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  1. Article ; Online: Numerical modelling of acoustic streaming during the ultrasonic melt treatment of direct-chill (DC) casting.

    Lebon, G S Bruno / Salloum-Abou-Jaoude, Georges / Eskin, Dmitry / Tzanakis, Iakovos / Pericleous, Koulis / Jarry, Philippe

    Ultrasonics sonochemistry

    2019  Volume 54, Page(s) 171–182

    Abstract: Acoustic streaming and its attendant effects in the sump of a direct-chill (DC) casting process are successfully predicted under ultrasonic treatment for the first time. The proposed numerical model couples acoustic cavitation, fluid flow, heat and ... ...

    Abstract Acoustic streaming and its attendant effects in the sump of a direct-chill (DC) casting process are successfully predicted under ultrasonic treatment for the first time. The proposed numerical model couples acoustic cavitation, fluid flow, heat and species transfer, and solidification to predict the flow pattern, acoustic pressure, and temperature fields in the sump. The model is numerically stable with time steps of the order of 0.01 s and therefore computationally attractive for optimization studies necessitating simulation times of the order of a minute. The sump profile is altered by acoustic streaming, with the slurry region depressed along the centreline of the billet by a strong central jet. The temperature gradient in the transition zone is increased, potentially interfering with grain refinement. The cooling rate in the sump is also altered, thereby modifying the dendrite arm spacing of the as-cast billet. The relative position of the sonotrode affects the sump profile, with the sump depth decreased by around 5 mm when the sonotrode is moved above the graphite ring level by 100 mm. The acoustic streaming jet penetrates into the slurry zone and, as a result, the growth direction of dendritic grains in the off-centre position is altered.
    Language English
    Publishing date 2019-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1208333-1
    ISSN 1873-2828 ; 1350-4177
    ISSN (online) 1873-2828
    ISSN 1350-4177
    DOI 10.1016/j.ultsonch.2019.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication.

    Grandclaudon, Maximilien / Perrot-Dockès, Marie / Trichot, Coline / Karpf, Léa / Abouzid, Omar / Chauvin, Camille / Sirven, Philémon / Abou-Jaoudé, Wassim / Berger, Frédérique / Hupé, Philippe / Thieffry, Denis / Sansonnet, Laure / Chiquet, Julien / Lévy-Leduc, Céline / Soumelis, Vassili

    Cell

    2019  Volume 179, Issue 2, Page(s) 432–447.e21

    Abstract: Cell-cell communication involves a large number of molecular signals that function as words of a complex language whose grammar remains mostly unknown. Here, we describe an integrative approach involving (1) protein-level measurement of multiple ... ...

    Abstract Cell-cell communication involves a large number of molecular signals that function as words of a complex language whose grammar remains mostly unknown. Here, we describe an integrative approach involving (1) protein-level measurement of multiple communication signals coupled to output responses in receiving cells and (2) mathematical modeling to uncover input-output relationships and interactions between signals. Using human dendritic cell (DC)-T helper (Th) cell communication as a model, we measured 36 DC-derived signals and 17 Th cytokines broadly covering Th diversity in 428 observations. We developed a data-driven, computationally validated model capturing 56 already described and 290 potentially novel mechanisms of Th cell specification. By predicting context-dependent behaviors, we demonstrate a new function for IL-12p70 as an inducer of Th17 in an IL-1 signaling context. This work provides a unique resource to decipher the complex combinatorial rules governing DC-Th cell communication and guide their manipulation for vaccine design and immunotherapies.
    MeSH term(s) Adolescent ; Adult ; Aged ; Cell Communication/immunology ; Cells, Cultured ; Coculture Techniques ; Dendritic Cells/immunology ; Healthy Volunteers ; Humans ; Interleukin-1/metabolism ; Interleukin-12/physiology ; Middle Aged ; Models, Biological ; Th17 Cells/immunology ; Young Adult
    Chemical Substances Interleukin-1 ; Interleukin-12 (187348-17-0)
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.

    Abou-Jaoude, Antoine / Badiqué, Lise / Mlih, Mohamed / Awan, Sara / Guo, Sunning / Lemle, Alexandre / Abboud, Clauda / Foppolo, Sophie / Host, Lionel / Terrand, Jérôme / Justiniano, Hélène / Herz, Joachim / Matz, Rachel L / Boucher, Philippe

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 9577

    Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    Abstract A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-27564-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.

    Abou-Jaoude, Antoine / Badiqué, Lise / Mlih, Mohamed / Awan, Sara / Guo, Sunning / Lemle, Alexandre / Abboud, Clauda / Foppolo, Sophie / Host, Lionel / Terrand, Jérôme / Justiniano, Hélène / Herz, Joachim / Matz, Rachel L / Boucher, Philippe

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 4501

    Abstract: ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of ... ...

    Abstract ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of endothelial ShcA in atherosclerotic lesion formation. We found that atherosclerosis progression was markedly attenuated in mice deleted for ShcA in endothelial cells, that macrophage content was reduced at the sites of lesions, and that adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) were severely reduced. Our data indicate that transcriptional regulation of ShcA by the zinc-finger E-box-binding homeobox 1 (ZEB1) and the Hippo pathway effector YAP, promotes ICAM-1 expression independently of p-NF-κB, the primary driver of adhesion molecules expressions. In addition, ShcA suppresses endothelial Akt and nitric oxide synthase (eNOS) expressions. Thus, through down regulation of eNOS and ZEB1-mediated ICAM-1 up regulation, endothelial ShcA promotes monocyte-macrophage adhesion and atherosclerotic lesion formation. Reducing ShcA expression in endothelial cells may represent an obvious therapeutic approach to prevent atherosclerosis.
    Language English
    Publishing date 2018-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-22819-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bicarbonate therapy in the treatment of septic shock: a second look.

    El-Solh, Ali A / Abou Jaoude, Philippe / Porhomayon, Jahan

    Internal and emergency medicine

    2010  Volume 5, Issue 4, Page(s) 341–347

    Abstract: The use of supplemental sodium bicarbonate for the treatment of patients with septic shock and elevated blood lactate levels remains a controversial therapy. We conducted a retrospective study between March 2004 and February 2009 of 36 consecutive ... ...

    Abstract The use of supplemental sodium bicarbonate for the treatment of patients with septic shock and elevated blood lactate levels remains a controversial therapy. We conducted a retrospective study between March 2004 and February 2009 of 36 consecutive patients diagnosed with septic shock who received continuous infusion of bicarbonate therapy. A control group was matched 1:1 for age, site of infection, and predicted mortality by APACHE II. All patients were managed according to standard protocols. The median time until reversal of shock did not achieve statistical significance between the bicarbonate group (44.5 h [95% confidence interval [CI] 34-54] and the control group (55.0 h [95% CI 39-60] (p = 0.09). The median time to liberation of mechanical ventilation was significantly reduced in the bicarbonate group (10 days [95% CI 5.0-13.0] compared to the control group (14 days [95% CI 9.0-19.0], p = 0.02). The length of intensive care unit (ICU) stay was also shorter in the surviving patients who received bicarbonate compared to controls (median 11.5 days (95% CI 6.0-16.0) vs. 16.0 days (95% CI 13.5-19.0), respectively; p = 0.01). However, there was no difference in 28-day mortality between the two study groups (28%; 95% CI 14-45% vs. 33%; 95% CI 19-51%, respectively; p = 0.79). Infusion of sodium bicarbonate in septic patients with arterial hyperlactatemia may facilitate weaning from mechanical ventilation and reduce length of ICU stay.
    MeSH term(s) APACHE ; Aged ; Aged, 80 and over ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Retrospective Studies ; Shock, Septic/drug therapy ; Shock, Septic/mortality ; Sodium Bicarbonate/administration & dosage ; Sodium Bicarbonate/therapeutic use ; United States/epidemiology
    Chemical Substances Sodium Bicarbonate (8MDF5V39QO)
    Language English
    Publishing date 2010-02-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-010-0351-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication

    Grandclaudon, Maximilien / Abou-Jaoudé, Wassim / Abouzid, Omar / Berger, Frédérique / Chauvin, Camille / Chiquet, Julien / Hupé, Philippe / Karpf, Léa / Lévy-Leduc, Céline / Perrot-Dockès, Marie / Sansonnet, Laure / Sirven, Philémon / Soumelis, Vassili / Thieffry, Denis / Trichot, Coline

    Cell. 2019 Oct. 03, v. 179, no. 2

    2019  

    Abstract: Cell-cell communication involves a large number of molecular signals that function as words of a complex language whose grammar remains mostly unknown. Here, we describe an integrative approach involving (1) protein-level measurement of multiple ... ...

    Abstract Cell-cell communication involves a large number of molecular signals that function as words of a complex language whose grammar remains mostly unknown. Here, we describe an integrative approach involving (1) protein-level measurement of multiple communication signals coupled to output responses in receiving cells and (2) mathematical modeling to uncover input-output relationships and interactions between signals. Using human dendritic cell (DC)-T helper (Th) cell communication as a model, we measured 36 DC-derived signals and 17 Th cytokines broadly covering Th diversity in 428 observations. We developed a data-driven, computationally validated model capturing 56 already described and 290 potentially novel mechanisms of Th cell specification. By predicting context-dependent behaviors, we demonstrate a new function for IL-12p70 as an inducer of Th17 in an IL-1 signaling context. This work provides a unique resource to decipher the complex combinatorial rules governing DC-Th cell communication and guide their manipulation for vaccine design and immunotherapies.
    Keywords cell communication ; dendritic cells ; humans ; immunotherapy ; interleukin-1 ; interleukin-12 ; mathematical models ; model validation ; multivariate analysis ; prediction ; protein content ; vaccine development
    Language English
    Dates of publication 2019-1003
    Size p. 432-447.e21.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.09.012
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Author Correction

    Antoine Abou-Jaoude / Lise Badiqué / Mohamed Mlih / Sara Awan / Sunning Guo / Alexandre Lemle / Clauda Abboud / Sophie Foppolo / Lionel Host / Jérôme Terrand / Hélène Justiniano / Joachim Herz / Rachel L. Matz / Philippe Boucher

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

    2018  Volume 1

    Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    Abstract A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2018-06-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation

    Antoine Abou-Jaoude / Lise Badiqué / Mohamed Mlih / Sara Awan / Sunning Guo / Alexandre Lemle / Clauda Abboud / Sophie Foppolo / Lionel Host / Jérôme Terrand / Hélène Justiniano / Joachim Herz / Rachel L. Matz / Philippe Boucher

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Volume 12

    Abstract: Abstract ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role ... ...

    Abstract Abstract ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the role of endothelial ShcA in atherosclerotic lesion formation. We found that atherosclerosis progression was markedly attenuated in mice deleted for ShcA in endothelial cells, that macrophage content was reduced at the sites of lesions, and that adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) were severely reduced. Our data indicate that transcriptional regulation of ShcA by the zinc-finger E-box-binding homeobox 1 (ZEB1) and the Hippo pathway effector YAP, promotes ICAM-1 expression independently of p-NF-κB, the primary driver of adhesion molecules expressions. In addition, ShcA suppresses endothelial Akt and nitric oxide synthase (eNOS) expressions. Thus, through down regulation of eNOS and ZEB1-mediated ICAM-1 up regulation, endothelial ShcA promotes monocyte-macrophage adhesion and atherosclerotic lesion formation. Reducing ShcA expression in endothelial cells may represent an obvious therapeutic approach to prevent atherosclerosis.
    Keywords Medicine ; R ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Survey instruments used in clinical and epidemiological research on waterpipe tobacco smoking: a systematic review.

    Akl, Elie A / Aleem, Sohaib / Gunukula, Sameer K / Honeine, Roland / Abou Jaoude, Philippe / Irani, Jihad

    BMC public health

    2010  Volume 10, Page(s) 415

    Abstract: Background: The primary objective was to systematically review the medical literature for instruments validated for use in epidemiological and clinical research on waterpipe smoking.: Methods: We searched the following databases: MEDLINE, EMBASE, and ...

    Abstract Background: The primary objective was to systematically review the medical literature for instruments validated for use in epidemiological and clinical research on waterpipe smoking.
    Methods: We searched the following databases: MEDLINE, EMBASE, and ISI the Web of Science. We selected studies using a two-stage duplicate and independent screening process. We included papers reporting on the development and/or validation of survey instruments to measure waterpipe tobacco consumption or related concepts. Two reviewers used a standardized and pilot tested data abstraction form to collect data from each eligible study using a duplicate and independent screening process. We also determined the percentage of observational studies assessing the health effects of waterpipe tobacco smoking and the percentage of studies of prevalence of waterpipe tobacco smoking that have used validated survey instruments.
    Results: We identified a total of five survey instruments. One instrument was designed to measure knowledge, attitudes, and waterpipe use among pregnant women and was shown to have internal consistency and content validity. Three instruments were designed to measure waterpipe tobacco consumption, two of which were reported to have face validity. The fifth instrument was designed to measure waterpipe dependence and was rigorously developed and validated. One of the studies of prevalence and none of the studies of health effects of waterpipe smoking used validated instruments.
    Conclusions: A number of instruments for measuring the use of and dependence on waterpipe smoking exist. Future research should study content validity and cross cultural adaptation of these instruments.
    MeSH term(s) Data Collection/methods ; Epidemiologic Methods ; Female ; Humans ; Pregnancy ; Smoking/epidemiology ; Validation Studies as Topic
    Language English
    Publishing date 2010-07-13
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/1471-2458-10-415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Validity of severity scores in hospitalized patients with nursing home-acquired pneumonia.

    El-Solh, Ali A / Alhajhusain, Ahmad / Abou Jaoude, Philippe / Drinka, Paul

    Chest

    2010  Volume 138, Issue 6, Page(s) 1371–1376

    Abstract: Background: Several severity scores have been advanced to predict a patient's outcome from community-acquired pneumonia (CAP). The purpose of this study is to compare the accuracy of confusion, urea, respiratory rate, BP (CURB); CURB plus age ≥ 65 years ...

    Abstract Background: Several severity scores have been advanced to predict a patient's outcome from community-acquired pneumonia (CAP). The purpose of this study is to compare the accuracy of confusion, urea, respiratory rate, BP (CURB); CURB plus age ≥ 65 years (CURB-65); CURB-65 minus urea (CRB-65); and systolic BP, oxygenation, age, and respiratory rate (SOAR) scoring systems in predicting 30-day mortality and ICU admission in patients with nursing home-acquired pneumonia (NHAP).
    Methods: A retrospective analysis of a prospectively collected database of 457 nursing home residents hospitalized with pneumonia at two university-affiliated tertiary care facilities. Clinical and laboratory features were used to compute severity scores using the British Thoracic Society severity rules and the SOAR criteria. The sensitivity, specificity, and positive and negative predictive values were compared for need for ICU admission and 30-day mortality.
    Results: The overall 30-day mortality and ICU admission rates were 23% and 25%, respectively. CURB, CURB-65, and CRB-65 performed similarly in predicting mortality with areas under the receiver operating characteristic curves (AUCs) of 0.605 (95% CI, 0.559-0.650), 0.593 (95% CI, 0.546-0.638), and 0.592 (95% CI, 0.546-0.638), respectively, whereas SOAR showed superior accuracy with an AUC of 0.765 (95% CI, 0.724-0.803) (P < .001). The need for ICU care was also better identified with the SOAR model compared with the other scoring rules.
    Conclusions: All three British Thoracic Society rules had lower performance accuracy in predicting 30-day mortality of hospitalized NHAP than SOAR. SOAR is also a superior alternative for better identification of severe NHAP. An improved rule for severity assessment of hospitalized NHAP is needed.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Cohort Studies ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/mortality ; Community-Acquired Infections/therapy ; Female ; Follow-Up Studies ; Geriatric Assessment ; Hospital Mortality/trends ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units ; Length of Stay ; Male ; New York ; Nursing Homes/statistics & numerical data ; Pneumonia/diagnosis ; Pneumonia/mortality ; Pneumonia/therapy ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Validation Studies
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1378/chest.10-0494
    Database MEDical Literature Analysis and Retrieval System OnLINE

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