LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 38

Search options

  1. Article ; Online: Could Home Monitoring parameters provide information about the impact of the pandemic period on CIED patients? A comparison between 2019 and 2020.

    Bontempi, Luca / Aboelhassan, Mohamed / Cerini, Manuel / Salghetti, Francesca / Fabbricatore, Davide / Maiolo, Vincenzo / Freda, Laura / Giacopelli, Daniele / Curnis, Antonio

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2021  Volume 22, Issue 7, Page(s) 606–608

    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/epidemiology ; Arrhythmias, Cardiac/physiopathology ; Arrhythmias, Cardiac/therapy ; COVID-19/epidemiology ; COVID-19/prevention & control ; Defibrillators, Implantable/statistics & numerical data ; Exercise/physiology ; Exercise/statistics & numerical data ; Humans ; Infection Control/methods ; Monitoring, Ambulatory/methods ; Monitoring, Ambulatory/statistics & numerical data ; Monitoring, Ambulatory/trends ; Outcome and Process Assessment, Health Care ; Pacemaker, Artificial/statistics & numerical data ; Remote Sensing Technology/methods ; SARS-CoV-2 ; Sedentary Behavior
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Letter
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Abandoned and fractured ICD lead with complete superior veins occlusion: Is transvenous lead extraction still possible?

    Bontempi, Luca / Aboelhassan, Mohamed / Cerini, Manuel / Salghetti, Francesca / Arabia, Gianmarco / Fabbricatore, Davide / Maiolo, Vincenzo / Giacopelli, Daniele / Curnis, Antonio

    Journal of cardiovascular electrophysiology

    2020  Volume 31, Issue 11, Page(s) 3042–3044

    MeSH term(s) Defibrillators, Implantable/adverse effects ; Device Removal ; Electrodes, Implanted ; Equipment Failure ; Humans ; Pacemaker, Artificial/adverse effects ; Retrospective Studies ; Treatment Outcome ; Veins
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.14752
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Flu vaccination in multiple sclerosis patients: a monocentric prospective vaccine-vigilance study.

    Maniscalco, Giorgia Teresa / Scavone, Cristina / Moreggia, Ornella / Di Giulio Cesare, Daniele / Aiezza, Maria Luisa / Guglielmi, Gaspare / Longo, Giuseppe / Maiolo, Massimo / Raiola, Eliana / Russo, Giuseppe / Capuano, Annalisa

    Expert opinion on drug safety

    2022  Volume 21, Issue 7, Page(s) 979–984

    Abstract: Background: In 2020, the Italian Medicines Agency recommended to bring forward the flu vaccination campaign, whose importance was also emphasized for patients with Multiple Sclerosis (MS). We aimed to assess the safety profile of flu vaccines in terms ... ...

    Abstract Background: In 2020, the Italian Medicines Agency recommended to bring forward the flu vaccination campaign, whose importance was also emphasized for patients with Multiple Sclerosis (MS). We aimed to assess the safety profile of flu vaccines in terms of occurrence of short-term and long-term Adverse Events Following Immunization (AEFIs).
    Methods: This is an observational study that enrolled MS patients who were eligible for any of the flu vaccines recommended by the Italian medicines Agency.
    Results: 194 patients were enrolled. Out of 133 patients who accepted to be vaccinated, 45 experienced not serious short-term AEFIs (pain at the injection site, headache, flu-like symptoms, fatigue). Long-term AEs were detected in 12 vaccinated patients (flu-like symptoms, COVID-19 and MS relapse). No statistically significant differences in terms of infections or MS relapse were found between vaccinated and unvaccinated groups. Using Kaplan-Meier analysis we observed no differences in the cumulative survival rate in both groups.
    Conclusion: Flu vaccines were well tolerated in MS patients, who mainly experienced not serious short term AEFIs. Considering that COVID-19 vaccines campaign is still ongoing among MS patients, our results might bring new knowledge concerning the safety profile of vaccines in this frail population.
    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Influenza Vaccines/adverse effects ; Multiple Sclerosis/chemically induced ; Recurrence ; Vaccination/adverse effects ; Vaccination/methods
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2088728-0
    ISSN 1744-764X ; 1474-0338
    ISSN (online) 1744-764X
    ISSN 1474-0338
    DOI 10.1080/14740338.2022.2044787
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: The polyplex, protein corona, cell interplay: Tips and drawbacks

    Maiolo, Daniele / Colombo, Jessica / Beretta, Jennifer / Malloggi, Chiara / Candiani, Gabriele / Baldelli Bombelli, Francesca

    Colloids and surfaces. 2018 Aug. 01, v. 168

    2018  

    Abstract: Polyplexes (PX) are soft materials, obtained by blending polycations and nucleic acids, designed for gene delivery applications. While much is known about the transfection properties of PX, their protein corona, the biomolecules interacting with colloids ...

    Abstract Polyplexes (PX) are soft materials, obtained by blending polycations and nucleic acids, designed for gene delivery applications. While much is known about the transfection properties of PX, their protein corona, the biomolecules interacting with colloids once in a biological environment, represents an underlooked parameter in gene transfection. In this study, linear and branched polyethylenimines (lPEI and bPEI), the golden standard among non-viral vectors, were selected and used throughout the work: their physicochemical properties and protein corona when complexed to DNA were studied and linked to the toxicity and transfection efficiency arisen upon their delivery to cells. Interestingly, lPEIDNA and bPEIDNA complexes were characterized by similar physicochemical features, but different biological behavior. In fact, the biological milieu where cells and PX interact greatly influences their size, stability and transfection abilities. Using PX as a soft material model system, we spotlighted structure-activity relationships and methodologies that can help interpret their biological behavior and guide future studies in the field.
    Keywords DNA ; cations ; colloids ; genes ; mixing ; models ; physicochemical properties ; polyethyleneimine ; protein corona ; structure-activity relationships ; toxicity ; transfection
    Language English
    Dates of publication 2018-0801
    Size p. 60-67.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2018.01.040
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  5. Article ; Online: The polyplex, protein corona, cell interplay: Tips and drawbacks.

    Maiolo, Daniele / Colombo, Jessica / Beretta, Jennifer / Malloggi, Chiara / Candiani, Gabriele / Baldelli Bombelli, Francesca

    Colloids and surfaces. B, Biointerfaces

    2018  Volume 168, Page(s) 60–67

    Abstract: Polyplexes (PX) are soft materials, obtained by blending polycations and nucleic acids, designed for gene delivery applications. While much is known about the transfection properties of PX, their protein corona, the biomolecules interacting with colloids ...

    Abstract Polyplexes (PX) are soft materials, obtained by blending polycations and nucleic acids, designed for gene delivery applications. While much is known about the transfection properties of PX, their protein corona, the biomolecules interacting with colloids once in a biological environment, represents an underlooked parameter in gene transfection. In this study, linear and branched polyethylenimines (lPEI and bPEI), the golden standard among non-viral vectors, were selected and used throughout the work: their physicochemical properties and protein corona when complexed to DNA were studied and linked to the toxicity and transfection efficiency arisen upon their delivery to cells. Interestingly, lPEIDNA and bPEIDNA complexes were characterized by similar physicochemical features, but different biological behavior. In fact, the biological milieu where cells and PX interact greatly influences their size, stability and transfection abilities. Using PX as a soft material model system, we spotlighted structure-activity relationships and methodologies that can help interpret their biological behavior and guide future studies in the field.
    MeSH term(s) Cell Survival/genetics ; DNA/chemistry ; DNA/genetics ; Electrophoresis, Polyacrylamide Gel ; Gene Transfer Techniques ; HeLa Cells ; Humans ; Polyethyleneimine/chemistry ; Protein Corona/chemistry ; Protein Corona/metabolism ; Static Electricity
    Chemical Substances Protein Corona ; Polyethyleneimine (9002-98-6) ; DNA (9007-49-2)
    Language English
    Publishing date 2018-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2018.01.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Transvenous lead extraction in patients with persistent left superior vena cava.

    Curnis, Antonio / Aboelhassan, Mohamed / Cerini, Manuel / Salghetti, Francesca / Fabbricatore, Davide / Maiolo, Vincenzo / Arabia, Gianmarco / Giacopelli, Daniele / Fouad, Doaa A / Bontempi, Luca

    Journal of cardiovascular electrophysiology

    2021  Volume 32, Issue 5, Page(s) 1407–1410

    Abstract: Purpose: Predictors of difficulty and complications of transvenous lead extraction (TLE) have been investigated in several studies; however, little is known about the venous anatomical characteristics that can have an impact on procedural outcomes. ... ...

    Abstract Purpose: Predictors of difficulty and complications of transvenous lead extraction (TLE) have been investigated in several studies; however, little is known about the venous anatomical characteristics that can have an impact on procedural outcomes. Among them, the persistent left superior vena cava (PLSVC) is a common anomaly often discovered incidentally during cardiac device implantation and could raise concerns if TLE is indicated. We report technical considerations and outcomes of TLE for two patients with leads implanted via PLSVC.
    Methods and results: Two cardiac implantable electronic device recipients with isolated PLSVC required TLE due to infective endocarditis in one case and lead failure in the other. In the first case, TLE procedure was performed in a hybrid operating room with minimally invasive video-assisted thoracoscopic monitoring due to the high procedural risk. Two active fixation 20-year-old pacing leads were removed with a relatively short fluoroscopy time. In the second case, we successfully extracted a single-coil active fixation lead without the need of a locking stylet or advanced extraction tools. There were no procedural complications or adverse events at 1-year follow-up.
    Conclusion: TLE procedures for two patients with isolated PLSVC were successfully completed with less difficulty and tools than expected based on the characteristics of the targeted leads. If indicated, TLE in the presence of a PLSVC should be considered in experienced centers.
    MeSH term(s) Device Removal ; Fluoroscopy ; Humans ; Persistent Left Superior Vena Cava ; Treatment Outcome ; Vena Cava, Superior/diagnostic imaging ; Vena Cava, Superior/surgery
    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Halogenation of the

    Maiolo, Daniele / Pizzi, Andrea / Gori, Alessandro / Gazzera, Lara / Demitri, Nicola / Genoni, Alessandro / Baggi, Fulvio / Moda, Fabio / Terraneo, Giancarlo / Baldelli Bombelli, Francesca / Metrangolo, Pierangelo / Resnati, Giuseppe

    ChemistryOpen

    2020  Volume 9, Issue 2, Page(s) 253–260

    Abstract: Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid- ... ...

    Abstract Here, we demonstrate that introduction of halogen atoms at the tyrosine 10 phenol ring of the DSGYEV sequence derived from the flexible amyloid-β
    MeSH term(s) Amino Acid Sequence ; Amino Acids/chemistry ; Amyloid beta-Peptides/chemistry ; Bromine/chemistry ; Crystallization ; Halogenation ; Hydrogen Bonding ; Molecular Conformation ; Oxidation-Reduction ; Tyrosine/chemistry
    Chemical Substances Amino Acids ; Amyloid beta-Peptides ; Tyrosine (42HK56048U) ; Bromine (SBV4XY874G)
    Language English
    Publishing date 2020-02-25
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2655605-4
    ISSN 2191-1363
    ISSN 2191-1363
    DOI 10.1002/open.201900350
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Interaction of nanoparticles with lipid membranes: a multiscale perspective.

    Montis, Costanza / Maiolo, Daniele / Alessandri, Ivano / Bergese, Paolo / Berti, Debora

    Nanoscale

    2014  Volume 6, Issue 12, Page(s) 6452–6457

    Abstract: Freestanding lipid bilayers were challenged with 15 nm Au nanospheres either coated by a citrate layer or passivated by a protein corona. The effect of Au nanospheres on the bilayer morphology, permeability and fluidity presents strong differences or ... ...

    Abstract Freestanding lipid bilayers were challenged with 15 nm Au nanospheres either coated by a citrate layer or passivated by a protein corona. The effect of Au nanospheres on the bilayer morphology, permeability and fluidity presents strong differences or similarities, depending on the observation length scale, from the colloidal to the molecular domains. These findings suggest that the interaction between nanoparticles and lipid membranes should be conveniently treated as a multiscale phenomenon.
    MeSH term(s) Diffusion ; Gold/chemistry ; Lipid Bilayers/chemistry ; Materials Testing ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/ultrastructure ; Models, Chemical ; Models, Molecular
    Chemical Substances Lipid Bilayers ; Gold (7440-57-5)
    Language English
    Publishing date 2014-06-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c4nr00838c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Nanomedicine delivery: does protein corona route to the target or off road?

    Maiolo, Daniele / Del Pino, Pablo / Metrangolo, Pierangelo / Parak, Wolfgang J / Baldelli Bombelli, Francesca

    Nanomedicine (London, England)

    2015  Volume 10, Issue 21, Page(s) 3231–3247

    Abstract: Nanomedicine aims to find novel solutions for urgent biomedical needs. Despite this, one of the most challenging hurdles that nanomedicine faces is to successfully target therapeutic nanoparticles to cells of interest in vivo. As for any biomaterials, ... ...

    Abstract Nanomedicine aims to find novel solutions for urgent biomedical needs. Despite this, one of the most challenging hurdles that nanomedicine faces is to successfully target therapeutic nanoparticles to cells of interest in vivo. As for any biomaterials, once in vivo, nanoparticles can interact with plasma biomolecules, forming new entities for which the name protein coronas (PCs) have been coined. The PC can influence the in vivo biological fate of a nanoparticle. Thus for guaranteeing the desired function of an engineered nanomaterial in vivo, it is crucial to dissect its PC in terms of formation and evolution within the body. In this contribution we will review the 'good' and 'bad' sides of the PC, starting from the scientific aspects to the technological applications.
    MeSH term(s) Drug Administration Routes ; Nanomedicine ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm.15.163
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Surfactant Titration of Nanoparticle–Protein Corona

    Maiolo, Daniele / Bergese Paolo / Dawson Kenneth A / Mahon Eugene / Monopoli Marco P

    Analytical chemistry. 2014 Dec. 16, v. 86, no. 24

    2014  

    Abstract: Nanoparticles (NP), when exposed to biological fluids, are coated by specific proteins that form the so-called protein corona. While some adsorbing proteins exchange with the surroundings on a short time scale, described as a “dynamic” corona, others ...

    Abstract Nanoparticles (NP), when exposed to biological fluids, are coated by specific proteins that form the so-called protein corona. While some adsorbing proteins exchange with the surroundings on a short time scale, described as a “dynamic” corona, others with higher affinity and long-lived interaction with the NP surface form a “hard” corona (HC), which is believed to mediate NP interaction with cellular machineries. In-depth NP protein corona characterization is therefore a necessary step in understanding the relationship between surface layer structure and biological outcomes. In the present work, we evaluate the protein composition and stability over time and we systematically challenge the formed complexes with surfactants. Each challenge is characterized through different physicochemical measurements (dynamic light scattering, ζ-potential, and differential centrifugal sedimentation) alongside proteomic evaluation in titration type experiments (surfactant titration). 100 nm silicon oxide (Si) and 100 nm carboxylated polystyrene (PS-COOH) NPs cloaked by human plasma HC were titrated with 3-[(3-Cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS, zwitterionic), Triton X-100 (nonionic), sodium dodecyl sulfate (SDS, anionic), and dodecyltrimethylammonium bromide (DTAB, cationic) surfactants. Composition and density of HC together with size and ζ-potential of NP–HC complexes were tracked at each step after surfactant titration. Results on Si NP–HC complexes showed that SDS removes most of the HC, while DTAB induces NP agglomeration. Analogous results were obtained for PS NP–HC complexes. Interestingly, CHAPS and Triton X-100, thanks to similar surface binding preferences, enable selective extraction of apolipoprotein AI (ApoAI) from Si NP hard coronas, leaving unaltered the dispersion physicochemical properties. These findings indicate that surfactant titration can enable the study of NP–HC stability through surfactant variation and also selective separation of certain proteins from the HC. This approach thus has an immediate analytical value as well as potential applications in HC engineering.
    Keywords apolipoprotein A-I ; engineering ; humans ; light scattering ; nanoparticles ; octoxynol ; physicochemical properties ; polystyrenes ; protein composition ; proteomics ; silicon ; sodium dodecyl sulfate ; surfactants ; titration ; zeta potential ; zwitterions
    Language English
    Dates of publication 2014-1216
    Size p. 12055-12063.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021%2Fac5027176
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

To top