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Article ; Online: Use of chloride gradient for rapid identification of CSF leaks.

Hickman, Peter E / Salib, Marie M / Simpson, Aaron / Potter, Julia M

2023

Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Letter
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2023.08.013
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Article: Troponins in myocardial infarction and injury.

Potter, Julia M / Hickman, Peter E / Cullen, Louise

Australian prescriber

2022 Volume 45, Issue 2, Page(s) 53–57

Abstract: Troponins are proteins that are integral components of the contractile mechanism of muscle, including cardiac muscle. Cardiac troponins Iand T can be detected in the blood of most people after puberty, at concentrations reflecting cardiac mass, sex and ... ...

Abstract	Troponins are proteins that are integral components of the contractile mechanism of muscle, including cardiac muscle. Cardiac troponins Iand T can be detected in the blood of most people after puberty, at concentrations reflecting cardiac mass, sex and age. Current laboratory assays are approximately 1000 times more sensitive than those used previously. They also have higher sensitivity than point-of-care assays. The measurement of cardiac troponins is used primarily to assist in the diagnosis or exclusion of myocardial injury. Serial tests in acute coronary syndrome are guided by the Universal Definition of Myocardial Infarction.
Language	English
Publishing date	2022-04-01
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1075442-8
ISSN	0312-8008
ISSN	0312-8008
DOI	10.18773/austprescr.2022.006
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Zs.A 3233: Show issues

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Article ; Online: Intravenous immunoglobulin as a source of passively acquired thyroid autoantibodies.

Salib, Marie M / Morkos, Marina / Yu, Cheryl / D'Souza, Melanie / Yosar, Jason / Potter, Julia M / Hickman, Peter E

Pathology

2023 Volume 56, Issue 1, Page(s) 129–130

MeSH term(s)	Humans ; Immunoglobulins, Intravenous ; Thyroid Gland ; Immunoglobulin G ; Autoantibodies
Chemical Substances	Immunoglobulins, Intravenous ; Immunoglobulin G ; Autoantibodies
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Letter
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1016/j.pathol.2023.05.020
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Article ; Online: Are the changes in diagnostic criteria for gestational diabetes mellitus reflected in perinatal outcomes? A retrospective assessment.

Ehmann, David M T / Hickman, Peter E / Potter, Julia M

The Australian & New Zealand journal of obstetrics & gynaecology

2019 Volume 59, Issue 5, Page(s) 693–698

Abstract: Background: Gestational diabetes mellitus (GDM) is glucose intolerance first diagnosed during pregnancy not due to overt diabetes. Recent changes to the diagnostic guidelines have been shown to increase the apparent occurrence of GDM.: Aim: The aim ... ...

Abstract	Background: Gestational diabetes mellitus (GDM) is glucose intolerance first diagnosed during pregnancy not due to overt diabetes. Recent changes to the diagnostic guidelines have been shown to increase the apparent occurrence of GDM. Aim: The aim of this study was to compare retrospectively the neonatal outcomes between groups defined using the new and old criteria to assess the impact of guideline changes on pregnancy outcomes. Methods: The study was of singleton babies delivered of 641 women, who had oral glucose tolerance testing and pregnancy care at a single tertiary centre between 2011 and 2015. Results: Compared to the population of women not now considered to have GDM by International Association of Diabetes and Pregnancy Study Groups criteria (two-hour glucose concentration ≤8.4 mmol/L), neonates born to women with the new lower fasting criterion (5.1-5.4 mmol/L) and/or the new 60-min group (glucose ≥10 mmol/L) combined were significantly more likely to have birthweight ≥90th percentile (22% vs 5%, P < 0.0001). In contradistinction, there was a significant excess number of small-for-dates babies (birthweight ≤10th percentile) in all subgroups previously diagnosed and treated for GDM by the Australian Diabetes in Pregnancy Society criteria (17% vs 7%, P = 0.001). Rates for lower uterine segment caesarean section, admission to the neonatal intensive care unit / special care nursery and Apgar scores at one and five minutes were not statistically different across all groups. Conclusions: Outcomes support the lowering of the fasting criterion to extend management of GDM to limit growth of large birthweight neonates. An unexpected outcome was that in women previously treated for GDM, there were increased numbers of low-birthweight neonates.
MeSH term(s)	Adult ; Australian Capital Territory ; Diabetes, Gestational/blood ; Diabetes, Gestational/diagnosis ; Female ; Fetal Macrosomia ; Glucose Tolerance Test ; Humans ; Infant, Newborn ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Outcome ; Prenatal Diagnosis ; Retrospective Studies
Language	English
Publishing date	2019-02-27
Publishing country	Australia
Document type	Journal Article
ZDB-ID	390815-x
ISSN	1479-828X ; 0004-8666
ISSN (online)	1479-828X
ISSN	0004-8666
DOI	10.1111/ajo.12956
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Zs.A 424: Show issues

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Article ; Online: Reality check for cardiac troponin testing - Sometimes the result is wrong.

Kavsak, Peter A / Saenger, Amy K / Hickman, Peter E

Clinical biochemistry

2016 Volume 49, Issue 15, Page(s) 1107–1108

MeSH term(s)	Diagnostic Errors ; Humans ; Troponin I/blood ; Troponin I/standards ; Troponin T/blood ; Troponin T/standards
Chemical Substances	Troponin I ; Troponin T
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Editorial
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2016.09.007
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Zs.A 624: Show issues

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Article ; Online: Biomarkers and cardiac disease in patients with end-stage renal disease on dialysis.

Hickman, Peter E

The Clinical biochemist. Reviews

2010 Volume 32, Issue 2, Page(s) 115–119

Abstract: Very soon after troponin was introduced to routine clinical use in the mid-1990s, it was observed that troponin T was often increased in the blood of asymptomatic patients undergoing chronic dialysis for end-stage renal disease. Observation of these ... ...

Abstract	Very soon after troponin was introduced to routine clinical use in the mid-1990s, it was observed that troponin T was often increased in the blood of asymptomatic patients undergoing chronic dialysis for end-stage renal disease. Observation of these patients showed that the presence of troponin T in blood was predictive of a worse outcome for these patients.Cardiac disease is the major cause of death in dialysis patients. This review considers the heterogeneous cardiac disease that is found in these patients and reviews the role of cardiac biomarkers in identifying patients at risk of an adverse outcome.
Language	English
Publishing date	2010-10-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1018054-0
ISSN	1838-0212 ; 0159-8090
ISSN (online)	1838-0212
ISSN	0159-8090
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Zs.A 2815: Show issues

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Article ; Online: The intra-individual variation of cardiac troponin I: the effects of sex, age, climatic season, and time between samples.

Koerbin, Gus / Potter, Julia M / Pinto do Nascimento, Marcela / Cullen, Louise / Scanlan, Samuel L / Woods, Catherine / Hickman, Peter E

Clinical chemistry and laboratory medicine

2022 Volume 60, Issue 7, Page(s) 1101–1109

Abstract: Objectives: Knowing the intra-individual variation (CVi), also termed within subject biological variation, of an analyte is essential to properly interpret apparent changes in concentration. While there have been many studies assessing the CVi of ... ...

Abstract	Objectives: Knowing the intra-individual variation (CVi), also termed within subject biological variation, of an analyte is essential to properly interpret apparent changes in concentration. While there have been many studies assessing the CVi of cardiac troponin (cTnI), they have been limited in looking at CVi in different settings, and there is no data available on whether CVi might change in different settings. Methods: We used our large cTnI data bank to look at the CVi of cTnI in Emergency Department (ED) patients who had an acute myocardial infarction event excluded. We looked at the effects of gender, age, climatic season, and time between samples to assess whether CVi changed. To assess the effect of age, after exclusion, we collected two samples from each subject for each study which were used to calculate the CVi between those identified groups. There were 139 males and 98 females aged <65 years and 109 males and 98 females aged ≥65 years. For gender and season, there were 122 males and 94 females in the summer period and 126 males and 102 females in the winter period. To assess long term variation there were 195 males and 153 females who had further admissions after more than 12 months. Results: For the four variables listed, there were no significant differences in within individual variation (CVi), but there was a significant difference in between individual variation (CVg) for men and women with regard to age. The Index of Individuality (II) was <0.20 for all conditions studied. We noted that >90% of subjects had an reference change value (RCV) <9 ng/L. Conclusions: Because troponin concentration in patients without an identified cardiac condition change so little, delta changes are potentially of great value in assessing patients in the ED. Significant delta changes in troponin can occur without the 99th percentile being exceeded.
MeSH term(s)	Age Factors ; Aged ; Biomarkers ; Emergency Service, Hospital ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction ; Reference Values ; Seasons ; Sex Factors ; Troponin I/blood
Chemical Substances	Biomarkers ; Troponin I
Language	English
Publishing date	2022-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0125
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Zs.A 121: Show issues

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Article ; Online: Age-related differences in hs-cTnI concentration in healthy adults.

Hickman, Peter E / Abhayaratna, Walter P / Potter, Julia M / Koerbin, Gus

Clinical biochemistry

2019 Volume 69, Page(s) 26–29

Abstract: Background: Because the 99th percentile is of such importance in defining myocardial injury and myocardial infarction, it is important to know whether there are real age-related differences in troponin 99th percentiles.: Methods: We went to our ... ...

Abstract	Background: Because the 99th percentile is of such importance in defining myocardial injury and myocardial infarction, it is important to know whether there are real age-related differences in troponin 99th percentiles. Methods: We went to our database from the Canberra Heart Study where 1062 apparently healthy subjects were extensively screened for occult cardiac disease, and looking at persons aged <65 years and >65 years, for men and women separately, we compared a variety of cutpoints from the 99th percentile down to the 50th percentile. Results: With our rigorous criteria for defining cardiac health, we excluded 67.2% of males aged >65 years and 53.8% of women aged 65 years and older. Even with these rigorous exclusions we found that at every cutpoint examined between the 99th percentile and the 50th percentile, persons aged <65 years had lower troponin I concentrations that persons aged 65 years and older. Similarly, at every cutpoint examined, women had lower troponin I concentrations than did men. For the 4 separate groups examined (men and women, age < 65 years and 65 years and older) after the exclusions of persons with subclinical cardiac disease, the distributions were not significantly different to a Gaussian distribution. Conclusions: With the rigorous exclusions of persons with subclinical cardiac disease, and the fact that our populations have a Gaussian distribution, our data suggests that age-related hs-cTnI concentrations are real. This has important implications particularly when assessing older persons in the Emergency Department.
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/blood ; Troponin I/blood
Chemical Substances	Troponin I
Language	English
Publishing date	2019-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2019.04.014
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Article ; Online: Strict Preanalytical Oral Glucose Tolerance Test Blood Sample Handling Is Essential for Diagnosing Gestational Diabetes Mellitus.

Potter, Julia M / Hickman, Peter E / Oakman, Carmen / Woods, Catherine / Nolan, Christopher J

Diabetes care

2020 Volume 43, Issue 7, Page(s) 1438–1441

Abstract: Objective: Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose ... ...

Abstract	Objective: Preanalytical processing of blood samples can affect plasma glucose measurement because ongoing glycolysis by cells prior to centrifugation can lower its concentration. In June 2017, ACT Pathology changed the processing of oral glucose tolerance test (OGTT) blood samples for pregnant women from a delayed to an early centrifugation protocol. The effect of this change on the rate of gestational diabetes mellitus (GDM) diagnosis was determined. Research design and methods: All pregnant women in the Australian Capital Territory (ACT) are recommended for GDM testing with a 75-g OGTT using the World Health Organization diagnostic criteria. From January 2015 to May 2017, OGTT samples were collected into sodium fluoride (NaF) tubes and kept at room temperature until completion of the test (delayed centrifugation). From June 2017 to October 2018, OGTT samples in NaF tubes were centrifuged within 10 min (early centrifugation). Results: A total of 7,509 women were tested with the delayed centrifugation protocol and 4,808 with the early centrifugation protocol. The mean glucose concentrations for the fasting, 1-h, and 2-h OGTT samples were, respectively, 0.24 mmol/L (5.4%), 0.34 mmol/L (4.9%), and 0.16 mmol/L (2.3%) higher using the early centrifugation protocol ( Conclusions: The findings of this study highlight the critical importance of the preanalytical processing protocol of OGTT blood samples used for diagnosing GDM. Delay in centrifuging of blood collected into NaF tubes will result in substantially lower rates of diagnosis than if blood is centrifuged early.
MeSH term(s)	Adult ; Australia ; Blood Glucose/analysis ; Blood Specimen Collection/methods ; Blood Specimen Collection/standards ; Centrifugation/standards ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Diabetes, Gestational/blood ; Diabetes, Gestational/diagnosis ; Endocrinology/methods ; Endocrinology/standards ; False Positive Reactions ; Fasting/blood ; Female ; Glucose Tolerance Test/methods ; Glucose Tolerance Test/standards ; Guideline Adherence/standards ; Humans ; Pre-Analytical Phase/methods ; Pre-Analytical Phase/standards ; Pregnancy ; Reproducibility of Results ; Specimen Handling/methods ; Specimen Handling/standards ; Time Factors ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc20-0304
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Zs.MO 365: Show issues

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Article: Recommendations for lipid testing and reporting by Australian pathology laboratories.

Hickman, Peter E

Pathology

2007 Volume 39, Issue 3, Page(s) 297–298

MeSH term(s)	Australia ; Hematologic Tests/standards ; Humans ; Laboratories/standards ; Lipids/blood ; Pathology/standards
Chemical Substances	Lipids
Language	English
Publishing date	2007-06
Publishing country	England
Document type	Editorial
ZDB-ID	7085-3
ISSN	1465-3931 ; 0031-3025
ISSN (online)	1465-3931
ISSN	0031-3025
DOI	10.1080/00313020701358129
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