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  1. Article ; Online: Vitamin D in CKD: An Unfinished Story.

    Hsu, Simon / Vervloet, Marc G / de Boer, Ian H

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2023  Volume 82, Issue 5, Page(s) 512–514

    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2023.07.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1669: Show issues Location:
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  2. Article ; Online: Continuous Glucose Monitoring: A Rapidly Evolving New Tool to Understand Pathophysiology and Enhance Clinical Care in CKD.

    de Boer, Ian H / Hirsch, Irl B

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 4, Page(s) 421–423

    MeSH term(s) Humans ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 2 ; Diabetes Mellitus, Type 1 ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Blood Glucose
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Invited Perspective: Still Hazy? Air Pollution and Acute Kidney Injury.

    Hsu, Simon / Bi, Jianzhao / de Boer, Ian H

    Environmental health perspectives

    2023  Volume 131, Issue 4, Page(s) 41302

    MeSH term(s) Humans ; Air Pollution/analysis ; Air Pollutants/toxicity ; Air Pollutants/analysis ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Particulate Matter/toxicity ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP12860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 379: Show issues

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  4. Article ; Online: Vitamin D supplementation in people with chronic kidney disease.

    Vervloet, Marc G / Hsu, Simon / de Boer, Ian H

    Kidney international

    2023  Volume 104, Issue 4, Page(s) 698–706

    Abstract: Vitamin D supplements have long been advocated for people with chronic kidney disease based on data from observational studies among the general population and people with chronic kidney disease. These data consistently suggested that higher circulating ... ...

    Abstract Vitamin D supplements have long been advocated for people with chronic kidney disease based on data from observational studies among the general population and people with chronic kidney disease. These data consistently suggested that higher circulating concentrations of 25-hydroxyvitamin D are associated with improved fracture, cardiovascular, cancer, and mortality outcomes. In the past few years, large clinical trials have been conducted to assess the effects of vitamin D supplements on a range of clinically relevant outcomes. Most of these studies were performed in the general population, but they also enrolled people with chronic kidney disease. Virtually all of these trials were negative and contradicted the observational data. In this review, the key observational data and clinical trials are summarized, and potential explanations for the discrepancies between these studies are discussed.
    MeSH term(s) Humans ; Dietary Supplements ; Fractures, Bone ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Vitamin D/therapeutic use ; Observational Studies as Topic
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.07.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The expanding résumé of SGLT2 inhibitors.

    de Boer, Ian H

    The lancet. Diabetes & endocrinology

    2019  Volume 7, Issue 8, Page(s) 585–587

    MeSH term(s) Benzhydryl Compounds ; Diabetes Mellitus, Type 2 ; Glucosides ; Humans ; Kidney Diseases ; Sodium-Glucose Transporter 2 Inhibitors
    Chemical Substances Benzhydryl Compounds ; Glucosides ; Sodium-Glucose Transporter 2 Inhibitors ; dapagliflozin (1ULL0QJ8UC)
    Language English
    Publishing date 2019-06-10
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(19)30183-4
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  6. Article ; Online: Chronic Kidney Disease in Diabetes: Guidelines from KDIGO.

    Khunti, Kamlesh / de Boer, Ian H / Rossing, Peter

    American family physician

    2021  Volume 103, Issue 11, Page(s) 698–700

    MeSH term(s) Diabetes Mellitus/therapy ; Humans ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  7. Article ; Online: Nephrology at a Crossroads.

    de Boer, Ian H

    Clinical journal of the American Society of Nephrology : CJASN

    2018  Volume 13, Issue 2, Page(s) 324

    MeSH term(s) Attitude of Health Personnel ; Burnout, Professional/psychology ; Career Choice ; Forecasting ; Health Knowledge, Attitudes, Practice ; Humans ; Job Description ; Job Satisfaction ; Nephrologists/psychology ; Nephrologists/trends ; Nephrology/trends ; Workload
    Language English
    Publishing date 2018-01-11
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.09070817
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  8. Article ; Online: A New Chapter for Diabetic Kidney Disease.

    de Boer, Ian H

    The New England journal of medicine

    2017  Volume 377, Issue 9, Page(s) 885–887

    MeSH term(s) Diabetic Nephropathies ; Humans ; Kidney
    Language English
    Publishing date 2017--31
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1708949
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  9. Article ; Online: SGLT2 Inhibitors in Diabetic Kidney Disease.

    Zoungas, Sophia / de Boer, Ian H

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 4, Page(s) 631–633

    MeSH term(s) Aged ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/prevention & control ; Humans ; Male ; Renal Insufficiency, Chronic/complications ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.18881220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Environmental exposure to melamine and its derivatives and kidney outcomes in children.

    Day, Drew B / Melough, Melissa M / Flynn, Joseph T / Zhu, Hongkai / Kannan, Kurunthachalam / Ruzinski, John / de Boer, Ian H / Sathyanarayana, Sheela

    Environmental research

    2024  Volume 252, Issue Pt 1, Page(s) 118789

    Abstract: Melamine caused acute nephrotoxicity in a past food adulteration incident, but it is unclear whether and how widespread ambient exposure to melamine and related compounds might affect pediatric kidney health. We assessed cross-sectional associations ... ...

    Abstract Melamine caused acute nephrotoxicity in a past food adulteration incident, but it is unclear whether and how widespread ambient exposure to melamine and related compounds might affect pediatric kidney health. We assessed cross-sectional associations between childhood exposure to melamine and its derivatives and biomarkers of kidney injury and health and explored potential heterogeneity by sex suggested by sex-dependent differences in renal physiology. We measured melamine and its derivatives ammeline, ammelide, and cyanuric acid (CYA) in spot urine samples collected from 192 children from an urban site (Seattle, WA) and 187 children from a rural site (Yakima, WA) aged 4-8 years in the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) Study. In addition, biomarkers of kidney injury were measured in the same urine samples, including albumin, total protein, KIM-1, NAG, NGAL, and EGF. We utilized linear regressions to examine associations between individual chemical exposures and kidney biomarkers. Interaction terms examined association modification by sex, as well as potential interactions between melamine and CYA. Despite comparable exposures, girls had higher levels of many kidney injury biomarkers compared to boys. A ten-fold higher melamine concentration was associated with a 18% (95% CI: 5.6%, 31%) higher EGF in the full sample, while ten-fold higher melamine was associated with a 76% (14.1%, 173%) higher KIM-1 in boys but not in girls (-10.1% (-40.6%, 36.1%), interaction p = 0.026). Melamine exhibited significant negative interactions with CYA in association with total protein and NAG that appeared to be specific to girls. Our results suggest possible associations between melamine exposure and markers of kidney injury that may be more pronounced in boys. These findings provide novel insights into melamine and related derivative compound health effects at low levels of exposure in children and emphasize the role of sex in mediating the relationship between nephrotoxicant exposure and kidney injury.
    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118789
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