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  1. Article ; Online: Formation of Biologic Plug and Patch Mesh for Use in Perforated Femoral Hernia.

    Stolz, Michael P / Chambers, James G / Mahalati, Kamran

    The American surgeon

    2023  Volume 89, Issue 12, Page(s) 6307–6308

    Abstract: Incarcerated inguinal hernias with contamination frequently lead to an open inguinal hernia primary repair. If no contamination is present, a tension-free repair with mesh is a good option. In this case, we encountered an incarcerated femoral hernia with ...

    Abstract Incarcerated inguinal hernias with contamination frequently lead to an open inguinal hernia primary repair. If no contamination is present, a tension-free repair with mesh is a good option. In this case, we encountered an incarcerated femoral hernia with perforation of the small bowel. We will describe and demonstrate via video how to incorporate a tension-free repair with mesh in a contaminated field with formation of a plug and patch made from biologic mesh.
    MeSH term(s) Humans ; Hernia, Femoral/complications ; Hernia, Femoral/surgery ; Surgical Mesh ; Hernia, Inguinal/complications ; Hernia, Inguinal/surgery ; Prostheses and Implants ; Biological Products ; Herniorrhaphy
    Chemical Substances Biological Products
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231157911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.106: Show issues Location:
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  2. Article: Extraction-Free Detection of SARS-CoV-2 Viral RNA Using LumiraDx's RNA Star Complete Assay from Clinical Nasal Swabs Stored in a Novel Collection and Transport Medium.

    Daum, Luke T / Rodriguez, John D / Ward, Susan R / Chambers, James P

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 18

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13183010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sydney 'lockout' liquor licensing law restrictions have been associated with a sustained reduction in emergency department presentations from assaults over 5 years.

    Deacon, James W / Preisz, Paul / Chambers, Anthony J

    Emergency medicine Australasia : EMA

    2022  Volume 34, Issue 5, Page(s) 698–703

    Abstract: ... The mean number of presentations annually fell from 342 to 255 after the introduction of the laws (P = 0.01 ...

    Abstract Objectives: The present study assessed the impact of changes to the New South Wales Liquor Act in 2014 on assault-related presentations to the ED of St Vincent's Hospital. This hospital is the primary receiving hospital for the area affected by these laws.
    Methods: Patients presenting to the ED with an assault-related diagnosis were identified from the ED and trauma registry databases from 2009 to 2019 and retrospectively reviewed. The number of presentations in the 5 years prior to the introduction of the laws in 2014 was compared to the number occurring in the 5 years following this. Admission to the intensive care unit (ICU) and in-hospital death were used as markers for severe injury.
    Results: From 2009 to 2019 there were 2983 assault-related presentations to the ED, with 153 requiring ICU admission and 12 deaths. The mean number of presentations annually fell from 342 to 255 after the introduction of the laws (P = 0.01). The reduction in presentations was sustained for the entire 5-year period after the introduction of the laws. Although the mean number of patients requiring ICU admission per year fell from 17 to 14, and the mean number of deaths annually fell from 1.6 to 0.8, neither of these were statistically significant.
    Conclusions: There has been a significant reduction in assault-related presentations to St Vincent's Hospital following the changes to the liquor licensing laws that has been sustained for 5 years with no significant decrease in the those with severe assault injuries.
    MeSH term(s) Alcoholic Beverages ; Emergency Service, Hospital ; Hospital Mortality ; Humans ; Licensure ; Retrospective Studies
    Language English
    Publishing date 2022-03-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2161824-0
    ISSN 1742-6723 ; 1742-6731 ; 1035-6851
    ISSN (online) 1742-6723
    ISSN 1742-6731 ; 1035-6851
    DOI 10.1111/1742-6723.13955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5940: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: A mutation in switch I alters the load-dependent kinetics of myosin Va.

    Marang, Christopher / Scott, Brent / Chambers, James / Gunther, Laura K / Yengo, Christopher M / Debold, Edward P

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3137

    Abstract: ... by the transduction of chemical energy from ATP into mechanical work. The coupling of the powerstroke and phosphate (P ...

    Abstract Myosin Va is the molecular motor that drives intracellular vesicular transport, powered by the transduction of chemical energy from ATP into mechanical work. The coupling of the powerstroke and phosphate (P
    MeSH term(s) Kinetics ; Myosins/metabolism ; Actins/metabolism ; Mechanical Phenomena ; Mutation ; Adenosine Triphosphate/metabolism
    Chemical Substances Myosins (EC 3.6.4.1) ; Actins ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38535-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inactivating Host Bacteria for Characterization and Use of Phages

    James P. Chambers / Elena T. Wright / Barbara Hunter / Philip Serwer

    Biophysica, Vol 3, Iss 4, Pp 558-

    2023  Volume 568

    Abstract: Phage characterization for research and therapy can involve newly isolated phages propagated in pathogenic bacteria. If so, characterization requires safety-managing the bacteria. In the current study, we adapt a common and inexpensive reagent, ... ...

    Abstract Phage characterization for research and therapy can involve newly isolated phages propagated in pathogenic bacteria. If so, characterization requires safety-managing the bacteria. In the current study, we adapt a common and inexpensive reagent, PrimeStore (Longhorn Vaccines and Diagnostics, San Antonio, TX, USA), to safety-manage bacteria in 20 min by selectively inactivating the bacteria. No bacterial survivors are observed among >10 9 bacteria per ml for a representative of both Gram-negative bacteria ( Escherichia coli ) and Gram-positive bacteria ( Bacillus thuringiensis ). This procedure causes no detected inactivation of podophage T3, myophage T4 and siphophage 0105phi7-2. Margins of safety for PrimeStore concentration exist for bacterial inactivation and phage non-inactivation. Thus, general applicability is expected. Subsequent dialysis is used to block long-term effects on phages. Nonetheless, comparable tests should be performed for each pathogenic bacterial strain/phage. Electron microscopy of thin sections reveals inactivation-altered bacterial cytoplasm and a non-disintegrated bacterial envelope (ghosts). Ghosting of E. coli includes re-arrangement of the cytoplasm and the release of endotoxin. The activity of the released endotoxin is >99% reduced after subsequent dialysis, which also removes PrimeStore components. Ghosting of B. thuringiensis includes apparent phase separation within the cytoplasm. The primary application envisaged is biophysical and other screening of phages for therapy of infectious disease.
    Keywords electron microscopy ; phage characterization ; multi-drug resistant bacteria ; phage therapy ; thin sectioning ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Factors Associated with Biosimilar Exclusions and Step Therapy Restrictions Among US Commercial Health Plans.

    Yu, Tianzhou / Jin, Shihan / Li, Chang / Chambers, James D / Hlávka, Jakub P

    BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

    2023  Volume 37, Issue 4, Page(s) 531–540

    Abstract: Background: Biosimilars have been introduced with the goal of competing with high-priced biologic therapies, yet their adoption has been slower than expected and resulted in limited efficiency gains. We aimed to explore factors associated with ... ...

    Abstract Background: Biosimilars have been introduced with the goal of competing with high-priced biologic therapies, yet their adoption has been slower than expected and resulted in limited efficiency gains. We aimed to explore factors associated with biosimilar coverage relative to their reference products by commercial plans in the United States (US).
    Methods and data: We identified 1181 coverage decisions for 19 commercially available biosimilars, corresponding to 7 reference products and 28 indications from the Tufts Medical Center Specialty Drug Evidence and Coverage database. We also drew on the Tufts Medical Center Cost-Effectiveness Analysis Registry for cost-effectiveness evidence, and the Merative™ Micromedex
    Results: Compared with reference products, health plans imposed coverage exclusions or step therapy restrictions on biosimilars in 229 (19.4%) decisions. Plans were more likely to restrict biosimilar coverage for the pediatric population (odds ratio [OR] 11.558, 95% confidence interval [CI] 3.906-34.203), in diseases with US prevalence higher than 1,000,000 (OR 2.067, 95% CI 1.060-4.029), and if the plan did not contract with one of the three major pharmacy benefit managers (OR 1.683, 95% CI 1.129-2.507). Compared with the reference product, plans were less likely to impose restrictions on the biosimilar-indication pairs if the biosimilar was indicated for cancer treatments (OR 0.019, 95% CI 0.008-0.041), if the product was the first biosimilar (OR 0.225, 95% CI 0.118-0.429), if the biosimilar had two competitors (reference product included; OR 0.060, 95% CI 0.006-0.586), if the biosimilar could generate annual list price savings of more than $15,000 per patient (OR 0.171, 95% CI 0.057-0.514), if the biosimilar's reference product was restricted by the plan (OR 0.065, 95% CI 0.038-0.109), or if a cost-effectiveness measure was not available (OR 0.066, 95% CI 0.023-0.186).
    Conclusion: Our study offered novel insights on the factors associated with biosimilar coverage by commercial health plans in the US relative to their reference products. Cancer treatment, pediatric population, and coverage restriction of the reference products are some of the most significant factors that are associated with biosimilar coverage decisions.
    MeSH term(s) Child ; Humans ; United States ; Biosimilar Pharmaceuticals/therapeutic use ; Pharmacy
    Chemical Substances Biosimilar Pharmaceuticals
    Language English
    Publishing date 2023-04-01
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1364202-9
    ISSN 1179-190X ; 1173-8804
    ISSN (online) 1179-190X
    ISSN 1173-8804
    DOI 10.1007/s40259-023-00593-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4112: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Insights into

    Jeffreys, Sean / Chambers, James P / Yu, Jieh-Juen / Hung, Chiung-Yu / Forsthuber, Thomas / Arulanandam, Bernard P

    Frontiers in immunology

    2022  Volume 13, Page(s) 1070424

    Abstract: Acinetobacter ... ...

    Abstract Acinetobacter baumannii
    MeSH term(s) Humans ; Acinetobacter baumannii ; Pandemics ; Cross Infection ; Antibodies, Monoclonal ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2022-11-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1070424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against

    Jeffreys, Sean / Tompkins, Megan P / Aki, Jadelynn / Papp, Sara B / Chambers, James P / Guentzel, M Neal / Hung, Chiung-Yu / Yu, Jieh-Juen / Arulanandam, Bernard P

    Vaccines

    2024  Volume 12, Issue 4

    Abstract: Multi-drug-resistant (MDR) ...

    Abstract Multi-drug-resistant (MDR)
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12040358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Influence of Fetuin-A on

    Mahjabeen, Faria / Yu, Jieh-Juen / Chambers, James P / Gupta, Rishein / Arulanandam, Bernard P

    International journal of microbiology

    2022  Volume 2022, Page(s) 6082140

    Abstract: Fetuin-A is an acute phase glycoprotein shown to counter in a regulatory manner proinflammatory cytokine production to maintain homeostasis during inflammation. We report here that in wild-type mice 12 days ... ...

    Abstract Fetuin-A is an acute phase glycoprotein shown to counter in a regulatory manner proinflammatory cytokine production to maintain homeostasis during inflammation. We report here that in wild-type mice 12 days after
    Language English
    Publishing date 2022-04-19
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2467270-1
    ISSN 1687-9198 ; 1687-918X
    ISSN (online) 1687-9198
    ISSN 1687-918X
    DOI 10.1155/2022/6082140
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  10. Article: SARS-CoV-2, Early Entry Events.

    Chambers, James P / Yu, Jieh / Valdes, James J / Arulanandam, Bernard P

    Journal of pathogens

    2020  Volume 2020, Page(s) 9238696

    Abstract: Viruses are obligate intracellular parasites, and host cell entry is the first step in the viral life cycle. The SARS-CoV-2 (COVID-19) entry process into susceptible host tissue cells is complex requiring (1) attachment of the virus via the conserved ... ...

    Abstract Viruses are obligate intracellular parasites, and host cell entry is the first step in the viral life cycle. The SARS-CoV-2 (COVID-19) entry process into susceptible host tissue cells is complex requiring (1) attachment of the virus via the conserved spike (S) protein receptor-binding motif (RBM) to the host cell angiotensin-converting-enzyme 2 (ACE2) receptor, (2) S protein proteolytic processing, and (3) membrane fusion. Spike protein processing occurs at two cleavage sites, i.e., S
    Language English
    Publishing date 2020-11-24
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2662334-1
    ISSN 2090-3065 ; 2090-3057
    ISSN (online) 2090-3065
    ISSN 2090-3057
    DOI 10.1155/2020/9238696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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