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Article: Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma.

Le Joncour, Vadim / Guichet, Pierre-Olivier / Dembélé, Kleouforo-Paul / Mutel, Alexandre / Campisi, Daniele / Perzo, Nicolas / Desrues, Laurence / Modzelewski, Romain / Couraud, Pierre-Olivier / Honnorat, Jérôme / Ferracci, François-Xavier / Marguet, Florent / Laquerrière, Annie / Vera, Pierre / Bohn, Pierre / Langlois, Olivier / Morin, Fabrice / Gandolfo, Pierrick / Castel, Hélène

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 652544

Abstract: ... chemoattractant G protein-coupled receptors (GPCRs) to their advantage. We investigated the role of the vasoactive ...

Abstract	Glioblastomas (GBMs) are the most common primary brain tumors characterized by strong invasiveness and angiogenesis. GBM cells and microenvironment secrete angiogenic factors and also express chemoattractant G protein-coupled receptors (GPCRs) to their advantage. We investigated the role of the vasoactive peptide urotensin II (UII) and its receptor UT on GBM angiogenesis and tested potential ligand/therapeutic options based on this system. On glioma patient samples, the expression of UII and UT increased with the grade with marked expression in the vascular and peri-necrotic mesenchymal hypoxic areas being correlated with vascular density.
Language	English
Publishing date	2021-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.652544
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Article ; Online: Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma

Vadim Le Joncour / Pierre-Olivier Guichet / Kleouforo-Paul Dembélé / Alexandre Mutel / Daniele Campisi / Nicolas Perzo / Laurence Desrues / Romain Modzelewski / Pierre-Olivier Couraud / Jérôme Honnorat / François-Xavier Ferracci / Florent Marguet / Annie Laquerrière / Pierre Vera / Pierre Bohn / Olivier Langlois / Fabrice Morin / Pierrick Gandolfo / Hélène Castel

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 9

Abstract: ... chemoattractant G protein-coupled receptors (GPCRs) to their advantage. We investigated the role of the vasoactive ...

Abstract	Glioblastomas (GBMs) are the most common primary brain tumors characterized by strong invasiveness and angiogenesis. GBM cells and microenvironment secrete angiogenic factors and also express chemoattractant G protein-coupled receptors (GPCRs) to their advantage. We investigated the role of the vasoactive peptide urotensin II (UII) and its receptor UT on GBM angiogenesis and tested potential ligand/therapeutic options based on this system. On glioma patient samples, the expression of UII and UT increased with the grade with marked expression in the vascular and peri-necrotic mesenchymal hypoxic areas being correlated with vascular density. In vitro human UII stimulated human endothelial HUV-EC-C and hCMEC/D3 cell motility and tubulogenesis. In mouse-transplanted Matrigel sponges, mouse (mUII) and human UII markedly stimulated invasion by macrophages, endothelial, and smooth muscle cells. In U87 GBM xenografts expressing UII and UT in the glial and vascular compartments, UII accelerated tumor development, favored hypoxia and necrosis associated with increased proliferation (Ki67), and induced metalloproteinase (MMP)-2 and -9 expression in Nude mice. UII also promoted a “tortuous” vascular collagen-IV expressing network and integrin expression mainly in the vascular compartment. GBM angiogenesis and integrin αvβ3 were confirmed by in vivo99mTc-RGD tracer imaging and tumoral capture in the non-necrotic area of U87 xenografts in Nude mice. Peptide analogs of UII and UT antagonist were also tested as potential tumor repressor. Urotensin II-related peptide URP inhibited angiogenesis in vitro and failed to attract vascular and inflammatory components in Matrigel in vivo. Interestingly, the UT antagonist/biased ligand urantide and the non-peptide UT antagonist palosuran prevented UII-induced tubulogenesis in vitro and significantly delayed tumor growth in vivo. Urantide drastically prevented endogenous and UII-induced GBM angiogenesis, MMP, and integrin activations, associated with GBM tumoral growth. These findings ...
Keywords	glioblastoma ; urotensin II ; UT receptor ; angiogenesis ; necrosis ; biased ligand ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Reducing the anxiety of patients undergoing an oral biopsy by means of graphic novels: an open-label randomized clinical trial.

Bazzano, M / Mauceri, R / Marcon, G / Campisi, G

Medicina oral, patologia oral y cirugia bucal

2023 Volume 28, Issue 6, Page(s) e545–e552

Abstract: Background: The use of graphic novels is a trending topic in health communication as a new form of visual storytelling which explores narratives of health care, cancer, healing, and disability. The objective of the present study was to evaluate - for ... ...

Abstract	Background: The use of graphic novels is a trending topic in health communication as a new form of visual storytelling which explores narratives of health care, cancer, healing, and disability. The objective of the present study was to evaluate - for the first time in the literature - the effect of graphic novels in reducing the anxiety of patients waiting for an incisional biopsy in an oral oncology setting. Material and methods: This open-label randomized clinical trial comprised 50 patients with a clinical suspicion of oral potentially malignant disorders. Twenty-five patients were randomly allocated to the test group, and a colourful graphic novel was provided. Subsequently, the Beck Depression Inventory and the Depression Anxiety Stress Scales-21 were administered to all 50 recruited patients, after which a biopsy was performed on each patient. Results: No statistically significant difference was observed between the test and control groups for the variables regarding the demographic data (p>0.2). There was a significant difference after the introduction of the graphic novel, regardless of which questionnaire was used. The graphic novel demonstrated an improvement in the ability of the test group to tolerate anxiety while waiting for an oral biopsy in both psychological tests (p<0.05). Conclusions: In light of these initial positive results, the authors of this study would like to suggest the use of graphic novels in oral oncology, dentistry, and medicine with the aim of reducing patient anxiety.
MeSH term(s)	Humans ; Anxiety/etiology ; Anxiety/prevention & control ; Anxiety Disorders ; Precancerous Conditions
Language	English
Publishing date	2023-11-01
Publishing country	Spain
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2171573-7
ISSN	1698-6946 ; 1698-4447
ISSN (online)	1698-6946
ISSN	1698-4447
DOI	10.4317/medoral.25950
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Article: Genetic, lifestyle and metabolic factors contributing to cardiovascular disease in the Italian population: a literature review.

Ojeda-Granados, Claudia / Campisi, Elisabetta / Barchitta, Martina / Agodi, Antonella

Frontiers in nutrition

2024 Volume 11, Page(s) 1379785

Abstract: ... environmental, lifestyle/behavioral (e.g., unhealthy diet, physical inactivity, smoking, and alcohol abuse ...

Abstract	Cardiovascular diseases (CVD) represent a major health problem worldwide. In Italy, despite the decline in CVD mortality and disability-adjusted life years recently observed, CVD remains the leading cause of death. The development of CVD has a complex and multifactorial etiology that involves environmental, lifestyle/behavioral (e.g., unhealthy diet, physical inactivity, smoking, and alcohol abuse), metabolic, and genetic factors. Although a large number of CVD susceptibility genetic variants have been identified, some seem to confer risk according to the genetic background or ethnicity of the population. Some CVD-associated polymorphisms with appreciable frequency in the Italian population may be important contributors to the development and progression of the most prevalent CVD in the population. This literature review aims to provide an overview of the epidemiology of CVD in Italy, as well as to highlight the main genetic, lifestyle/behavioral, and metabolic factors contributing to CVD risk in this population.
Language	English
Publishing date	2024-04-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2024.1379785
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Article: Ranula: Modified Micro-Marsupialization: Case Report and Review of Literature.

Verro, Barbara / Mauceri, Rodolfo / Campisi, Giuseppina / Saraniti, Carmelo

Iranian journal of otorhinolaryngology

2023 Volume 35, Issue 127, Page(s) 113–117

Abstract: Introduction: Ranula is a limited mucus retention on the floor of mouth. Due to the young age of patients, over the years, attempts were made to find minimally invasive and effective surgical techniques. To date, however, there is still no gold standard. ...

Abstract	Introduction: Ranula is a limited mucus retention on the floor of mouth. Due to the young age of patients, over the years, attempts were made to find minimally invasive and effective surgical techniques. To date, however, there is still no gold standard. The modified micro-marsupialization is an effective and minimally invasive technique, with minimal risk of relapse, although there are very few reports about it. Case report: A 12-year-old male presented to our ENT Clinic with a rounded swelling with regular and defined margins, measuring 4x3 cm, soft and painless, non-compressible and bluish. Clinical diagnosis of ranula was made and a modified micro-marsupialization was performed: eight interrupted sutures using silk 3-0 were placed perpendicularly to the major axis of the lesion, from one side of the lesion to the other, without reaching the underlying tissue. No sutures were lost during follow-up, no complications occurred. Complete healing was reached after removing sutures on the 30th postoperative day. At 6 months control no relapse was observed. Conclusion: Modified micro-marsupialization is strongly indicated and recommended, especially in pediatric patient, due to its low invasiveness and its very low relapse rate. The poor case history found in the literature is probably an indication of the lack of knowledge of modified micro-marsupialization which, in our opinion, could be considered the gold standard.
Language	English
Publishing date	2023-05-22
Publishing country	Iran
Document type	Case Reports
ZDB-ID	3018470-8
ISSN	2251-726X ; 2251-7251
ISSN (online)	2251-726X
ISSN	2251-7251
DOI	10.22038/IJORL.2023.61890.3131
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Article ; Online: Oral health status of 916 children in Tibetan settlement (Bylakuppe, India): A cross-sectional descriptive study.

Campisi, Giuseppina / Buttacavoli, Fortunato / Neri, Bruno / Capocasale, Giorgia / Mauceri, Nicola / Mauceri, Rodolfo

International journal of paediatric dentistry

2024

Abstract: Background: Dietary and oral hygiene habits among integrated migrant cultural minorities can vary and could impact susceptibility to caries.: Aim: This study aimed to assess and compare the oral health status of Tibetan schoolchildren living in the ... ...

Abstract	Background: Dietary and oral hygiene habits among integrated migrant cultural minorities can vary and could impact susceptibility to caries. Aim: This study aimed to assess and compare the oral health status of Tibetan schoolchildren living in the Tibetan settlement of Bylakuppe, India, stratified by type of residence. Design: A descriptive cross-sectional study was conducted among Tibetan schoolchildren attending nine schools in the Bylakuppe region. Results: The study population consisted of 916 children aged 5-17: 702 (76.6%) living in secular houses (LSH) and 214 (23.4%) living in monasteries (LM). The prevalence of dental caries was 70.9%, and the mean value of decayed, missing, filled teeth for mixed and primary dentition (DMFT; dmft) of LSH children (1.56 ± 2.34/1.74 ± 2.66) was higher than of LM ones (1.14 ± 2.34/0.83 ± 2.80; p < .001). DMFT for LM children (1.46 ± 2.04) was slightly higher than for LSH children (1.38 ± 1.96; p > .05). Among the sample, 99.1% had a good simplified Oral Hygiene Index (OHI) and LM children showed higher rates of good values (99.5% vs. 98.2% in LSH children). Most children needed preventive/routine dental treatment, whereas 16.6% needed urgent dental treatment. In 4.5% of children, oral mucosal lesions were present. Conclusion:* This study confirms the high need for dental treatment in the children of the Tibetan settlement investigated.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1070942-3
ISSN	1365-263X ; 0960-7439
ISSN (online)	1365-263X
ISSN	0960-7439
DOI	10.1111/ipd.13193
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Article: Tezepelumab for asthma.

Nolasco, Santi / Pelaia, Corrado / Scioscia, Giulia / Campisi, Raffaele / Crimi, Claudia

Drugs of today (Barcelona, Spain : 1998)

2023 Volume 58, Issue 12, Page(s) 591–603

Abstract: The epithelium, once simply considered a protective barrier against harmful agents, has in recent times gained considerable relevance as an entity that can promote and regulate inflammatory processes through the production of cytokines, namely ... ...

Abstract	The epithelium, once simply considered a protective barrier against harmful agents, has in recent times gained considerable relevance as an entity that can promote and regulate inflammatory processes through the production of cytokines, namely interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), known as "alarmins". TSLP, in particular, has been extensively studied as a possible therapeutic target in patients with severe asthma because it is involved in the inflammatory processes of both type 2-high and type 2-low inflammation. In this regard, tezepelumab (AMG-157/MEDI-9929), a TSLP-targeted first-in-class fully human monoclonal antibody, has been shown in phase II and III studies to be effective and safe in treating patients with severe asthma, regardless of the underlying endotype or phenotype and irrespective of baseline biomarkers, such as blood eosinophil count and fraction of exhaled nitric oxide. Here, we provide a comprehensive review of TSLP function in airway inflammatory processes, the clinical development of tezepelumab for severe asthma as well as its possible future indications.
MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/therapy ; Cytokines ; Thymic Stromal Lymphopoietin
Chemical Substances	Antibodies, Monoclonal, Humanized ; Cytokines ; tezepelumab (RJ1IW3B4QX) ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
Language	English
Publishing date	2023-01-18
Publishing country	Spain
Document type	Review ; Journal Article
ISSN	1699-3993
ISSN	1699-3993
DOI	10.1358/dot.2022.58.12.3449205
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Article ; Online: One changing and challenging scenario: the treatment of cancer patients with bone metastases by bisphosphonates and denosumab, the cost-benefit evaluation of different options, and the risk of medication-related osteonecrosis of the jaw (MRONJ).

Fusco, Vittorio / Campisi, Giuseppina / Bedogni, Alberto

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2022 Volume 30, Issue 9, Page(s) 7047–7051

Abstract: Antiresorptive drugs (bisphosphonates and denosumab) have become the cornerstone of medical supportive treatment of bone metastases in solid cancer patients. In the beginning, the choice of available antiresorptive agents was limited to bisphosphonates ... ...

Abstract	Antiresorptive drugs (bisphosphonates and denosumab) have become the cornerstone of medical supportive treatment of bone metastases in solid cancer patients. In the beginning, the choice of available antiresorptive agents was limited to bisphosphonates and the treatment options restricted principally to monthly pamidronate and monthly zoledronic acid. Introduction of new antiresorptive therapies (monthly denosumab) and schedules (zoledronic acid every 3 months, upfront or after initial period of monthly infusion) in the last decade increased the range of available options, thus challenging treatment decision making. Direct and indirect costs of very different treatment options are difficult to interpret in a global cost-benefit analysis. In addition, awareness of the increased risk of medication-related osteonecrosis of the jaw (MRONJ) in bone metastatic cancer patients receiving long-term antiresorptive medications is likely to influence therapy choice in the real-life scenario. We discuss the possible threat of MRONJ risk underestimation and the need for long-term risk stratification of patients based on actuarial data, the role of bisphosphonates and denosumab in that scenario, and the emerging role of surgical therapy to successfully cure MRONJ, in the light of the improved quality of life and survival of patients with bone metastases from solid cancers.
MeSH term(s)	Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/surgery ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Cost-Benefit Analysis ; Denosumab/adverse effects ; Denosumab/therapeutic use ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Humans ; Pamidronate/therapeutic use ; Quality of Life ; Risk Assessment ; Zoledronic Acid/therapeutic use
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; Denosumab (4EQZ6YO2HI) ; Zoledronic Acid (6XC1PAD3KF) ; Pamidronate (OYY3447OMC)
Language	English
Publishing date	2022-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-022-06982-y
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Article ; Online: RE: American Association of Oral and Maxillofacial Surgeons' Position Paper on Medication-Related Osteonecrosis of the Jaws-2022 Update: Quantitative Risk Assessment and Controversial Issues.

Fusco, Vittorio / Mauceri, Rodolfo / Campisi, Giuseppina / Bedogni, Alberto

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2022 Volume 80, Issue 12, Page(s) 1871–1873

MeSH term(s)	Humans ; Oral and Maxillofacial Surgeons ; Osteonecrosis/chemically induced ; Osteonecrosis/surgery ; Risk Assessment ; Jaw
Language	English
Publishing date	2022-12-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2022.07.143
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Article ; Online: Re: AAOMS Position Paper on Medication-Related Osteonecrosis of the Jaw-2022 Update.

Campisi, Giuseppina / Mauceri, Rodolfo / Bedogni, Alberto / Fusco, Vittorio

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2022 Volume 80, Issue 11, Page(s) 1723–1724

MeSH term(s)	Humans ; Osteonecrosis/chemically induced ; Bisphosphonate-Associated Osteonecrosis of the Jaw/etiology ; Bone Density Conservation Agents/adverse effects ; Diphosphonates/adverse effects
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2022.07.149
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