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  1. Article ; Online: Therapeutic Drug Monitoring of Oral Oncology Drugs: Another Example of Maslow's Hammer.

    Ratain, Mark J

    Clinical pharmacology and therapeutics

    2024  

    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 20: Show issues Location:
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  2. Article ; Online: Sotorasib dosing and incremental cost ineffectiveness - implications and lessons for stakeholders.

    Strohbehn, Garth W / Ratain, Mark J

    Nature reviews. Clinical oncology

    2024  Volume 21, Issue 5, Page(s) 331–332

    MeSH term(s) Humans ; Cost-Benefit Analysis ; Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Drug Costs
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-024-00862-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Designing Dose-Finding Phase I Clinical Trials: Top Questions That Should Be Discussed With Your Clinical Pharmacologist.

    Ratain, Mark J

    JCO precision oncology

    2022  Volume 5, Page(s) 935–936

    MeSH term(s) Humans ; Physicians
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.21.00065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oncology Drug Prescribing: The Influences of Greed and Fear.

    Ratain, Mark J

    JCO oncology practice

    2022  Volume 18, Issue 9, Page(s) e1384–e1387

    MeSH term(s) Drug Prescriptions ; Fear ; Humans ; Medical Oncology
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Special designations and the US Food and Drug Administration's "dual mandate".

    Strohbehn, Garth W / Ratain, Mark J

    Journal of the National Cancer Institute

    2024  Volume 116, Issue 2, Page(s) 177–179

    MeSH term(s) United States ; Humans ; Pharmaceutical Preparations ; United States Food and Drug Administration ; Antineoplastic Agents ; Neoplasms/drug therapy
    Chemical Substances Pharmaceutical Preparations ; Antineoplastic Agents
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad235
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  6. Article ; Online: Project Optimus: Is the US Food and Drug Administration Waiving Dose Optimization for Orphan Drugs?

    Wesevich, Austin / Ratain, Mark J

    JAMA oncology

    2023  Volume 9, Issue 11, Page(s) 1489–1490

    MeSH term(s) United States ; Humans ; Orphan Drug Production ; United States Food and Drug Administration ; Drug Approval ; Product Surveillance, Postmarketing
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.3292
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  7. Article ; Online: Do patent applications and Cooperative Research and Development Agreements between the National Cancer Institute and industry serve the public interest?

    Wesevich, Austin / Ratain, Mark J

    Nature biotechnology

    2023  Volume 41, Issue 11, Page(s) 1517–1519

    MeSH term(s) United States ; National Cancer Institute (U.S.) ; Industry ; Biomedical Research ; Neoplasms/therapy
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-02004-2
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    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  8. Article ; Online: Combining atezolizumab 1200 mg with bevacizumab 15 mg/kg: based on science or just revenues?

    Ratain, Mark J / Strohbehn, Garth W

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 194, Page(s) 113349

    Abstract: Dose optimisation is increasingly important in oncology, as exemplified by the US Food and Drug Administration's Project Optimus initiative, which is aligned with similar initiatives in other countries. In parallel, multiple stakeholders have raised ... ...

    Abstract Dose optimisation is increasingly important in oncology, as exemplified by the US Food and Drug Administration's Project Optimus initiative, which is aligned with similar initiatives in other countries. In parallel, multiple stakeholders have raised concerns about anticancer drug prices, affordability, and access. This is of particular concern to government payers as well as patients and physicians in low- and middle-income countries. As anticancer drugs have historically been approved at the maximally tolerated dose, it is now highly relevant to question whether lower doses are equally effective and can be delivered at lower doses, resulting in less toxicity for patients, and lower costs for patients and payers. We illustrate this opportunity by discussing the combination of atezolizumab and bevacizumab, approved in multiple countries for both non-small cell lung cancer and hepatocellular cancer. Our conclusion is that the cost of this regimen can be reduced by more than 80%, an opportunity that should be considered by patients, prescribers, payers, and policymakers.
    MeSH term(s) Humans ; Bevacizumab/adverse effects ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Antibodies, Monoclonal, Humanized
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.113349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Rightsizing the Dosing of Modern Oncology Drugs: Mind the Gap

    Ratain, Mark J.

    Indian Journal of Medical and Paediatric Oncology

    2022  Volume 43, Issue 03, Page(s) 304–305

    Language English
    Publishing date 2022-06-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2181724-8
    ISSN 0975-2129 ; 0971-5851 ; 0975-2129
    ISSN (online) 0975-2129
    ISSN 0971-5851 ; 0975-2129
    DOI 10.1055/s-0042-1748490
    Database Thieme publisher's database

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  10. Article ; Online: Precision and Accuracy in the Brave New World of Basket Trials.

    Strohbehn, Garth W / Ratain, Mark J

    JCO precision oncology

    2022  Volume 3, Page(s) 1–5

    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.19.00074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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