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  1. Article ; Online: Introduction: Kidney Safety Science.

    Vaidya, Vishal S

    Seminars in nephrology

    2019  Volume 39, Issue 2, Page(s) 117–119

    MeSH term(s) Kidney Diseases/chemically induced ; Kidney Diseases/diagnosis ; Kidney Diseases/prevention & control ; Kidney Diseases/therapy ; Risk Assessment
    Language English
    Publishing date 2019-03-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2018.12.001
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  2. Book: Biomarkers

    Vaidya, Vishal S. / Bonventre, Joseph V.

    in medicine, drug discovery, and environmental health

    2010  

    Author's details ed. by Vishal S. Vaidya ; Joseph V. Bonventre
    Keywords Biological Markers ; Diagnostic Techniques and Procedures ; Drug Discovery ; Environmental Monitoring / methods
    Language English
    Size XXVIII, 602 S., [8] Bl. : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT016589631
    ISBN 978-0-470-45224-0 ; 0-470-45224-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1673 order for loan Magazin

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  3. Article ; Online: Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA.

    Fader, Kelly A / Gosink, Mark M / Xia, Shuhua / Lanz, Thomas A / Halsey, Charles / Vaidya, Vishal S / Radi, Zaher A

    Toxicology and applied pharmacology

    2023  Volume 473, Page(s) 116582

    Abstract: A high incidence of thymic lymphoma has been noted in mice deficient of retinoid-related orphan receptor γ2 (RORγ2), which is required for differentiation of naïve ... ...

    Abstract A high incidence of thymic lymphoma has been noted in mice deficient of retinoid-related orphan receptor γ2 (RORγ2), which is required for differentiation of naïve CD4
    MeSH term(s) Animals ; Humans ; Infant ; Mice ; Cell-Free Nucleic Acids/genetics ; Mice, Knockout ; Neoplasms ; Nuclear Receptor Subfamily 1, Group F, Member 3
    Chemical Substances 5-hydroxymethylcytosine (1123-95-1) ; Cell-Free Nucleic Acids ; Nuclear Receptor Subfamily 1, Group F, Member 3
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116582
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  4. Article ; Online: MicroRNAs in injury and repair.

    Gerlach, Cory V / Vaidya, Vishal S

    Archives of toxicology

    2017  Volume 91, Issue 8, Page(s) 2781–2797

    Abstract: Organ damage and resulting pathologies often involve multiple deregulated pathways. MicroRNAs (miRNAs) are short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. Since their discovery over two decades ago, miRNAs ... ...

    Abstract Organ damage and resulting pathologies often involve multiple deregulated pathways. MicroRNAs (miRNAs) are short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. Since their discovery over two decades ago, miRNAs have been established as key players in the molecular mechanisms of mammalian biology including the maintenance of normal homeostasis and the regulation of disease pathogenesis. In recent years, there has been substantial progress in innovative techniques to measure miRNAs along with advances in targeted delivery of agents modulating their expression. This has expanded the scope of miRNAs from being important mediators of cell signaling to becoming viable quantitative biomarkers and therapeutic targets. Currently, miRNA therapeutics are in clinical trials for multiple disease areas and vast numbers of patents have been filed for miRNAs involved in various pathological states. In this review, we summarize miRNAs involved in organ injury and repair, specifically with regard to organs that are the most susceptible to injury: the liver, heart and kidney. In addition, we review the current state of knowledge on miRNA biology, miRNA biomarkers and nucleotide-based therapeutics designed to target miRNAs to prevent organ injury and promote repair.
    MeSH term(s) Animals ; Genetic Markers/genetics ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Humans ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Liver Diseases/genetics ; Liver Diseases/metabolism ; MicroRNAs/administration & dosage ; MicroRNAs/genetics ; Signal Transduction/genetics
    Chemical Substances Genetic Markers ; MicroRNAs
    Language English
    Publishing date 2017-05-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-017-1974-1
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  5. Article ; Online: Harihara M. Mehendale: A Life Dedicated to Mentoring and Research.

    Apte, Udayan / Anand, S Satheesh / Badanthadka, Murali / Chilakapati, Jaya / Curtis, Lawrence R / Dadhania, Vivek / Digavalli, Sivarao V / Kodavanti, Urmila / Kodavanti, Prasada Rao / Limaye, Pallavi / Mangipudy, Raja / Murthy, Subramanya N / Philip, Binu / Rao, Pratibha / Sawant, Sharmilee / Shankar, Kartik / Vaidya, Vishal / Wang, Tao

    International journal of toxicology

    2023  Volume 42, Issue 4, Page(s) 301–308

    MeSH term(s) Humans ; Mentoring ; Mentors
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818231174567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species.

    Fader, Kelly A / Pardo, Ingrid D / Kovi, Ramesh C / Somps, Christopher J / Wang, Helen Hong / Vaidya, Vishal S / Ramaiah, Shashi K / Sirivelu, Madhu P

    Molecular therapy. Methods & clinical development

    2022  Volume 25, Page(s) 264–277

    Abstract: Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration. As ... ...

    Abstract Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration. As AAV vectors become an increasingly common platform for novel therapeutics, non-invasive biomarkers are needed to better characterize and manage the risk of DRG neurotoxicity in both nonclinical and clinical studies. Based on biological relevance, reagent availability, antibody cross-reactivity, DRG protein expression, and assay performance, neurofilament light chain (NF-L) emerged as a promising biomarker candidate. Dose- and time-dependent changes in NF-L were evaluated in male Wistar Han rats and cynomolgus monkeys following intravenous or intrathecal AAV injection, respectively. NF-L profiles were then compared against microscopic DRG lesions on day 29 post-dosing. In animals exhibiting DRG toxicity, plasma/serum NF-L was strongly associated with the severity of neuronal degeneration/necrosis and nerve fiber degeneration, with elevations beginning as early as day 8 in rats (≥5 × 10
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2872938-9
    ISSN 2329-0501 ; 2329-0501
    ISSN (online) 2329-0501
    ISSN 2329-0501
    DOI 10.1016/j.omtm.2022.03.017
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  7. Article ; Online: MicroRNAs and drug-induced kidney injury.

    Pavkovic, Mira / Vaidya, Vishal S

    Pharmacology & therapeutics

    2016  Volume 163, Page(s) 48–57

    Abstract: Drug-induced kidney injury (DIKI) is a severe complication in hospitalized patients associated with higher probabilities of developing progressive chronic kidney disease or end-stage renal diseases. Furthermore, DIKI is a problem during preclinical and ... ...

    Abstract Drug-induced kidney injury (DIKI) is a severe complication in hospitalized patients associated with higher probabilities of developing progressive chronic kidney disease or end-stage renal diseases. Furthermore, DIKI is a problem during preclinical and clinical phases of drug development leading to high rates of project terminations. Understanding the molecular perturbations caused by DIKI would pave the way for a new class of therapeutics to mitigate the damage. Yet, another approach to ameliorate DIKI is identifying sensitive and specific translational biomarkers that outperform the current diagnostic analytes like serum creatinine and facilitate early diagnosis. MicroRNAs (miRNAs), a class of non-coding RNAs, are increasingly being recognized to have a two-pronged approach toward DIKI management: 1) miRNAs have a regulatory role in gene expression and signaling pathways thereby making them novel interventional targets and 2) miRNAs enable diagnosis and prognosis of DIKI because of their stable presence in biofluids. In this review, apart from summarizing the literature on miRNAs in DIKI, we report small RNA sequencing results showing miRNA expression profiles at baseline in normal kidney samples from mice and humans. Additionally, we also compared the miRNA expression in biopsies of normal human kidneys to patients with acute tubular necrosis, and found 76 miRNAs significantly downregulated and 47 miRNAs upregulated (FDR adjusted p<0.05, +/-2-fold change). In summary, we highlight the transformative potential of miRNAs in therapeutics and translational medicine with a focus on drug-induced kidney damage.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Animals ; Biomarkers ; Creatinine/blood ; Gene Expression/physiology ; Humans ; MicroRNAs/biosynthesis ; MicroRNAs/metabolism ; Reproducibility of Results ; Signal Transduction/physiology
    Chemical Substances Biomarkers ; MicroRNAs ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2016-04-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2016.03.016
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  8. Article ; Online: Industry Perspective on Biomarker Development and Qualification.

    Gerlach, Cory V / Derzi, Mazin / Ramaiah, Shashi K / Vaidya, Vishal S

    Clinical pharmacology and therapeutics

    2017  

    Abstract: Pharmaceutical and biotechnology companies routinely use biomarkers to obtain quantitative metrics for drug exposure, efficacy, and safety and to inform clinical trial design with regard to patient selection, treatments, and outcomes. Biomarker science ... ...

    Abstract Pharmaceutical and biotechnology companies routinely use biomarkers to obtain quantitative metrics for drug exposure, efficacy, and safety and to inform clinical trial design with regard to patient selection, treatments, and outcomes. Biomarker science has the unique capability to catalyze precompetitive collaborations between academia, industry, regulatory agencies, and other stakeholders with the ultimate goal of accelerating the delivery of safe and effective medicines to patients, particularly in areas of high unmet need.
    Language English
    Publishing date 2017-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.919
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  9. Article ; Online: Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics.

    Basit, Abdul / Radi, Zaher / Vaidya, Vishal S / Karasu, Matthew / Prasad, Bhagwat

    Drug metabolism and disposition: the biological fate of chemicals

    2019  Volume 47, Issue 8, Page(s) 802–808

    Abstract: Limited understanding of species differences in kidney transporters is a critical knowledge gap for prediction of drug-induced acute kidney injury, drug interaction, and pharmacokinetics in humans. Here, we report protein abundance data of 19 ... ...

    Abstract Limited understanding of species differences in kidney transporters is a critical knowledge gap for prediction of drug-induced acute kidney injury, drug interaction, and pharmacokinetics in humans. Here, we report protein abundance data of 19 transporters in the kidney cortex across five species (human, monkey, dog, rat, and mouse). In general, the abundance of all of the 19 membrane transporters was higher in preclinical species compared with human except for multidrug resistance protein 1 (MDR1), organic cation transporter (OCT) 3, and OCTN1. In nonhuman primate, the total abundance of 12 transporters for which absolute data were available was 2.1-fold higher (
    MeSH term(s) Animals ; Dogs ; Drug Evaluation, Preclinical ; Female ; Humans ; Kidney Cortex/metabolism ; Macaca fascicularis ; Male ; Membrane Transport Proteins/analysis ; Membrane Transport Proteins/metabolism ; Mice ; Proteomics ; Rats ; Renal Elimination ; Species Specificity
    Chemical Substances Membrane Transport Proteins
    Language English
    Publishing date 2019-05-23
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186795-7
    ISSN 1521-009X ; 0090-9556
    ISSN (online) 1521-009X
    ISSN 0090-9556
    DOI 10.1124/dmd.119.086579
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  10. Article ; Online: A High-Throughput Screening Assay to Identify Kidney Toxic Compounds.

    Ramm, Susanne / Adler, Melanie / Vaidya, Vishal S

    Current protocols in toxicology

    2016  Volume 69, Page(s) 9.10.1–9.10.26

    Abstract: Kidney toxicity due to drugs and chemicals poses a significant health burden for patients and a financial risk for pharmaceutical companies. However, currently no sensitive and high-throughput in vitro method exists for predictive nephrotoxicity ... ...

    Abstract Kidney toxicity due to drugs and chemicals poses a significant health burden for patients and a financial risk for pharmaceutical companies. However, currently no sensitive and high-throughput in vitro method exists for predictive nephrotoxicity assessment. Primary human proximal tubular epithelial cells (HPTECs) possess characteristics of differentiated epithelial cells, making them a desirable model to use in in vitro screening systems. Additionally, heme oxygenase 1 (HO-1) protein expression is upregulated as a protective mechanism during kidney toxicant-induced oxidative stress or inflammation in HPTECs and can therefore be used as a biomarker for nephrotoxicity. In this article, we describe two different methods to screen for HO-1 increase: A homogeneous time resolved fluorescence (HTRF) assay and an immunofluorescence assay. The latter provides lower throughput but higher sensitivity due to the combination of two readouts, HO-1 intensity and cell number. The methods described in the protocol are amendable for other cell types as well. © 2016 by John Wiley & Sons, Inc.
    MeSH term(s) Biomarkers/metabolism ; Cells, Cultured ; Cryopreservation ; Enzyme Induction/drug effects ; Fluorescence Resonance Energy Transfer ; Fluoroimmunoassay ; Heme Oxygenase-1/chemistry ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; High-Throughput Screening Assays ; Humans ; Kidney Tubules, Proximal/cytology ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/immunology ; Kidney Tubules, Proximal/metabolism ; Kinetics ; Oxidative Stress/drug effects ; Toxicity Tests, Acute/instrumentation ; Toxicity Tests, Acute/methods ; Xenobiotics/toxicity
    Chemical Substances Biomarkers ; Xenobiotics ; HMOX1 protein, human (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18)
    Language English
    Publishing date 2016-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1934-9262
    ISSN (online) 1934-9262
    DOI 10.1002/cptx.12
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