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Article ; Online: Examination of a Structural Preference in Quaternary Alkali-Metal (A) Rare-Earth (R) Copper Tellurides by Combining Experimental and Quantum-chemical Means.

Gladisch, Fabian C / Pippinger, Thomas / Meyer, Jens / Pries, Julian / Richter, Jens / Steinberg, Simon

2022 Volume 61, Issue 24, Page(s) 9269–9282

Abstract: In the quest for materials addressing the grand challenges of the future, there is a critical need for a broad understanding of their electronic structures because the knowledge of the electronic structure of a given solid allows us to recognize its ... ...

Abstract	In the quest for materials addressing the grand challenges of the future, there is a critical need for a broad understanding of their electronic structures because the knowledge of the electronic structure of a given solid allows us to recognize its structural preferences and to rationalize its properties. As previous research on quaternary chalcogenides containing active metals (a group-I- or -II-element), early transition-metals, and late transition-metals indicated that such materials could pose as alluring systems in the developments of thermoelectrics, our impetus was stimulated to probe the suitability of tellurides belonging to the prolific A
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.2c01002
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Article: Effects of unfractionated heparin, low molecular weight heparin and r-hirudin on leukocyte adhesion in ischemia/reperfusion.

Habazettl, Helmut / Lindert, Jens / Baeter, Simonida / Neumann, Konrad / Kuppe, Hermann / Kuebler, Wolfgang M / Pries, Axel R / Koster, Andreas

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2004 Volume 15, Issue 5, Page(s) 375–381

Abstract: ... of the anticoagulants unfractionated heparin (UFH), low molecular weight heparin (LMWH) and r-hirudin on leukocyte ... Saline (control), UFH, LMWH or r-hirudin were given 15 min prior to reperfusion and infused for the rest ... IU, 100 IU/h; LMWH, 100 IU, 3 ml/h saline; or r-hirudin, 0.3 mg, 0.15 mg/h. In collecting venules ...

Abstract	Activation of the coagulation cascade during myocardial ischemia and reperfusion may contribute to the post-ischemic inflammatory response, mostly via generation of thrombin. We assessed the effect of the anticoagulants unfractionated heparin (UFH), low molecular weight heparin (LMWH) and r-hirudin on leukocyte adhesion and emigration after ischemia and reperfusion in rats. The rat cremaster muscle was prepared for intravital microscopy. One hundred and twenty minutes of ischemia were followed by 90 min of reperfusion. Saline (control), UFH, LMWH or r-hirudin were given 15 min prior to reperfusion and infused for the rest of the observation period. Dosages per kilogram of body weight were (bolus, infusion): saline, 3 ml, 3 ml/h; UFH, 400 IU, 100 IU/h; LMWH, 100 IU, 3 ml/h saline; or r-hirudin, 0.3 mg, 0.15 mg/h. In collecting venules, rolling, adherent, and extravasated leukocytes were counted from recordings of the intravital microscopy. All three anticoagulants similarly attenuated post-ischemic endothelial leukocyte adhesion. In contrast, emigration of leukocytes was only attenuated by r-hirudin. The emigration efficiency of adherent leukocytes (control, 1.21) was unchanged after UFH (1.74), and LMWH (1.51) but decreased after r-hirudin treatment (0.12). The different efficacy of the three anticoagulants in affecting emigration of adherent leukocytes suggests a specific role for the direct thrombin inhibitor r-hirudin in attenuating the post-ischemic inflammatory response. This effect may contribute to the benefits of direct thrombin inhibitors seen in clinical studies after treatment for acute coronary syndromes.
MeSH term(s)	Animals ; Cell Adhesion/drug effects ; Cell Movement/drug effects ; Endothelium/pathology ; Fibrinolytic Agents/administration & dosage ; Heparin/administration & dosage ; Heparin, Low-Molecular-Weight/administration & dosage ; Hirudins/administration & dosage ; Leukocytes/pathology ; Male ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/pathology ; Myocardial Ischemia/physiopathology ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Fibrinolytic Agents ; Heparin, Low-Molecular-Weight ; Hirudins ; Heparin (9005-49-6)
Language	English
Publishing date	2004-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1033551-1
ISSN	0957-5235
ISSN	0957-5235
DOI	10.1097/01.mbc.0000114445.59147.43
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Zs.A 2920: Show issues

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Article ; Online: Microvascular hemodynamics: System properties1.

Pries, Axel R

Biorheology

2019 Volume 56, Issue 1, Page(s) 1–13

Abstract: The hemodynamics of the microcirculation reflect system properties of the involved components. The blood itself is a complex suspension of water, small and large molecules and different cell types. Under most conditions, its rheologic properties are ... ...

Abstract	The hemodynamics of the microcirculation reflect system properties of the involved components. The blood itself is a complex suspension of water, small and large molecules and different cell types. Under most conditions, its rheologic properties are dominated by the different behaviour of fluid and cellular compartments. When perfused through small-bore tubes or vessels, the suspension exhibits specific emergent properties. The Fahraeus-effect and the Fahreaeus-Lindqvist-effect result from the interaction of cellular particles with each other and with the vessel wall. Additional phenomena occur in vascular networks due to the uneven distribution of blood cells and blood plasma at divergent microvascular bifurcations. In order to understand microvascular hemodynamics in vivo but also in artificial microfluidic geometries it is thus necessary to recognize the pertinent system properties on the level of the blood, the microvessels and the microvascular networks or perfused structures.
MeSH term(s)	Animals ; Hemodynamics ; Microvessels/physiology ; Rats
Language	English
Publishing date	2019-02-27
Publishing country	Netherlands
Document type	Journal Article ; Lecture
ZDB-ID	82015-5
ISSN	1878-5034 ; 0006-355X
ISSN (online)	1878-5034
ISSN	0006-355X
DOI	10.3233/BIR-190207
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Zs.A 394: Show issues

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Article: 1,8-Cineol Attenuates Checkpoint Molecule PDL-1 and Adhesion Molecule CX3CR1 in Circulating Monocytes in Otitis Media Patients.

Leichtle, Anke / Jeschke, Stephanie / Plötze-Martin, Kirstin / Idel, Christian / Bruchhage, Karl-Ludwig / Pries, Ralph

Journal of personalized medicine

2024 Volume 14, Issue 3

Abstract: Background: Peripheral blood monocytes can be subdivided into different subsets based on the CD14/CD16 surface characteristics. Monocytes are a major source of cytokine secretion of pro-inflammatory immune responses, whereas CD16: Materials and ... ...

Abstract	Background: Peripheral blood monocytes can be subdivided into different subsets based on the CD14/CD16 surface characteristics. Monocytes are a major source of cytokine secretion of pro-inflammatory immune responses, whereas CD16 Materials and methods: In this study, we analyzed individual distributions of circulating monocyte subsets and associated protein expression levels of adhesion protein and chemokine receptors CD11a (integrin-α L; LFA-1), CD11b (integrin-α M; Mac-1), and CD11c (integrin-α X), CX3CR1 (CX3CL1 receptor), as well as checkpoint molecule PD-L1 (programmed cell death ligand-1), in a gender-balanced cohort of 14 patients with chronic otitis media using flow cytometry, especially in view of the therapeutic impact of the natural plant-derived monoterpene oxide 1,8-Cineol. Furthermore, using the human monocyte cell line THP-1 as a model, we investigated the influence of anti-inflammatory 1,8-Cineol on monocytic cytokine secretion patterns using human cytokine arrays and ELISA measurements. Results: The data revealed significantly elevated expression levels of all analyzed adhesion molecules in certain monocyte subsets in COM patients; CX3CR1 was especially significantly down-regulated in response to 1,8-Cineol administration. Moreover, the data revealed significantly increased monocytic PD-L1 expression levels in circulating classical and intermediate monocyte subsets from COM patients compared to healthy donors, but also a significant decrease in PD-L1 in intermediate monocytes upon 1,8-Cineol therapy compared to the pre-treatment situation. Furthermore, the increased secretion of cytokine CXCL10 by THP-1 monocytes in response to LPS was found to be strongly attenuated by 1,8-Cineol. Plasma levels of CXCL10 were also significantly increased in COM patients, but no significant differences between the pre and post 1,8-Cineol situation were observed. Conclusions: The present study revealed new insights into the bioactive anti-inflammatory effects of 1,8-Cineol in terms of monocyte adhesion and immune regulation. Our data suggest the potential role of cytokine CXCL10 in COM development and maintenance, which is also involved in the activity of its concomitant disease, rheumatoid arthritis.
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14030279
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Article: Modes of Action of 1,8-Cineol in Infections and Inflammation.

Pries, Ralph / Jeschke, Stephanie / Leichtle, Anke / Bruchhage, Karl-Ludwig

Metabolites

2023 Volume 13, Issue 6

Abstract: The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear in the recent ... ...

Abstract	The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear in the recent years that 1,8-Cineol spreads almost everywhere in the human body after its oral administration, from the gut to the blood to the brain. Its anti-microbial potential and even its anti-viral effects have been observed to include numerous bacteria and fungi species. Many recent studies help to better understand the cellular and molecular immunological consequences of 1,8-Cineol treatment in inflammatory diseases and further provide information concerning the mechanistic modes of action in the regulation of distinct inflammatory biosynthetic pathways. This review aims to present a holistic and understandable overview of the different aspects of 1,8-Cineol in infections and inflammation.
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13060751
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Article ; Online: Physiologische Grundlagen der Mikrozirkulation: vaskuläre Adaptation.

Pries, A R

Klinische Monatsblatter fur Augenheilkunde

2015 Volume 232, Issue 2, Page(s) 127–132

Abstract: The microcirculation is the functional "business end" of the cardiovascular system. In vessels with diameters below about 300 µm processes including the regulation of perfusion, exchange processes and relevant components of the immune system are ... ...

Title translation	Physiological basis of the microcirculation: vascular adaptation.
Abstract	The microcirculation is the functional "business end" of the cardiovascular system. In vessels with diameters below about 300 µm processes including the regulation of perfusion, exchange processes and relevant components of the immune system are localised. A large number of individual mechanisms are involved, including micro-rheology, the endothelial surface layer, vascular permeability, endothelial function, regulation of smooth muscle tone, leukocyte endothelial interaction, vascular adaptation and angiogenesis. The present article focusses mainly on the role of vascular adaptation. Much more than in large vessels, the microcirculation is characterised by constant adaptation to haemodynamic and metabolic signals. In reaction to changes in parenchymal demand, changes of the diameter of existing vessels (by changes in tone or by structural remodelling) as well as generation of new vessels (angiogenesis) or the pruning of vessels are elicited. These mechanisms are part of the so-called "angioadaptation" which is of great clinical relevance for the pathophysiological consequences of hypertension and age-related macular degeneration.
MeSH term(s)	Adaptation, Physiological/physiology ; Animals ; Blood Flow Velocity/physiology ; Humans ; Macular Degeneration/physiopathology ; Microcirculation/physiology ; Models, Cardiovascular ; Neovascularization, Physiologic/physiology ; Ocular Hypertension/physiopathology ; Retinal Artery/physiology ; Retinal Vein/physiology
Language	German
Publishing date	2015-02
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	80175-6
ISSN	1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
ISSN (online)	1439-3999
ISSN	0344-6360 ; 0344-6387 ; 0023-2165
DOI	10.1055/s-0034-1383394
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Ul I Zs.20: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ul I Zs.20/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Improved levels of checkpoint molecule PD-L1 on peripheral blood monocyte subsets in obstructive sleep apnea syndrome patients upon hypoglossal nerve stimulation.

Pries, Ralph / Plötze-Martin, Kirstin / Lange, Christian / Behn, Nicole / Werner, Lotte / Bruchhage, Karl-Ludwig / Steffen, Armin

Journal of sleep research

2024 , Page(s) e14178

Abstract: Oxidative stress in patients suffering from obstructive sleep apnea syndrome (OSAS) is associated with a low-grade systemic inflammation, immune disturbance, and increased invasion of monocytes into the endothelium. Besides continuous positive airway ... ...

Abstract	Oxidative stress in patients suffering from obstructive sleep apnea syndrome (OSAS) is associated with a low-grade systemic inflammation, immune disturbance, and increased invasion of monocytes into the endothelium. Besides continuous positive airway pressure (PAP), hypoglossal nerve stimulation (HNS) has become a promising treatment option for patients with OSAS. We aimed to analyse the influence of HNS therapy on the cellular characteristics relevant for adhesion and immune regulation of circulating CD14/CD16 monocyte subsets. Whole blood flow cytometric measurements were performed to analyse the expression levels of different adhesion molecules and checkpoint molecule PD-L1 (programmed death-ligand 1) in connection with pro-inflammatory plasma cytokine IL-8 and the clinical values of BMI (body mass index), AHI (apnea-hypopnea index), ODI (oxygen desaturation index), and ESS (Epworth sleepiness scale) upon HNS treatment. Hypoglossal nerve stimulation treatment significantly improved the expression of adhesion molecule CD162 (P-selectin receptor) on non-classical monocytes and significantly downregulated the expression of PD-L1 on all three monocyte subsets. We conclude that the holistic improvement of different parameters such as the oxygenation of the peripheral blood, a reduced systemic inflammation, and the individual sleeping situation upon HNS respiratory support, leads to an improved immunologic situation.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1122722-9
ISSN	1365-2869 ; 0962-1105
ISSN (online)	1365-2869
ISSN	0962-1105
DOI	10.1111/jsr.14178
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Zs.A 3464: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 343: Show issues

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Article ; Online: Obesity-related Plasma CXCL10 Drives CX3CR1-dependent Monocytic Secretion of Macrophage Migration Inhibitory Factor.

Meyhöfer, Svenja / Steffen, Armin / Plötze-Martin, Kirstin / Marquardt, Jens-Uwe / Meyhöfer, Sebastian M / Bruchhage, Karl-Ludwig / Pries, Ralph

ImmunoHorizons

2024 Volume 8, Issue 1, Page(s) 19–28

Abstract: Obesity is characterized by excessive body fat accumulation and comorbidities such as diabetes mellitus, cardiovascular disease, and obstructive sleep apnea syndrome (OSAS). Both obesity and OSAS are associated with immune disturbance, alterations of ... ...

Abstract	Obesity is characterized by excessive body fat accumulation and comorbidities such as diabetes mellitus, cardiovascular disease, and obstructive sleep apnea syndrome (OSAS). Both obesity and OSAS are associated with immune disturbance, alterations of systemic inflammatory mediators, and immune cell recruitment to metabolic tissues. Chemokine CXCL10 is an important regulator of proinflammatory immune responses and is significantly increased in patients with severe obesity. This research project aims to investigate the impact of CXCL10 on human monocytes in patients with obesity. We studied the distribution of the CD14/CD16 monocyte subsets as well as their CX3CR1 expression patterns in whole-blood measurements from 92 patients with obesity and/or OSAS with regard to plasma CXCL10 values and individual clinical parameters. Furthermore, cytokine secretion by THP-1 monocytes in response to CXCL10 was analyzed. Data revealed significantly elevated plasma CXCL10 in patients with obesity with an additive effect of OSAS. CXCL10 was found to drive monocytic secretion of macrophage migration inhibitory factor via receptor protein CX3CR1, which significantly correlated with the individual body mass index. Our data show, for the first time, to our knowledge, that CX3CR1 is involved in alternative CXCL10 signaling in human monocytes in obesity-related inflammation. Obesity is a multifactorial disease, and further investigations regarding the complex interplay between obesity-related inflammatory mediators and systemic immune balances will help to better understand and improve the individual situation of our patients.
MeSH term(s)	Humans ; Chemokine CXCL10 ; CX3C Chemokine Receptor 1 ; Inflammation Mediators ; Macrophage Migration-Inhibitory Factors ; Monocytes ; Obesity ; Sleep Apnea, Obstructive
Chemical Substances	Chemokine CXCL10 ; CX3C Chemokine Receptor 1 ; CX3CR1 protein, human ; CXCL10 protein, human ; Inflammation Mediators ; Macrophage Migration-Inhibitory Factors ; MIF protein, human (EC 5.3.2.1)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2300114
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Article ; Online: Protective impact of nicotinamide mononucleotide (NMN) and platelet-rich fibrin (PRF) on replicative and radiation-induced senescence of human osteoblasts.

Hakim, Samer G / von der Gracht, Anij / Pries, Ralph / Rades, Dirk / Steller, Daniel

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2023 Volume 51, Issue 7-8, Page(s) 497–507

Abstract: The aim of this study was to investigate the cellular changes induced by spontaneous/replicative senescence and radiation in human osteoblasts (OBs), and the impact of cultivation with nicotinamide mononucleotide (NMN) and platelet-rich fibrin (PRF) on ... ...

Abstract	The aim of this study was to investigate the cellular changes induced by spontaneous/replicative senescence and radiation in human osteoblasts (OBs), and the impact of cultivation with nicotinamide mononucleotide (NMN) and platelet-rich fibrin (PRF) on apoptosis, senescence-associated β-galactosidase staining (SA β-gal), and senescence-related gene expression using RT
MeSH term(s)	Humans ; Aged ; Platelet-Rich Fibrin ; Nicotinamide Mononucleotide/pharmacology ; Cellular Senescence ; Cells, Cultured ; Osteoblasts
Chemical Substances	Nicotinamide Mononucleotide (1094-61-7)
Language	English
Publishing date	2023-07-07
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2023.06.008
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Zs.A 882: Show issues

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Article ; Online: Percutaneous balloon calcaneoplasty versus open reduction and internal fixation (ORIF) for intraarticular SANDERS 2B calcaneal fracture: Comparison of primary stability using a finite element method.

Delmon, Romain / Vendeuvre, Tanguy / Pries, Pierre / Aubert, Kevin / Germaneau, Arnaud / Severyns, Mathieu

Injury

2023

Abstract: Introduction: Fractures of the calcaneus are common, with 65% being intra-articular, which can lead to a major impairment of the patient's quality of life. Open reduction and internal fixation with locking plates can be considered as gold-standard ... ...

Abstract	Introduction: Fractures of the calcaneus are common, with 65% being intra-articular, which can lead to a major impairment of the patient's quality of life. Open reduction and internal fixation with locking plates can be considered as gold-standard technique but has a high rate of post-operative complications. Minimally invasive calcaneoplasty combined with minimally invasive screw osteosynthesis is largely drawn from the management of depressed lumbar or tibial plateau fractures. The hypothesis of this study is that calcaneoplasty associated with minimally invasive percutaneous screw osteosynthesis presents biomechanical characteristics comparable with conventional osteosynthesis. Materials and methods: Eight hind feet were collected. A SANDERS 2B fracture was reproduced on each specimen, while four calcanei were reduced by a balloon calcaneoplasty method and fixed with a lateral screw, four others were manually reduced and fixed with conventional osteosynthesis. Each calcaneus was then segmented for 3D finite element modeling. A vertical load was applied to the joint surface in order to measure the displacement fields and the stress distribution according to the type of osteosynthesis. Results: Analyses of the intra-articular displacement fields showed lower overall displacements in calcaneal joints treated with calcaneoplasty and lateral screw fixation. Better stress distribution was found in the calcaneoplasty group with lower equivalent joint stresses. These results could be explained by the role of the PMMA cement as a strut, enabling better load transfer. Conclusion: Balloon Calcaneoplasty combined with lateral screw osteosynthesis has biomechanical characteristics at least comparable to locking plate fixation in the treatment of SANDERS 2B calcaneal joint fractures in terms of displacement fields and stress distribution under the premise of anatomical reduction.
Language	English
Publishing date	2023-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.03.019
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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