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  1. Article ; Online: Air pollution prediction and backcasting through a combination of mobile monitoring and historical on-road traffic emission inventories.

    Ganji, Arman / Saeedi, Milad / Lloyd, Marshall / Xu, Junshi / Weichenthal, Scott / Hatzopoulou, Marianne

    The Science of the total environment

    2024  Volume 915, Page(s) 170075

    Abstract: An important challenge for studies of air pollution and health effects is the derivation of historical exposures. These generally entail some form of backcasting, which refers to a range of approaches that aim to project a current surface into the past. ... ...

    Abstract An important challenge for studies of air pollution and health effects is the derivation of historical exposures. These generally entail some form of backcasting, which refers to a range of approaches that aim to project a current surface into the past. Accurate backcasting is conditional upon the availability of historical data for predictor variables and the ability to capture spatial and temporal trends in these variables. This study proposes a method to backcast traffic-related air pollution surfaces developed using land-use regression models by including temporal variability of traffic and emissions and trends in concentrations measured at reference stations. Nitrogen dioxide (NO2) concentrations collected in the City of Toronto using the Urban Scanner mobile platform were adjusted for historical trends captured at reference stations. The Bayesian Estimator of Abrupt change, Seasonal change, and Trend (BEAST), a powerful tool for time series decomposition, was employed to isolate seasonal variations, annual trends, and abrupt changes in NO2 at reference stations, hence decomposing the signal. Exposure surfaces were generated for a period extending from 2006 to 2020, exhibiting decreases ranging from 10 to 50 % depending on the neighborhood, with an average of 20.46 % across the city. Yearly surfaces were intersected with mobility patterns of Torontonians extracted from travel survey data for 2006 and 2016, illustrating strong spatial gradients in the evolution of NO2 over time, with larger decreases along major roads and highways and in the central core. These findings demonstrate that air pollution improvements throughout the 14 years are inhomogeneous across space.
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fine Particulate Air Pollution and the "No-Multiple-Versions-of-Treatment" Assumption: Does Particle Composition Matter for Causal Inference?

    Weichenthal, Scott / Ripley, Susannah / Korsiak, Jill

    American journal of epidemiology

    2022  Volume 192, Issue 2, Page(s) 147–153

    Abstract: Here we discuss possible violations of the "no-multiple-versions-of-treatment" assumption in studies of outdoor fine particulate air pollution (particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5)) owing to differences in ... ...

    Abstract Here we discuss possible violations of the "no-multiple-versions-of-treatment" assumption in studies of outdoor fine particulate air pollution (particulate matter with an aerodynamic diameter less than or equal to 2.5 μm (PM2.5)) owing to differences in particle composition, which in turn influence health. This assumption is part of the potential outcomes framework for causal inference, and it is needed for well-defined potential outcomes, as multiple versions of the same treatment could lead to different health risks for the same level of treatment. Since 2 locations can have the same outdoor PM2.5 mass concentration (i.e., treatment) but different chemical compositions (i.e., versions of treatment), violations of the "no-multiple-versions-of-treatment" assumption seem likely. Importantly, violations of this assumption will not bias health risk estimates for PM2.5 mass concentrations if there are no unmeasured confounders of the "version of treatment"-outcome relationship. However, confounding can occur if these factors are not identified and controlled for in the analysis. We describe situations in which this may occur and provide simulations to estimate the magnitude and direction of this possible bias. In general, violations of the "no-multiple-versions-of-treatment" assumption could be an underappreciated source of bias in studies of outdoor PM2.5. Analysis of the health impacts of outdoor PM2.5 mass concentrations across spatial domains with similar composition could help to address this issue.
    MeSH term(s) Humans ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Dust/analysis ; Causality ; Environmental Monitoring
    Chemical Substances Air Pollutants ; Particulate Matter ; Dust
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2937-3
    ISSN 1476-6256 ; 0002-9262
    ISSN (online) 1476-6256
    ISSN 0002-9262
    DOI 10.1093/aje/kwac191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Randomized Cross-Over Study of In-Vehicle Cabin Air Filtration, Air Pollution Exposure, and Acute Changes to Heart Rate Variability, Saliva Cortisol, and Cognitive Function.

    Mallach, Gary / Shutt, Robin / Thomson, Errol M / Valcin, Frédéric / Kulka, Ryan / Weichenthal, Scott

    Environmental science & technology

    2023  Volume 57, Issue 8, Page(s) 3238–3247

    Abstract: To determine how traffic-related air pollution (TRAP) exposures affect commuter health, and whether cabin air filtration (CAF) can mitigate exposures, we conducted a cross-over study of 48 adults exposed to TRAP during two commutes with and without CAF. ... ...

    Abstract To determine how traffic-related air pollution (TRAP) exposures affect commuter health, and whether cabin air filtration (CAF) can mitigate exposures, we conducted a cross-over study of 48 adults exposed to TRAP during two commutes with and without CAF. Measurements included particulate air pollutants (PM
    MeSH term(s) Adult ; Humans ; Female ; Air Pollutants/analysis ; Heart Rate ; Cross-Over Studies ; Hydrocortisone ; Saliva/chemistry ; Air Pollution/analysis ; Particulate Matter/analysis ; Cognition
    Chemical Substances Air Pollutants ; Hydrocortisone (WI4X0X7BPJ) ; Particulate Matter
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.2c06556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Personal Mobility Choices and Disparities in Carbon Emissions.

    Wang, An / Weichenthal, Scott / Lloyd, Marshall / Hong, Kris / Saxe, Shoshanna / Hatzopoulou, Marianne

    Environmental science & technology

    2023  Volume 57, Issue 23, Page(s) 8548–8558

    Abstract: The promotion of sustainable mobility choices is a crucial element of transport decarbonization. It requires a fundamental understanding of the choices available to urban dwellers and of the equity and justice implications of green mobility solutions. In ...

    Abstract The promotion of sustainable mobility choices is a crucial element of transport decarbonization. It requires a fundamental understanding of the choices available to urban dwellers and of the equity and justice implications of green mobility solutions. In this study, we quantified personal mobility-related greenhouse gas (GHG) emissions in the Greater Toronto and Hamilton Area (GTHA) and their associations with various land use, built environment, and socioeconomic factors. Our study captured personal, household, and neighborhood-level characteristics that are related to high emissions and disparities in emissions across the study region. We observed that the top 30% of emitters generated 70% of all transportation GHG emissions. Household income, family size, and vehicle ownership were associated with increased mobility emissions, while increased population density was associated with lower emissions. The percentage of visible minorities in a neighborhood was associated with lower emissions, but this effect was small. We further contrasted the spatial distribution of traffic-related air pollution with mobility GHG emissions. The results suggest that individuals who emit less GHG live in areas with higher air pollution. A computer vision-based model was used to predict GHG emissions from aerial images of neighborhoods, demonstrating that areas with high land use mixture were linked to a lower generation of mobility-based GHG emissions.
    MeSH term(s) Humans ; Carbon ; Greenhouse Gases/analysis ; Air Pollution/analysis ; Vehicle Emissions/analysis ; Computer Simulation ; Greenhouse Effect
    Chemical Substances Carbon (7440-44-0) ; Greenhouse Gases ; Vehicle Emissions
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.2c06993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selected physiological effects of ultrafine particles in acute cardiovascular morbidity.

    Weichenthal, Scott

    Environmental research

    2012  Volume 115, Page(s) 26–36

    Abstract: Ultrafine particles (UFPs) have emerged as a potentially important environmental health concern as they are produced in large numbers by vehicle emissions and may contribute to previously reported associations between traffic pollution and acute ... ...

    Abstract Ultrafine particles (UFPs) have emerged as a potentially important environmental health concern as they are produced in large numbers by vehicle emissions and may contribute to previously reported associations between traffic pollution and acute cardiovascular morbidity. This review examines recent epidemiological evidence of UFP exposures and selected physiological outcomes that may be modified as part of the underlying causal pathway(s) linking particulate air pollution and acute cardiovascular morbidity. Outcomes examined included changes in heart rate variability (HRV) (autonomic function), ST-segment depression (myocardial ischemia), QT-interval (ventricular repolarization), and endothelial vasomotor function. Twenty-two studies were reviewed in total: 10 prospective panel studies and 12 randomized cross-over studies. Sixteen studies identified a significant relationship between UFPs and at least one of the above outcomes and current evidence generally supports the biological plausibility of a relationship between UFPs and acute cardiovascular morbidity. However, discrepancies were apparent in the direction of observed associations, particularly for HRV and ventricular repolarization. Reasons for these discrepancies may include differences in particle composition, time-point of clinical evaluation, and population susceptibilities. Nevertheless, evidence to date suggests that UFPs have a measureable impact on physiological measures known to be altered in cases of acute cardiovascular morbidity. Moving forward, expanded use of personal exposure measures is recommended for prospective panel studies to minimize exposure misclassification. In addition, effort should be made to include more women in studies of the acute cardiovascular effects of UFPs as findings to date generally reflect responses in men.
    MeSH term(s) Adolescent ; Adult ; Cardiovascular Diseases/chemically induced ; Environmental Exposure/adverse effects ; Female ; Heart Rate/drug effects ; Humans ; Male ; Particulate Matter/poisoning ; Young Adult
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2012-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2012.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Predicting Traffic-Related Air Pollution Using Feature Extraction from Built Environment Images.

    Ganji, Arman / Minet, Laura / Weichenthal, Scott / Hatzopoulou, Marianne

    Environmental science & technology

    2020  Volume 54, Issue 17, Page(s) 10688–10699

    Abstract: This study develops a set of algorithms to extract built environment features from Google aerial and street view images, reflecting the microcharacteristics of an urban location as well as the different functions of buildings. These features were used to ...

    Abstract This study develops a set of algorithms to extract built environment features from Google aerial and street view images, reflecting the microcharacteristics of an urban location as well as the different functions of buildings. These features were used to train a Bayesian regularized artificial neural network (BRANN) model to predict near-road air quality based on measurements of ultrafine particles (UFPs) and black carbon (BC) in Toronto, Canada. The resulting models [adjusted
    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; Bayes Theorem ; Built Environment ; Canada ; Environmental Monitoring ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.0c00412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predicting outdoor ultrafine particle number concentrations, particle size, and noise using street-level images and audio data.

    Hong, Kris Y / Pinheiro, Pedro O / Weichenthal, Scott

    Environment international

    2020  Volume 144, Page(s) 106044

    Abstract: Outdoor ultrafine particles (UFPs) (<0.1 µm) may have an important impact on public health but exposure assessment remains a challenge in epidemiological studies. We developed a novel method of estimating spatiotemporal variations in outdoor UFP number ... ...

    Abstract Outdoor ultrafine particles (UFPs) (<0.1 µm) may have an important impact on public health but exposure assessment remains a challenge in epidemiological studies. We developed a novel method of estimating spatiotemporal variations in outdoor UFP number concentrations and particle diameters using street-level images and audio data in Montreal, Canada. As a secondary aim, we also developed models for noise. Convolutional neural networks were first trained to predict 10-second average UFP/noise parameters using a large database of images and audio spectrogram data paired with measurements collected between April 2019 and February 2020. Final multivariable linear regression and generalized additive models were developed to predict 5-minute average UFP/noise parameters including covariates from deep learning models based on image and audio data along with outdoor temperature and wind speed. The best performing final models had mean cross-validation R
    MeSH term(s) Air Pollutants/analysis ; Canada ; Environmental Monitoring ; Particle Size ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2020-08-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2020.106044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early life exposure to pollens and increased risks of childhood asthma: a prospective cohort study in Ontario children.

    Stanescu, Cristina / Talarico, Robert / Weichenthal, Scott / Villeneuve, Paul J / Smargiassi, Audrey / Stieb, David M / To, Teresa / Hebbern, Christopher / Crighton, Eric / Lavigne, Éric

    The European respiratory journal

    2024  Volume 63, Issue 4

    MeSH term(s) Child ; Humans ; Prospective Studies ; Ontario/epidemiology ; Asthma/epidemiology ; Pollen ; Environmental Exposure/adverse effects
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01568-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Within-city spatial variations in long-term average outdoor oxidant gas concentrations and cardiovascular mortality: Effect modification by oxidative potential in the Canadian Census Health and Environment Cohort.

    Ripley, Susannah / Gao, Dong / Pollitt, Krystal J Godri / Lakey, Pascale S J / Shiraiwa, Manabu / Hatzopoulou, Marianne / Weichenthal, Scott

    Environmental epidemiology (Philadelphia, Pa.)

    2023  Volume 7, Issue 4, Page(s) e257

    Abstract: Health effects of oxidant gases may be enhanced by components of particulate air pollution that contribute to oxidative stress. Our aim was to examine if : Methods: We conducted a retrospective cohort study of participants in the Canadian Census ... ...

    Abstract Health effects of oxidant gases may be enhanced by components of particulate air pollution that contribute to oxidative stress. Our aim was to examine if
    Methods: We conducted a retrospective cohort study of participants in the Canadian Census Health and Environment Cohort who lived in Toronto or Montreal, Canada, from 2002 to 2015. Cox proportional hazards models were used to estimate associations between outdoor concentrations of oxidant gases (O
    Results: PM
    Conclusion: Within-city spatial variations in PM
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 2474-7882
    ISSN (online) 2474-7882
    DOI 10.1097/EE9.0000000000000257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Long-term exposure to wildfires and cancer incidence in Canada: a population-based observational cohort study.

    Korsiak, Jill / Pinault, Lauren / Christidis, Tanya / Burnett, Richard T / Abrahamowicz, Michal / Weichenthal, Scott

    The Lancet. Planetary health

    2022  Volume 6, Issue 5, Page(s) e400–e409

    Abstract: Background: Wildfires emit many carcinogenic pollutants that contaminate air, water, terrestrial, and indoor environments. However, little is known about the relationship between exposure to wildfires and cancer risk. We aimed to assess the associations ...

    Abstract Background: Wildfires emit many carcinogenic pollutants that contaminate air, water, terrestrial, and indoor environments. However, little is known about the relationship between exposure to wildfires and cancer risk. We aimed to assess the associations between residential exposure to wildfires and the incidence of several cancer outcomes (lung cancer, brain cancer, non-Hodgkin lymphoma, multiple myeloma, and leukaemia) in Canada.
    Methods: We did a population-based observational cohort study of participants in the 1996 Canadian Census Health and Environment Cohort. The 1996 Canadian Census Health and Environment Cohort is a nationally representative sample of Canadian adults, followed up for cancer incidence and mortality from 1996 to 2015. For this analysis, we excluded participants who lived in major Canadian cities (with a population size greater than 1·5 million people), recent immigrants, and individuals younger than 25 years or 90 years of age or older at baseline. Exposures to wildfires were assigned on the basis of area burned within a 20 km or 50 km radius of residential locations and updated for annual residential mobility. Multivariable Cox proportional hazards models were used to estimate associations between exposure to wildfires and specific cancers associated with carcinogenic compounds released by wildfires, including lung and brain cancer, non-Hodgkin lymphoma, multiple myeloma, and leukaemia, adjusted for many personal and neighbourhood-level covariates.
    Findings: Our analyses included more than 2 million people followed up for a median of 20 years, for a total of 34 million person-years. Wildfire exposure was associated with slightly increased incidence of lung cancer and brain tumours. For example, cohort members exposed to a wildfire within 50 km of residential locations in the past 10 years had a 4·9% relatively higher incidence (adjusted hazard ratio [HR] 1·049, 95% CI 1·028-1·071) of lung cancer than unexposed populations, and a 10% relatively higher incidence (adjusted HR 1·100, 1·026-1·179) of brain tumours. Similar associations were observed for the 20 km buffer size. Wildfires were not associated with haematological cancers in this study, and concentration-response trends were not readily apparent when area burned was modelled as a continuous variable.
    Interpretation: Long-term exposure to wildfires might increase the risk of lung cancer and brain tumours. Further work is needed to develop long-term estimates of wildfire exposures that capture the complex mixture of environmental pollutants released during these events.
    Funding: Canadian Institute for Health Research and Fonds de recherche du Quebec.
    MeSH term(s) Adult ; Air Pollutants/analysis ; Brain Neoplasms ; Canada/epidemiology ; Cohort Studies ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Humans ; Incidence ; Leukemia ; Lung Neoplasms/epidemiology ; Lymphoma, Non-Hodgkin/epidemiology ; Lymphoma, Non-Hodgkin/etiology ; Multiple Myeloma/epidemiology ; Particulate Matter/analysis ; Wildfires
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2022-05-12
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2542-5196
    ISSN (online) 2542-5196
    DOI 10.1016/S2542-5196(22)00067-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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