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Article ; Online: The effect of UV-B irradiation on structural and functional properties of corn and potato starches and their components.

Kurdziel, Magdalena / Łabanowska, Maria / Pietrzyk, Sławomir / Pająk, Paulina / Królikowska, Karolina / Szwengiel, Artur

Carbohydrate polymers

2022 Volume 289, Page(s) 119439

Abstract: In this work, UV-B irradiation, an environmentally friendly modification method, was applied ... UV-B irradiation was found to be a milder modification method than chemical oxidation. The potato ... Similarly, functional properties were not significantly influenced by UV-B treatment. EPR studies revealed ...

Abstract	In this work, UV-B irradiation, an environmentally friendly modification method, was applied to corn and potato carbohydrates. The influence of irradiation on starch properties was compared with that observed for starch oxidation with NaClO. The changes in the structures of starch carbohydrates were investigated by X-ray diffraction (XRD), electron paramagnetic resonance (EPR) and chromatographic methods. Functional properties such as viscosity, water binding capacity and solubility as well as pasting characteristics and thermodynamic parameters of gelatinization, resulting from structural changes were determined. UV-B irradiation was found to be a milder modification method than chemical oxidation. The potato carbohydrates, especially amylose, appeared to be more susceptible to changes upon irradiation, whereas corn ones, particularly amylopectin, were more stable and their properties changed to a smaller extent. Similarly, functional properties were not significantly influenced by UV-B treatment. EPR studies revealed the mechanism of depolymerization of starch carbohydrates via formation of stable carbon-centered radicals.
MeSH term(s)	Amylose/chemistry ; Amylose/radiation effects ; Solanum tuberosum/chemistry ; Starch/chemistry ; Starch/radiation effects ; Ultraviolet Rays ; Zea mays/chemistry
Chemical Substances	Starch (9005-25-8) ; Amylose (9005-82-7)
Language	English
Publishing date	2022-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.119439
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Article ; Online: Atypical course of infective endocarditis in a patient with complex congenital heart disease, chronic hepatitis B virus infection, and splenic marginal zone lymphoma.

Szczepanek, Elżbieta / Kostkiewicz, Magdalena / Małecka, Barbara / Giza, Agnieszka / Gałązka, Krystyna / Tomkiewicz-Pająk, Lidia

Polish archives of internal medicine

2020 Volume 130, Issue 7-8, Page(s) 697–699

MeSH term(s)	Endocarditis/complications ; Endocarditis/diagnostic imaging ; Heart Defects, Congenital ; Hepatitis B, Chronic/complications ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Lymphoma
Language	English
Publishing date	2020-05-19
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15367
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Article: The effect of UV-B irradiation on structural and functional properties of corn and potato starches and their components

Kurdziel, Magdalena / Łabanowska, Maria / Pietrzyk, Sławomir / Pająk, Paulina / Królikowska, Karolina / Szwengiel, Artur

Carbohydrate polymers. 2022 Aug. 01, v. 289

2022

Abstract	In this work, UV-B irradiation, an environmentally friendly modification method, was applied to corn and potato carbohydrates. The influence of irradiation on starch properties was compared with that observed for starch oxidation with NaClO. The changes in the structures of starch carbohydrates were investigated by X-ray diffraction (XRD), electron paramagnetic resonance (EPR) and chromatographic methods. Functional properties such as viscosity, water binding capacity and solubility as well as pasting characteristics and thermodynamic parameters of gelatinization, resulting from structural changes were determined. UV-B irradiation was found to be a milder modification method than chemical oxidation. The potato carbohydrates, especially amylose, appeared to be more susceptible to changes upon irradiation, whereas corn ones, particularly amylopectin, were more stable and their properties changed to a smaller extent. Similarly, functional properties were not significantly influenced by UV-B treatment. EPR studies revealed the mechanism of depolymerization of starch carbohydrates via formation of stable carbon-centered radicals.
Keywords	X-ray diffraction ; amylopectin ; amylose ; chromatography ; corn ; depolymerization ; electron paramagnetic resonance spectroscopy ; gelatinization ; irradiation ; oxidation ; potatoes ; solubility ; thermodynamics ; viscosity
Language	English
Dates of publication	2022-0801
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2022.119439
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Article: Looking for the Holy Grail-Drug Candidates for Glioblastoma Multiforme Chemotherapy.

Pająk, Beata

Biomedicines

2022 Volume 10, Issue 5

Abstract: Glioblastoma multiforme (GBM) is the deadliest and the most heterogeneous brain cancer. The median survival time of GBM patients is approximately 8 to 15 months after initial diagnosis. GBM development is determined by numerous signaling pathways and is ... ...

Abstract	Glioblastoma multiforme (GBM) is the deadliest and the most heterogeneous brain cancer. The median survival time of GBM patients is approximately 8 to 15 months after initial diagnosis. GBM development is determined by numerous signaling pathways and is considered one of the most challenging and complicated-to-treat cancer types. Standard GBM therapy consist of surgery followed by radiotherapy or chemotherapy, and combined treatment. Current standard of care (SOC) does not offer a significant chance for GBM patients to combat cancer, and the selection of available drugs is limited. For almost 20 years, there has been only one drug, Temozolomide (TMZ), approved as a first-line GBM treatment. Due to the limited efficacy of TMZ and the high rate of resistant patients, the implementation of new chemotherapeutics is highly desired. However, due to the unique properties of GBM, many challenges still need to be overcome before reaching a 'breakthrough'. This review article describes the most recent compounds introduced into clinical trials as drug candidates for GBM chemotherapy.
Language	English
Publishing date	2022-04-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10051001
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Article ; Online: Functional Dissection of a Viral DNA Packaging Machine's Walker B Motif.

delToro, Damian / Ortiz, David / Ordyan, Mariam / Pajak, Joshua / Sippy, Jean / Catala, Alexis / Oh, Choon-Seok / Vu, Amber / Arya, Gaurav / Smith, Douglas E / Catalano, Carlos E / Feiss, Michael

Journal of molecular biology

2019 Volume 431, Issue 22, Page(s) 4455–4474

Abstract: ... single-molecule techniques to confirm the predicted Walker-B ATP-binding motif in the phage λ motor and ...

Abstract	Many viruses employ ATP-powered motors for genome packaging. We combined genetic, biochemical, and single-molecule techniques to confirm the predicted Walker-B ATP-binding motif in the phage λ motor and to investigate the roles of the conserved residues. Most changes of the conserved hydrophobic residues resulted in >10
MeSH term(s)	AAA Domain/genetics ; Bacteriophage lambda/enzymology ; DNA, Viral/chemistry ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Endodeoxyribonucleases/chemistry ; Endodeoxyribonucleases/genetics ; Endodeoxyribonucleases/metabolism ; Molecular Dynamics Simulation ; Mutation ; Nucleoproteins/chemistry ; Nucleoproteins/genetics ; Nucleoproteins/metabolism ; Protein Structure, Quaternary ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Assembly/genetics ; Virus Assembly/physiology
Chemical Substances	DNA, Viral ; Nucleoproteins ; Viral Proteins ; Endodeoxyribonucleases (EC 3.1.-) ; terminase (EC 3.1.-)
Language	English
Publishing date	2019-08-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2019.08.012
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Zs.A 867: Show issues

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Article: Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail.

Kryczka, Jakub / Papiewska-Pajak, Izabela / Kowalska, M Anna / Boncela, Joanna

Cells

2019 Volume 8, Issue 3

Abstract: ... pericellular activity of cathepsin B. It appears that the pericellular localization of cathepsin B, also ...

Abstract	During tumor development and ongoing metastasis the acquisition of mesenchymal cell traits by epithelial carcinoma cells is achieved through a programmed phenotypic shift called the epithelial-to-mesenchymal transition, EMT. EMT contributes to increased cancer cell motility and invasiveness mainly through invadosomes, the adhesion structures that accompany the mesenchymal migration. The invadosomes and their associated proteases restrict protease activity to areas of the cell in direct contact with the ECM, thus precisely controlling cell invasion. Our data prove that Snail-overexpressing HT-29 cells that imitate the phenotype of colon cancer cells in the early stage of the EMT showed an increase in the expression and pericellular activity of cathepsin B. It appears that the pericellular localization of cathepsin B, also observed in colon and rectum adenocarcinoma tissue samples, plays a key role in its function.
MeSH term(s)	Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Extracellular Matrix/metabolism ; HT29 Cells ; Humans ; Neoplasm Invasiveness ; Podosomes/metabolism ; Snail Family Transcription Factors/metabolism ; Up-Regulation/genetics
Chemical Substances	Snail Family Transcription Factors ; Cathepsin B (EC 3.4.22.1)
Language	English
Publishing date	2019-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409
ISSN	2073-4409
DOI	10.3390/cells8030203
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Article ; Online: Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.

Horvat, Pia / Gardiner, Julian / Kubinova, Ruzena / Pajak, Andrzej / Tamosiunas, Abdonas / Schöttker, Ben / Pikhart, Hynek / Peasey, Anne / Jansen, Eugene / Bobak, Martin

Experimental gerontology

2016 Volume 76, Page(s) 33–38

Abstract: Background: Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related ... to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function ... adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word ...

Abstract	Background: Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive. Objective: The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations. Methods: Men and women aged 45-69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006-2008. Serum concentrations of biomarkers at baseline were measured in a sub-sample of participants. Associations of vitamin quartiles with baseline (n=4166) and follow-up (n=2739) cognitive domain-specific z-scores were estimated using multiple linear regression. Results: After adjusting for confounders, folate was positively associated with letter search and vitamin B-12 with word recall in cross-sectional analyses. In prospective analyses, participants in the highest quartile of folate had higher verbal fluency (p<0.01) and immediate recall (p<0.05) scores compared to those in the bottom quartile. In addition, participants in the highest quartile of vitamin B-12 had significantly higher verbal fluency scores (β=0.12; 95% CI=0.02, 0.21). Conclusions: Folate and vitamin B-12 were positively associated with performance in some but not all cognitive domains in older Central and Eastern Europeans. These findings do not lend unequivocal support to potential importance of folate and vitamin B-12 status for cognitive function in older age. Long-term longitudinal studies and randomised trials are required before drawing conclusions on the role of these vitamins in cognitive decline.
MeSH term(s)	Age Factors ; Aged ; Aging/blood ; Aging/psychology ; Biomarkers/blood ; Cognition ; Cross-Sectional Studies ; Europe ; Female ; Folic Acid/blood ; Geriatric Assessment ; Humans ; Linear Models ; Male ; Memory, Short-Term ; Middle Aged ; Neuropsychological Tests ; Nutrition Assessment ; Nutritional Status ; Prospective Studies ; Verbal Behavior ; Vitamin B 12/blood
Chemical Substances	Biomarkers ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
Language	English
Publishing date	2016-01-22
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2016.01.011
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Zs.A 579: Show issues

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Article ; Online: IL-6, IL-10, c-Jun and STAT3 expression in B-CLL.

Antosz, Halina / Wojciechowska, Katarzyna / Sajewicz, Joanna / Choroszyńska, Dorota / Marzec-Kotarska, Barbara / Osiak, Magdalena / Pająk, Natalia / Tomczak, Waldemar / Jargiełło-Baszak, Małgorzata / Baszak, Jacek

Blood cells, molecules & diseases

2015 Volume 54, Issue 3, Page(s) 258–265

Abstract: ... monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen, resulting ... transcription factors gene expression, may underlie the basis of immune failure in B-CLL. The aim of the study was ... of leukemic lymphocytes (CD5+ CD19+) and CD19+ B cells from healthy donors (control group). Our results provide evidence ...

Abstract	Chronic lymphocytic leukemia is characterized by the accumulation of functionally abnormal, monoclonal B lymphocytes in the peripheral blood, bone marrow, lymph nodes and spleen, resulting in a reduction count of normal immunocompetent cells and their impaired immune function. The defect in transmission of signals from various types of extracellular receptors, leading to aberrant cytokines and transcription factors gene expression, may underlie the basis of immune failure in B-CLL. The aim of the study was to assess of IL-6, IL-10, c-Jun, and STAT3 expression. In response to antigenic stimulation IL-6, IL-10, c-Jun, and STAT3 proteins induce mutual activity. The subject of the study was subpopulations of leukemic lymphocytes (CD5+ CD19+) and CD19+ B cells from healthy donors (control group). Our results provide evidence that the regulation of IL-6, IL-10, c-Jun, and STAT3 gene expression in CLL B cells is clearly different from normal B lymphocytes. In B-CLL STAT3 expression in unstimulated lymphocytes is significantly higher (p<0.0001) compared with normal subpopulation of B cell. In contrast, IL-6, IL-10, and c-Jun mRNA expressions are statistically lower in B-CLL in comparison with the control group, in all cases (p<0.0001). When analyzing the relationship between c-Jun expression and B-CLL stage according Rai we revealed decreasing c-Jun expression, both at the mRNA and protein levels, along with advancing stage of disease.
MeSH term(s)	Aged ; Aged, 80 and over ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Female ; Gene Expression Regulation, Leukemic ; Humans ; Interleukin-10/analysis ; Interleukin-10/genetics ; Interleukin-6/analysis ; Interleukin-6/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Proto-Oncogene Proteins c-jun/analysis ; Proto-Oncogene Proteins c-jun/genetics ; RNA, Messenger/genetics ; STAT3 Transcription Factor/analysis ; STAT3 Transcription Factor/genetics
Chemical Substances	Interleukin-6 ; Proto-Oncogene Proteins c-jun ; RNA, Messenger ; STAT3 Transcription Factor ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1237083-6
ISSN	1096-0961 ; 1079-9796
ISSN (online)	1096-0961
ISSN	1079-9796
DOI	10.1016/j.bcmd.2014.11.006
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Zs.A 1138: Show issues

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Article ; Online: Methylated derivatives of l-tyrosine in reaction catalyzed by l-amino acid oxidase: isotope and inhibitory effects.

Pająk, Małgorzata

Journal of biochemistry

2020 Volume 168, Issue 5, Page(s) 509–514

Abstract: ... of methyl substituent on its activity as methylated derivatives of l-tyrosine, labelled with short-lived B+ ...

Abstract	l-Amino acid oxidase (LAAO) is widely distributed in nature and shows important biological activity. It induces cell apoptosis and has antibacterial properties. This study was designed to investigate the effect of methyl substituent on its activity as methylated derivatives of l-tyrosine, labelled with short-lived B+ emitters, have been used in oncological diagnostics. To study isotope effects in the oxidative deamination of O-methyl-l-tyrosine, the deuterated isotopomer, i.e. O-methyl-[2-2H]-l-tyrosine, was synthesized by isotope exchange, catalyzed enzymatically by tryptophanase. Isotope effects were determined using the spectrophotometric non-competitive method. The values of isotope effects indicate that the α-C-H bond cleavage occurs in the rate determining step of the investigated reaction and α-hydrogen plays a role in the substrate binding process at the enzyme active site. The inhibitory effect on LAAO activity was studied with α-methyl-l-tyrosine and N-methyl-l-tyrosine. The mode of inhibition was determined based on Lineweavear-Burk plots intersections. α-Methyl-l-tyrosine has been found a mixed type inhibitor of the investigated enzyme, whereas N-methyl-l-tyrosine is a non-competitive inhibitor of LAAO.
MeSH term(s)	Animals ; Catalysis ; Crotalus/metabolism ; Isotope Labeling ; Kinetics ; L-Amino Acid Oxidase/antagonists & inhibitors ; L-Amino Acid Oxidase/chemistry ; L-Amino Acid Oxidase/metabolism ; Methylation ; Methyltyrosines/chemistry ; Methyltyrosines/pharmacology ; Substrate Specificity ; Tyrosine/analogs & derivatives ; Tyrosine/chemistry ; Tyrosine/pharmacology
Chemical Substances	Methyltyrosines ; Tyrosine (42HK56048U) ; L-Amino Acid Oxidase (EC 1.4.3.2)
Language	English
Publishing date	2020-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvaa066
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Article: A Meta-Analysis of the Global Prevalence of Temporomandibular Disorders.

Zieliński, Grzegorz / Pająk-Zielińska, Beata / Ginszt, Michał

Journal of clinical medicine

2024 Volume 13, Issue 5

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13051365
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