Article ; Online: MarkUs: a server to navigate sequence-structure-function space.
2011 Volume 39, Issue Web Server issue, Page(s) W357–61
Abstract: We describe MarkUs, a web server for analysis and comparison of the structural and functional ...
| Abstract | We describe MarkUs, a web server for analysis and comparison of the structural and functional properties of proteins. In contrast to a 'structure in/function out' approach to protein function annotation, the server is designed to be highly interactive and to allow flexibility in the examination of possible functions, suggested either automatically by various similarity measures or specified by a user directly. This is combined with tools that allow a user to assess independently whether or not a suggested function is consistent with the bioinformatic and biophysical properties of a given query structure, further allowing the user to generate testable hypotheses. The server is available at http://wiki.c2b2.columbia.edu/honiglab_public/index.php/Software:Mark-Us. |
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| MeSH term(s) | Bacterial Proteins/chemistry ; Internet ; Protein Conformation ; Proteins/chemistry ; Proteins/physiology ; Software ; Structure-Activity Relationship |
| Chemical Substances | Bacterial Proteins ; Proteins |
| Language | English |
| Publishing date | 2011-06-14 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 186809-3 |
| ISSN | 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048 |
| ISSN (online) | 1362-4962 ; 1362-4954 |
| ISSN | 0301-5610 ; 0305-1048 |
| DOI | 10.1093/nar/gkr468 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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