LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 572

Search options

  1. Article ; Online: Introduction to the Bisphosphonate Special Issue.

    Eastell, Richard / Russell, R Graham G

    Bone

    2023  Volume 172, Page(s) 116754

    MeSH term(s) Diphosphonates/adverse effects ; Bone Density Conservation Agents/adverse effects
    Chemical Substances Diphosphonates ; Bone Density Conservation Agents
    Language English
    Publishing date 2023-04-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2023.116754
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1571: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 332: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Advances in the molecular pharmacology of bone and cancer-related bone diseases.

    Edwards, Claire M / Russell, R Graham G

    British journal of pharmacology

    2021  Volume 178, Issue 9, Page(s) 1889–1890

    MeSH term(s) Bone Diseases/drug therapy ; Bone and Bones ; Humans ; Neoplasms/drug therapy ; Pharmacology
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Editorial
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15431
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Conference proceedings: Novel approaches to treatment of osteoporosis

    Russell, R. G. G.

    [two-day workshop held in November 1997 in Berlin, Germany]. With 10 tables

    (Ernst Schering Research Foundation workshop ; 25)

    1998  

    Author's details R. G. G. Russell ... ed
    Series title Ernst Schering Research Foundation workshop ; 25
    Collection
    Keywords Osteoporose ; Therapie
    Subject Medizinische Behandlung ; Behandlung ; Krankenbehandlung ; Knochenrarefikation ; Osteoporosis
    Language English
    Size XIII, 262 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book ; Conference proceedings
    HBZ-ID HT009621781
    ISBN 3-540-64813-5 ; 978-3-540-64813-0
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 649 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Pharmacological diversity among drugs that inhibit bone resorption.

    Russell, R Graham G

    Current opinion in pharmacology

    2015  Volume 22, Page(s) 115–130

    Abstract: ... The historic use of oestrogens for osteoporosis led on to SERMs (Selective Estrogen Receptor Modulators, e.g ...

    Abstract Drugs that inhibit bone resorption ('anti-resorptives') continue to dominate the therapy of bone diseases characterized by enhanced bone destruction, including Paget's disease, osteoporosis and cancers. The historic use of oestrogens for osteoporosis led on to SERMs (Selective Estrogen Receptor Modulators, e.g. raloxifene and bazedoxifene). Currently the mainstay of treatment worldwide is still with bisphosphonates, as used clinically for over 40 years. The more recently introduced anti-RANK-ligand antibody, denosumab, is also very effective in reducing vertebral, non-vertebral and hip fractures. Odanacatib is the only cathepsin K inhibitor likely to be registered for clinical use. The pharmacological basis for the action of each of these drug classes is different, enabling choices to be made to ensure their optimal use in clinical practice.
    MeSH term(s) Animals ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/therapeutic use ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use ; Bone Diseases/drug therapy ; Bone Diseases/physiopathology ; Bone Resorption/drug therapy ; Denosumab/pharmacology ; Denosumab/therapeutic use ; Diphosphonates/pharmacology ; Diphosphonates/therapeutic use ; Humans ; Selective Estrogen Receptor Modulators/pharmacology ; Selective Estrogen Receptor Modulators/therapeutic use
    Chemical Substances Biphenyl Compounds ; Bone Density Conservation Agents ; Diphosphonates ; Selective Estrogen Receptor Modulators ; Denosumab (4EQZ6YO2HI) ; odanacatib (N673F6W2VH)
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2015.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen

    Sedghizadeh, Parish P / Cherian, Philip / Roshandel, Sahar / Tjokro, Natalia / Chen, Casey / Junka, Adam F / Hu, Eric / Neighbors, Jeffrey / Pawlak, Jacek / Russell, R Graham G / McKenna, Charles E / Ebetino, Frank H / Sun, Shuting / Sodagar, Esmat

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Osteomyelitis is a limb- and life-threatening orthopedic infection predominantly caused ... ...

    Abstract Osteomyelitis is a limb- and life-threatening orthopedic infection predominantly caused by
    MeSH term(s) Humans ; Staphylococcus aureus ; Diphosphonates/therapeutic use ; Moxifloxacin ; Etidronic Acid/therapeutic use ; Electric Impedance ; Anti-Bacterial Agents/chemistry ; Staphylococcal Infections/drug therapy ; Osteomyelitis/drug therapy ; Ciprofloxacin/pharmacology ; Ciprofloxacin/therapeutic use ; Biofilms ; Durapatite/chemistry ; Microbial Sensitivity Tests
    Chemical Substances Diphosphonates ; Moxifloxacin (U188XYD42P) ; Etidronic Acid (M2F465ROXU) ; Anti-Bacterial Agents ; Ciprofloxacin (5E8K9I0O4U) ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031985
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Conference proceedings: Osteoarthritis

    Russell, R. G. G.

    current research and prospects for pharmacological intervention ; [based upon a conference ... in November 1988]

    1991  

    Author's details ed. by R. G. G. Russell
    Keywords Osteoarthritis / congresses ; Osteoarthritis / drug therapy / congresses
    Language English
    Size 223 S. : Ill., graph. Darst.
    Publisher IBC Technical Services
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT004254378
    ISBN 1-85271-093-4 ; 978-1-85271-093-4
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1994 A 5198 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Conference proceedings: Glucocorticoids and bone

    Russell, R. G. G.

    proceedings of a Symposium [Entitled Glucocorticoids and Bone] held in Vienna, Austria, 12 March 1991 [during the XIVth European Symposium on Calcified Tissues, in Vienna, Austria]

    (British journal of rheumatology ; 32, Suppl. 2)

    1993  

    Event/congress Symposium Glucocorticoids and Bone (1991, Wien)
    Author's details guest ed.: R. G. G. Russell
    Series title British journal of rheumatology ; 32, Suppl. 2
    Collection
    Keywords Bone and Bones / drug effects / congresses ; Bone Diseases / chemically induced / congresses ; Glucocorticoids / congresses
    Language English
    Size III, 48 S. : graph. Darst.
    Publisher Baillière Tindall
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT004984388
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 240 -32,Suppl.2- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Conference proceedings: Tumour induced hypercalcaemia and its management

    Russell, R. G. G.

    proceedings of a symposium ..., held in London, 16 July, 1990

    (International congress and symposium series / Royal Society of Medicine ; 176)

    1991  

    Author's details ed. by R. G. G. Russell
    Series title International congress and symposium series / Royal Society of Medicine ; 176
    Collection
    Keywords Hypercalcemia / etiology / congresses ; Hypercalcemia / drug therapy / congresses ; Neoplasms / complications / congresses ; Krebs ; Hyperkalzämie
    Subject Hypercalcämie ; Hyperkalziämie ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Size IV, 82 S. : Ill., graph. Darst.
    Publisher Royal Society of Medicine Services
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003859402
    ISBN 1-85315-151-3 ; 978-1-85315-151-4
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 3840 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: In vitro

    Samakkarnthai, Parinya / Saul, Dominik / Zhang, Lei / Aversa, Zaira / Doolittle, Madison L / Sfeir, Jad G / Kaur, Japneet / Atkinson, Elizabeth J / Edwards, James R / Russell, R Graham G / Pignolo, Robert J / Kirkland, James L / Tchkonia, Tamar / Niedernhofer, Laura J / Monroe, David G / LeBrasseur, Nathan K / Farr, Joshua N / Robbins, Paul D / Khosla, Sundeep

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the ... ...

    Abstract In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. To test this, we first performed
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.23.529777
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: History of alendronate.

    Cummings, Steven R / Santora, Arthur C / Black, Dennis M / Russell, R Graham G

    Bone

    2020  Volume 137, Page(s) 115411

    Abstract: Alendronate was synthesized in 1970s in a search for inhibitors of calcification. Istituto Gentili investigators identified it as a potent inhibitor of bone resorption and obtained a patent covering its use in the treatment of osteoporosis and other ... ...

    Abstract Alendronate was synthesized in 1970s in a search for inhibitors of calcification. Istituto Gentili investigators identified it as a potent inhibitor of bone resorption and obtained a patent covering its use in the treatment of osteoporosis and other disorders of excessive bone resorption in the 1980s. Merck licensed alendronate in 1988 and its pharmaceutical chemists reformulated it as a sodium salt with good solubility in a tablet that reduced its potential for esophageal irritation. Clinical trials proved that it reduced bone turnover, increased BMD and reduced the risk of vertebral fractures in postmenopausal osteoporotic women. Merck sponsored a large clinical trials that won FDA approval for treatment of osteoporosis in postmenopausal women and showed that it reduced the risk of spine and hip fractures. Its approval in the US in 1995 spurred sales of bone densitometers and BMD testing to screen for low bone mineral density and identify osteoporosis. Bone mass measurement was supported by medical society guidelines and reimbursement by Medicare and other insurers in the USA. A 70 mg weekly instead of 10 mg daily dose of alendronate produced the same effect on BMD and biochemical markers of bone remodelling with greater convenience and reduced potential for upper GI adverse events. Consequently, by 2006, about 30 million prescriptions for alendronate were written annually in the U.S. for about 15% of postmenopausal women in the U.S. Thereafter, publicity about rare but concerning atypical femoral fractures (AFF) and osteonecrosis of the jaw (ONJ) along with the expiry of Merck's patent (in 2008) and cessation of their promotion of alendronate, and a decline in use of densitometry led to a steady slide in its use even among patients for whom the benefits of alendronate far outweigh its potential risks. Nevertheless, in 25 years since its regulatory approval, alendronate has undoubtedly prevented millions of fractures world-wide.
    MeSH term(s) Aged ; Alendronate/adverse effects ; Bone Density ; Bone Remodeling ; Female ; Humans ; Medicare ; Osteoporosis, Postmenopausal ; United States
    Chemical Substances Alendronate (X1J18R4W8P)
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2020.115411
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1571: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 332: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top