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Article ; Online: microRNA‑202 suppresses MYCN expression under the control of E2F1 in the neuroblastoma cell line LAN‑5.

Li, Yu-Guang / He, Jin-Hua / Yu, Liu / Hang, Ze-Ping / Li, Wang / Shun, Wen-Hong / Huang, Guo Xian

Molecular medicine reports

2014 Volume 9, Issue 2, Page(s) 541–546

Abstract: ... the regulation of MYCN expression by miR‑202 in the LAN‑5 human neuroblastoma cell line and to confirm ... the presence of binding sites for E2F1 in the miR‑202 promoter region. LAN‑5 cells were transfected ... used to confirm binding sites for E2F1 in the miR‑202 promoter region. Overexpression of miR‑202 in LAN ...

Abstract	microRNAs (miRNAs) are small non‑coding RNAs that regulate gene expression by binding to the untranslated regions (UTRs) of target mRNAs. Bioinformatic software predicted that MYCN, a gene overexpressed in aggressive neuroblastoma cells, is a target gene of miRNA‑202 (miR‑202) and that the promoter region of miR‑202 contains binding sites for the transcription factor E2F1. The aims of this study were to explore the regulation of MYCN expression by miR‑202 in the LAN‑5 human neuroblastoma cell line and to confirm the presence of binding sites for E2F1 in the miR‑202 promoter region. LAN‑5 cells were transfected with a synthetic miR‑202 mimic, an miRNA inhibitor or appropriate control miRNAs. miR‑202 expression levels prior to and following transfection were measured by quantitative polymerase chain reaction (PCR) and MYCN protein expression was measured by western blot analysis. The interaction between miR‑202 and MYCN was examined using a luciferase reporter assay. The transcription start site of miR‑202 was determined by the rapid amplification of 5'cDNA ends (5'RACE) test and a chromatin immunoprecipitation (ChIP) assay was used to confirm binding sites for E2F1 in the miR‑202 promoter region. Overexpression of miR‑202 in LAN‑5 cells specifically inhibited MYCN protein expression. The 5'RACE test showed that the transcription start site of miR‑202 was at a thymidine, 312 bp upstream of the stem‑loop sequence. A ChIP assay demonstrated that E2F1 binds directly to the miR‑202 promoter region. miR‑202 is activated by E2F1 and in turn downregulates MYCN protein expression in the neuroblastoma cell line LAN‑5. Upregulation of miR‑202 may therefore be a novel strategy for neuroblastoma treatment.
MeSH term(s)	Binding Sites ; Cell Line, Tumor ; E2F1 Transcription Factor/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Promoter Regions, Genetic ; RNA, Messenger/genetics ; Transcription, Genetic ; Transcriptional Activation/genetics
Chemical Substances	E2F1 Transcription Factor ; E2F1 protein, human ; MicroRNAs ; RNA, Messenger
Language	English
Publishing date	2014-02
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2013.1845
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: First evaluation of a 99mTc-tricarbonyl complex, 99mTc(CO)3(LAN), as a new renal radiopharmaceutical in humans.

Lipowska, Malgorzata / He, Haiyang / Malveaux, Eugene / Xu, Xiaolong / Marzilli, Luigi G / Taylor, Andrew

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2006 Volume 47, Issue 6, Page(s) 1032–1040

Abstract: ... 99m)Tc(CO)(3)(LAN), a new renal radiopharmaceutical.: Methods: Biodistribution studies were ... performed on Sprague-Dawley rats with (99m)Tc(CO)(3)(LAN) isomers, meso-LAN and dd,ll-LAN (an enantiomeric ... with the plasma clearance averaging 228 mL/min for (99m)Tc(CO)(3)(meso-LAN) and 176 mL/min for (99m)Tc(CO)(3)(dd ...

Abstract	Unlabelled: (99m)Tc-Mercaptoacetyltriglycine ((99m)Tc-MAG3), (99m)Tc-dd- and ll-ethylene-dicysteine ((99m)Tc-EC), and (99m)Tc-mercaptoacetamide-ethylene-cysteine ((99m)Tc-MAEC) contain N(3)S or N(2)S(2) ligands designed to accommodate the 4 ligating sites of the ((99m)TcO)(3+) core; they are all excellent renal imaging agents but have renal clearances lower than that of (131)I-orthoiodohippurate ((131)I-OIH). To explore the potential of the newly accessible but less polar [(99m)Tc(CO)(3)](+) core with 3 ligating sites, we decided to build on the success of (99m)Tc-EC, with its N(2)S(2) ligand and 2 dangling carboxylate groups; we chose an N(2)S ligand that also has 2 dangling carboxylate groups, lanthionine, to form (99m)Tc(CO)(3)(LAN), a new renal radiopharmaceutical. Methods: Biodistribution studies were performed on Sprague-Dawley rats with (99m)Tc(CO)(3)(LAN) isomers, meso-LAN and dd,ll-LAN (an enantiomeric mixture), coinjected with (131)I-OIH. Human studies also were performed by coinjecting each (99m)Tc-labeled product ( approximately 74 MBq [ approximately 2 mCi]) and (131)I-OIH ( approximately 7.4 MBq [ approximately 0.2 mCi]) into 3 healthy volunteers and then performing dual-isotope imaging by use of a camera system fitted with a high-energy collimator. Blood samples were obtained from 3 to 90 min after injection, and urine samples were obtained at 30, 90, and 180 min. Results: Biodistribution studies in rats revealed rapid blood clearance as well as rapid renal extraction for both preparations, with the dose in urine at 60 min averaging 88% that of (131)I-OIH. In humans, both agents provided excellent renal images, with the plasma clearance averaging 228 mL/min for (99m)Tc(CO)(3)(meso-LAN) and 176 mL/min for (99m)Tc(CO)(3)(dd,ll-LAN). At 3 h, both (99m)Tc(CO)(3)(meso-LAN) and (99m)Tc(CO)(3)(dd,ll-LAN) showed good renal excretion, averaging 85% and 77% that of (131)I-OIH, respectively. Plasma protein binding was minimal (10% and 2%, respectively), and erythrocyte uptake was similar (24% and 21%, respectively) for (99m)Tc(CO)(3)(meso-LAN) and (99m)Tc(CO)(3)(dd,ll-LAN). Conclusion: Although the plasma clearance and the rate of renal excretion of the (99m)Tc(CO)(3)(LAN) complexes were still lower than those of (131)I-OIH, the results of this first application of a (99m)Tc-tricarbonyl complex as a renal radiopharmaceutical in humans demonstrate that (99m)Tc(CO)(3)(LAN) complexes are excellent renal imaging agents and support continued renal radiopharmaceutical development based on the (99m)Tc-tricarbonyl core.
MeSH term(s)	Adult ; Animals ; Female ; Humans ; Kidney/diagnostic imaging ; Kidney/metabolism ; Male ; Metabolic Clearance Rate ; Organ Specificity ; Organotechnetium Compounds/pharmacokinetics ; Radionuclide Imaging ; Radiopharmaceuticals/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Reference Values ; Tissue Distribution
Chemical Substances	99mTc(CO)3(LAN) ; Organotechnetium Compounds ; Radiopharmaceuticals
Language	English
Publishing date	2006-06
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0161-5505 ; 0097-9058 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0161-5505 ; 0097-9058 ; 0022-3123
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Book: Lan jiang guo yu man yue ju

Gu, Yin / He, Shanan

2001

Title variant	Blueberry and cranberry
Author's details	Gu Yin, He Shanan zhu bian
Keywords	Bluberries. ; Cranberries.
Language	Chinese
Size	5, 10, 8, 480 p., 22 p. of plates :, ill. (chiefly col.), maps ;, 21 cm.
Edition	Di 1 ban.
Publisher	Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
Publishing place	Beijing Shi
Document type	Book
ISBN	7109067521 ; 9787109067523
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Selenosis in a Woman With Systemic Lupus Erythematosus.

Tang, Ying-Lan / He, Ya-Qiong

JAMA neurology

2024

Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2024.0975
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Article: Radical nephrectomy for a giant chromophobe renal cell carcinoma diagnosed > 17 years previously: a case report and literature review.

Lan, Jianhua / Lan, Dong / Yuan, Wenqiang / Ying, Qiao / He, Jiahong / Gu, Yonglin

Frontiers in oncology

2024 Volume 14, Page(s) 1352689

Abstract: Early diagnosis of renal cell carcinoma relies on imaging tests such as ultrasound, computed tomography, or magnetic resonance imaging. Since surgery is associated with a favorable prognosis, the standard treatment for clinically limited renal cell ... ...

Abstract	Early diagnosis of renal cell carcinoma relies on imaging tests such as ultrasound, computed tomography, or magnetic resonance imaging. Since surgery is associated with a favorable prognosis, the standard treatment for clinically limited renal cell carcinoma remains surgical resection. Among asymptomatic patients with localized renal cell carcinoma, a small number refuse surgical treatment and survive. We report a case involving a 59-year-old female who underwent a difficult radical nephrectomy 17 years after being diagnosed with malignant tumors due to primary renal cell carcinoma.
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1352689
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Article: Integrated traditional Chinese and Western medicine in the prevention and treatment of non-alcoholic fatty liver disease: future directions and strategies.

Ding, Xin / He, Xu / Tang, Bulang / Lan, Tian

Chinese medicine

2024 Volume 19, Issue 1, Page(s) 21

Abstract: Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD has become the most prevalent form of chronic liver disease worldwide and can ... ...

Abstract	Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD has become the most prevalent form of chronic liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. However, there is still a lack of effective treatment strategies in Western medicine. The development of NAFLD is driven by multiple mechanisms, including genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, and adipose tissue dysfunction. Currently, certain drugs, including insulin sensitizers, statins, vitamin E, ursodeoxycholic acid and betaine, are proven to be beneficial for the clinical treatment of NAFLD. Due to its complex pathogenesis, personalized medicine that integrates various mechanisms may provide better benefits to patients with NAFLD. The holistic view and syndrome differentiation of TCM have advantages in treating NAFLD, which are similar to the principles of personalized medicine. In TCM, NAFLD is primarily classified into five types based on clinical experience. It is located in the liver and is closely related to spleen and kidney functions. However, due to the multi-component characteristics of traditional Chinese medicine, its application in the treatment of NAFLD has been considerably limited. In this review, we summarize the advances in the pathogenesis and treatment of NAFLD, drawn from both the Western medicine and TCM perspectives. We highlight that Chinese and Western medicine have complementary advantages and should receive increased attention in the prevention and treatment of NAFLD.
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-024-00894-1
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Article: The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion.

Zhu, Junwen / He, Lan

Microorganisms

2024 Volume 12, Issue 4

Abstract: Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise ... ...

Abstract	Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin's ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatment of cardiovascular disease. Nevertheless, owing to the limited bioavailability of CUR, it is difficult to validate its specific mechanism of action in the treatment of diseases. However, the restricted bioavailability of CUR makes it challenging to confirm its precise mode of action in disease treatment. Recent research indicates that the oral intake of curcumin may lead to elevated levels of residual curcumin in the gastrointestinal system, hinting at curcumin's potential to directly influence gut microbiota. Furthermore, the ecological dysregulation of the gut microbiota has been shown to be critical in the pathogenesis of human diseases. This review summarizes the impact of gut dysbiosis on host health and the various ways in which curcumin modulates dysbiosis and ameliorates various diseases caused by it through the administration of curcumin.
Language	English
Publishing date	2024-03-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12040642
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Article ; Online: Causal associations between human gut microbiota and hemorrhoidal disease: A two-sample Mendelian randomization study.

Yang, Fang / Lan, Zhihua / Chen, Huabing / He, Rongfang

Medicine

2024 Volume 103, Issue 13, Page(s) e37599

Abstract: Hemorrhoidal disease (HEM) is a common condition affecting a significant proportion of the population. However, the causal relationship between the gut microbiota and hemorrhoids remains unclear. In this study, we employed a Mendelian randomization (MR) ... ...

Abstract	Hemorrhoidal disease (HEM) is a common condition affecting a significant proportion of the population. However, the causal relationship between the gut microbiota and hemorrhoids remains unclear. In this study, we employed a Mendelian randomization (MR) approach to investigate the potential associations between them. In this study, the exposure factor was determined by selecting summary statistics data from a large-scale gut microbiome whole-genome association study conducted by the MiBioGen Consortium, which involved a sample size of 18,340 individuals. The disease outcome data consisted of 218,920 cases of HEM and 725,213 controls of European ancestry obtained from the European Bioinformatics Institute dataset. Two-sample MR analyses were performed to assess the causalities between gut microbiota and hemorrhoids using various methods, including inverse-variance weighting, MR-Egger regression, MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), simple mode, and weighted median. Reverse MR analyses were performed to examine reverse causal association. Our findings suggest phylum Cyanobacteria (OR = 0.947, 95% CI: 0.915-0.980, P = 2.10 × 10 - 3), genus Phascolarctobacterium (OR = 0.960, 95% CI: 0.924-0.997, P = .034) and family FamilyXI (OR = 0.974, 95% CI: 0.952-0.997, P = .027) have potentially protective causal effects on the risk of HEM, while genus Ruminococcaceae_UCG_002 (OR = 1.036, 95% CI: 1.001-1.071, P = .042), family Peptostreptococcaceae (OR = 1.042, 95% CI: 1.004-1.082, P = .029), genus Oscillospira (OR = 1.048, 95% CI: 1.005-1.091, P = .026), family Alcaligenaceae (OR = 1.048, 95% CI: 1.005-1.091, P = .036) and order Burkholderiales (OR = 1.074, 95% CI: 1.020-1.130, P = 6.50 × 10-3) have opposite effect. However, there was a reverse causal relationship between HEM and genus Oscillospira (OR = 1.140, 95% CI: 1.002-1.295, P = .046) This is the first MR study to explore the causalities between specific gut microbiota taxa and hemorrhoidal disease, which may offer valuable insights for future clinical interventions for hemorrhoidal disease.
MeSH term(s)	Humans ; Hemorrhoids/genetics ; Gastrointestinal Microbiome/genetics ; Mendelian Randomization Analysis ; Academies and Institutes ; Causality ; Clostridiales ; Genome-Wide Association Study
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037599
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Article: Predicting types of human-related maritime accidents with explanations using selective ensemble learning and SHAP method.

Lan, He / Wang, Shutian / Zhang, Wenfeng

Heliyon

2024 Volume 10, Issue 9, Page(s) e30046

Abstract: Maritime accidents frequently lead to severe property damage and casualties, and an accurate and reliable risk prediction model is necessary to help maritime stakeholders assess the current risk situation. Therefore, the present study proposes a hybrid ... ...

Abstract	Maritime accidents frequently lead to severe property damage and casualties, and an accurate and reliable risk prediction model is necessary to help maritime stakeholders assess the current risk situation. Therefore, the present study proposes a hybrid methodology to develop an explainable prediction model for maritime accident types. Based on the advantages of selective ensemble learning method, this study pioneers to introduce a two-stage model selection method, aiming to enhance the predictive accuracy and stability of the model. Then, SHAP (Shapley Additive Explanations) method is integrated to identify effective mapping associations of seafarers' unsafe acts and their risk factors with the prediction results. The results demonstrate that the model developed achieves good prediction performance with an accuracy of 87.50 % and an F1-score of 84.98 %, which benefits stakeholders in assessing the type of maritime accident in advance, so as to make proactive intervention measures.
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e30046
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Article ; Online: Neovascularised Giant Left Atrial Mass.

He, Albert / Lan, Nick S R / Rankin, James M / Anvardeen, Kalilur / Ihdayhid, Abdul Rahman / Dwivedi, Girish

Acta cardiologica

2024 , Page(s) 1–2

Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	390197-x
ISSN	1784-973X ; 0001-5385
ISSN (online)	1784-973X
ISSN	0001-5385
DOI	10.1080/00015385.2024.2339059
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