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  1. Article ; Online: Correction to: Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report.

    Conners, Kristin / Woods, Scott E / Webb, Michael

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 481

    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-04217-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The relationship between body size and stridulatory sound production in loricariid catfishesa).

    Webb McAdams, Amanda L / Smith, Michael E

    The Journal of the Acoustical Society of America

    2023  Volume 154, Issue 6, Page(s) 3672–3683

    Abstract: Sound production capabilities and characteristics in Loricariidae, the largest catfish family, have not been well examined. Sounds produced by three loricariid catfish species, Otocinclus affinis, Pterygoplichthys gibbiceps, and Pterygoplichthys pardalis, ...

    Abstract Sound production capabilities and characteristics in Loricariidae, the largest catfish family, have not been well examined. Sounds produced by three loricariid catfish species, Otocinclus affinis, Pterygoplichthys gibbiceps, and Pterygoplichthys pardalis, were recorded. Each of these species produces pulses via pectoral-fin spine stridulation by rubbing the ridged condyle of the dorsal process of the pectoral-fin spine base against a matching groove-like socket in the pectoral girdle. Light and scanning electron microscopy were used to examine the dorsal process of the pectoral-fin spines of these species. Mean distances between dorsal process ridges of O. affinis, P. gibbiceps, and P. pardalis were 53, 161, and 329 μm, respectively. Stridulation sounds occurred during either abduction (type A) or adduction (type B). O. affinis produced sounds through adduction only and P. pardalis through abduction only, whereas P. gibbiceps often produced pulse trains alternating between abduction and adduction. In these species, dominant frequency was an inverse function of sound duration, fish total length, and inter-ridge distance on the dorsal process of the pectoral-fin spine and sound duration increased with fish total length. While stridulation sounds are used in many behavioral contexts in catfishes, the functional significance of sound production in Loricariidae is currently unknown.
    MeSH term(s) Animals ; Sound ; Catfishes ; Animal Communication ; Body Size ; Sound Spectrography
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0022575
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  3. Article ; Online: Correction to

    Kristin Conners / Scott E. Woods / Michael Webb

    Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-

    Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report

    2023  Volume 1

    Keywords Medicine ; R
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Mutagenic Plasticity of the Cholera Toxin B-Subunit Surface Residues: Stability and Affinity.

    Au, Cheuk W / Manfield, Iain / Webb, Michael E / Paci, Emanuele / Turnbull, W Bruce / Ross, James F

    Toxins

    2024  Volume 16, Issue 3

    Abstract: Mastering selective molecule trafficking across human cell membranes poses a formidable challenge in healthcare biotechnology while offering the prospect of breakthroughs in drug delivery, gene therapy, and diagnostic imaging. The cholera toxin B-subunit ...

    Abstract Mastering selective molecule trafficking across human cell membranes poses a formidable challenge in healthcare biotechnology while offering the prospect of breakthroughs in drug delivery, gene therapy, and diagnostic imaging. The cholera toxin B-subunit (CTB) has the potential to be a useful cargo transporter for these applications. CTB is a robust protein that is amenable to reengineering for diverse applications; however, protein redesign has mostly focused on modifications of the N- and C-termini of the protein. Exploiting the full power of rational redesign requires a detailed understanding of the contributions of the surface residues to protein stability and binding activity. Here, we employed Rosetta-based computational saturation scans on 58 surface residues of CTB, including the GM1 binding site, to analyze both ligand-bound and ligand-free structures to decipher mutational effects on protein stability and GM1 affinity. Complimentary experimental results from differential scanning fluorimetry and isothermal titration calorimetry provided melting temperatures and GM1 binding affinities for 40 alanine mutants among these positions. The results showed that CTB can accommodate diverse mutations while maintaining its stability and ligand binding affinity. These mutations could potentially allow modification of the oligosaccharide binding specificity to change its cellular targeting, alter the B-subunit intracellular routing, or impact its shelf-life and in vivo half-life through changes to protein stability. We anticipate that the mutational space maps presented here will serve as a cornerstone for future CTB redesigns, paving the way for the development of innovative biotechnological tools.
    MeSH term(s) Humans ; Mutagens ; Cholera Toxin ; G(M1) Ganglioside ; Ligands ; Mutagenesis
    Chemical Substances Mutagens ; Cholera Toxin (9012-63-9) ; G(M1) Ganglioside (37758-47-7) ; Ligands
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16030133
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  5. Article ; Online: Challenges in the use of sortase and other peptide ligases for site-specific protein modification.

    Morgan, Holly E / Turnbull, W Bruce / Webb, Michael E

    Chemical Society reviews

    2022  Volume 51, Issue 10, Page(s) 4121–4145

    Abstract: Site-specific protein modification is a widely-used biochemical tool. However, there are many challenges associated with the development of protein modification techniques, in particular, achieving site-specificity, reaction efficiency and versatility. ... ...

    Abstract Site-specific protein modification is a widely-used biochemical tool. However, there are many challenges associated with the development of protein modification techniques, in particular, achieving site-specificity, reaction efficiency and versatility. The engineering of peptide ligases and their substrates has been used to address these challenges. This review will focus on sortase, peptidyl asparaginyl ligases (PALs) and variants of subtilisin; detailing how their inherent specificity has been utilised for site-specific protein modification. The review will explore how the engineering of these enzymes and substrates has led to increased reaction efficiency mainly due to enhanced catalytic activity and reduction of reversibility. It will also describe how engineering peptide ligases to broaden their substrate scope is opening up new opportunities to expand the biochemical toolkit, particularly through the development of techniques to conjugate multiple substrates site-specifically onto a protein using orthogonal peptide ligases.
    MeSH term(s) Bacterial Proteins/metabolism ; Catalysis ; Cysteine Endopeptidases/metabolism ; Ligases/metabolism ; Peptides/metabolism ; Protein Engineering/methods ; Protein Processing, Post-Translational ; Substrate Specificity
    Chemical Substances Bacterial Proteins ; Peptides ; Cysteine Endopeptidases (EC 3.4.22.-) ; Ligases (EC 6.-)
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d0cs01148g
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  6. Book: Diagnosis and management of adult congenital heart disease

    Gatzoulis, Michael A. / Webb, Gary D. / Daubeney, Piers E. F.

    (Expert consult)

    2011  

    Author's details Michael A. Gatzoulis ; Gary D. Webb ; Piers E. F. Daubeney
    Series title Expert consult
    Keywords Heart Defects, Congenital / diagnosis ; Heart Defects, Congenital / therapy ; Adult
    Language English
    Size XVIII, 508 S. : Ill., graph. Darst., 29 cm
    Edition 2. ed.
    Publisher Elsevier Saunders
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    Note Previous ed.: 2003. - Includes Internet access. - Formerly CIP Uk. - Formerly CIP Uk. - Includes bibliographical references and index
    Accompanying material Zugang zur Internetausgabe über Code
    HBZ-ID HT017007646
    ISBN 978-0-7020-3426-8 ; 0-7020-3426-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 4339 order for loan Magazin
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  7. Article ; Online: The N-terminal substrate specificity of the SurE peptide cyclase.

    Fazal, Asif / Wheeler, Jake / Webb, Michael E / Seipke, Ryan F

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 36, Page(s) 7232–7235

    Abstract: SurE is a standalone peptide cyclase essential for the production of surugamide antibiotics. Although SurE catalyses the cyclisation of varied nonribosomal ... ...

    Abstract SurE is a standalone peptide cyclase essential for the production of surugamide antibiotics. Although SurE catalyses the cyclisation of varied nonribosomal peptides
    MeSH term(s) Anti-Bacterial Agents ; Cyclization ; Kinetics ; Peptide Synthases/metabolism ; Peptides/chemistry ; Substrate Specificity
    Chemical Substances Anti-Bacterial Agents ; Peptides ; Peptide Synthases (EC 6.3.2.-)
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01061e
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  8. Article ; Online: The effect of population model choice and network topologies on extinction time patterns in dendritic ecological networks.

    Ekanayake, E M E K / Angus Webb, J / Stewardson, Michael J

    Journal of theoretical biology

    2022  Volume 556, Page(s) 111314

    Abstract: Models of populations in habitat networks are vital for understanding and linking processes and patterns across individuals, environments, ecological interactions, and population structures. River ecosystem models combine the physical structure of the ... ...

    Abstract Models of populations in habitat networks are vital for understanding and linking processes and patterns across individuals, environments, ecological interactions, and population structures. River ecosystem models combine the physical structure of the networks with the biological processes of the organisms using structural and functional models, respectively. Previous studies on dendritic river networks have employed different functional (population) models and either directly claimed or implied that the results illustrate general properties of actual river systems. However, these studies have used different approaches and assumptions when modeling population characteristics and behavior, and it is possible that inferences regarding a system may vary based on the combination of functional model and the spatial structure of a network. This study aims to understand if different functional models in river systems produce substantially different model results and, therefore, whether conclusions are model-dependent. We compare variation in extinction time and occupancy proportion of river networks with linear, trellis, dendritic and ring-lattice topologies, using three population models (uniform, age-class and individual based) and one metapopulation-based (patch-occupancy) model. Dendritic, linear, and trellis structures did not show notable differences among extinction times for any of the four models. The difference between topologies was higher for the patch-occupancy model compared to the three population models. There were significant differences in the variations of patch-occupancy between the metapopulation and the population models, but the three population models of differing complexity produced broadly similar results. Therefore, if the occupancy data is obtained based on local subpopulations, spatial arrangement and connectivity does not appear to be the sole predictor of single-species metapopulation responses. We conclude that the outputs from functional models are robust to assumptions and varying levels of detail as long as they contain at least some detail at the level of individuals within habitat nodes. Also, if we are modeling network-scale populations, models that include at least some detailed information on individuals are a far better choice than considering populations implicitly.
    MeSH term(s) Humans ; Ecosystem ; Population Dynamics ; Models, Biological ; Rivers
    Language English
    Publishing date 2022-10-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2022.111314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Racial/ethnic disparities in preventive dental services use and dental caries among children.

    Luo, Huabin / Moss, Mark E / Wright, Wanda / Webb, Michael / Pardi, Vanessa / Lazorick, Suzanne

    Journal of public health dentistry

    2023  Volume 83, Issue 2, Page(s) 161–168

    Abstract: ... dental caries from 2016 to 2020 and tested two 2-way interactions (i.e., year by race/ethnicity, year by income ...

    Abstract Objective: To assess disparities in preventive dental service use in four major racial/ethnic groups and assess whether racial/ethnic and income-related disparities among children were reduced from 2016 to 2020.
    Methods: Data were from the 2016 and 2020 National Survey of Children's Health (NSCH). The outcomes of interest were having dental sealants, fluoride treatment, and dental caries in the past 12 months. Racial/ethnic groups included non-Hispanic (NH) whites, blacks, Hispanics, Asians, and others. Family income level was categorized as below or above the 200% federal poverty level (low-income vs. high-income). Children ages 2-17 were included (N = 161,539). All data were self-reported by parents/guardians. We estimated the trends of racial/ethnic disparities in having fluoride treatment, dental sealants, and dental caries from 2016 to 2020 and tested two 2-way interactions (i.e., year by race/ethnicity, year by income) and one 3-way interaction (year by income by race/ethnicity) to assess the change in disparities from 2016 to 2020.
    Results: Overall, no significant trends in receipt of fluoride treatment, dental sealants, or having dental caries were found from 2016 to 2020 among the racial/ethnic groups, except for a decreasing trend in dental sealants for Asian American children (p = 0.03). Overall, NH white children were more likely to have received preventive dental services than children from minority groups (all p < 0.05); Asian American children (AOR = 1.31) were more likely to have dental caries than NH white children.
    Conclusion: Disparities in receipt of evidence-based preventive services by children persisted. Continuous efforts are needed to promote the use of preventive dental services among children of minority populations.
    MeSH term(s) Humans ; Child ; United States/epidemiology ; Dental Caries/epidemiology ; Dental Caries/prevention & control ; Fluorides ; Pit and Fissure Sealants/therapeutic use ; Ethnicity ; Dental Care ; Healthcare Disparities
    Chemical Substances Fluorides (Q80VPU408O) ; Pit and Fissure Sealants
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 410719-6
    ISSN 1752-7325 ; 0022-4006
    ISSN (online) 1752-7325
    ISSN 0022-4006
    DOI 10.1111/jphd.12563
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  10. Article ; Online: Combined Application of Orthogonal Sortases and Depsipeptide Substrates for Dual Protein Labeling.

    Morgan, Holly E / Arnott, Zoe L P / Kamiński, Tomasz P / Turnbull, W Bruce / Webb, Michael E

    Bioconjugate chemistry

    2022  Volume 33, Issue 12, Page(s) 2341–2347

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus aureus
    MeSH term(s) Humans ; Aminoacyltransferases/metabolism ; Bacterial Proteins/chemistry ; Staphylococcus aureus ; Staphylococcal Infections ; Indicators and Reagents ; Glycine ; Depsipeptides
    Chemical Substances Aminoacyltransferases (EC 2.3.2.-) ; Bacterial Proteins ; Indicators and Reagents ; Glycine (TE7660XO1C) ; Depsipeptides
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.2c00411
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