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  1. Article ; Online: PET/MR Imaging in Musculoskeletal Precision Imaging - Third wave after X-Ray and MR.

    Hancin, Emily C / Borja, Austin J / Nikpanah, Moozhan / Raynor, William Y / Haldar, Debanjan / Werner, Thomas J / Morris, Michael A / Saboury, Babak / Alavi, Abass / Gholamrezanezhad, Ali

    PET clinics

    2020  Volume 15, Issue 4, Page(s) 521–534

    Abstract: 18F-Fluorodeoxyglucose PET has been used to evaluate a wide array of inflammatory and neoplastic ... PET with MR imaging offers substantial advantages in musculoskeletal imaging. Specifically, evidence ... demonstrates the potential of imaging of bone marrow, soft tissue, and synovia by PET/MR imaging ...

    Abstract 18F-Fluorodeoxyglucose PET has been used to evaluate a wide array of inflammatory and neoplastic pathologies. MR imaging has great soft tissue resolution and high accuracy for detection of edema. Combining PET with MR imaging offers substantial advantages in musculoskeletal imaging. Specifically, evidence demonstrates the potential of imaging of bone marrow, soft tissue, and synovia by PET/MR imaging. Because of inherent limitations of
    MeSH term(s) Humans ; Magnetic Resonance Imaging/methods ; Multimodal Imaging/methods ; Musculoskeletal Diseases/diagnostic imaging ; Musculoskeletal System/diagnostic imaging ; Positron-Emission Tomography/methods ; Radiography
    Language English
    Publishing date 2020-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2020.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Einzelsignatur: Show issues

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  2. Book ; Online ; E-Book: Tissue engineering using ceramics and polymers

    Boccaccini, A. R. / Ma, Peter X. / Liverani, Liliana

    (Woodhead Publishing series in biomaterials)

    2022  

    Author's details edited by Aldo R. Boccaccini, P.X. Ma, Liliana Liverani
    Series title Woodhead Publishing series in biomaterials
    Keywords Tissue engineering ; Organ culture ; Ceramics in medicine
    Subject code 610.28
    Language English
    Size 1 online resource (890 pages)
    Edition Third edition.
    Publisher Woodhead Publishing
    Publishing place Duxford, England ; Cambridge, Massachusetts ; Kidlington, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-820579-2 ; 0-12-820508-3 ; 978-0-12-820579-2 ; 978-0-12-820508-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Biomaterials and regenerative medicine

    Ma, Peter X.

    2014  

    Abstract: Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, ...

    Author's details edited by Peter X. Ma
    Abstract "Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine"--Provided by publisher
    Keywords Tissue Engineering / methods ; Biocompatible Materials ; Regenerative Medicine / methods ; Tissue Scaffolds ; Stem Cells / cytology
    Language English
    Size xvi, 703 Seiten, Illustrationen
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019117590
    ISBN 978-1-107-01209-7 ; 1-107-01209-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 2280 available for loan (reading room) Lesesaal EG

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  4. Book: Scaffolding in tissue engineering

    Ma, Peter X.

    2006  

    Author's details ed. by Peter X. Ma
    Keywords Tissue Engineering / methods ; Polymers ; Biocompatible Materials
    Language English
    Size XVI, 638 S. : Ill., graph. Darst.
    Publisher CRC Press Taylor & Francis
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT014481045
    ISBN 1-57444-521-9 ; 978-1-57444-521-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 A 961 order for loan Magazin

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  5. Article ; Online: Biodegradable Honeycomb-Mimic Scaffolds Consisting of Nanofibrous Walls.

    Ko, Young Gun / Smith Callahan, Laura A / Ma, Peter X

    Macromolecular bioscience

    2024  , Page(s) e2300540

    Abstract: The scaffold is a porous three-dimensional (3D) material that supports cell growth and tissue regeneration. Such 3D structures should be generated with simple techniques and nontoxic ingredients to mimic bio-environment and facilitate tissue regeneration. ...

    Abstract The scaffold is a porous three-dimensional (3D) material that supports cell growth and tissue regeneration. Such 3D structures should be generated with simple techniques and nontoxic ingredients to mimic bio-environment and facilitate tissue regeneration. In this work, simple but powerful techniques are demonstrated for the fabrication of lamellar and honeycomb-mimic scaffolds with poly(L-lactic acid). The honeycomb-mimic scaffolds with tunable pore size ranging from 70 to 160 µm are fabricated by crystal needle-guided thermally induced phase separation in a directional freezing apparatus. The compressive modulus of the honeycomb-mimic scaffold is ≈4 times higher than that of scaffold with randomly oriented pore structure. The fabricated honeycomb-mimic scaffold exhibits a hierarchical structure from nanofibers to micro-/macro-tubular structures. Pre-osteoblast MC3T3-E1 cells cultured on the honeycomb-mimic nanofibrous scaffolds exhibit an enhanced osteoblastic phenotype, with elevated expression levels of osteogenic marker genes, than those on either porous lamellar scaffolds or porous scaffolds with randomly oriented pores. The advanced techniques for the fabrication of the honeycomb-mimic structure may potentially be used for a wide variety of advanced functional materials.
    Language English
    Publishing date 2024-03-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039130-4
    ISSN 1616-5195 ; 1616-5187
    ISSN (online) 1616-5195
    ISSN 1616-5187
    DOI 10.1002/mabi.202300540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Dentin Sialoprotein/Phosphophoryn (DSP/PP) as Bio-Inductive Materials for Direct Pulp Capping.

    Chuang, Shu-Fen / Chen, Yu-Hsuan / Ma, Peter X / Ritchie, Helena H

    Polymers

    2022  Volume 14, Issue 17

    Abstract: Conventional direct pulp capping, such as calcium hydroxide (Ca(OH) ...

    Abstract Conventional direct pulp capping, such as calcium hydroxide (Ca(OH)
    Language English
    Publishing date 2022-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14173656
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  7. Article ; Online: Poly(N-isopropylacrylamide) based smart nanofibrous scaffolds for use as on-demand delivery systems for oral and dental tissue regeneration.

    Farahat, Dina S / Dang, Ming / El-Fallal, Abeer / Badr, Nadia / Ma, Peter X

    Journal of biomedical materials research. Part A

    2024  Volume 112, Issue 6, Page(s) 852–865

    Abstract: Stimuli-responsive domains capable of releasing loaded molecules, "on-demand," have garnered increasing attention due to their enhanced delivery, precision targeting, and decreased adverse effects. The development of an on-demand delivery system that can ...

    Abstract Stimuli-responsive domains capable of releasing loaded molecules, "on-demand," have garnered increasing attention due to their enhanced delivery, precision targeting, and decreased adverse effects. The development of an on-demand delivery system that can be easily triggered by dental clinicians might have major roles in dental and oral tissue engineering. A series of random graft poly(NIPAm-co-HEMA-Lactate) copolymers were synthesized using 95:5, 85:5, 60:40, and 40:60 ratios of thermosensitive NIPAm and HEMA-poly lactate respectively then electrospun to produce nanofibrous scaffolds loaded with bovine serum albumin (BSA). Cumulative BSA release was assessed at 25C and 37°C. To appraise the use of scaffolds as on-demand delivery systems, they were subjected to thermal changes in the form cooling and warming cycles during which BSA release was monitored. To confirm the triggered releasing ability of the synthesized scaffolds, the copolymer made with 60% NIPAm was selected, based on the results of the release tests, and loaded with bone morphogenetic protein-2 (BMP-2). The loaded scaffolds were placed with mesenchymal-like stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs), and subjected to temperature alterations. Then, the osteogenic differentiation of iMSCs, which might have resulted from the released protein, was evaluated after 10 days by analyzing runt-related transcription factor 2 (RUNX-2) osteogenic gene expression by the cells using real-time quantitative polymerase chain reaction (qRT-PCR). BSA release profiles showed a burst release at the beginning followed by a more linear pattern at 25°C, and a much slower release at 37°C. The release also decreased when the PNIPAm content decreased in the scaffolds. Thermal triggering led to a step-like release pattern in which the highest release was reported 30 min through the warming cycles. The iMSCs cultivated with scaffolds loaded with BMP-2 and exposed to temperature alteration showed significantly higher RUNX-2 gene expression than cells in the other experimental groups. The synthesized scaffolds are thermo-responsive and could be triggered to deliver biological biomolecules to be used in oral and dental tissue engineering. Thermal stimuli could be simulated by dental clinicians using simple means of cold therapy, for example, cold packs in intraoral accessible sites for specified times.
    MeSH term(s) Osteogenesis ; Nanofibers ; Polymers/pharmacology ; Tissue Engineering/methods ; Serum Albumin, Bovine/pharmacology ; Lactic Acid/pharmacology ; Tissue Scaffolds ; Acrylic Resins
    Chemical Substances poly-N-isopropylacrylamide (25189-55-3) ; Polymers ; Serum Albumin, Bovine (27432CM55Q) ; Lactic Acid (33X04XA5AT) ; Acrylic Resins
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099989-6
    ISSN 1552-4965 ; 1549-3296 ; 0021-9304
    ISSN (online) 1552-4965
    ISSN 1549-3296 ; 0021-9304
    DOI 10.1002/jbm.a.37664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Retraction of "Branched Glycerol-Based Copolymer with Ultrahigh p65 siRNA Delivery Efficiency for Enhanced Cancer Therapy".

    Zhou, Li / Qu, Xiaoyan / Guo, Yi / Wang, Min / Lei, Bo / Ma, Peter X

    ACS applied materials & interfaces

    2021  Volume 14, Issue 1, Page(s) 2429

    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Retraction of Publication
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c23370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Recent progress in polymeric gene vectors: Delivery mechanisms, molecular designs, and applications.

    Xiu, Kemao / Zhang, Jifeng / Xu, Jie / Chen, Y Eugene / Ma, Peter X

    Biophysics reviews

    2023  Volume 4, Issue 1, Page(s) 11313

    Abstract: Gene therapy and gene delivery have drawn extensive attention in recent years especially when the COVID-19 mRNA vaccines were developed to prevent severe symptoms caused by the corona virus. Delivering genes, such as DNA and RNA into cells, is the ... ...

    Abstract Gene therapy and gene delivery have drawn extensive attention in recent years especially when the COVID-19 mRNA vaccines were developed to prevent severe symptoms caused by the corona virus. Delivering genes, such as DNA and RNA into cells, is the crucial step for successful gene therapy and remains a bottleneck. To address this issue, vehicles (vectors) that can load and deliver genes into cells are developed, including viral and non-viral vectors. Although viral gene vectors have considerable transfection efficiency and lipid-based gene vectors become popular since the application of COVID-19 vaccines, their potential issues including immunologic and biological safety concerns limited their applications. Alternatively, polymeric gene vectors are safer, cheaper, and more versatile compared to viral and lipid-based vectors. In recent years, various polymeric gene vectors with well-designed molecules were developed, achieving either high transfection efficiency or showing advantages in certain applications. In this review, we summarize the recent progress in polymeric gene vectors including the transfection mechanisms, molecular designs, and biomedical applications. Commercially available polymeric gene vectors/reagents are also introduced. Researchers in this field have never stopped seeking safe and efficient polymeric gene vectors via rational molecular designs and biomedical evaluations. The achievements in recent years have significantly accelerated the progress of polymeric gene vectors toward clinical applications.
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2688-4089
    ISSN (online) 2688-4089
    DOI 10.1063/5.0123664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: X-ray attenuation of bone, soft and adipose tissue in CT from 70 to 140 kV and comparison with 3D printable additive manufacturing materials.

    Ma, Xiangjie / Figl, Michael / Unger, Ewald / Buschmann, Martin / Homolka, Peter

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 14580

    Abstract: ... in real patients with regard to X-ray attenuation, as well as dependence on X-ray spectra. If used ... with different X-ray energies, or to optimize the spectrum for a certain procedure, the energy dependence ...

    Abstract Additive manufacturing and 3D printing are widely used in medical imaging to produce phantoms for image quality optimization, imaging protocol definition, comparison of image quality between different imaging systems, dosimetry, and quality control. Anthropomorphic phantoms mimic tissues and contrasts in real patients with regard to X-ray attenuation, as well as dependence on X-ray spectra. If used with different X-ray energies, or to optimize the spectrum for a certain procedure, the energy dependence of the attenuation must replicate the corresponding energy dependence of the tissues mimicked, or at least be similar. In the latter case the materials' Hounsfield values need to be known exactly to allow to correct contrast and contrast to noise ratios accordingly for different beam energies. Fresh bovine and porcine tissues including soft and adipose tissues, and hard tissues from soft spongious bone to cortical bone were scanned at different energies, and reference values of attenuation in Hounsfield units (HU) determined. Mathematical model equations describing CT number dependence on kV for bones of arbitrary density, and for adipose tissues are derived. These data can be used to select appropriate phantom constituents, compare CT values with arbitrary phantom materials, and calculate correction factors for phantoms consisting of materials with an energy dependence different to the tissues. Using data on a wide number of additive manufacturing and 3D printing materials, CT numbers and their energy dependence were compared to those of the tissues. Two commercially available printing filaments containing calcium carbonate powder imitate bone tissues with high accuracy at all kV values. Average adipose tissue can be duplicated by several off-the-shelf printing polymers. Since suitable printing materials typically exhibit a too high density for the desired attenuation of especially soft tissues, controlled density reduction by underfilling might improve tissue equivalence.
    MeSH term(s) Adipose Tissue ; Animals ; Bone and Bones ; Cattle ; Phantoms, Imaging ; Printing, Three-Dimensional ; Swine ; Tomography, X-Ray Computed ; X-Rays
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18741-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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