scale (mRS) 0-1 at 90 days. The secondary efficacy outcomes encompass favourable functional outcome defined as mRS 0-2, major neurological improvement on the National Institutes of Health Stroke Scale, ordinal distribution of mRS and Barthel Index score of at least 95 points at 90 days. The primary safety outcomes are symptomatic intracranial haemorrhage at 36 hours within 90 days.
    Discussion: The RAISE trial will provide crucial insights into the selection of thrombolytic agents for stroke thrombolysis.
    Trial registration number: NCT05295173.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ISSN 2059-8696
    ISSN (online) 2059-8696
    DOI 10.1136/svn-2023-003035
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  8. Article ; Online: In situ

    Luan, Xiaoyu / Qi, Lu / Zheng, Zhiqiang / Zhao, Shuya / Gao, Yaqi / Xue, Yurui / Li, Yuliang

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 49, Page(s) 7611–7614

    Abstract: The development of new catalysts with high selectivity and efficiency for the electrocatalytic nitrate reduction reaction (NtRR) to produce ammonia ( ... ...

    Abstract The development of new catalysts with high selectivity and efficiency for the electrocatalytic nitrate reduction reaction (NtRR) to produce ammonia (NH
    MeSH term(s) Ammonia ; Electric Conductivity ; Nitrates
    Chemical Substances Ammonia (7664-41-7) ; Nitrates
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01428b
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  9. Article ; Online: Implication of androgen receptor gene dysfunction in human Müllerian duct anomalies.

    Li, Lin / Chen, Shuya / Li, Shenghui / Duan, Ai-Hong / Lu, Dan / Chu, Chunfang

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 294, Page(s) 198–205

    Abstract: Background: Müllerian duct anomalies (MDAs) are congenital developmental disorders exhibiting as a variety of malformations of female reproductive tract. The identified etiology of MDAs is limited. The present study aimed to unravel the underlying ... ...

    Abstract Background: Müllerian duct anomalies (MDAs) are congenital developmental disorders exhibiting as a variety of malformations of female reproductive tract. The identified etiology of MDAs is limited. The present study aimed to unravel the underlying genetic causes of MDAs.
    Methods: Rare variants in androgen receptor (AR) were called from the cohort consists of patients with MDAs and underwent whole exome sequencing (WES) at Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Sanger sequencing was used to confirm the causative genetic mutations. In silico analysis were used to classify the pathogenicity of each variant. Molecular modeling and simulations were conducted to investigate the conformational changes between the wild-type (WT) and mutant proteins.
    Results: A total of 3 rare heterozygous variants in AR from the MDAs cohort in our institution were identified, with unknown effects. All variants were missense mutations, including c.173A > T, c.558C > A and c.1208C > T, and were absent or rare in East Asian populations in Genome Aggregation Database and the Exome Aggregation Consortium Database. According to the American College of Medical Genetics and Genomics guidelines, c.1208C > T variant was classified as likely pathogenic, while the other two were variants of uncertain significance. During molecular dynamics simulations, WT and mutant proteins all reached stable status according to root-mean-square variance. Values of radius of gyration showed that Q58L and S186R protein would be more compact than WT, while the structure of A403V became looser. Despite, in comparison with WT, the number of hydrogen bonds increased in Q58L, while decreased in the other two variants. Furthermore, the solvent-accessible surface area diminished in Q58L and A403V while enlarged in S186R proteins, when compared with WT.
    Conclusions: To our knowledge, this is the first report regarding the association of AR mutation and MDAs. The identification of these variants, predicted to damage the structure and function of AR protein, not only expanded the mutational spectrum of causative genes of MDAs, but provide novel molecular genetic reference for future studies.
    MeSH term(s) Pregnancy ; Humans ; Female ; Mullerian Ducts/abnormalities ; Receptors, Androgen/genetics ; Mutation ; Mutation, Missense ; Mutant Proteins
    Chemical Substances Receptors, Androgen ; Mutant Proteins
    Language English
    Publishing date 2024-01-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.01.032
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 837: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: A new chemotherapy-free regimen of olverembatinib in combination with venetoclax and dexamethasone for newly diagnosed Ph+ acute lymphoblastic leukemia: Preliminary outcomes of a prospective study.

    Tang, Hailong / Jia, Weijing / Jia, Shuangshuang / Dong, Runan / Gao, Shan / Feng, Juan / Dong, Hongjuan / Gu, Hongtao / Zhang, Tao / Yuan, Ruifeng / Liu, Xiangxiang / Cheng, Lu / Zhou, Shuya / Gao, Guangxun

    American journal of hematology

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.27289
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
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