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Article ; Online: Abnormal preoperative haematological parameters in Endometrial cancer; reflecting tumour aggressiveness or reduced response to radiotherapy?

Vrede, Stephanie W / Donkers, Hannah / Reijnen, Casper / Smits, Anke / Visser, Nicole C M / Geomini, Peggy M / Ngo, Huy / van Hamont, Dennis / Pijlman, Brenda M / Vos, Maria Caroline / Snijders, Marc P L M / Kruitwagen, Roy / Bekkers, Ruud L M / Galaal, Khadra / Pijnenborg, Johanna M A

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2024 Volume 44, Issue 1, Page(s) 2294332

Abstract: Background: In endometrial cancer (EC), preoperative anaemia, thrombocytosis and leucocytosis appear to be associated with worse prognosis. It remains unclear whether these parameters solely reflect tumour aggressiveness, or also impact response to ... ...

Abstract	Background: In endometrial cancer (EC), preoperative anaemia, thrombocytosis and leucocytosis appear to be associated with worse prognosis. It remains unclear whether these parameters solely reflect tumour aggressiveness, or also impact response to adjuvant treatment. Therefore, our primary aim is to evaluate the prognostic relevance of anaemia, thrombocytosis and leucocytosis on survival in EC. Secondary, to explore their predictive relevance in response to radiotherapy in EC. Methods: A retrospective multicentre cohort study was performed within 10 hospitals. Preoperative haematological parameters were defined as: Anaemia - haemoglobin <7.45 mmol/L (<12 g/Dl), thrombocytosis - platelets >400 × 10 Results: A total of 894 patients were included with a median follow-up of 4.5 years. Anaemia was present in 103 (11.5%), thrombocytosis in 79 (8.8%) and leucocytosis in 114 (12.7%) patients. The presence of anaemia or thrombocytosis was significantly associated with ESGO/ESTRO/ESP high-risk (respectively, Conclusions: Current data demonstrate the importance of preoperative anaemia as independent prognostic factor in patients with EC. Moreover, anaemia seems to be associated with reduced response to radiotherapy. Prospective validation in a larger study cohort is needed to verify anaemia as predictive biomarker for radiotherapy.
MeSH term(s)	Female ; Humans ; Anemia/etiology ; Biomarkers ; Cohort Studies ; Endometrial Neoplasms/complications ; Endometrial Neoplasms/radiotherapy ; Endometrial Neoplasms/surgery ; Leukocytosis ; Thrombocytosis/etiology ; Retrospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-01-07
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2023.2294332
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Zs.B 2461: Show issues

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Article ; Online: Bispecific T-Cell Engagers (BiTEs) as Treatment of B-Cell Lymphoma.

Smits, Nicole C / Sentman, Charles L

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2016 Volume 34, Issue 10, Page(s) 1131–1133

MeSH term(s)	Antibodies, Bispecific/administration & dosage ; Antibodies, Bispecific/adverse effects ; Antibodies, Bispecific/therapeutic use ; Antigens, CD19/drug effects ; Antigens, CD19/immunology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; CD3 Complex/drug effects ; CD3 Complex/immunology ; Drug Administration Schedule ; Humans ; Immunotherapy/methods ; Infusions, Intravenous ; Lymphocyte Activation/drug effects ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/immunology ; Maximum Tolerated Dose ; Molecular Targeted Therapy/methods ; Nervous System Diseases/chemically induced ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Treatment Outcome
Chemical Substances	Antibodies, Bispecific ; Antigens, CD19 ; Antineoplastic Agents ; CD3 Complex ; blinatumomab (4FR53SIF3A)
Language	English
Publishing date	2016-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2015.64.9970
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinical consequences of diagnostic variability in the histopathological evaluation of early rectal cancer.

Smits, Lisanne J H / van Lieshout, Annabel S / Bosker, Robbert J I / Crobach, Stijn / de Graaf, Eelco J R / Hage, Mariska / Laclé, Miangela M / Moll, Freek C P / Moons, Leon M G / Peeters, Koen C M J / van Westreenen, Henderik L / van Grieken, Nicole C T / Tuynman, Jurriaan B

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2023 Volume 49, Issue 7, Page(s) 1291–1297

Abstract: Introduction: In early rectal cancer, organ sparing treatment strategies such as local excision have gained popularity. The necessity of radical surgery is based on the histopathological evaluation of the local excision specimen. This study aimed to ... ...

Abstract	Introduction: In early rectal cancer, organ sparing treatment strategies such as local excision have gained popularity. The necessity of radical surgery is based on the histopathological evaluation of the local excision specimen. This study aimed to describe diagnostic variability between pathologists, and its impact on treatment allocation in patients with locally excised early rectal cancer. Materials and methods: Patients with locally excised pT1-2 rectal cancer were included in this prospective cohort study. Both quantitative measures and histopathological risk factors (i.e. poor differentiation, deep submucosal invasion, and lymphatic- or venous invasion) were evaluated. Interobserver variability was reported by both percentages and Fleiss' Kappa- (ĸ) or intra-class correlation coefficients. Results: A total of 126 patients were included. Ninety-four percent of the original histopathological reports contained all required parameters. In 73 of the 126 (57.9%) patients, at least one discordant parameter was observed, which regarded histopathological risk factors for lymph node metastases in 36 patients (28.6%). Interobserver agreement among different variables varied between 74% and 95% or ĸ 0.530-0.962. The assessment of lymphovascular invasion showed discordances in 26% (ĸ = 0.530, 95% CI 0.375-0.684) of the cases. In fourteen (11%) patients, discordances led to a change in treatment strategy. Conclusion: This study demonstrated that there is substantial interobserver variability between pathologists, especially in the assessment of lymphovascular invasion. Pathologists play a key role in treatment allocation after local excision of early rectal cancer, therefore interobserver variability needs to be reduced to decrease the number of patients that are over- or undertreated.
MeSH term(s)	Humans ; Prospective Studies ; Neoplasm Staging ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Lymphatic Metastasis ; Digestive System Surgical Procedures
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2023.02.008
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 549: Show issues

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Article ; Online: Patients' perspectives and the perceptions of healthcare providers in the treatment of early rectal cancer; a qualitative study.

Smits, Lisanne J H / van Lieshout, Annabel S / Debets, Saskia / Spoor, Sacha / Moons, Leon M G / Peeters, Koen C M J / van Oostendorp, Stefan E / Damman, Olga C / Janssens, Rien J P A / Lameris, Wytze / van Grieken, Nicole C T / Tuynman, Jurriaan B

BMC cancer

2023 Volume 23, Issue 1, Page(s) 1266

Abstract: Background: Shared decision-making has become of increased importance in choosing the most suitable treatment strategy for early rectal cancer, however, clinical decision-making is still primarily based on physicians' perspectives. Balancing quality of ... ...

Abstract	Background: Shared decision-making has become of increased importance in choosing the most suitable treatment strategy for early rectal cancer, however, clinical decision-making is still primarily based on physicians' perspectives. Balancing quality of life and oncological outcomes is difficult, and guidance on patients' involvement in this subject in early rectal cancer is limited. Therefore, this study aimed to explore preferences and priorities of patients as well as physicians' perspectives in treatment for early rectal cancer. Methods: In this qualitative study, semi-structured interviews were performed with early rectal cancer patients (n = 10) and healthcare providers (n = 10). Participants were asked which factors influenced their preferences and how important these factors were. Thematic analyses were performed. In addition, participants were asked to rank the discussed factors according to importance to gain additional insights. Results: Patients addressed the following relevant factors: the risk of an ostomy, risk of poor bowel function and treatment related complications. Healthcare providers emphasized oncological outcomes as tumour recurrence, risk of an ostomy and poor bowel function. Patients perceived absolute risks of adverse outcome to be lower than healthcare providers and were quite willing undergo organ preservation to achieve a better prospect of quality of life. Conclusion: Patients' preferences in treatment of early rectal cancer vary between patients and frequently differ from assumptions of preferences by healthcare providers. To optimize future shared decision-making, healthcare providers should be aware of these differences and should invite patients to explore and address their priorities more explicitly during consultation. Factors deemed important by both physicians and patients should be expressed during consultation to decide on a tailored treatment strategy.
MeSH term(s)	Humans ; Quality of Life ; Decision Making ; Neoplasm Recurrence, Local ; Health Personnel ; Rectal Neoplasms/therapy
Language	English
Publishing date	2023-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11734-0
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Article: The perceived quality of video consultations in geriatric outpatient care by early adopters.

Spronk, Romy / van der Zaag-Loonen, Hester J / Bottenberg-Wigbold, Nicole / Bovee, Nadine / Smits, Rosalinde / van Offenbeek, Marjolein / Vos, Janita F J / Luttik, Marie Louise / van Munster, Barbara C

European geriatric medicine

2022 Volume 13, Issue 5, Page(s) 1169–1176

Abstract: Purpose: The COVID-19 pandemic caused rapid implementation and upscaling of video consulting. This study examined the perceived quality of care delivered through video consulting at a geriatric outpatient clinic, and how this related to adoption issues ... ...

Abstract	Purpose: The COVID-19 pandemic caused rapid implementation and upscaling of video consulting. This study examined the perceived quality of care delivered through video consulting at a geriatric outpatient clinic, and how this related to adoption issues and barriers early adopting professionals found themselves confronted with. Methods: We performed a qualitative study using semi-structured interviews with healthcare professionals complemented by the views of geriatric patients, family caregivers and medical secretaries. Participants from five academic centers and six teaching hospitals were included. Three researchers conducted the interviews, coded the data, and used thematic analysis. Results: Interviews were conducted with 13 healthcare professionals, 8 patients, 7 family caregivers, and 4 medical secretaries. From these early adopters, we infer five criteria positively contributing to perceived quality of care provided by video consulting: (1) the patient has an intact cognitive function; (2) a family caregiver with digital literacy can be present; (3) doctor and patient already have an established relationship; (4) no immediate need for physical examination or intervention; and (5) the prior availability of a comprehensive and concise medical history. Overall, the uptake of video consulting in geriatric outpatient care appeared to be slow and laborious due to several implementation barriers. Conclusion: The implementation of video consulting use among geriatricians and geriatric patients at the geriatric outpatient clinic was slow due to the absence of many facilitating factors, but video consulting might be offered as an alternative to face-to-face follow-up to suitable patients in geriatric outpatient clinics.
MeSH term(s)	Aged ; Ambulatory Care ; COVID-19/epidemiology ; Humans ; Pandemics ; Referral and Consultation ; Telemedicine
Language	English
Publishing date	2022-08-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2556794-9
ISSN	1878-7657 ; 1878-7649
ISSN (online)	1878-7657
ISSN	1878-7649
DOI	10.1007/s41999-022-00678-6
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Article ; Online: VISTA Targeting of T-cell Quiescence and Myeloid Suppression Overcomes Adaptive Resistance.

Schaafsma, Evelien / Croteau, Walburga / ElTanbouly, Mohamed / Nowak, Elizabeth C / Smits, Nicole C / Deng, Jie / Sarde, Aurelien / Webber, Cecilia A / Rabadi, Dina / Cheng, Chao / Noelle, Randolph / Lines, J Louise

Cancer immunology research

2022 Volume 11, Issue 1, Page(s) 38–55

Abstract: V domain immunoglobulin suppressor of T-cell activation (VISTA) is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 ... ...

Abstract	V domain immunoglobulin suppressor of T-cell activation (VISTA) is a premier target for cancer treatment due to its broad expression in many cancer types and enhanced expression upon development of adaptive immune checkpoint resistance. In the CT26 colorectal cancer model, monotherapy of small tumors with anti-VISTA resulted in slowed tumor growth. In a combination therapy setting, large CT26 tumors showed complete adaptive resistance to anti-PD-1/CTLA-4, but inclusion of anti-VISTA led to rejection of half the tumors. Mechanisms of enhanced antitumor immunity were investigated using single-cell RNA sequencing (scRNA-seq), multiplex image analysis, and flow cytometry of the tumor immune infiltrate. In both treatment models, anti-VISTA upregulated stimulated antigen presentation pathways and reduced myeloid-mediated suppression. Imaging revealed an anti-VISTA stimulated increase in contacts between T cells and myeloid cells, further supporting the notion of increased antigen presentation. scRNA-seq of tumor-specific CD8+ T cells revealed that anti-VISTA therapy induced T-cell pathways highly distinct from and complementary to those induced by anti-PD-1 therapy. Whereas anti-CTLA-4/PD-1 expanded progenitor exhausted CD8+ T-cell subsets, anti-VISTA promoted costimulatory genes and reduced regulators of T-cell quiescence. Notably, this is the first report of a checkpoint regulator impacting CD8+ T-cell quiescence, and the first indication that quiescence may be a target in the context of T-cell exhaustion and in cancer. This study builds a foundation for all future studies on the role of anti-VISTA in the development of antitumor immunity and provides important mechanistic insights that strongly support use of anti-VISTA to overcome the adaptive resistance seen in contemporary treatments involving PD-1 and/or CTLA-4. See related Spotlight by Wei, p. 3.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors ; B7 Antigens/immunology ; Neoplasms/immunology ; CD8-Positive T-Lymphocytes/immunology ; Lymphocyte Activation/immunology ; Immunoglobulins
Chemical Substances	Immune Checkpoint Inhibitors ; B7 Antigens ; Immunoglobulins
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	2732489-8
ISSN	2326-6074 ; 2326-6066
ISSN (online)	2326-6074
ISSN	2326-6066
DOI	10.1158/2326-6066.CIR-22-0116
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Zs.A 7022: Show issues

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Article ; Online: Diagnostic variability in the histopathological assessment of advanced colorectal adenomas and early colorectal cancer in a screening population.

Smits, Lisanne J H / Vink-Börger, Elisa / van Lijnschoten, Gesina / Focke-Snieders, Isabelle / van der Post, Rachel S / Tuynman, Jurriaan B / van Grieken, Nicole C T / Nagtegaal, Iris D

Histopathology

2022 Volume 80, Issue 5, Page(s) 790–798

Abstract: Aim: The aim of this study was to evaluate interobserver variability between individual pathologists and a panel of pathologists in the histopathological assessment of advanced colorectal neoplasms in the Dutch bowel cancer screening population.: ... ...

Abstract	Aim: The aim of this study was to evaluate interobserver variability between individual pathologists and a panel of pathologists in the histopathological assessment of advanced colorectal neoplasms in the Dutch bowel cancer screening population. Methods and results: Histological slides of adenomas with high-grade dysplasia and early colorectal carcinomas (CRC) from 20 different laboratories were reviewed by the pathology panel of the Dutch bowel screening programme. Interobserver variability was reported by descriptive statistics. In addition, potential clinical consequences of discrepancies were evaluated. A total of 104 cases of adenomas with high-grade dysplasia and 83 early CRCs were reviewed. Discrepancies were observed in 41 of 104 (39.4%) adenoma cases, which potentially had clinical consequences in 16 (15.4%) cases. For CRC, discrepancies were shown in 44 of 83 cases (53.0%) and would have potentially led to alternative treatment strategies in 25 (30.1%) cases. Most frequently, discrepancies were observed in the assessment of lymphovascular invasion (23 of 73 cases, 31.5%). Conclusion: This study showed that considerable interobserver variability is present in the histopathological assessment of advanced colorectal neoplasia, which may impact upon treatment choices. Additional stains and education, as well as intercollegial consultation, might decrease this variability.
MeSH term(s)	Adenoma/diagnosis ; Adenoma/pathology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/pathology ; Diagnosis, Differential ; Early Detection of Cancer ; Expert Testimony ; Humans ; Netherlands ; Observer Variation ; Pathologists ; Referral and Consultation
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14601
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Zs.A 1328: Show issues

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Article ; Online: Designing multivalent proteins based on natural killer cell receptors and their ligands as immunotherapy for cancer.

Smits, Nicole C / Coupet, Tiffany A / Godbersen, Claire / Sentman, Charles L

Expert opinion on biological therapy

2016 Volume 16, Issue 9, Page(s) 1105–1112

Abstract: Introduction: Natural killer (NK) cells are an important component of the innate immune system that play a key role in host immunity against cancer. NK cell recognition and activation is based on cell surface receptors recognizing specific ligands that ... ...

Abstract	Introduction: Natural killer (NK) cells are an important component of the innate immune system that play a key role in host immunity against cancer. NK cell recognition and activation is based on cell surface receptors recognizing specific ligands that are expressed on many types of tumor cells. Some of these receptors are capable of activating NK cell function while other receptors inhibit NK cell function. Therapeutic approaches to treat cancer have been developed based on preventing NK cell inhibition or using NK cell receptors and their ligands to activate NK cells or T cells to destroy tumor cells. Areas covered: This article describes the various strategies for targeting NK cell receptors and NK cell receptor ligands using multivalent proteins to activate immunity against cancer. Expert opinion: NK cell receptors work in synergy to activate NK cell effector responses. Effective anti-cancer strategies will need to not only kill tumor cells but must also lead to the destruction of the tumor microenvironment. Immunotherapy based on NK cells and their receptors has the capacity to accomplish this through triggering lymphocyte cytotoxicity and cytokine production.
MeSH term(s)	Animals ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials as Topic/methods ; Cytotoxicity, Immunologic/drug effects ; Cytotoxicity, Immunologic/immunology ; Drug Design ; Humans ; Immunotherapy/methods ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Ligands ; Neoplasms/immunology ; Neoplasms/therapy ; Receptors, Immunologic/antagonists & inhibitors ; Receptors, Immunologic/immunology ; Receptors, Natural Killer Cell/antagonists & inhibitors ; Receptors, Natural Killer Cell/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism
Chemical Substances	Antibodies, Monoclonal ; Ligands ; Receptors, Immunologic ; Receptors, Natural Killer Cell
Language	English
Publishing date	2016-06-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2016.1195364
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Article ; Online: Covered versus bare-metal stenting of the mesenteric arteries in patients with chronic mesenteric ischaemia (CoBaGI): a multicentre, patient-blinded and investigator-blinded, randomised controlled trial.

The lancet. Gastroenterology & hepatology

2024 Volume 9, Issue 4, Page(s) 299–309

Abstract: Background: Mesenteric artery stenting with a bare-metal stent is the current treatment for atherosclerotic chronic mesenteric ischaemia. Long-term patency of bare-metal stents is unsatisfactory due to in-stent intimal hyperplasia. Use of covered stents ...

Abstract	Background: Mesenteric artery stenting with a bare-metal stent is the current treatment for atherosclerotic chronic mesenteric ischaemia. Long-term patency of bare-metal stents is unsatisfactory due to in-stent intimal hyperplasia. Use of covered stents might improve long-term patency. We aimed to compare the patency of covered stents and bare-metal stents in patients with chronic mesenteric ischaemia. Methods: We conducted a multicentre, patient-blinded and investigator-blinded, randomised controlled trial including patients with chronic mesenteric ischaemia undergoing mesenteric artery stenting. Six centres in the Netherlands participated in this study, including two national chronic mesenteric ischaemia expert centres. Patients aged 18 years or older were eligible for inclusion when an endovascular mesenteric artery revascularisation was scheduled and a consensus diagnosis of chronic mesenteric ischaemia was made by a multidisciplinary team of gastroenterologists, interventional radiologists, and vascular surgeons. Exclusion criteria were stenosis length of 25 mm or greater, stenosis caused by median arcuate ligament syndrome or vasculitis, contraindication for CT angiography, or previous target vessel revascularisation. Digital 1:1 block randomisation with block sizes of four or six and stratification by inclusion centre was used to allocate patients to undergo stenting with bare-metal stents or covered stents at the start of the procedure. Patients, physicians performing follow-up, investigators, and radiologists were masked to treatment allocation. Interventionalists performing the procedure were not masked. The primary study outcome was the primary patency of covered stents and bare-metal stents at 24 months of follow-up, evaluated in the modified intention-to-treat population, in which stents with missing data for the outcome were excluded. Loss of primary patency was defined as the performance of a re-intervention to preserve patency, or 75% or greater luminal surface area reduction of the target vessel. CT angiography was performed at 6 months, 12 months, and 24 months post intervention to assess patency. The study is registered with ClinicalTrials.gov (NCT02428582) and is complete. Findings: Between April 6, 2015, and March 11, 2019, 158 eligible patients underwent mesenteric artery stenting procedures, of whom 94 patients (with 128 stents) provided consent and were included in the study. 47 patients (62 stents) were assigned to the covered stents group (median age 69·0 years [IQR 63·0-76·5], 28 [60%] female) and 47 patients (66 stents) were assigned to the bare-metal stents group (median age 70·0 years [63·5-76·5], 33 [70%] female). At 24 months, the primary patency of covered stents (42 [81%] of 52 stents) was superior to that of bare-metal stents (26 [49%] of 53; odds ratio [OR] 4·4 [95% CI 1·8-10·5]; p<0·0001). A procedure-related adverse event occurred in 17 (36%) of 47 patients in the covered stents group versus nine (19%) of 47 in the bare-metal stent group (OR 2·4 [95% CI 0·9-6·3]; p=0·065). Most adverse events were related to the access site, including haematoma (five [11%] in the covered stents group vs six [13%] in the bare-metal stents group), pseudoaneurysm (five [11%] vs two [4%]), radial artery thrombosis (one [2%] vs none), and intravascular closure device (none vs one [2%]). Six (13%) patients in the covered stent group versus one (2%) in the bare-metal stent group had procedure-related adverse events not related to the access site, including stent luxation (three [6%] vs none), major bleeding (two (4%) vs none), mesenteric artery perforation (one [2%] vs one [2%]), mesenteric artery dissection (one [2%] vs one [2%]), and death (one [2%] vs none). Interpretation: The findings of this trial support the use of covered stents for mesenteric artery stenting in patients with chronic mesenteric ischaemia. Funding: Atrium Maquet Getinge Group.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Mesenteric Ischemia/surgery ; Constriction, Pathologic/etiology ; Stents/adverse effects ; Atherosclerosis ; Mesenteric Arteries
Language	English
Publishing date	2024-01-29
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(23)00402-8
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Article ; Online: VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways.

ElTanbouly, Mohamed A / Schaafsma, Evelien / Smits, Nicole C / Shah, Parth / Cheng, Chao / Burns, Christopher / Blazar, Bruce R / Noelle, Randolph J / Mabaera, Rodwell

Frontiers in immunology

2020 Volume 11, Page(s) 580187

Abstract: We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the ability ...

Abstract	We present the novel finding that V-domain Ig suppressor of T cell activation (VISTA) negatively regulates innate inflammation through the transcriptional and epigenetic re-programming of macrophages. Representative of VISTA re-programming is the ability of VISTA agonistic antibodies to augment LPS tolerance and reduce septic shock lethality in mice. This anti-inflammatory effect of anti-VISTA was mimicked
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; B7 Antigens/genetics ; B7 Antigens/metabolism ; Cell Differentiation ; Cellular Reprogramming ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Tolerance ; Immunity, Innate ; Immunomodulation ; Inflammation/genetics ; Inflammation/metabolism ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Shock, Septic/drug therapy ; Shock, Septic/genetics ; Shock, Septic/metabolism ; Signal Transduction ; Transcriptome
Chemical Substances	Anti-Inflammatory Agents ; B7 Antigens ; Immune Checkpoint Inhibitors ; VSIR protein, human
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.580187
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