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Article ; Online: The Value of Peer Mentoring Networks for Developing Leaders and Inspiring Change.

Bruce, Chrystal D / Flatt, Patricia M / Kirk, Sarah R / Roberts-Kirchhoff, Elizabeth / Schepmann, Hala G

Journal of chemical information and modeling

2022 Volume 62, Issue 24, Page(s) 6292–6296

Abstract: A peer-mentoring network, funded by the National Science Foundation ADVANCE program, profoundly impacted the career trajectory of five women chemistry faculty at predominantly undergraduate institutions. By providing each other support, encouragement, ... ...

Abstract	A peer-mentoring network, funded by the National Science Foundation ADVANCE program, profoundly impacted the career trajectory of five women chemistry faculty at predominantly undergraduate institutions. By providing each other support, encouragement, information, and accountability, we advanced our careers, became leaders in our own right, and implemented change at our institutions. To extend this benefit to more women STEM faculty, we have developed and implemented a model to support 74 faculty and administrators representing 51 institutions across the country.
MeSH term(s)	Humans ; Female ; Mentoring ; Program Evaluation ; Mentors ; Peer Group ; Faculty
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	190019-5
ISSN	1549-960X ; 0095-2338
ISSN (online)	1549-960X
ISSN	0095-2338
DOI	10.1021/acs.jcim.2c00155
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Article ; Online: The structural and social determinants of Alzheimer's disease related dementias.

Adkins-Jackson, Paris B / George, Kristen M / Besser, Lilah M / Hyun, Jinshil / Lamar, Melissa / Hill-Jarrett, Tanisha G / Bubu, Omonigho M / Flatt, Jason D / Heyn, Patricia C / Cicero, Ethan C / Zarina Kraal, A / Pushpalata Zanwar, Preeti / Peterson, Rachel / Kim, Boeun / Turner, Robert W / Viswanathan, Jaya / Kulick, Erin R / Zuelsdorff, Megan / Stites, Shana D /

Arce Rentería, Miguel / Tsoy, Elena / Seblova, Dominika / Ng, Ted K S / Manly, Jennifer J / Babulal, Ganesh

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 7, Page(s) 3171–3185

Abstract: Introduction: The projected growth of Alzheimer's disease (AD) and AD-related dementia (ADRD) cases by midcentury has expanded the research field and impelled new lines of inquiry into structural and social determinants of health (S/SDOH) as fundamental ...

Abstract	Introduction: The projected growth of Alzheimer's disease (AD) and AD-related dementia (ADRD) cases by midcentury has expanded the research field and impelled new lines of inquiry into structural and social determinants of health (S/SDOH) as fundamental drivers of disparities in AD/ADRD. Methods: In this review, we employ Bronfenbrenner's ecological systems theory as a framework to posit how S/SDOH impact AD/ADRD risk and outcomes. Results: Bronfenbrenner defined the "macrosystem" as the realm of power (structural) systems that drive S/SDOH and that are the root cause of health disparities. These root causes have been discussed little to date in relation to AD/ADRD, and thus, macrosystem influences, such as racism, classism, sexism, and homophobia, are the emphasis in this paper. Discussion: Under Bronfenbrenner's macrosystem framework, we highlight key quantitative and qualitative studies linking S/SDOH with AD/ADRD, identify scientific gaps in the literature, and propose guidance for future research. Highlights: Ecological systems theory links structural/social determinants to AD/ADRD. Structural/social determinants accrue and interact over the life course to impact AD/ADRD. Macrosystem is made up of societal norms, beliefs, values, and practices (e.g., laws). Most macro-level determinants have been understudied in the AD/ADRD literature.
MeSH term(s)	Humans ; Alzheimer Disease ; Dementia ; Social Determinants of Health
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13027
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Article: Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.

Flatt, Patricia M / Mahmud, Taifo

Natural product reports

2007 Volume 24, Issue 2, Page(s) 358–392

Abstract: This review covers the biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds, particularly from the molecular genetic perspectives. 195 references are cited. ...

Abstract	This review covers the biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds, particularly from the molecular genetic perspectives. 195 references are cited.
MeSH term(s)	Aminoglycosides/biosynthesis ; Anti-Bacterial Agents/biosynthesis ; Biological Products/biosynthesis ; Cyclohexenes ; Hexosamines/biosynthesis ; Molecular Structure
Chemical Substances	Aminoglycosides ; Anti-Bacterial Agents ; Biological Products ; Cyclohexenes ; Hexosamines ; valienamine (38231-86-6)
Language	English
Publishing date	2007-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b603816f
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Article ; Online: Correction to Limazepines A-F, Pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.

Fotso, Serge / Zabriskie, T Mark / Proteau, Philip J / Flatt, Patricia M / Santosa, Dwi Andreas / Sulastri / Mahmud, Taifo

Journal of natural products

2016 Volume 79, Issue 1, Page(s) 259

Language	English
Publishing date	2016-01-22
Publishing country	United States
Document type	Published Erratum
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.5b01098
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Article ; Online: Genetic insights into pyralomicin biosynthesis in Nonomuraea spiralis IMC A-0156.

Flatt, Patricia M / Wu, Xiumei / Perry, Steven / Mahmud, Taifo

Journal of natural products

2013 Volume 76, Issue 5, Page(s) 939–946

Abstract: The biosynthetic gene cluster for the pyralomicin antibiotics has been cloned and sequenced from Nonomuraea spiralis IMC A-0156. The 41 kb gene cluster contains 27 ORFs predicted to encode all of the functions for pyralomicin biosynthesis. This includes ... ...

Abstract	The biosynthetic gene cluster for the pyralomicin antibiotics has been cloned and sequenced from Nonomuraea spiralis IMC A-0156. The 41 kb gene cluster contains 27 ORFs predicted to encode all of the functions for pyralomicin biosynthesis. This includes nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) required for the formation of the benzopyranopyrrole core unit, as well as a suite of tailoring enzymes (e.g., four halogenases, an O-methyltransferase, and an N-glycosyltransferase) necessary for further modifications of the core structure. The N-glycosyltransferase is predicted to transfer either glucose or a pseudosugar (cyclitol) to the aglycone. A gene cassette encoding C7-cyclitol biosynthetic enzymes was identified upstream of the benzopyranopyrrole-specific ORFs. Targeted disruption of the gene encoding the N-glycosyltransferase, prlH, abolished pyralomicin production, and recombinant expression of PrlA confirms the activity of this enzyme as a sugar phosphate cyclase involved in the formation of the C7-cyclitol moiety.
MeSH term(s)	Actinobacteria/genetics ; Actinobacteria/metabolism ; Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/metabolism ; Bacterial Proteins/metabolism ; Chromones/chemistry ; Chromones/metabolism ; Cyclitols/metabolism ; Electron Spin Resonance Spectroscopy ; Glucosyltransferases/metabolism ; Molecular Structure ; Multigene Family ; Peptide Synthases/metabolism ; Polyketide Synthases/metabolism ; Pyrroles/chemistry ; Pyrroles/metabolism
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Chromones ; Cyclitols ; Pyrroles ; pyralomicin 1a ; Polyketide Synthases (79956-01-7) ; Glucosyltransferases (EC 2.4.1.-) ; N-glycosyltransferase, Nocardia aerocolonigenes (EC 2.4.1.-) ; Peptide Synthases (EC 6.3.2.-) ; non-ribosomal peptide synthase (EC 6.3.2.-)
Language	English
Publishing date	2013-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np400159a
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Article: A Qualitative Study on the Types and Purposes of Social Activities in Late Life.

Flatt, Jason D / Hughes, Tiffany F / Documét, Patricia I / Lingler, Jennifer H / Trauth, Jeanette M / Albert, Steven M

Activities, adaptation & aging

2016 Volume 39, Issue 2, Page(s) 109–132

Abstract: This qualitative study examines older adults' subjective views on the types and purposes of social activities. In-depth interviews were conducted with a purposive sample of 20 older adults, with low (n = 10) and high (n = 10) memory performance. We used ... ...

Abstract	This qualitative study examines older adults' subjective views on the types and purposes of social activities. In-depth interviews were conducted with a purposive sample of 20 older adults, with low (n = 10) and high (n = 10) memory performance. We used grounded theory methods to analyze the narrative data. Four types of social activities-Altruism, Creativity, Game, and Motion-were identified. The purpose of social activities included enjoyment, relaxation, stimulation, and belongingness. Those in the low memory group seemed to face more barriers to participation. Different types of social activities may be important for cognitive health and well-being.
Language	English
Publishing date	2016-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	783984-4
ISSN	0192-4788
ISSN	0192-4788
DOI	10.1080/01924788.2015.1024485
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Article ; Online: The association of social support and education with breast and cervical cancer screening.

Documet, Patricia / Bear, Todd M / Flatt, Jason D / Macia, Laura / Trauth, Jeanette / Ricci, Edmund M

Health education & behavior : the official publication of the Society for Public Health Education

2014 Volume 42, Issue 1, Page(s) 55–64

Abstract: Background: Disparities in breast and cervical cancer screening by socioeconomic status persist in the United States. It has been suggested that social support may facilitate screening, especially among women of low socioeconomic status. However, at ... ...

Abstract	Background: Disparities in breast and cervical cancer screening by socioeconomic status persist in the United States. It has been suggested that social support may facilitate screening, especially among women of low socioeconomic status. However, at present, it is unclear whether social support enables mammogram and Pap test compliance. Purpose: This study examines the association between social support and compliance with mammogram and Pap test screening guidelines, and whether social support provides added value for women of low education. Method: Data were from a countywide 2009-2010 population-based survey, which included records of 2,588 women 40 years and older (mammogram) and 2,123 women 21 to 65 years old (Pap test). Compliance was determined using the guidelines in effect at the time of data collection. Results: Social support was significantly related to mammogram (adjusted odds ratio = 1.43; 95% confidence interval [1.16, 1.77]) and Pap test (adjusted odds ratio = 1.71; 95% confidence interval [1.27, 2.29]) compliance after controlling for age, race, having a regular health care provider, and insurance status. The interaction between social support and education had a significant effect on Pap test compliance only among women younger than 40; the effect was not significant for mammogram compliance. Conclusion: Social support is associated with breast and cervical cancer screening compliance. The association between education and cancer screening behavior may be moderated by social support; however, results hold only for Pap tests among younger women. Practitioners and researchers should focus on interventions that activate social support networks as they may help increase both breast and cervical cancer screening compliance among women with low educational attainment.
MeSH term(s)	Adult ; Aged ; Breast Neoplasms/diagnosis ; Early Detection of Cancer/statistics & numerical data ; Educational Status ; Female ; Health Knowledge, Attitudes, Practice ; Health Surveys ; Healthcare Disparities ; Humans ; Mammography/statistics & numerical data ; Middle Aged ; Multivariate Analysis ; Papanicolaou Test/statistics & numerical data ; Patient Compliance/statistics & numerical data ; Pennsylvania ; Social Support ; Socioeconomic Factors ; Uterine Cervical Neoplasms/diagnosis ; Young Adult
Language	English
Publishing date	2014-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1362906-2
ISSN	1552-6127 ; 1090-1981
ISSN (online)	1552-6127
ISSN	1090-1981
DOI	10.1177/1090198114557124
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Article: Genetic Insights into Pyralomicin Biosynthesis in Nonomuraea spiralis IMC A-0156

Flatt, Patricia M / Wu Xiumei / Perry Steven / Mahmud Taifo

Journal of natural products. 2013 May 24, v. 76, no. 5

2013

Abstract	The biosynthetic gene cluster for the pyralomicin antibiotics has been cloned and sequenced from Nonomuraea spiralis IMC A-0156. The 41 kb gene cluster contains 27 ORFs predicted to encode all of the functions for pyralomicin biosynthesis. This includes nonribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) required for the formation of the benzopyranopyrrole core unit, as well as a suite of tailoring enzymes (e.g., four halogenases, an O-methyltransferase, and an N-glycosyltransferase) necessary for further modifications of the core structure. The N-glycosyltransferase is predicted to transfer either glucose or a pseudosugar (cyclitol) to the aglycone. A gene cassette encoding Câ-cyclitol biosynthetic enzymes was identified upstream of the benzopyranopyrrole-specific ORFs. Targeted disruption of the gene encoding the N-glycosyltransferase, prlH, abolished pyralomicin production, and recombinant expression of PrlA confirms the activity of this enzyme as a sugar phosphate cyclase involved in the formation of the Câ-cyclitol moiety.
Keywords	Nonomuraea spiralis ; antibiotics ; biosynthesis ; glucose ; ligases ; molecular cloning ; multigene family ; open reading frames ; polyketide synthases ; sequence analysis
Language	English
Dates of publication	2013-0524
Size	p. 939-946.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021%2Fnp400159a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Global rural health disparities in Alzheimer's disease and related dementias: State of the science.

Wiese, Lisa Ann Kirk / Gibson, Allison / Guest, Marc Aaron / Nelson, Amy R / Weaver, Raven / Gupta, Aditi / Carmichael, Owen / Lewis, Jordan P / Lindauer, Allison / Loi, Samantha / Peterson, Rachel / Radford, Kylie / Rhodus, Elizabeth K / Wong, Christina G / Zuelsdorff, Megan / Saidi, Ladan Ghazi / Valdivieso-Mora, Esmeralda / Franzen, Sanne / Pope, Caitlin N /

Killian, Timothy S / Shrestha, Hom L / Heyn, Patricia C / Ng, Ted Kheng Siang / Prusaczyk, Beth / John, Samantha / Kulshreshtha, Ambar / Sheffler, Julia L / Besser, Lilah / Daniel, Valerie / Tolea, Magdalena I / Miller, Justin / Musyimi, Christine / Corkey, Jon / Yank, Veronica / Williams, Christine L / Rahemi, Zahra / Park, JuYoung / Magzamen, Sheryl / Newton, Robert L / Harrington, Candace / Flatt, Jason D / Arora, Sonakshi / Walter, Sarah / Griffin, Percy / Babulal, Ganesh M

Alzheimer's & dementia : the journal of the Alzheimer's Association

2023 Volume 19, Issue 9, Page(s) 4204–4225

Abstract: Introduction: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors ... ...

Abstract	Introduction: Individuals living in rural communities are at heightened risk for Alzheimer's disease and related dementias (ADRD), which parallels other persistent place-based health disparities. Identifying multiple potentially modifiable risk factors specific to rural areas that contribute to ADRD is an essential first step in understanding the complex interplay between various barriers and facilitators. Methods: An interdisciplinary, international group of ADRD researchers convened to address the overarching question of: "What can be done to begin minimizing the rural health disparities that contribute uniquely to ADRD?" In this state of the science appraisal, we explore what is known about the biological, behavioral, sociocultural, and environmental influences on ADRD disparities in rural settings. Results: A range of individual, interpersonal, and community factors were identified, including strengths of rural residents in facilitating healthy aging lifestyle interventions. Discussion: A location dynamics model and ADRD-focused future directions are offered for guiding rural practitioners, researchers, and policymakers in mitigating rural disparities. Highlights: Rural residents face heightened Alzheimer's disease and related dementia (ADRD) risks and burdens due to health disparities. Defining the unique rural barriers and facilitators to cognitive health yields insight. The strengths and resilience of rural residents can mitigate ADRD-related challenges. A novel "location dynamics" model guides assessment of rural-specific ADRD issues.
MeSH term(s)	Humans ; Alzheimer Disease/epidemiology ; Rural Population ; Rural Health ; Risk Factors
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13104
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Article ; Online: Breast cancer survivors' perception of survivorship.

Documet, Patricia I / Trauth, Jeanette M / Key, Meghan / Flatt, Jason / Jernigan, Jan

Oncology nursing forum

2012 Volume 39, Issue 3, Page(s) 309–315

Abstract: Purpose/objectives: To explore (a) how women who were diagnosed with breast cancer (BC) defined themselves as survivors and when this occurred, and (b) the types of benefits they derived from their experiences.: Research approach: An exploratory, ... ...

Abstract	Purpose/objectives: To explore (a) how women who were diagnosed with breast cancer (BC) defined themselves as survivors and when this occurred, and (b) the types of benefits they derived from their experiences. Research approach: An exploratory, qualitative approach. Participants: 112 women who had BC (response rate = 70%). Setting: Participants were recruited from two cancer survivor organizations in a northeastern U.S. city. Methodologic approach: Responses to open-ended questions in telephone interviews were examined by age at diagnosis using thematic analysis. Chi squares were used to conduct analyses by age (younger than 51 years; aged 51 years or older). Main research variables: Meaning of survivorship, defining moment, benefits derived from surviving from breast cancer. Findings: Participants' perceptions of survivorship included two main components, a defining moment and the meaning attached to being a survivor. Becoming a survivor is an active process, except in the case of those participants who realized they were survivors when informed by a third party. Meanings differed by age at diagnosis. Most participants listed at least one benefit from surviving cancer. Conclusions: The definitions of survivorship and benefits outlined here suggest that many positive aspects of the survivorship experience exist that may inform future interventions' designs. Implications for practice: Providers should acknowledge the strength survivors show in the process of meaning-making and finding benefits in their adverse experiences. The use of expressive and supportive interventions may hold promise for women facing difficulties in coping with their diagnosis.
MeSH term(s)	Adaptation, Psychological ; Adult ; Aged ; Aged, 80 and over ; Attitude to Health ; Breast Neoplasms/nursing ; Breast Neoplasms/psychology ; Female ; Humans ; Interviews as Topic ; Life Change Events ; Middle Aged ; Oncology Nursing/methods ; Spirituality ; Survivors/psychology
Language	English
Publishing date	2012-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604886-9
ISSN	1538-0688 ; 0190-535X ; 1538-0688
ISSN (online)	1538-0688 ; 0190-535X
ISSN	1538-0688
DOI	10.1188/12.ONF.309-315
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