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Article ; Online: Nonlinear evolution of the modified Simon-Hoh instability via a cascade of sideband instabilities in a weak beam plasma system.

Sakawa / Joshi / Kaw / Jain / Johnston / Chen / Dawson

1992 Volume 69, Issue 1, Page(s) 85–88

Language	English
Publishing date	1992-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.69.85
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Article ; Online: Non-medical prescribing in critical care: A mixed methods study.

Ross Deveau, Simon / Plowright, Catherine / Dawson, Deborah

Intensive & critical care nursing

2024 , Page(s) 103704

Abstract: Background: Little is known about non-medical prescribers in critical care in the United Kingdom. In 2007, a small survey identified few non-medical prescribers; however, in the intervening years, there have been many changes to the Medicine Act 1968. ... ...

Abstract	Background: Little is known about non-medical prescribers in critical care in the United Kingdom. In 2007, a small survey identified few non-medical prescribers; however, in the intervening years, there have been many changes to the Medicine Act 1968. It is likely that prescribing within the non-medical workforce in critical care has changed significantly. Aim/s: This survey aimed to explore the breadth and diversity of prescribing practices of non-medical prescribers working within the wider critical care environment in the United Kingdom. Method: Data were collected via an online questionnaire adapted from the 2007 version and distributed by the BACCN to their members between 26th October 2021 and 19th November 2021. Freedom of Information requests were made to the Nursing and Midwifery Council, The Health and Care Professions Council and the General Pharmaceutical Council to understand the number of non-medical prescribers. Results: The survey elicited 259 responses; 105 respondents identified themselves as non-medical prescribers, and 57 used Patient Group Directions only. In the ICU/HDU, 75 respondents identified as non-medical prescribers, with an additional 45 using Patient Group Directions. Conclusion: Since the last survey, there has been a large increase in the number and representation across all professional groups identifying as a non-medical prescriber and/or utilising patient group directions across critical care. Many staff responded to this survey who were neither NMPs nor utilising PGDs; of these, a large proportion were interested in taking on this additional responsibility. Implications for practice: Many people working within critical care are interested in becoming non-medical prescribers. Assists with understanding characteristics of those working as non-medical prescribers within critical care. Shows variations in practice in respect to PGDs, authorising of blood products and prescribing.
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1105892-4
ISSN	1532-4036 ; 0964-3397
ISSN (online)	1532-4036
ISSN	0964-3397
DOI	10.1016/j.iccn.2024.103704
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Article ; Online: Effect of vegetation treatment and water stress on evapotranspiration in bioretention systems.

De-Ville, Simon / Edmondson, Jill / Green, Daniel / Stirling, Ross / Dawson, Richard / Stovin, Virginia

Water research

2024 Volume 252, Page(s) 121182

Abstract: Evapotranspiration is a key hydrological process for reducing stormwater runoff in bioretention systems, regardless of their physical configuration. Understanding the volumes of stormwater that can be returned to the atmosphere via evapotranspiration is, ...

Abstract	Evapotranspiration is a key hydrological process for reducing stormwater runoff in bioretention systems, regardless of their physical configuration. Understanding the volumes of stormwater that can be returned to the atmosphere via evapotranspiration is, therefore, a key consideration in the design of any bioretention system. This study establishes the evapotranspiration dynamics of three common, structurally different, bioretention vegetation treatments (an Amenity Grass mix, and mono-cultures of Deschampsia cespitosa and Iris sibirica) compared with an un-vegetated control using lab-scale column experiments. Via continuous mass and moisture loss data, observed evapotranspiration rates were compared with those predicted by the FAO-56 Penman-Monteith model for five 14-day dry periods during Spring 2021, Summer 2021, and Spring 2022. Soil moisture reductions over the 14-day trials led to reduced rates of evapotranspiration. This necessitated the use of a soil moisture extraction function alongside a crop coefficient to represent actual evapotranspiration from FAO-56 Penman-Monteith reference evapotranspiration estimates. Crop coefficients (K
MeSH term(s)	Humans ; Dehydration ; Soil ; Seasons ; Hydrology ; Ireland ; Rain
Chemical Substances	Soil
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2024.121182
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Article ; Online: Prospective, open-label, multicenter clinical study to assess the performance of a new donation system for the collection of source plasma.

Mason, Emily / Dawson, Kati / Rhodes, Jack / Kelley, James / Meyer, Erin Goodhue / Simon, Toby L

Journal of clinical apheresis

2023 Volume 38, Issue 4, Page(s) 457–462

Abstract: Background: Safe, efficient, and reliable innovations among donation systems are needed to meet the growing global demand for source plasma. This study assessed the ability of a new donation system to collect appropriate product weights based on the US ... ...

Abstract	Background: Safe, efficient, and reliable innovations among donation systems are needed to meet the growing global demand for source plasma. This study assessed the ability of a new donation system to collect appropriate product weights based on the US Food and Drug Administration nomogram for source plasma collections. Procedure duration and safety endpoints were also collected. Study design and methods: The Rika Plasma Donation System (Terumo BCT, Inc., Lakewood, CO) was evaluated in a prospective, open-label, multicenter study. Healthy adults meeting FDA and Plasma Protein Therapeutics Association requirements for source plasma donor eligibility were consented and enrolled in the study resulting in 124 evaluable products. Results: The target product collection weights (ie, including plasma and anticoagulant) by participant weight category were: 705 g (110-149 lbs), 845 g (150-174 lbs), and 900 g (≥175 lbs). The mean reported product collection weights by participant weight category were 705.0 ± 0.00, 845.0 ± 0.20, and 899.9 ± 0.31 g, respectively. The mean overall procedure time was 31.5 ± 5.41 minutes. The mean procedure times by participant weight category were 25.6 ± 3.13, 30.5 ± 4.45, and 33.7 ± 4.80 minutes, respectively. Procedure-emergent adverse events (PEAEs) occurred in five participants. All PEAEs were consistent with known risks for apheresis donation, and none were related to the donation system. Conclusions: The new donation system collected the target product collection weight in 100% of evaluable products. The mean procedure collection time was 31.5 minutes. The system is a new efficient platform that consistently collects the appropriate weight of the source plasma.
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Blood Component Removal/methods ; Blood Donors
Language	English
Publishing date	2023-04-02
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	604912-6
ISSN	1098-1101 ; 0733-2459
ISSN (online)	1098-1101
ISSN	0733-2459
DOI	10.1002/jca.22050
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Article ; Online: Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines.

Ju, Yi / Carreño, Juan Manuel / Simon, Viviana / Dawson, Kenneth / Krammer, Florian / Kent, Stephen J

Nature reviews. Immunology

2022 Volume 23, Issue 3, Page(s) 135–136

MeSH term(s)	Humans ; COVID-19 ; COVID-19 Vaccines ; SARS-CoV-2 ; Vaccines, Synthetic ; Antibodies, Neutralizing
Chemical Substances	COVID-19 Vaccines ; Vaccines, Synthetic ; Antibodies, Neutralizing
Language	English
Publishing date	2022-12-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-022-00825-x
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Improving water quality in a hypereutrophic lake and tributary through agricultural nutrient mitigation: A Multi-year monitoring analysis.

Husk, Barry / Julian, Paul / Simon, Dana / Tromas, Nicolas / Phan, Dawson / Painter, Kristin / Baulch, Helen / Sauvé, Sébastien

Journal of environmental management

2024 Volume 354, Page(s) 120411

Abstract: Anthropogenic eutrophication remains a critical global issue, significantly impacting surface water quality. Numerous regions have implemented beneficial management practices to combat agricultural nonpoint pollution, often evaluating efficacy at the ... ...

Abstract	Anthropogenic eutrophication remains a critical global issue, significantly impacting surface water quality. Numerous regions have implemented beneficial management practices to combat agricultural nonpoint pollution, often evaluating efficacy at the field scale, but not downstream. In this study, we conducted an extensive, 11-year (2010-2020), all-season, weekly monitoring program in a small, shallow, hypereutrophic lake and main tributary located in a cold climate, northern temperate zone, within a predominantly agricultural-forested mesoscale watershed. The monitoring took place before and after the implementation of field-scale agricultural nutrient mitigation measures in the catchment, allowing assessment of changes over time in the downstream tributary and lake. We analyzed long-term trends and temporal change points for nitrogen and phosphorus concentrations, aquatic trophic status, and nutrient stoichiometric ratios. The results revealed significant reductions in nitrogen and phosphorus concentrations, improved lake trophic status from hypereutrophic to eutrophic, and an increase in total nitrogen : total phosphorus ratios following the implementation of field-scale agricultural nutrient mitigation measures. Notably, both the lake and its main tributary exhibited significant temporal change points for these parameters. Our findings offer evidence of a relatively rapid, positive effect of the implementation of field-scale agricultural nutrient mitigation measures contributing to subsequent improvements in downstream water quality.
MeSH term(s)	Water Quality ; Lakes ; Environmental Monitoring ; Nutrients ; Phosphorus/analysis ; Nitrogen/analysis ; Eutrophication ; China
Chemical Substances	Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120411
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Article ; Online: Bushmeat

Dawson, Simon

Food Ethics Education

Abstract: Since Homo erectus, an ancient ancestor of the modern human, was discovered to have evolved from Africa 2 million years ago, animals have been hunted for their skin and meat . Animal meat is a nutritious, a convenient, and an easily accessible source of ... ...

Abstract	Since Homo erectus, an ancient ancestor of the modern human, was discovered to have evolved from Africa 2 million years ago, animals have been hunted for their skin and meat . Animal meat is a nutritious, a convenient, and an easily accessible source of protein in the diet. However, over the turn of the last century, a sharp increase in widespread human populations, clusters of extreme poverty in areas surrounded by wildlife, and highly profitable trade revenues have exploited bushmeat at an unprecedented level. It is at a point now whereby some species are on the brink of extinction, and others will follow suit unless a drastic change occurs. This case study will focus on the ethical demand for bushmeat, focusing on the UK and European markets, and zoonotic diseases that have caused a major threat to the existence of human and animals alike.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/978-3-319-64738-8_12
Database	COVID19

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Article ; Online: Modification of small ubiquitin-related modifier 2 (SUMO2) by phosphoubiquitin in HEK293T cells.

Dongdem, Julius T / Dawson, Simon P / Layfield, Robert

Proteomics

2021 Volume 21, Issue 15, Page(s) e2000234

Abstract: Additional complexity in the post-translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1-parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins ... ...

Abstract	Additional complexity in the post-translational modification of proteins by ubiquitin is achieved by ubiquitin phosphorylation, for example within PINK1-parkin mediated mitophagy. We performed a preliminary proteomic analysis to identify proteins differentially modified by ubiquitin in HEK293T, compared to phosphomimetic ubiquitin (Ser65Asp), and identified small ubiquitin-related modifier 2 (SUMO2) as a candidate. By transfecting SUMO2 and its C-terminal-GG deletion mutant, along with phosphomimetic ubiquitin, we confirm that ubiquitin modifies SUMO2, rather than vice versa. Further investigations revealed that transfected SUMO2 can also be conjugated by endogenous phospho-Ser65-(poly)ubiquitin in HEK293T cells, pointing to a previously unappreciated level of complexity in SUMO2 modification, and that unanchored (substrate-free) polyubiquitin chains may also be subject to phosphorylation.
MeSH term(s)	HEK293 Cells ; Humans ; Phosphorylation ; Polyubiquitin ; Proteomics ; Small Ubiquitin-Related Modifier Proteins/genetics ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Ubiquitin/metabolism
Chemical Substances	SUMO2 protein, human ; Small Ubiquitin-Related Modifier Proteins ; Ubiquitin ; Polyubiquitin (120904-94-1)
Language	English
Publishing date	2021-06-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2032093-0
ISSN	1615-9861 ; 1615-9853
ISSN (online)	1615-9861
ISSN	1615-9853
DOI	10.1002/pmic.202000234
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Article ; Online: Hematological and Other Cancers in People Using Clozapine: Analysis of Australian Spontaneous Reports Between 1995 and 2020.

Dawson, Jessica L / Sluggett, Janet K / Procter, Nicholas G / Myles, Nicholas / Bell, J Simon

Journal of clinical psychopharmacology

2023 Volume 43, Issue 4, Page(s) 333–338

Abstract: Background: Recent observational study evidence suggests that clozapine, unlike other antipsychotics, may be associated with a small increased risk of hematological malignancy. This study described characteristics of hematological and other cancers in ... ...

Abstract	Background: Recent observational study evidence suggests that clozapine, unlike other antipsychotics, may be associated with a small increased risk of hematological malignancy. This study described characteristics of hematological and other cancers in those taking clozapine reported to the Australian Therapeutic Goods Administration. Methods: We analyzed public case reports for "clozapine," "Clozaril," or "Clopine" from January 1995 to December 2020 classified as "neoplasm benign, malignant and unspecified" by the Australian Therapeutic Goods Administration. Data on age, sex, dose, clozapine start and cessation dates, Medical Dictionary for Regulatory Activities reaction terms, and date of cancer were extracted. Results: Overall, 384 spontaneous reports of cancers in people taking clozapine were analyzed. The mean age of patients was 53.9 years (SD, 11.4 years), and 224 (58.3%) were male. The most frequent cancers were hematological (n = 104 [27.1%]), lung (n = 50 [13.0%]), breast (n = 37 [9.6%]), and colorectal (n = 28 [7.3%]). The outcome was fatal for 33.9% of cancer reports. Lymphoma comprised 72.1% of all hematological cancers (mean patient age, 52.1 years; SD, 11.6 years). The median daily dose of clozapine at the time of hematological cancer report was 400 mg (interquartile range, 300-543.8 mg), and the median duration of clozapine use before hematological cancer diagnosis was 7.0 years (interquartile range, 2.8-13.2 years). Conclusions: Lymphoma and other hematological cancers are overrepresented in spontaneous adverse event reports compared with other cancer types. Clinicians should be aware of the possible association with hematological cancers and monitor for and report any hematological cancers identified. Future studies should examine histology of lymphomas in people using clozapine and corresponding blood level of clozapine.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Clozapine/therapeutic use ; Australia/epidemiology ; Antipsychotic Agents/therapeutic use ; Neoplasms/chemically induced ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Hematologic Neoplasms/chemically induced ; Hematologic Neoplasms/drug therapy
Chemical Substances	Clozapine (J60AR2IKIC) ; Antipsychotic Agents
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001699
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Article ; Online: Clozapine and the risk of haematological malignancies - Authors' reply.

Tiihonen, Jari / Tanskanen, Antti / Bell, J Simon / Dawson, Jessica L / Kataja, Vesa / Taipale, Heidi

The lancet. Psychiatry

2022 Volume 9, Issue 7, Page(s) 539–540

MeSH term(s)	Antipsychotic Agents/adverse effects ; Clozapine/adverse effects ; Hematologic Neoplasms/drug therapy ; Humans
Chemical Substances	Antipsychotic Agents ; Clozapine (J60AR2IKIC)
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Letter ; Comment
ISSN	2215-0374
ISSN (online)	2215-0374
DOI	10.1016/S2215-0366(22)00204-8
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