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  1. Book ; Thesis: Context-dependent vitamin D signalling via CTCF

    Warwick, Timothy

    2022  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Timothy Warwick aus Dudley, Vereinigtes Königreich
    Language English
    Size 107 Seiten, Illustrationen, 30 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2023
    Note Zusammenfassung auf Deutsch und Englisch ; Enthält 2 Sonderabdrucke bzw. Manuskripte
    HBZ-ID HT030069858
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1149 order for loan Magazin

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  2. Article ; Online: Chapter 15 A Global Approach to Energy and the Environment The G-Cubed Model

    McKibbin, Warwick J. / Wilcoxen, Peter J.

    Handbook of Computable General Equilibrium Modeling

    Abstract: Abstract G-Cubed is a multi-country, multi-sector, intertemporal general equilibrium model that has ...

    Abstract Abstract G-Cubed is a multi-country, multi-sector, intertemporal general equilibrium model that has been used to study a variety of policies in the areas of environmental regulation, tax reform, monetary and fiscal policy, and international trade. It is designed to bridge the gaps between three areas of research – econometric general equilibrium modeling, international trade theory, and modern macroeconomics – by incorporating the best features of each. This chapter describes the theoretical and empirical structure of the model, summarizes its applications and contributions to the literature, and discusses two example applications in detail.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/b978-0-444-59568-3.00015-8
    Database COVID19

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  3. Book ; Online ; E-Book: Apley & Solomon's concise system of orthopaedics and trauma

    Apley, Alan / Warwick, David J. / Blom, Ashley / Whitehouse, Michael

    2022  

    Title variant Apley and Solomon's concise system of orthopaedics and trauma ; Concise system of orthopaedics and trauma
    Author's details edited by David Warwick, Ashley Blom, Michael Whitehouse
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xv, 746 Seiten), Illustrationen, Diagramme
    Edition Fifth edition
    Publisher CRC Press, Taylor & Francis Group
    Publishing place Boca Raton
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021142034
    ISBN 978-0-429-52073-0 ; 978-0-429-24397-4 ; 9780367198954 ; 9780367198770 ; 0-429-52073-5 ; 0-429-24397-9 ; 0367198959 ; 0367198770
    DOI 10.1021/
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  4. Article ; Online: Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation.

    Whiley, Phillip J / Parsons, Michael T / Leary, Jennifer / Tucker, Kathy / Warwick, Linda / Dopita, Belinda / Thorne, Heather / Lakhani, Sunil R / Goldgar, David E / Brown, Melissa A / Spurdle, Amanda B

    PloS one

    2014  Volume 9, Issue 1, Page(s) e86836

    Abstract: ... in aberrant mRNA transcripts predicted to encode truncated proteins. The BRCA1:c.122A>G(p.His41Arg) RING ...

    Abstract Rare exonic, non-truncating variants in known cancer susceptibility genes such as BRCA1 and BRCA2 are problematic for genetic counseling and clinical management of relevant families. This study used multifactorial likelihood analysis and/or bioinformatically-directed mRNA assays to assess pathogenicity of 19 BRCA1 or BRCA2 variants identified following patient referral to clinical genetic services. Two variants were considered to be pathogenic (Class 5). BRCA1:c.4484G> C(p.Arg1495Thr) was shown to result in aberrant mRNA transcripts predicted to encode truncated proteins. The BRCA1:c.122A>G(p.His41Arg) RING-domain variant was found from multifactorial likelihood analysis to have a posterior probability of pathogenicity of 0.995, a result consistent with existing protein functional assay data indicating lost BARD1 binding and ubiquitin ligase activity. Of the remaining variants, seven were determined to be not clinically significant (Class 1), nine were likely not pathogenic (Class 2), and one was uncertain (Class 3).These results have implications for genetic counseling and medical management of families carrying these specific variants. They also provide additional multifactorial likelihood variant classifications as reference to evaluate the sensitivity and specificity of bioinformatic prediction tools and/or functional assay data in future studies.
    MeSH term(s) Alternative Splicing/genetics ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Computational Biology ; Exons/genetics ; Genetic Predisposition to Disease ; Humans ; Likelihood Functions ; Multifactorial Inheritance/genetics ; Mutation, Missense/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reproducibility of Results ; Sequence Deletion/genetics
    Chemical Substances BRCA1 Protein ; BRCA2 Protein ; RNA, Messenger
    Language English
    Publishing date 2014-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0086836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: G-cubed

    McKibbin, Warwick J / Wilcoxen, Peter J

    a dynamic multi-sector general equilibrium model of the global economy ; (quantifying the costs of curbing CO 2 emissions)

    (Brookings discussion papers in international economics ; 98)

    1992  

    Institution Brookings Institution
    Author's details Warwick J. McKibbin and Peter J. Wilcoxen
    Series title Brookings discussion papers in international economics ; 98
    Keywords 24;34;60
    Language English
    Size 92 S. : graph. Darst
    Document type Book
    Database ECONomics Information System

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  6. Article ; Online: Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation.

    Phillip J Whiley / Michael T Parsons / Jennifer Leary / Kathy Tucker / Linda Warwick / Belinda Dopita / Heather Thorne / Sunil R Lakhani / David E Goldgar / Melissa A Brown / Amanda B Spurdle

    PLoS ONE, Vol 9, Iss 1, p e

    2014  Volume 86836

    Abstract: ... in aberrant mRNA transcripts predicted to encode truncated proteins. The BRCA1:c.122A>G(p.His41Arg) RING ...

    Abstract Rare exonic, non-truncating variants in known cancer susceptibility genes such as BRCA1 and BRCA2 are problematic for genetic counseling and clinical management of relevant families. This study used multifactorial likelihood analysis and/or bioinformatically-directed mRNA assays to assess pathogenicity of 19 BRCA1 or BRCA2 variants identified following patient referral to clinical genetic services. Two variants were considered to be pathogenic (Class 5). BRCA1:c.4484G> C(p.Arg1495Thr) was shown to result in aberrant mRNA transcripts predicted to encode truncated proteins. The BRCA1:c.122A>G(p.His41Arg) RING-domain variant was found from multifactorial likelihood analysis to have a posterior probability of pathogenicity of 0.995, a result consistent with existing protein functional assay data indicating lost BARD1 binding and ubiquitin ligase activity. Of the remaining variants, seven were determined to be not clinically significant (Class 1), nine were likely not pathogenic (Class 2), and one was uncertain (Class 3).These results have implications for genetic counseling and medical management of families carrying these specific variants. They also provide additional multifactorial likelihood variant classifications as reference to evaluate the sensitivity and specificity of bioinformatic prediction tools and/or functional assay data in future studies.
    Keywords Medicine ; R ; Science ; Q
    Subject code 572
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Book ; Online: The G-Cubed (agriculture) model

    McKibbin, Warwick J / Wang, Zhi

    a tool for analyzing agriculture in a globalizing world

    (Brookings discussion papers in international economics ; 139)

    1998  

    Institution Brookings Institution
    Author's details Warwick J. McKibbin .̤
    Series title Brookings discussion papers in international economics ; 139
    Keywords 24#34#60#81
    Language English
    Size Online-Ressource
    Edition [Elektronische Ressource]
    Publisher Brookings Institution
    Publishing place Washington, DC
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  8. Article ; Online: Role of F-18 FDG PET-CT in neuropsychiatric systemic lupus erythematosus.

    Berndorfler, Bianca D / Warwick, James M / Doruyter, Alex G G

    Comprehensive psychiatry

    2024  Volume 132, Page(s) 152480

    Abstract: Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major contributor to morbidity and mortality in systemic lupus erythematosus (SLE) patients. To date no single clinical, laboratory or imaging test has proven accurate for NPSLE ... ...

    Abstract Background: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major contributor to morbidity and mortality in systemic lupus erythematosus (SLE) patients. To date no single clinical, laboratory or imaging test has proven accurate for NPSLE diagnosis which is a testament to the intricate and multifactorial pathophysiological mechanisms suspected to exist. Functional imaging with FDG PET-CT has shown promise in NPSLE diagnosis, detecting abnormalities prior to changes evident on anatomical imaging. Research indicates that NPSLE may be more aggressive in people of African descent with higher mortality rates, making rapid and correct diagnosis even more important in the African context.
    Methods: In this narrative review, we provide a thorough appraisal of the current literature on the role of FDG PET-CT in NPSLE. Large, well-known databases were searched using appropriate search terms. Manual searches of references of retrieved literature were also included.
    Findings: A total of 73 article abstracts were assessed, yielding 26 papers that were directly relevant to the topic of FDG PET-CT in NPSLE. Results suggest that FDG PET-CT is a sensitive imaging test for NPSLE diagnosis and may play a role in assessing treatment response. It is complementary to routine anatomical imaging, particularly in diffuse manifestations of the disease. Newer quantitative analyses are commonly used for interpretation and can detect even subtle abnormalities, missed on visual inspection. Findings of group-wise analyses of FDG PET-CT scans in NPSLE patients are important in furthering our understanding of the complicated pathophysiological mechanisms involved. Limitations of FDG PET-CT include its lack of specificity, high cost and poor access.
    Conclusion: FDG PET-CT is a sensitive test for NPSLE diagnosis but is hampered by lack of specificity. It is a valuable tool for clinicians managing SLE patients, particularly when anatomical imaging is negative. Its exact application will depend on the local context and clinical scenario.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/j.comppsych.2024.152480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: The theoretical and empirical structure of the G-Cubed model

    McKibbin, Warwick J / Wilcoxen, Peter J

    Economic modelling Vol. 16, No. 1 , p. 123-148

    1999  Volume 16, Issue 1, Page(s) 123–148

    Author's details Warwick J. McKibbin, Peter J. Wilcoxen
    Keywords Mehr-Länder-Modell ; Mehrsektoren-Modell ; Allgemeines Gleichgewicht ; Weltmodell ; Welt
    Language English
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 86824-3
    ISSN 0264-9993
    Database ECONomics Information System

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  10. Article: Splenectomy in two siblings with G-CSF-dependent glycogen storage disease type Ib.

    Boneh, A / Auldist, A W / Francis, D E / Casanelia, S / Warwick, L / Tiedemann, K

    Journal of inherited metabolic disease

    2001  Volume 24, Issue 3, Page(s) 419–421

    MeSH term(s) Child ; Female ; Glycogen Storage Disease Type I/complications ; Glycogen Storage Disease Type I/diagnosis ; Glycogen Storage Disease Type I/therapy ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Male ; Neutropenia/complications ; Neutropenia/therapy ; Oral Ulcer ; Splenectomy ; Splenomegaly/surgery
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2001-07-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 438341-2
    ISSN 1573-2665 ; 0141-8955
    ISSN (online) 1573-2665
    ISSN 0141-8955
    DOI 10.1023/a:1010585425473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1508: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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