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  1. Article ; Online: Culturing the Future of Medicine: The Imperative of Strengthening the ID Physician-Scientist Pipeline.

    Titanji, Boghuma K / Sereti, Irini / Singer, Benjamin D

    The Journal of infectious diseases

    2024  

    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae074
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  2. Article ; Online: Immune reconstruction inflammatory syndrome in HIV infection: beyond what meets the eye.

    Sereti, Irini

    Topics in antiviral medicine

    2020  Volume 27, Issue 4, Page(s) 106–111

    Abstract: ... in patients with TB meningitis and cryptococcal meningitis. This article summarizes a presentation by Irini ... Sereti, MD, MHS, at the International Antiviral Society-USA (IAS-USA) continuing education program held ...

    Abstract A high proportion of individuals with HIV infection currently are diagnosed at an advanced stage of disease (late presenters), increasing their risk for immune reconstitution inflammatory syndrome (IRIS). IRIS typically occurs within 6 months of initiation of antiretroviral therapy (ART) in patients with low CD4+ cell counts and can occur before any marked elevation in CD4+ count is achieved on ART. In addition to low CD4+ count at ART initiation, 2 other major clinical predictors of IRIS are preexisting opportunistic infection (including subclinical infection) and shorter treatment period for opportunistic infection prior to starting ART. Mycobacterial infection-associated IRIS, including tuberculosis (TB)-associated IRIS, and cryptococcal infection-associated IRIS are the most common forms of the syndrome. Corticosteroid prophylaxis and early treatment can be effective in reducing incidence of TB-IRIS and severity of symptoms in select patients. Sterilization of the cerebrospinal fluid should be achieved prior to starting ART in patients with TB meningitis and cryptococcal meningitis. This article summarizes a presentation by Irini Sereti, MD, MHS, at the International Antiviral Society-USA (IAS-USA) continuing education program held in Washington, DC, in April 2019.
    MeSH term(s) AIDS-Related Opportunistic Infections/drug therapy ; Anti-Retroviral Agents/adverse effects ; Anti-Retroviral Agents/agonists ; Anti-Retroviral Agents/immunology ; Anti-Retroviral Agents/therapeutic use ; CD4 Lymphocyte Count ; HIV Infections/drug therapy ; HIV Infections/immunology ; Humans ; Immune Reconstitution Inflammatory Syndrome/chemically induced ; Immune Reconstitution Inflammatory Syndrome/diagnostic imaging ; Immune Reconstitution Inflammatory Syndrome/epidemiology ; Incidence ; Meningitis, Cryptococcal/drug therapy ; Tuberculosis/drug therapy ; Viral Load
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
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  3. Article ; Online: A Gut Feeling: Inflammatory Disease Revealed During Immune Reconstitution.

    Rocco, Joseph M / Richterman, Aaron / Sereti, Irini

    Gastroenterology

    2023  Volume 165, Issue 3, Page(s) 541–544

    MeSH term(s) Humans ; Immune Reconstitution ; Acquired Immunodeficiency Syndrome ; Emotions ; HIV Infections
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2023.05.020
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  4. Article ; Online: Idiopathic CD4 Lymphocytopenia at 30 Years. Reply.

    Lisco, Andrea / Ortega-Villa, Ana M / Sereti, Irini

    The New England journal of medicine

    2023  Volume 389, Issue 7, Page(s) 675–676

    MeSH term(s) Humans ; Immunologic Deficiency Syndromes ; Primary Immunodeficiency Diseases ; Thymus Gland ; Lymphopenia/etiology
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2307362
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  5. Article ; Online: Probe how race and gender intersect in author attribution.

    Sereti, Irini / Akinyemiju, Tomi / Gianella, Sara

    Nature

    2023  Volume 611, Issue 7934, Page(s) 33

    MeSH term(s) Authorship/standards ; Research Report ; Research Personnel/supply & distribution ; Systemic Racism/prevention & control ; Sexism/prevention & control
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-03516-8
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  6. Article ; Online: Expanding role of biomarkers in characterising hyperinflammatory syndromes.

    Rocco, Joseph M / Sereti, Irini

    The Lancet. Rheumatology

    2021  Volume 3, Issue 10, Page(s) e684–e685

    Language English
    Publishing date 2021-09-07
    Publishing country England
    Document type Letter
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00273-3
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  7. Article ; Online: Residual immune dysfunction under antiretroviral therapy.

    Cai, Catherine W / Sereti, Irini

    Seminars in immunology

    2021  Volume 51, Page(s) 101471

    Abstract: The usage of combination antiretroviral therapy in people with HIV (PWH) has incited profound improvement in morbidity and mortality. Yet, PWH may not experience full restoration of immune function which can manifest with non-AIDS comorbidities that ... ...

    Abstract The usage of combination antiretroviral therapy in people with HIV (PWH) has incited profound improvement in morbidity and mortality. Yet, PWH may not experience full restoration of immune function which can manifest with non-AIDS comorbidities that frequently associate with residual inflammation and can imperil quality of life or longevity. In this review, we discuss the pathogenesis underlying chronic inflammation and residual immune dysfunction in PWH, as well as potential therapeutic interventions to ameliorate them and prevent incidence or progression of non-AIDS comorbidities. Current evidence advocates that early diagnosis and prompt initiation of therapy at high CD4 counts may represent the best available approach for an improved immune recovery in PWH.
    MeSH term(s) Disease Progression ; HIV Infections/drug therapy ; Humans ; Inflammation ; Quality of Life
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2021.101471
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  8. Article ; Online: A 34-Year-Old Man With HIV/AIDS and a Cavitary Pulmonary Lesion.

    Manion, Maura / Sereti, Irini

    Chest

    2021  Volume 160, Issue 1, Page(s) e35–e38

    Abstract: A 34-year-old man presented to a community hospital with fever and fatigue for 3 days and was found to be febrile and tachycardic with a cavitary pulmonary lesion and paratracheal adenopathy on CT imaging. One month before, he had presented to his ... ...

    Abstract A 34-year-old man presented to a community hospital with fever and fatigue for 3 days and was found to be febrile and tachycardic with a cavitary pulmonary lesion and paratracheal adenopathy on CT imaging. One month before, he had presented to his primary care provider with a palmar rash; he had been diagnosed and treated for syphilis and was also diagnosed with HIV. He had a CD4 count of 106 cells/μL and an HIV viral load of 1,290,000 copies/mL. Pneumocystis prophylaxis with trimethoprim-sulfamethoxazole and antiretroviral treatment with only tenofovir and emtricitabine therapy were started 2 weeks before presentation.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Adult ; Bronchoscopy ; Cryptococcus neoformans/isolation & purification ; HIV ; HIV Infections/complications ; Humans ; Lung/diagnostic imaging ; Lung/microbiology ; Lung Diseases, Fungal/complications ; Lung Diseases, Fungal/diagnosis ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.01.086
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  9. Article ; Online: Immunometabolism and HIV-1 pathogenesis: food for thought.

    Sáez-Cirión, Asier / Sereti, Irini

    Nature reviews. Immunology

    2020  Volume 21, Issue 1, Page(s) 5–19

    Abstract: Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to better understand the ...

    Abstract Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life. Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite treatment. There is, therefore, an urgent need to better understand the mechanisms driving HIV-1 pathogenesis and to identify new targets for therapeutic intervention. In the past few years, the decisive role of cellular metabolism in the fate and activity of immune cells has been uncovered, as well as its impact on the outcome of infectious diseases. Emerging evidence suggests that immunometabolism has a key role in HIV-1 pathogenesis. The metabolic pathways of CD4
    MeSH term(s) Amino Acids/metabolism ; Anti-Retroviral Agents/therapeutic use ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/virology ; Fatty Acids/biosynthesis ; Fatty Acids/metabolism ; Glycolysis/physiology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/pathology ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Lymphocyte Activation/immunology ; Macrophage Activation/immunology ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/virology ; Pentose Phosphate Pathway/physiology ; Virus Replication/physiology
    Chemical Substances Amino Acids ; Anti-Retroviral Agents ; Fatty Acids
    Language English
    Publishing date 2020-08-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0381-7
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  10. Article ; Online: Changing lanes in ICL.

    Sereti, Irini

    Blood

    2010  Volume 115, Issue 18, Page(s) 3648–3649

    Language English
    Publishing date 2010-05-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2010-02-263665
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