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Article ; Online: Antiresorptive Therapies for the Treatment of Malignant Osteolytic Bone Disease.

Mehrotra, Bhoomi

Oral and maxillofacial surgery clinics of North America

2015 Volume 27, Issue 4, Page(s) 561–566

Abstract: Osteolytic bone disease contributes to morbidity and mortality. Antiresorptive therapies reduce the morbidity of metastatic bone disease and alter the natural progression of malignant bone pathophysiology. Several trials showed improvement in quality of ... ...

Abstract	Osteolytic bone disease contributes to morbidity and mortality. Antiresorptive therapies reduce the morbidity of metastatic bone disease and alter the natural progression of malignant bone pathophysiology. Several trials showed improvement in quality of life, delay of skeletal-related events, and improvement in bone pain with these agents. Evolving data suggest a role of improvement in morbidity related to other cancer therapies that have potential side effects. Early indication shows they may alter survival in a subset of patients. This article reviews data confirming the efficacy of antiresorptive agents and discusses preliminary data on preventative therapy.
MeSH term(s)	Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/physiopathology ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Disease Progression ; Humans ; Osteolysis/drug therapy ; Osteolysis/physiopathology ; Quality of Life
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1316546-x
ISSN	1558-1365 ; 1042-3699
ISSN (online)	1558-1365
ISSN	1042-3699
DOI	10.1016/j.coms.2015.07.002
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Article ; Online: Bisphosphonates--role in cancer therapies.

Mehrotra, Bhoomi

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2009 Volume 67, Issue 5 Suppl, Page(s) 19–26

MeSH term(s)	Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Diphosphonates/administration & dosage ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Estrogens/deficiency ; Female ; Humans ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Injections, Intravenous ; Jaw Diseases/chemically induced ; Lung Neoplasms/pathology ; Male ; Multiple Myeloma/drug therapy ; Neoplasms/complications ; Osteonecrosis/chemically induced ; Prostatic Neoplasms/pathology ; Renal Insufficiency/virology
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; Estrogens
Language	English
Publishing date	2009-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2009.01.012
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Article: Safety profile of intravenous bisphosphonates.

Mehrotra, Bhoomi

Seminars in oncology

2007 Volume 34, Issue 6 Suppl 4, Page(s) S24–7

Abstract: Because of their proven efficacy, intravenous bisphosphonates play an important role in reducing the risk of skeletal-related events including pathologic fractures, spinal cord compression, and palliative radiotherapy to bone in patients with malignant ... ...

Abstract	Because of their proven efficacy, intravenous bisphosphonates play an important role in reducing the risk of skeletal-related events including pathologic fractures, spinal cord compression, and palliative radiotherapy to bone in patients with malignant bone lesions. Overall, intravenous bisphosphonates have an acceptable safety profile and are commonly associated with transient and manageable flu-like symptoms after initial infusions. In addition, bisphosphonates have dose- and infusion rate-dependent effects on renal function that can be proactively managed in patients with reduced creatinine clearance rates by following recommended dosing guidelines. Recently, there have been reports of osteonecrosis of the jaw (ONJ) in patients with advanced cancer receiving complex chemotherapeutic treatment regimens and supportive care with bisphosphonates. ONJ prevention and management recommendations have been developed that may reduce the risk of ONJ and the impact of ONJ on quality of life. Moreover, bisphosphonate therapy has resulted in considerable clinical benefits in patients with malignant bone disease; therefore, the potential for adverse events such as ONJ must be placed into context with these meaningful benefits.
MeSH term(s)	Bone Density Conservation Agents/adverse effects ; Clinical Trials as Topic ; Diphosphonates/administration & dosage ; Diphosphonates/adverse effects ; Dose-Response Relationship, Drug ; Humans ; Injections, Intravenous ; Jaw Diseases/chemically induced ; Jaw Diseases/therapy ; Kidney Diseases/chemically induced ; Osteonecrosis/chemically induced ; Osteonecrosis/therapy
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2007-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	189220-4
ISSN	1532-8708 ; 0093-7754
ISSN (online)	1532-8708
ISSN	0093-7754
DOI	10.1053/j.seminoncol.2007.10.007
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Article ; Online: Electrocardiographic manifestations of COVID-19: Effect on cardiac activation and repolarization.

Thakore, Avni / Nguyen, James / Pollack, Simcha / Muehlbauer, Stefan / Chi, Benjamin / Knight, Derek / Mehrotra, Bhoomi / Stern, Joshua / Cao, J Jane / Lucore, Charles / Levine, Joseph

EClinicalMedicine

2021 Volume 39, Page(s) 101057

Abstract: Background: Prolonged QT intervals are reported in patients with COVID-19. Additionally, virus particles in heart tissue and abnormal troponin levels have been reported. Consequently, we hypothesize that cardiac electrophysiologic abnormalities may be ... ...

Abstract	Background: Prolonged QT intervals are reported in patients with COVID-19. Additionally, virus particles in heart tissue and abnormal troponin levels have been reported. Consequently, we hypothesize that cardiac electrophysiologic abnormalities may be associated with COVID-19. Methods: This is a retrospective study between March 15 Findings: Baseline QTc of inpatients was prolonged compared to patients discharged (450.1±30.2 versus 423.4±21.7 msec, Interpretation: QRS and QTc intervals are early markers for COVID-19 disease progression and mortality. ECG, a readily accessible tool, identifies cardiac involvement and may be used to predict disease course. Funding: St. Francis Foundation.
Language	English
Publishing date	2021-08-06
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.101057
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Article ; Online: Electrocardiographic manifestations of COVID-19

Avni Thakore / James Nguyen / Simcha Pollack / Stefan Muehlbauer / Benjamin Chi / Derek Knight / Bhoomi Mehrotra / Joshua Stern / J. Jane Cao / Charles Lucore / Joseph Levine

EClinicalMedicine, Vol 39, Iss , Pp 101057- (2021)

Effect on cardiac activation and repolarization

2021

Abstract	Background: Prolonged QT intervals are reported in patients with COVID-19. Additionally, virus particles in heart tissue and abnormal troponin levels have been reported. Consequently, we hypothesize that cardiac electrophysiologic abnormalities may be associated with COVID-19. Methods: This is a retrospective study between March 15th, 2020 and May 30th, 2020 of 828 patients with COVID-19 and baseline ECG. Corrected QT (QTc) and QRS intervals were measured from ECGs performed prior to intervention or administration of QT prolonging drugs. QTc and QRS intervals were evaluated as a function of disease severity (patients admitted versus discharged; inpatients admitted to medical unit vs ICU) and cardiac involvement (troponin elevation >0.03 ng/ml, elevated B-natriuretic peptide (BNP) or NT pro-BNP >500 pg/ml). Multivariable analysis was used to test for significance. Odds ratios for predictors of disease severity and mortality were generated. Findings: Baseline QTc of inpatients was prolonged compared to patients discharged (450.1±30.2 versus 423.4±21.7 msec, p<0.0001) and relative to a control group of patients with influenza (p=0.006). Inpatients with abnormal cardiac biomarkers had prolonged QTc and QRS compared to those with normal levels (troponin - QTc: 460.9±34.6 versus 445.3±26.6 msec, p<0.0001, QRS: 98.7±24.6 vs 90.5±16.9 msec, p<0.0001; BNP - QTc: 465.9±33.0 versus 446.0±26.2 msec, p<0.0001, QRS: 103.6±25.3 versus 90.6±17.6 msec, p<0.0001). Findings were confirmed with multivariable analysis (all p<0.05). QTc prolongation independently predicted mortality (8.3% increase in mortality for every 10 msec increase in QTc; OR 1.083, CI [1.002, 1.171], p=0.04). Interpretation: QRS and QTc intervals are early markers for COVID-19 disease progression and mortality. ECG, a readily accessible tool, identifies cardiac involvement and may be used to predict disease course. Funding: St. Francis Foundation.
Keywords	COVID-19 ; SAR-COV-2 ; Cardiac involvement ; QT interval ; QTc interval ; repolarization ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Bisphosphonate-related osteonecrosis of the jaw: diagnosis, prevention, and management.

Ruggiero, Salvatore L / Mehrotra, Bhoomi

Annual review of medicine

2009 Volume 60, Page(s) 85–96

Abstract: Bisphosphonate therapy has been considered standard therapy in the management and care of cancer patients with metastatic bone disease and patients with osteoporosis. The efficacy of these drugs is due to their ability to inhibit osteoclast-mediated bone ...

Abstract	Bisphosphonate therapy has been considered standard therapy in the management and care of cancer patients with metastatic bone disease and patients with osteoporosis. The efficacy of these drugs is due to their ability to inhibit osteoclast-mediated bone resorption. However, the postmarketing experience with intravenous and, to a much lesser extent, oral bisphosphonates has raised concerns about potential side effects related to profound bone remodeling inhibition and osteonecrosis isolated to the jaws. We review the risk factors, incidence, pathogenesis, prevention strategies, and management of this new complication.
MeSH term(s)	Diphosphonates/adverse effects ; Humans ; Jaw Diseases/chemically induced ; Jaw Diseases/diagnosis ; Jaw Diseases/prevention & control ; Jaw Diseases/therapy ; Osteonecrosis/chemically induced ; Osteonecrosis/diagnosis ; Osteonecrosis/prevention & control ; Osteonecrosis/therapy ; Risk Factors
Chemical Substances	Diphosphonates
Language	English
Publishing date	2009
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207930-6
ISSN	1545-326X ; 0066-4219
ISSN (online)	1545-326X
ISSN	0066-4219
DOI	10.1146/annurev.med.60.063007.134350
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Article ; Online: Tracheostomy during SARS-CoV-2 pandemic: Recommendations from the New York Head and Neck Society.

Miles, Brett A / Schiff, Bradley / Ganly, Ian / Ow, Thomas / Cohen, Erik / Genden, Eric / Culliney, Bruce / Mehrotra, Bhoomi / Savona, Steven / Wong, Richard J / Haigentz, Missak / Caruana, Salvatore / Givi, Babak / Patel, Kepal / Hu, Kenneth

Head & neck

2020 Volume 42, Issue 6, Page(s) 1282–1290

Abstract: The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients ... ...

Abstract	The rapid spread of SARS-CoV-2 in 2019 and 2020 has resulted in a worldwide pandemic characterized by severe pulmonary inflammation, effusions, and rapid respiratory compromise. The result of this pandemic is a large and increasing number of patients requiring endotracheal intubation and prolonged ventilator support. The rapid rise in endotracheal intubations coupled with prolonged ventilation requirements will certainly lead to an increase in tracheostomy procedures in the coming weeks and months. Performing tracheostomy in the setting of active SARS-CoV-2, when necessary, poses a unique situation, with unique risks and benefits for both the patient and the health care providers. The New York Head and Neck Society has collaborated on this document to provide guidance on the performance of tracheostomies during the SARS-CoV-2 pandemic.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Intubation, Intratracheal ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Practice Guidelines as Topic ; SARS-CoV-2 ; Tracheostomy
Keywords	covid19
Language	English
Publishing date	2020-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.26166
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Article ; Online: Biomarkers and cardiovascular outcomes in chimeric antigen receptor T-cell therapy recipients.

Mahmood, Syed S / Riedell, Peter A / Feldman, Stephanie / George, Gina / Sansoterra, Stephen A / Althaus, Thomas / Rehman, Mahin / Mead, Elena / Liu, Jennifer E / Devereux, Richard B / Weinsaft, Jonathan W / Kim, Jiwon / Balkan, Lauren / Barbar, Tarek / Lee Chuy, Katherine / Harchandani, Bhisham / Perales, Miguel-Angel / Geyer, Mark B / Park, Jae H /

Palomba, M Lia / Shouval, Roni / Tomas, Ana A / Shah, Gunjan L / Yang, Eric H / Gaut, Daria L / Rothberg, Michael V / Horn, Evelyn M / Leonard, John P / Van Besien, Koen / Frigault, Matthew J / Chen, Zhengming / Mehrotra, Bhoomi / Neilan, Tomas G / Steingart, Richard M

European heart journal

2023 Volume 44, Issue 22, Page(s) 2029–2042

Abstract: Aims: Chimeric antigen receptor T-cell therapy (CAR-T) harnesses a patient's immune system to target cancer. There are sparse existing data characterizing death outcomes after CAR-T-related cardiotoxicity. This study examines the association between CAR- ...

Abstract	Aims: Chimeric antigen receptor T-cell therapy (CAR-T) harnesses a patient's immune system to target cancer. There are sparse existing data characterizing death outcomes after CAR-T-related cardiotoxicity. This study examines the association between CAR-T-related severe cardiovascular events (SCE) and mortality. Methods and results: From a multi-centre registry of 202 patients receiving anti-CD19 CAR-T, covariates including standard baseline cardiovascular and cancer parameters and biomarkers were collected. Severe cardiovascular events were defined as a composite of heart failure, cardiogenic shock, or myocardial infarction. Thirty-three patients experienced SCE, and 108 patients died during a median follow-up of 297 (interquartile range 104-647) days. Those that did and did not die after CAR-T were similar in age, sex, and prior anthracycline use. Those who died had higher peak interleukin (IL)-6 and ferritin levels after CAR-T infusion, and those who experienced SCE had higher peak IL-6, C-reactive protein (CRP), ferritin, and troponin levels. The day-100 and 1-year Kaplan-Meier overall mortality estimates were 18% and 43%, respectively, while the non-relapse mortality (NRM) cumulative incidence rates were 3.5% and 6.7%, respectively. In a Cox model, SCE occurrence following CAR-T was independently associated with increased overall mortality risk [hazard ratio (HR) 2.8, 95% confidence interval (CI) 1.6-4.7] after adjusting for age, cancer type and burden, anthracycline use, cytokine release syndrome grade ≥ 2, pre-existing heart failure, hypertension, and African American ancestry; SCEs were independently associated with increased NRM (HR 3.5, 95% CI 1.4-8.8) after adjusting for cancer burden. Conclusion: Chimeric antigen receptor T-cell therapy recipients who experience SCE have higher overall mortality and NRM and higher peak levels of IL-6, CRP, ferritin, and troponin.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen/therapeutic use ; Interleukin-6 ; Biomarkers ; Neoplasms ; Heart Failure ; C-Reactive Protein ; Troponin ; Cell- and Tissue-Based Therapy
Chemical Substances	Receptors, Chimeric Antigen ; Interleukin-6 ; Biomarkers ; C-Reactive Protein (9007-41-4) ; Troponin
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad117
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Article ; Online: Tracheostomy during SARS‐CoV ‐2 pandemic

Miles, Brett A. / Schiff, Bradley / Ganly, Ian / Ow, Thomas / Cohen, Erik / Genden, Eric / Culliney, Bruce / Mehrotra, Bhoomi / Savona, Steven / Wong, Richard J. / Haigentz, Missak / Caruana, Salvatore / Givi, Babak / Patel, Kepal / Hu, Kenneth

Head & Neck

Recommendations from the New York Head and Neck Society

2020 Volume 42, Issue 6, Page(s) 1282–1290

Keywords	Otorhinolaryngology ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ISSN	1043-3074
DOI	10.1002/hed.26166
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Article ; Online: Utility of immunocytochemistry in diagnosing leptomeningeal metastases from an intrahepatic cholangiocarcinoma.

Chaudhary, Shweta / Klein, Melissa / Mehrotra, Bhoomi / Morgenstern, Nora J

Diagnostic cytopathology

2014 Volume 42, Issue 1, Page(s) 54–57

Abstract: Isolated spinal leptomeningeal metastases (LMM) without brain metastases are infrequent, accounting for about 1% of all solid tumors. In LMM, cerebrospinal fluid (CSF) analyses are mostly abnormal. Demonstrations of intrathecal tumor markers are highly ... ...

Abstract	Isolated spinal leptomeningeal metastases (LMM) without brain metastases are infrequent, accounting for about 1% of all solid tumors. In LMM, cerebrospinal fluid (CSF) analyses are mostly abnormal. Demonstrations of intrathecal tumor markers are highly suggestive, but only a positive cytology is diagnostic. The initial CSF cytology can give a false negative result in up to 40-50% of patients with pathologically proven LMM on autopsy. We report a case of intrahepatic cholangiocarcinoma with spinal LMM confirmed using cytokeratin7 and pancytokeratin (AE1/AE3) immunocytochemical studies on paucicellular cerebrospinal fluid cytospin preparation. Given the paucicellularity of the smears and difficult morphologic categorization, immunocytochemistry is vital for confirmatory diagnosis and can help reduce false negative results. To the best of our knowledge this is the first case report of cytologically confirmed LMM from an intrahepatic cholangiocarcinoma while the patient was undergoing treatment.
MeSH term(s)	Aged ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Biomarkers, Tumor/analysis ; Biopsy, Large-Core Needle ; Bone Neoplasms/secondary ; Cholangiocarcinoma/cerebrospinal fluid ; Cholangiocarcinoma/chemistry ; Cholangiocarcinoma/pathology ; Cholangiocarcinoma/secondary ; Female ; Humans ; Immunohistochemistry/methods ; Keratin-19/analysis ; Keratin-7/analysis ; Liver Neoplasms/cerebrospinal fluid ; Liver Neoplasms/chemistry ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Lung Neoplasms/secondary ; Magnetic Resonance Imaging ; Meningeal Neoplasms/cerebrospinal fluid ; Meningeal Neoplasms/chemistry ; Meningeal Neoplasms/pathology ; Meningeal Neoplasms/secondary ; Neoplasm Invasiveness ; Ribs
Chemical Substances	Biomarkers, Tumor ; Keratin-19 ; Keratin-7
Language	English
Publishing date	2014-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.22946
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