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Article: Audit quality following the Public Company Accounting Oversight Board’s operation$HShe-Chih Chiu, Chin-Chen Chien and Hsuan-Chu Lin

Chiu, She Chih / Chien, Chin-chen / Lin, Hsuan-Chu

Corporate governance : the international journal for effective board performance Vol. 17, No. 5 , p. 927-946

2017 Volume 17, Issue 5, Page(s) 927–946

Keywords	Audit quality ; PCAOB ; Auditor size ; Sarbanes-Oxley Act of 2002
Language	English
Publisher	Emerald
Publishing place	Bradford
Document type	Article
ZDB-ID	2060206-6 ; 2108826-3
ISSN	1472-0701
ISSN	1472-0701
Database	ECONomics Information System

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Article ; Online: Commentary on small-volume biopsy of follicular lymphoma: Practical issues in the molecular era.

Chen, Chien-Chin

Cancer cytopathology

2023 Volume 132, Issue 3, Page(s) 136–138

Abstract: Follicular lymphoma (FL) is a common subtype of non-Hodgkin lymphoma derived from germinal center B-cells. Small-volume biopsies (SVBs), including fine-needle aspiration, needle core biopsy, and cell blocks, are often used for the assessment of patients ... ...

Abstract	Follicular lymphoma (FL) is a common subtype of non-Hodgkin lymphoma derived from germinal center B-cells. Small-volume biopsies (SVBs), including fine-needle aspiration, needle core biopsy, and cell blocks, are often used for the assessment of patients with FL. Recently, Fitzpatrick et al. found that additional biopsies were frequently needed to supplement SVB for the initial diagnosis of FL. However, regardless of the type of SVB used, additional biopsies were usually not necessary for assessments for transformed or recurrent FL. Their multi-institutional study reflects the fact that SVB may be sufficient for clinical decision-making in these medical settings, although surgical excision is the gold standard for a definitive diagnosis of FL. With ancillary tests and advances in molecular testing, SVB has become increasingly popular and helpful, although there are practical limitations.
MeSH term(s)	Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/pathology ; Biopsy ; Lymphoma, Non-Hodgkin ; Biopsy, Fine-Needle ; B-Lymphocytes/pathology ; Biopsy, Large-Core Needle
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2594979-2
ISSN	1934-6638 ; 1934-662X
ISSN (online)	1934-6638
ISSN	1934-662X
DOI	10.1002/cncy.22742
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Article ; Online: Evaluating the risk of malignancies of the diagnostic categories proposed by the World Health Organization System for Reporting Lung Cytopathology: a two-year single institutional experience.

Lai, Wei-An / Chen, Chien-Chin

Acta cytologica

2024

Abstract: Introduction The WHO System of Reporting Lung Cytopathology proposed a 5-tiered system in 2023. We report the risk of malignancies (ROMs) of bronchial washing/lavage and percutaneous fine needle aspiration (FNA) specimens. We also evaluated the change of ...

Abstract	Introduction The WHO System of Reporting Lung Cytopathology proposed a 5-tiered system in 2023. We report the risk of malignancies (ROMs) of bronchial washing/lavage and percutaneous fine needle aspiration (FNA) specimens. We also evaluated the change of ROMs when image correlation is required. Methods Lung cytology cases in 2021 and 2022 with histologic follow-up were included. CT reports were reviewed to identify cases with a solid nodule/tumor but benign cytological findings. These were reassigned from the "Benign" to "Non-diagnostic" category, and the ROMs were re-estimated. Results A total of 1031 bronchial washing/lavage and 206 FNAs were identified. The ROMs of bronchial washing/lavage were "Non-diagnostic" 56.5% (13/23), "Benign" 41.9% (320/764), "Atypical" 71.7% (71/99), "Suspicious for malignancy" 94.7% (72/76), and "Malignant" 100% (70/70). The ROMs of FNAs were "Non-diagnostic" 66% (33/50), "Benign" 58.2% (39/67), "Atypical" 70% (28/40), "Suspicious for malignancy" 96.2% (25/26), and "Malignant" 100% (70/70). When image finding was considered, cases initially assigned as "Benign" were re-classified to "Non-diagnostic" with decreases in ROMs for the "Benign " category. Conclusions Malignancy risks associated with the WHO System of Reporting Lung Cytopathology diagnostic groups were reported. Image correlation for the "Benign" category led to a decrease in case number and ROM.
Language	English
Publishing date	2024-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80003-x
ISSN	1938-2650 ; 0001-5547
ISSN (online)	1938-2650
ISSN	0001-5547
DOI	10.1159/000539154
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Article ; Online: The COVID-19 pandemic has impeded cytopathology practices and hindered cancer screening and management.

Huang, Cheng-Yi / Chen, Chien-Chin

Cytopathology : official journal of the British Society for Clinical Cytology

2023 Volume 34, Issue 5, Page(s) 406–416

Abstract: The COVID-19 pandemic has had a global impact on the environment and economy and has affected hospital administration and patient behaviour. Since human-to-human coronavirus transmission occurs via droplets and physical contact, health care professionals ...

Abstract	The COVID-19 pandemic has had a global impact on the environment and economy and has affected hospital administration and patient behaviour. Since human-to-human coronavirus transmission occurs via droplets and physical contact, health care professionals are particularly vulnerable to contracting COVID-19. Many cytopathology laboratories updated their workflow, established new standard biosafety protocols, and built digital pathology or telescope platforms to mitigate these risks and deal with the shortage of health care personnel. The COVID-19 pandemic also disrupted medical education-all indoor training events, including conferences, multidisciplinary tumour boards, seminars, and microscope inspections were postponed. As a result, many laboratories now use new web-based applications and platforms to maintain educational programs and multidisciplinary tumour boards. To comply with government directives, health care facilities postponed non-emergency surgeries, reduced the number of routine medical examinations, restricted visitor numbers, and scaled back cancer screening activities, resulting in a sharp decline in cytopathology diagnoses, cancer screening specimens, and molecular testing for cancer. Subsequent misses or delays in the diagnosis and treatment of cancer were not uncommon. This review aims to provide comprehensive summaries of the consequences of the COVID-19 pandemic for cytopathology, particularly in terms of cancer diagnosis, workload, human resources, and molecular testing.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Cytology ; Early Detection of Cancer ; Pandemics/prevention & control ; Neoplasms/diagnosis
Language	English
Publishing date	2023-06-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1034190-0
ISSN	1365-2303 ; 0956-5507 ; 1350-4037
ISSN (online)	1365-2303
ISSN	0956-5507 ; 1350-4037
DOI	10.1111/cyt.13259
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Article: Antioxidant potential of alkaloids and polyphenols of

Ahmad, Imtiaz / Huang, Pin-Jui / Malak, Nosheen / Khan, Adil / Asad, Fayaz / Chen, Chien-Chin

Frontiers in chemistry

2024 Volume 12, Page(s) 1379463

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2024.1379463
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Article ; Online: Detection and genetic characterization of circulating canine parvovirus from stray dogs in Shanghai, China.

Pu, Junyi / Zhang, Yan / Zhong, Dengke / Chen, Qiusheng

Virology

2024 Volume 595, Page(s) 110041

Abstract: ... of stray dogs suspected of CPV-2 infection were collected from January to March 2021 in Shanghai, China ... Canine parvovirus (CPV) is the main cause of viral diarrhea in dogs. CPV became a global disease ... in this study showed that the CPV-2c isolated strain was the same as the previous strains reported in China ...

Abstract	Canine parvovirus (CPV) is the main cause of viral diarrhea in dogs. CPV became a global disease in 1978 and was endemic all over the world. CPV-2 was the first strain to be identified, but with genetic mutations, new genotypes such as CPV-2a/2b/2c/new-2a/new-2b have emerged. In this study, 128 fecal samples of stray dogs suspected of CPV-2 infection were collected from January to March 2021 in Shanghai, China. All samples were screened by PCR and further analyzed by VP2 gene. The positive rate of CPV-2 was 9.4% (12/128), of which 6 CPV-2 isolates were successfully isolated. Phylogenetic tree analysis showed that 4 isolates were CPV-2c genotype and 2 were new-CPV-2b genotype. VP-2 is a key protein that determines the antigenic properties, host range and receptor binding of cpv-2. The results of VP2 amino acid sequence analysis in this study showed that the CPV-2c isolated strain was the same as the previous strains reported in China, including F267Y, Y324I, Q370R and A5G mutations in addition to the typical N426E mutations. Similarly, in addition to the conventional N426D, S297A, F267Y and Y324I mutations, the new CPV-2b isolate also had a new mutation of T440A. This study further confirmed the prevalence of CPV-2c and new-CPV-2b in Shanghai, and also found a new mutation site of new-CPV-2c, which provided a theoretical basis for further enriching the epidemiological data of CPV-2 in Shanghai, as well as the development of vaccines and the prevention and control of the disease.
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2024.110041
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Article: Genetic diversity of vector-borne zoonotic pathogens in companion dogs and cats, Tianjin, China.

Jian, Rui / Xue, Jing / Xu, Ze-Yun / Chen, Si-Si / Wang, Fang-Ni / Du, Luanying / Xie, Guang-Cheng / Guo, Wen-Ping

Frontiers in veterinary science

2024 Volume 11, Page(s) 1373178

Abstract: ... borne pathogens in companion dogs and cats in Tianjin city, China, with a relatively low positive rate ... from companion dogs and cats in Tianjin, China. ... Background: Dogs and cats are the hosts of many vector-borne human pathogens that can be ...

Abstract	Background: Dogs and cats are the hosts of many vector-borne human pathogens that can be transmitted to humans. Given their direct and intimate contact with humans, companion dogs and cats are considered direct sentinels of vector-borne human pathogens. However, limited information is currently available regarding canine and feline zoonotic pathogens in China. This study detected canine and feline vector-borne human pathogens to better understand the potential risk to humans. Methods: Blood samples were collected from 275 domestic companion animals (117 dogs and 158 cats) living in Tianjin city, China, and the presence of DNA from Results: A total of 24 blood samples tested positive for vector-borne pathogens in companion dogs and cats in Tianjin city, China, with a relatively low positive rate of 8.7%. Specifically, seven human pathogens, including Conclusion: Our results indicate substantial genetic diversity in the vector-borne human pathogens circulating in companion dogs and cats. Interventions based on "One Health" should be taken to reduce the potential risks of contracting infection from companion dogs and cats in Tianjin, China.
Language	English
Publishing date	2024-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2024.1373178
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Article ; Online: Prevalence and characteristics of a feline parvovirus-like virus in dogs in China.

Wang, Jiali / Chen, Xi / Zhou, Yuxing / Yue, Hua / Zhou, Ning / Gong, Hongyi / Tang, Cheng

Veterinary microbiology

2022 Volume 270, Page(s) 109473

Abstract: ... the molecular prevalence of canine parvovirus 2 (CPV-2) among dogs in Southwest China, and 113 samples were ... could efficiently infect dogs, and has been prevalent among dogs in China. Moreover, this study first reported ... 2 in GenBank revealed that the FPV-like virus had already existed among dogs in 4 Asian countries ...

Abstract	In this study, 192 diarrheal fecal samples were collected from 2019 to 2021 for monitoring the molecular prevalence of canine parvovirus 2 (CPV-2) among dogs in Southwest China, and 113 samples were detected as Carnivore protoparvovirus 1-positive. Surprisingly, 28/113 (24.8%) strains were identified as feline parvovirus (FPV)-like viruses based on the key amino acid (aa) residues in VP2. Further, 6 FPV-like strains were successfully isolated and genome sequenced, and phylogenetic trees based on the genome, VP2 and NS1 sequences showed that the 6 FPV-like strains were most genetically related with FPV instead of CPV-2. Interestingly, the VP2 proteins of the FPV-like virus contained all key aa residues typical for FPV and can be 100% identical to that of FPV, but the VP1 intron and NS1 aa sequences exhibited some unique molecular characteristics. The FPV-like isolate could hemagglutinate swine erythrocyte at pH values between 6 and 8, and replicated efficiently in MDCK cell line; moreover, the virus could cause canine systemic infection via oral administration. Further analysis based on VP2 sequences of FPV and CPV-2 in GenBank revealed that the FPV-like virus had already existed among dogs in 4 Asian countries, and have circulated widely in China. This study first confirmed that the FPV-like isolates could efficiently infect dogs, and has been prevalent among dogs in China. Moreover, this study first reported the genome characteristics of the FPV-like virus in dogs, which may represent a novel evolution pattern involving in the cross-species transmission of the virus from cats to dogs.
MeSH term(s)	Animals ; Cat Diseases/epidemiology ; Cats ; China/epidemiology ; Dog Diseases/epidemiology ; Dogs ; Feline Panleukopenia Virus/genetics ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/veterinary ; Parvovirus, Canine ; Phylogeny ; Prevalence ; Swine ; Swine Diseases
Language	English
Publishing date	2022-05-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2022.109473
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Article ; Online: Omega-3 and omega-6 polyunsaturated fatty acids and their potential therapeutic role in protozoan infections.

Rahman, Sajid Ur / Weng, Tzu-Nin / Qadeer, Abdul / Nawaz, Saqib / Ullah, Hanif / Chen, Chien-Chin

Frontiers in immunology

2024 Volume 15, Page(s) 1339470

Abstract: Protozoa exert a serious global threat of growing concern to human, and animal, and there is a need for the advancement of novel therapeutic strategies to effectively treat or mitigate the impact of associated diseases. Omega polyunsaturated fatty acids ( ...

Abstract	Protozoa exert a serious global threat of growing concern to human, and animal, and there is a need for the advancement of novel therapeutic strategies to effectively treat or mitigate the impact of associated diseases. Omega polyunsaturated fatty acids (ω-PUFAs), including Omega-3 (ω-3) and omega-6 (ω-6), are constituents derived from various natural sources, have gained significant attention for their therapeutic role in parasitic infections and a variety of essential structural and regulatory functions in animals and humans. Both ω-3 and ω-6 decrease the growth and survival rate of parasites through metabolized anti-inflammatory mediators, such as lipoxins, resolvins, and protectins, and have both
MeSH term(s)	Animals ; Humans ; Fatty Acids, Omega-3/therapeutic use ; Fatty Acids, Unsaturated ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Protozoan Infections/drug therapy ; Parasitic Diseases/drug therapy
Chemical Substances	Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated ; Anti-Inflammatory Agents
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1339470
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Article ; Online: Biomimetic Wax Interfaces Facilitating Rehealable Polymer Composites.

Kuo, Ching-Te / Chen, Chien-Chin

Polymers

2021 Volume 13, Issue 18

Abstract: Epicuticular wax, the first protective film for numerous ground plant species, is crucial for modulating the evolution in plants. Since the waxy film is inherently thermoresponsive, many efforts focus on engineering materials for water/oil proofing, ... ...

Abstract	Epicuticular wax, the first protective film for numerous ground plant species, is crucial for modulating the evolution in plants. Since the waxy film is inherently thermoresponsive, many efforts focus on engineering materials for water/oil proofing, delivery, and collection, as well as microactuators by mimicking such film nature. Nonetheless, relatively fewer works address the mechanism of how the underlying substrates direct the reconstruction of waxy films while their temperature approaches the melting point. Here, we presented a strategy in which distinct frameworks of molten wax films could be examined among various substrates. Both "waxphobic" and "waxphilic" traits were first unveiled and could be achieved by the hydrophilic (water contact angle (WCA) = 42~82°) and hydrophobic (WCA = 109°) substrates, respectively. A theoretical model, based on experimental results, fluidic dynamics, and balance of surface energy, was developed to elucidate the above findings. Moreover, we demonstrated the above biomimetic epicuticular surface (BeSurface) can be applied for rewritable paper, erasable coding, and rehealable electronics without manual repairing. Remarkably, the healing time can be reduced down to 30 s, and the cycled folding test can be continued up to 500 times. All the new findings present the potentials of the BeSurface to improve the study of rehealable materials.
Language	English
Publishing date	2021-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym13183052
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