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  1. Article: When Nothing Turns Itself Inside out and Becomes Something: Coating Poly(Lactic-

    Uskoković, Vuk / Wu, Victoria M

    Journal of functional biomaterials

    2022  Volume 13, Issue 3

    Abstract: To stabilize drugs physisorbed on the surface of hydroxyapatite (HAp) nanoparticles and prevent burst release, these nanoparticles are commonly coated with polymers. Bioactive HAp, however, becomes shielded from the surface of such core/shell entities, ... ...

    Abstract To stabilize drugs physisorbed on the surface of hydroxyapatite (HAp) nanoparticles and prevent burst release, these nanoparticles are commonly coated with polymers. Bioactive HAp, however, becomes shielded from the surface of such core/shell entities, which partially defeats the purpose of using it. The goal of this study was to assess the biological and pharmacokinetic effects of inverting this classical core/shell structure by coating poly(lactic-
    Language English
    Publishing date 2022-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb13030102
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  2. Article: Altering Microbiomes with Hydroxyapatite Nanoparticles: A Metagenomic Analysis.

    Uskoković, Vuk / Wu, Victoria M

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 17

    Abstract: Hydroxyapatite (HAp), the most abundant biological material among mammals, has been recently demonstrated to possess moderate antibacterial properties. Metagenomics provides a series of tools for analyzing the simultaneous interaction of materials with ... ...

    Abstract Hydroxyapatite (HAp), the most abundant biological material among mammals, has been recently demonstrated to possess moderate antibacterial properties. Metagenomics provides a series of tools for analyzing the simultaneous interaction of materials with larger communities of microbes, which may aid in optimizing the antibacterial activity of a material such as HAp. Here, a microbiome intrinsic to the sample of sandy soil collected from the base of an African Natal plum (
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15175824
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  3. Article ; Online: Toward chronopharmaceutical drug delivery patches and biomaterial coatings for the facilitation of wound healing.

    Uskoković, Vuk / Velie, Pooja Neogi / Wu, Victoria M

    Journal of colloid and interface science

    2023  Volume 659, Page(s) 355–363

    Abstract: Implantation of a biomaterial entails a form of injury where the integration of the implant into the host tissue greatly depends on the proper healing of the wound. Wound healing, itself, consists of a number of physiological processes, each occurring ... ...

    Abstract Implantation of a biomaterial entails a form of injury where the integration of the implant into the host tissue greatly depends on the proper healing of the wound. Wound healing, itself, consists of a number of physiological processes, each occurring within a characteristic time window. A composite, multilayered polymeric drug delivery carrier for adhesion to the wound site and its supply with molecules released at precise time windows at which the stages in the healing process that they target occur is conceptualized here. We also present a simplified version of one such multilayered composite fabricated by a combination of solvent casting and dip coating, comprising the base poly(ε-caprolactone) layer reinforced with hydroxyapatite nanoparticles, poly(glutamic acid) mesolayer and poly-l-lysine surface layer, each loaded with specific small molecules and released at moderately distinct timescales, partially matching the chronology of wound healing. To that end, the base layer proved suitable for the delivery of an anti-inflammatory molecule or an angiogenic agent, the mesolayer appeared appropriate for the delivery of an epithelialization promoter or a granulation factor, and the adhesive surface layer interfacing directly with the site of injury showed promise as a carrier of a vasodilator. The drug release mechanisms were diffusion-driven, suggesting that the drug/carrier interaction is a key determinant of the release kinetics, as important as the nature of the polymer and its hydrolytic degradation rate in the aqueous medium. Morphological and phase composition analyses were performed, along with the cell compatibility ones, demonstrating solid adhesion and proliferation of both transformed and primary fibroblasts on both surfaces of the composite films. The design of the multilayered composite drug delivery carriers presented here is prospective, but requires further upgrades to achieve the ideal of a perfect timing of the sequential drug release kinetics and a perfect resonance with the physiological processes defining the chronology of wound healing.
    MeSH term(s) Biocompatible Materials ; Prospective Studies ; Polyesters ; Drug Delivery Systems ; Wound Healing ; Drug Carriers ; Polymers
    Chemical Substances Biocompatible Materials ; Polyesters ; Drug Carriers ; Polymers
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.12.156
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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  4. Article ; Online: EGFR

    Lin, Huamao M / Yin, Yu / Crossland, Victoria / Wu, Yanyu / Ou, Sai-Hong Ignatius

    JTO clinical and research reports

    2022  Volume 3, Issue 3, Page(s) 100285

    Abstract: Introduction: EGFR: Methods: Data from 2011 to 2020 were extracted from the Flatiron Health electronic health record-derived deidentified database.: Results: Among 67,281 patients with advanced NSCLC and at least two clinic visits, 66.8% were ... ...

    Abstract Introduction: EGFR
    Methods: Data from 2011 to 2020 were extracted from the Flatiron Health electronic health record-derived deidentified database.
    Results: Among 67,281 patients with advanced NSCLC and at least two clinic visits, 66.8% were tested for
    Conclusions: EGFR
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2022.100285
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  5. Article ; Online: Correction to: Faintly tired: a systematic review of fatigue in patients with orthostatic syncope.

    Wu, Ryan E Y / Khan, Farhaan M / Hockin, Brooke C D / Lobban, Trudie C A / Sanatani, Shubhayan / Claydon, Victoria E

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 6, Page(s) 533

    Language English
    Publishing date 2022-09-20
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00886-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Magnetic Resonance Imaging in the Evaluation of Female Infertility.

    Wu, Victoria / Mar, Winnie / Milad, Magdy P / Horowitz, Jeanne M

    Current problems in diagnostic radiology

    2021  Volume 51, Issue 2, Page(s) 181–188

    Abstract: Pelvic MRI plays an important adjunctive role in the clinical workup of female infertility. Hysterosalpingography is the first line imaging modality in evaluation of female infertility, and hysterosalpingo-contrast sonography can also be used to evaluate ...

    Abstract Pelvic MRI plays an important adjunctive role in the clinical workup of female infertility. Hysterosalpingography is the first line imaging modality in evaluation of female infertility, and hysterosalpingo-contrast sonography can also be used to evaluate both the uterine cavity and fallopian tubes. Pelvic MRI can be helpful in the workup of female infertility, particularly in cases of Mullerian duct anomalies, fibroids, adenomyosis, endometriosis, and tubal disease. These conditions and their appearance on imaging will be reviewed in this article.
    Language English
    Publishing date 2021-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 198954-6
    ISSN 1535-6302 ; 0363-0188
    ISSN (online) 1535-6302
    ISSN 0363-0188
    DOI 10.1067/j.cpradiol.2020.11.011
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    In stock of ZB MED Cologne/Königswinter

    Se 233: Show issues Location:
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  7. Article ; Online: Factors associated with discussing HIV pre-exposure prophylaxis (PrEP) among Jamaican medical providers.

    Walcott, Melonie M / Tieu, Hong-Van / Tipre, Meghan / Nandi, Vijay / Davis, Alissa / Wu, Elwin / Wheatle, Marceleen / Frye, Victoria / Figueroa, J Peter

    International journal of STD & AIDS

    2023  Volume 35, Issue 3, Page(s) 188–196

    Abstract: Background: The Ministry of Health and Wellness of Jamaica has endorsed the use of pre-exposure prophylaxis (PrEP) as an HIV prevention strategy; however, PrEP was not included in the national HIV prevention program in 2021.: Methods: A cross- ... ...

    Abstract Background: The Ministry of Health and Wellness of Jamaica has endorsed the use of pre-exposure prophylaxis (PrEP) as an HIV prevention strategy; however, PrEP was not included in the national HIV prevention program in 2021.
    Methods: A cross-sectional online study involving physicians in Jamaica was conducted in 2021 to describe PrEP awareness, beliefs, attitudes, and practices. The study also assessed individual and social factors associated with discussing PrEP with patients and willingness to prescribe PrEP.
    Findings: The mean age and standard deviation (SD) of the 69 physicians who completed the survey were 45.5 ± 13.6 years. Most of the participants (80%) reported that they were somewhat familiar with PrEP. PrEP attitude and perceived comfort in prescribing PrEP were moderate among participating physicians, with a mean and SD of 3.9 ± 0.8 and 3.6 ± 0.9 respectively. Six percent of physicians reported that they had prescribed PrEP and 17% had discussed PrEP with their patients in the past year. However, most (90%) reported that they were willing to prescribe PrEP after being informed about it. In the unadjusted model, identifying as Christian (compared to non-Christian) and reporting stronger homophobic beliefs were associated with reduced odds of discussing PrEP with patients. In the multivariable model, only homophobia remained statistically significant (OR, 0.24; 95% CI: 0.07-0.63).
    Conclusion: The findings suggest that physicians in Jamacia may be willing to prescribe PrEP; however, homophobia is a barrier to discussions, underscoring the need for the Ministry of Health and Wellness to recognize the role that homophobia plays in the national HIV program to further reduce HIV incidence in Jamaica.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Jamaica ; Pre-Exposure Prophylaxis ; Physicians ; HIV Infections/prevention & control
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231201187
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2829: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Comprehensive analysis of HIV reservoirs in elite controllers.

    Kennedy, Brooke D / Blazkova, Jana / Justement, Jesse S / Shi, Victoria / Rai, M Ali / Manning, Maegan R / Praiss, Lauren / Gittens, Kathleen / Wender, Paul A / Patro, Sean / Wu, Xiaolin / Moir, Susan / Chun, Tae-Wook

    The Journal of clinical investigation

    2023  Volume 133, Issue 3

    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; HIV Infections ; Elite Controllers ; Viral Load ; HIV Long-Term Survivors
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI165446
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
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  9. Article ; Online: Surgical management of 1- to 2-cm neuroendocrine tumors of the appendix: Appendectomy or right hemicolectomy?

    Ahmed, Fasih Ali / Wu, Victoria S / Kakish, Hanna / Elshami, Mohamedraed / Ocuin, Lee M / Rothermel, Luke D / Mohamed, Amr / Hoehn, Richard S

    Surgery

    2023  Volume 175, Issue 2, Page(s) 251–257

    Abstract: Background: The surgical management of 1- to 2-cm neuroendocrine tumors of the appendix is an area of debate. We analyzed the clinical outcomes of appendectomy and compared them to right hemicolectomy.: Methods: We queried the National Cancer ... ...

    Abstract Background: The surgical management of 1- to 2-cm neuroendocrine tumors of the appendix is an area of debate. We analyzed the clinical outcomes of appendectomy and compared them to right hemicolectomy.
    Methods: We queried the National Cancer Database to identify patients treated for 1- to 2-cm ANETs from 2004 to 2018. Patients were stratified by surgical approach (appendectomy vs. hemicolectomy). Multivariable models were used to identify factors associated with the choice of surgical approach and the association between surgical approach and overall survival.
    Results: Of the 3,189 patients we included, 1,573 (49.3%) underwent right hemicolectomy and 1,616 (50.7%) appendectomy. The appendectomy rate increased from 37.7% in 2004 to 58.9% in 2018. On multivariable analysis, patients with grade 2 and 3 tumors were less likely to undergo appendectomy alone (odds ratio = 0.41, 95% confidence interval = 0.26-0.66). Longer travel distance was associated with a higher likelihood of undergoing appendectomy (odds ratio = 2.52, 95% confidence interval = 1.15-5.51). After adjusting for tumor grade, appendectomy alone had similar survival to hemicolectomy (hazard ratio = 1.03, 95% confidence interval = 0.67-1.59).
    Conclusion: In this updated analysis of the National Cancer Database, right hemicolectomy was not associated with improved overall survival compared to appendectomy alone for 1- to 2-cm neuroendocrine tumors of the appendix. Although patients with grade 2 or 3 tumors are more likely to undergo right hemicolectomy, this procedure may not improve their treatment or overall outcome.
    MeSH term(s) Humans ; Neuroendocrine Tumors ; Appendectomy/methods ; Appendiceal Neoplasms/surgery ; Appendiceal Neoplasms/pathology ; Proportional Hazards Models ; Colectomy/methods ; Retrospective Studies
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2023.09.048
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    Uk I Zs.129: Show issues Location:
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  10. Article ; Online: Developmental thyroid hormone action on pro-opiomelanocortin-expressing cells programs hypothalamic BMPR1A depletion and brown fat activation.

    Wu, Zhaofei / Martinez, M Elena / DeMambro, Victoria / Francois, Marie / Hernandez, Arturo

    Journal of molecular cell biology

    2022  Volume 14, Issue 9

    Abstract: Thyroid hormone excess secondary to global type 3 deiodinase (DIO3) deficiency leads to increased locomotor activity and reduced adiposity, but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict obesity. To ... ...

    Abstract Thyroid hormone excess secondary to global type 3 deiodinase (DIO3) deficiency leads to increased locomotor activity and reduced adiposity, but also to concurrent alterations in parameters of the leptin-melanocortin system that would predict obesity. To distinguish the underlying contributions to the energy balance phenotype of DIO3 deficiency, we generated mice with thyroid hormone excess targeted to pro-opiomelanocortin (POMC)-expressing cells via cell-specific DIO3 inactivation. These mice exhibit a male-specific phenotype of reduced hypothalamic Pomc expression, hyperphagia, and increased activity in brown adipose tissue, with adiposity and serum levels of leptin and thyroid hormones remained normal. These male mice also manifest a marked and widespread hypothalamic reduction in the expression of bone morphogenetic receptor 1a (BMPR1A), which has been shown to cause similar phenotypes when inactivated in POMC-expressing cells. Our results indicate that developmental overexposure to thyroid hormone in POMC-expressing cells programs energy balance mechanisms in a sexually dimorphic manner by suppressing adult hypothalamic BMPR1A expression.
    MeSH term(s) Animals ; Male ; Mice ; Adipose Tissue, Brown/metabolism ; Bone Morphogenetic Protein Receptors, Type I/genetics ; Bone Morphogenetic Protein Receptors, Type I/metabolism ; Leptin/metabolism ; Obesity/metabolism ; Pro-Opiomelanocortin/metabolism ; Thyroid Hormones/metabolism
    Chemical Substances Bmpr1a protein, mouse (EC 2.7.11.30) ; Bone Morphogenetic Protein Receptors, Type I (EC 2.7.11.30) ; iodothyronine deiodinase type III (EC 1.11.1.-) ; Leptin ; Pro-Opiomelanocortin (66796-54-1) ; Thyroid Hormones
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2500949-7
    ISSN 1759-4685 ; 1759-4685
    ISSN (online) 1759-4685
    ISSN 1759-4685
    DOI 10.1093/jmcb/mjac078
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