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Article ; Online: Investigation of June 2020 giant Saharan dust storm using remote sensing observations and model reanalysis.

Asutosh, A / Vinoj, V / Murukesh, Nuncio / Ramisetty, Ramakrishna / Mittal, Nishant

2022 Volume 12, Issue 1, Page(s) 6114

Abstract: This paper investigates the characteristics and impact of a major Saharan dust storm during June 14th-19th 2020 on atmospheric radiative and thermodynamics properties over the Atlantic Ocean. The event witnessed the highest ever aerosol optical depth for ...

Abstract	This paper investigates the characteristics and impact of a major Saharan dust storm during June 14th-19th 2020 on atmospheric radiative and thermodynamics properties over the Atlantic Ocean. The event witnessed the highest ever aerosol optical depth for June since 2002. The satellites and high-resolution model reanalysis products well captured the origin and spread of the dust storm. The Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) measured total attenuated backscatter and aerosol subtype profiles, lower angstrom exponent values (~ 0.12) from Modern-Era Retrospective Analysis for Research and Application-version 2 (MERRA-2) and higher aerosol index value from Ozone monitoring instrument (> 4) tracked the presence of elevated dust. It was found that the dust AOD was as much as 250-300% higher than their climatology resulting in an atmospheric radiative forcing ~ 200% larger. As a result, elevated warming (8-16%) was observed, followed by a drop in relative humidity (2-4%) in the atmospheric column, as evidenced by both in-situ and satellite measurements. Quantifications such as these for extreme dust events provide significant insights that may help in understanding their climate effects, including improvements to dust simulations using chemistry-climate models.
MeSH term(s)	Aerosols/analysis ; Air Pollutants/analysis ; Dust/analysis ; Environmental Monitoring/methods ; Remote Sensing Technology ; Retrospective Studies
Chemical Substances	Aerosols ; Air Pollutants ; Dust
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-10017-1
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Article: The mechanism linking the variability of the Antarctic sea ice extent in the Indian Ocean sector to Indian summer monsoon rainfall.

Azhar, Siti Syairah Atiqah / Chenoli, Sheeba Nettukandy / Samah, Azizan Abu / Kim, Seong-Joong / Murukesh, Nuncio

Climate dynamics

2022 Volume 60, Issue 9-10, Page(s) 2665–2685

Abstract: The study investigates the mechanism of teleconnection between the variability of sea ice extent (SIE) in the Indian Ocean sector of the Southern Ocean and the variability of Indian summer monsoon rainfall. We utilized reanalysis, satellite, in-situ ... ...

Abstract	The study investigates the mechanism of teleconnection between the variability of sea ice extent (SIE) in the Indian Ocean sector of the Southern Ocean and the variability of Indian summer monsoon rainfall. We utilized reanalysis, satellite, in-situ observation data, and model output from the coupled model intercomparison project phase 5 (CMIP5) from 1979 to 2013. The empirical orthogonal function (EOF) and correlation analysis show that the first and third modes of principal component (PC1 and PC3) of SIE in the Indian Ocean sector during April-May-June (AMJ) are significantly correlated with the second mode of principal component (PC2) of Indian summer monsoon rainfall. The reanalysis data revealed that the changes in the SIE in the Indian Ocean sector excite meridional wave train responses along the Indian Ocean for both principal component modes. Positive (negative) SIE anomalies based on first and third EOFs (EOF1 and EOF3), contribute to the strengthening (weakening) of the Polar, Ferrel, and Hadley cells, inducing stronger (weaker) convective activity over the Indian latitudes. The stronger (weaker) convective activity over the Indian region leads to more (less) rainfall over the region during high (low) ice phase years. Furthermore, a stronger (weaker) polar jet during the high (low) ice phase is also noted. The selected CMIP5 models captured certain atmospheric teleconnection features found in the reanalysis. During AMJ, the SIE simulated by the NorESM1-M model was significantly positively correlated with Indian summer monsoon rainfall, whereas the IPSL-CM54-LR model showed a negative correlation.
Language	English
Publishing date	2022-08-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-022-06466-z
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Article ; Online: Adenoid cystic carcinoma of the thymus gland.

Shatila, Mohamed / Hemead, Hanan / Murukesh, Nishanth / Taniere, Philippe / Russell, Caroline / Menon, Ashvini / Patel, Akshay J

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 307

Abstract: Background: Thymic carcinomas are rare and aggressive tumours. They constitute a heterogeneous group of tumours with various histological patterns and subtypes resembling epithelial tumours arising from other organs.: Case presentation: We hereby ... ...

Abstract	Background: Thymic carcinomas are rare and aggressive tumours. They constitute a heterogeneous group of tumours with various histological patterns and subtypes resembling epithelial tumours arising from other organs. Case presentation: We hereby represent a case of primary thymic carcinoma with adenoid cystic carcinoma-like features (TCACC) which is an extremely rare variant of thymic adenocarcinoma. To date and to the best of our knowledge, there are nine reported cases in literature and ours is the tenth. Our case was treated surgically but the implementation of adjuvant chemoradiotherapy has been reported in few of the published cases. Conclusions: TCACC constitutes a rare entity of thymic adenocarcinoma with limited available literature. The current data is derived from few case reports and case series. The histological overlap of these tumours and primary ACC of salivary glands poses a diagnostic challenge. Radiological investigations, immunohistochemical phenotyping and genetic analysis are crucial in establishing the diagnosis.
MeSH term(s)	Humans ; Carcinoma, Adenoid Cystic/diagnostic imaging ; Carcinoma, Adenoid Cystic/surgery ; Thymus Gland ; Adenocarcinoma/pathology ; Thymoma/diagnosis ; Thymoma/surgery ; Thymus Neoplasms/diagnosis ; Thymus Neoplasms/surgery ; Thymus Neoplasms/pathology
Language	English
Publishing date	2023-11-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02432-w
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Book ; Online: Pattern change of precipitation extremes in Bear Island

Ray, Arnob / Chakraborty, Tanujit / Radhakrishnan, Athulya / Hens, Chittaranjan / Dana, Syamal K. / Ghosh, Dibakar / Murukesh, Nuncio

2023

Abstract: Extreme precipitation in the Arctic region plays a crucial role in global weather and climate patterns. Bear Island (Bj{\o}rn{\o}ya) is located in the Norwegian Svalbard archipelago, which is, therefore, selected for our study on extreme precipitation. ... ...

Abstract	Extreme precipitation in the Arctic region plays a crucial role in global weather and climate patterns. Bear Island (Bj{\o}rn{\o}ya) is located in the Norwegian Svalbard archipelago, which is, therefore, selected for our study on extreme precipitation. The island occupies a unique geographic position at the intersection of the high and low Arctic, characterized by a flat and lake-filled northern region contrasting with mountainous terrain along its southern shores. Its maritime-polar climate is influenced by North Atlantic currents, resulting in relatively mild winter temperatures. An increase in precipitation level in Bear Island is a significant concern linked to climate change and has global implications. We have collected the amount of daily precipitation as well as daily maximum temperatures from the meteorological station of Bj{\o}rn{\o}ya located on the island, operated by the Norwegian Centre for Climate Services for a period spanning from January 1, 1960 to December 31, 2021. We observe that the trend of yearly mean precipitation during this period linearly increases. We analyze the recorded data to investigate the changing pattern of precipitation extremes over the climate scales. We employ the generalized extreme value distribution to model yearly and seasonal maxima of daily precipitation amount and determine the return levels and return period of precipitation extremes. We compare the variability of precipitation extremes between the two time periods: (i) 1960-1990 and (ii) 1991-2021. Our analysis reveals an increase in the frequency of precipitation extremes occurrences between 1991 and 2021. Our findings establish a better understanding of precipitation extremes in Bear Island from a statistical viewpoint, with an observation of seasonal and yearly variability, especially, during the period of the last 31 years.
Keywords	Physics - Atmospheric and Oceanic Physics ; Statistics - Applications
Subject code	910
Publishing date	2023-12-07
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combined influence of oceanic and atmospheric circulations on Greenland sea ice concentration

S. Chatterjee / R. P. Raj / L. Bertino / S. H. Mernild / M. P. Subeesh / N. Murukesh / M. Ravichandran

The Cryosphere, Vol 15, Pp 1307-

2021 Volume 1319

Abstract: The amount and spatial extent of Greenland Sea (GS) ice are primarily controlled by the sea ice export across the Fram Strait (FS) and by local seasonal sea ice formation, melting, and sea ice dynamics. In this study, using satellite passive microwave ... ...

Abstract	The amount and spatial extent of Greenland Sea (GS) ice are primarily controlled by the sea ice export across the Fram Strait (FS) and by local seasonal sea ice formation, melting, and sea ice dynamics. In this study, using satellite passive microwave sea ice observations, atmospheric and a coupled ocean-sea ice reanalysis system, TOPAZ4, we show that both the atmospheric and oceanic circulation in the Nordic Seas (NS) act in tandem to explain the SIC variability in the south-western GS. Northerly wind anomalies associated with anomalously low sea level pressure (SLP) over the NS reduce the sea ice export in the south-western GS due to westward Ekman drift of sea ice. On the other hand, the positive wind stress curl strengthens the cyclonic Greenland Sea Gyre (GSG) circulation in the central GS. An intensified GSG circulation may result in stronger Ekman divergence of surface cold and fresh waters away from the south-western GS. Both of these processes can reduce the freshwater content and weaken the upper-ocean stratification in the south-western GS. At the same time, warm and saline Atlantic Water (AW) anomalies are recirculated from the FS region to the south-western GS by a stronger GSG circulation. Under weakly stratified conditions, enhanced vertical mixing of these subsurface AW anomalies can warm the surface waters and inhibit new sea ice formation, further reducing the SIC in the south-western GS.
Keywords	Environmental sciences ; GE1-350 ; Geology ; QE1-996.5
Subject code	551 ; 290
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: The impact of atmospheric and oceanic circulations on the Greenland Sea iceconcentration

Chatterjee, Sourav / Raj, Roshin P. / Bertino, Laurent / Merlind, Sebastian H. / Murukesh, Nuncio / Ravichandran, Muthalagu

eISSN: 1994-0424

2020

Abstract: The amount and spatial extent of Greenland Sea (GS) sea ice are primarily driven by the sea ice export across the Fram Strait (FS) and by local seasonal sea ice formation, melting and sea ice dynamics. Maximum sea ice concentration (SIC) variability is ... ...

Abstract	The amount and spatial extent of Greenland Sea (GS) sea ice are primarily driven by the sea ice export across the Fram Strait (FS) and by local seasonal sea ice formation, melting and sea ice dynamics. Maximum sea ice concentration (SIC) variability is found in the marginal ice zone and ‘Odden’ region in the central GS. In this study, using satellite passive microwave sea ice observations, atmospheric and a coupled ocean-sea ice reanalysis system we show that both the atmospheric and oceanic circulation in the GS act in tandem to explain the SIC variability in the GS. Anomalous low/high sea level pressure (SLP) over the Nordic Seas is found to strengthen/weaken the Greenland Sea Gyre (GSG) circulation. The large-scale atmospheric circulation pattern associated with this GSG variability features North Atlantic Oscillation (NAO) like SLP pattern with its northern center of action shifted north-eastward from its canonical position. During anomalous low SLP periods, northerly wind anomalies reduce the sea ice export in the central GS due to westward Ekman drift of sea ice. This in turn decreases the freshwater content and weakens ocean stratification in the central GS. At the same time, the associated positive wind stress curl anomaly strengthens the GSG circulation which recirculates warm and saline Atlantic water (AW) into this region. Under a weakly stratified condition, the subsurface AW anomalies can reach the surface to inhibit new sea ice formation, further reducing the SIC in the central GS. Thus, this study highlights combined influence of atmospheric and oceanic circulation in the central GS SIC variability.
Subject code	551 ; 290
Language	English
Publishing date	2020-06-05
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Combined influence of oceanic and atmospheric circulations on Greenland sea ice concentration

Chatterjee, Sourav / Raj, Roshin P. / Bertino, Laurent / Mernild, Sebastian H. / Subeesh, Meethale Puthukkottu / Murukesh, Nuncio / Ravichandran, Muthalagu

eISSN: 1994-0424

2021

Abstract	The amount and spatial extent of Greenland Sea (GS) ice are primarily controlled by the sea ice export across the Fram Strait (FS) and by local seasonal sea ice formation, melting, and sea ice dynamics. In this study, using satellite passive microwave sea ice observations, atmospheric and a coupled ocean-sea ice reanalysis system, TOPAZ4, we show that both the atmospheric and oceanic circulation in the Nordic Seas (NS) act in tandem to explain the SIC variability in the south-western GS. Northerly wind anomalies associated with anomalously low sea level pressure (SLP) over the NS reduce the sea ice export in the south-western GS due to westward Ekman drift of sea ice. On the other hand, the positive wind stress curl strengthens the cyclonic Greenland Sea Gyre (GSG) circulation in the central GS. An intensified GSG circulation may result in stronger Ekman divergence of surface cold and fresh waters away from the south-western GS. Both of these processes can reduce the freshwater content and weaken the upper-ocean stratification in the south-western GS. At the same time, warm and saline Atlantic Water (AW) anomalies are recirculated from the FS region to the south-western GS by a stronger GSG circulation. Under weakly stratified conditions, enhanced vertical mixing of these subsurface AW anomalies can warm the surface waters and inhibit new sea ice formation, further reducing the SIC in the south-western GS.
Subject code	551 ; 290
Language	English
Publishing date	2021-03-12
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biomarkers of angiogenesis and their role in the development of VEGF inhibitors.

Murukesh, N / Dive, C / Jayson, G C

British journal of cancer

2009 Volume 102, Issue 1, Page(s) 8–18

Abstract: Vascular endothelial growth factor (VEGF) has been confirmed as an important therapeutic target in randomised clinical trials in multiple disease settings. However, the extent to which individual patients benefit from VEGF inhibitors is unclear. If we ... ...

Abstract	Vascular endothelial growth factor (VEGF) has been confirmed as an important therapeutic target in randomised clinical trials in multiple disease settings. However, the extent to which individual patients benefit from VEGF inhibitors is unclear. If we are to optimise the use of these drugs or develop combination regimens that build on this efficacy, it is critical to identify those patients who are likely to benefit, particularly as these agents can be toxic and are expensive. To this end, biomarkers have been evaluated in tissue, in circulation and by imaging. Consistent drug-induced increases in plasma VEGF-A and blood pressure, as well as reductions in soluble VEGF-R2 and dynamic contrast-enhanced MRI parameters have been reported. In some clinical trials, biomarker changes were statistically significant and associated with clinical end points, but there is considerable heterogeneity between studies that are to some extent attributable to methodological issues. On the basis of observations with these biomarkers, it is now appropriate to conduct detailed prospective studies to define a suite of predictive, pharmacodynamic and surrogate response biomarkers that identify those patients most likely to benefit from and monitor their response to this novel class of drugs.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/pharmacology ; Antibodies, Neutralizing/therapeutic use ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Bevacizumab ; Biomarkers ; Blood Pressure/drug effects ; Cell Hypoxia ; Contrast Media ; Drug Delivery Systems ; Endothelial Cells/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Neoplasms/blood ; Neoplasms/blood supply ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neovascularization, Pathologic/blood ; Neovascularization, Pathologic/diagnostic imaging ; Neovascularization, Pathologic/drug therapy ; Neovascularization, Pathologic/pathology ; Patient Selection ; Polymorphism, Single Nucleotide ; Positron-Emission Tomography ; Randomized Controlled Trials as Topic ; Receptors, Vascular Endothelial Growth Factor/blood ; Receptors, Vascular Endothelial Growth Factor/drug effects ; Research Design ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/immunology
Chemical Substances	Angiogenesis Inhibitors ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antineoplastic Agents ; Biomarkers ; Contrast Media ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2009-12-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/sj.bjc.6605483
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Article: Metabolites and bioactivities of Rhizophoraceae mangroves

Nebula, Murukesh / Harisankar, H. S / Chandramohanakumar, N

Natural products and bioprospecting. 2013 Oct., v. 3, no. 5

2013

Abstract: This review examines the chemical compositions and bioactivities of mangrove plants belonging to the Rhizophoraceae family. The Rhizophoraceae family of true mangrove plants is the most common and is also widely distributed species. It consists of 24 ... ...

Abstract	This review examines the chemical compositions and bioactivities of mangrove plants belonging to the Rhizophoraceae family. The Rhizophoraceae family of true mangrove plants is the most common and is also widely distributed species. It consists of 24 species across four genera. Of the 24 species, 12 species remain unexamined for their phytochemical constituents. There have been 268 metabolites reported from 16 species. The key phytochemical constituents identified across the family are the diterpenoids and triterpenoids. The major diterpenoids include pimaranes, beyeranes, kaurenes, dolabranes and labdanes whereas the significant triterpenoids are lupanes, dammaranes and oleananes. Disulphides, dolabranes and labdanes are considered to be the chemotaxonomic markers of the genera Bruguiera, Ceriops and Rhizophora respectively.
Keywords	Bruguiera ; Ceriops ; Rhizophora ; bioactive properties ; chemical composition ; diterpenoids ; metabolites ; triterpenoids
Language	English
Dates of publication	2013-10
Size	p. 207-232.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2636293-4
ISSN	2192-2209
ISSN	2192-2209
DOI	10.1007/s13659-013-0012-0
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Metabolic profile in right lobe living donor hepatectomy

Lakshmi Kumar / Murukesh Seetharaman / Nisha Rajmohan / Pavithra Ramamurthi / Sunil Rajan / Rekha Varghese

Indian Journal of Anaesthesia, Vol 60, Iss 10, Pp 719-

Comparison of lactated Ringer′s solution and normal saline versus acetate based balanced salt solution - a pilot study

2016 Volume 725

Abstract: ... lobe donors (n = 53) were alternatively allotted to lactated Ringer′s solution and normal saline (Group ...

Abstract	Background and Aims: Lactate levels predict outcomes after hepatectomy. We compared metabolic effects of lactated versus lactate free solutions in living donor hepatectomy. Methods: Consecutive right lobe donors (n = 53) were alternatively allotted to lactated Ringer′s solution and normal saline (Group L-control) or acetated crystalloid (Sterofundin B Braun ® Group S -study group) in an observational prospective randomised study. The primary outcome measure was lactate level, and secondary outcomes were base excess, bicarbonate, glucose and chloride intra- and post-operatively. Mann-Whitney and Chi-square tests were used for analysis. Results: The intraoperative, post-operative lactate levels and the time for normalisation were comparable. Group L had significantly lower intraoperative bicarbonate levels (mmol/L) at 6 and 8 h (20.0 ± 2.14 vs. 21.3 ± 1.6, P = 0.0471; 18.68 ± 2.04 vs. 20.39 ± 17, P = 0.002), base excess at 4 and 6 h (mmol/L) (−3.64 ± 2.73 vs. −3.0 ± 1.52, P = 0.031; −6.64 ± 2.76 vs. −4.35 ± 1.7 P = 0.006). The intraoperative chloride levels (mmol/L) were higher in group L at 4 and 8 h (108 ± 5.9 vs. 105.99 ± 2.76, P = 0.0471; 109.51 ± 3.86 vs. 106.93 ± 3.09, P = 0.002). Intraoperative glucose (mg/dL) at 6 h was higher in group L, 160.55 ± 31.52 vs. 145.5 ± 24.29, P = 0.043. The highest post-operative chloride (mmol/L) was higher in Group L (112.3 ± 3.86 vs. 109.81 ± 3.72, P = 0.034). Post-operative base excess and bicarbonate showed an improved profile in Group S (−7.37 ± 2.99 vs. −5.06 ± 1.71 P = 0.001 and 17.79 ± 2.23 vs. 19.68 ± 1.51 P = 0.005). Conclusion: Acetated fluids were associated with higher levels of bicarbonate, lesser base deficit, glucose and chloride but no difference in lactate levels in comparison with Ringer′s lactate and normal saline in living donor hepatectomy.
Keywords	Acetate ; balanced salt solution ; hepatectomy ; Ringer′s lactate ; Anesthesiology ; RD78.3-87.3 ; Surgery ; RD1-811 ; Medicine ; R
Subject code	796
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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