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Article ; Online: Designing nanodiscs as versatile platforms for on-demand therapy.

Mu, Qianwen / Deng, Haolan / An, Xiaoyu / Liu, Gang / Liu, Chao

2024 Volume 16, Issue 5, Page(s) 2220–2234

Abstract: Nowadays, there has been an increasing utilization of nanomedicines for disease treatment. Nanodiscs (NDs) have emerged as a novel platform technology that garners significant attention in biomedical research and drug discovery. NDs are nanoscale ... ...

Abstract	Nowadays, there has been an increasing utilization of nanomedicines for disease treatment. Nanodiscs (NDs) have emerged as a novel platform technology that garners significant attention in biomedical research and drug discovery. NDs are nanoscale phospholipid bilayer discs capable of incorporating membrane proteins and lipids within a native-like environment. They are assembled using amphiphilic biomacromolecular materials, such as apolipoprotein A1 or membrane scaffold proteins (MSPs), peptides, and styrene-maleic acid polymers (SMAs). NDs possess well-defined sizes and shapes, offering a stable, homogeneous, and biologically relevant environment for studying membrane proteins and lipids. Their unique properties have made them highly desirable for diverse applications, including cancer immunotherapy, vaccine development, antibacterial and antiviral therapy, and treating Alzheimer's disease (AD) and diabetes-related conditions. This review discusses the classifications, advantages, and applications of NDs in disease therapy.
MeSH term(s)	Lipid Bilayers/chemistry ; Nanostructures/therapeutic use ; Nanostructures/chemistry ; Membrane Proteins/chemistry ; Phospholipids ; Peptides
Chemical Substances	Lipid Bilayers ; Membrane Proteins ; Phospholipids ; Peptides
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr05457h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3D Analysis of Breast Morphological Changes after Vertical-Scar Reduction Mammoplasty: A Prospective Study.

Li, Haoran / Lin, Yan / Zhang, Xiaoyu / Li, Zhengyao / Mu, Dali

Aesthetic plastic surgery

2024

Abstract: Background: In addition to symptom relief, the crucial objective of reduction mammoplasty is to achieve a stable and esthetically pleasing postoperative breast shape. However, the morphological changes in breasts following reduction mammoplasty have not ...

Abstract	Background: In addition to symptom relief, the crucial objective of reduction mammoplasty is to achieve a stable and esthetically pleasing postoperative breast shape. However, the morphological changes in breasts following reduction mammoplasty have not been comprehensively understood. In this study, we applied three-dimensional (3D) scanning technology for long-term follow-up monitoring of breast morphological changes to discern their changing trends. Our goal was to provide a reliable basis for assessing postoperative effects and determining follow-up time points. Methods: This prospective study included patients undergoing vertical-scar reduction mammoplasty. We utilized a combination of linear measurements and 3D scanning to measure various parameters, including breast volume, breast volume distribution, nipple position, and scar length at various time points: pre-surgery, immediately post-surgery, 3-month postoperative, 6-month postoperative, and 1-year postoperative. Results: A total of 115 patients were enrolled in this study. Throughout the initial 3 months of postoperative follow-up, there was a gradual reduction in breast volume, which tended to stabilize from 3 to 12 months. The nipple position showed a gradual shift both laterally, inferiorly, and posteriorly. The volume of the lower and lateral part of the breast increased gradually. Notably, at 1 year after surgery, the scar length was approximately 6.3% shorter compared to the immediate postoperative measurement. Conclusions: Our 3D analysis unveiled comprehensive changes in breast morphology: The overall breast volume shifted laterally and inferiorly, the nipple position moved laterally, inferiorly, and posteriorly, and there was a significant reduction in scar length. Concurrently, breast volume exhibited a gradual decrease and stabilization after 3 months, establishing it as a suitable follow-up point for assessing postoperative results. Additionally, surgical plans can be formulated based on the overall trend of changes in breast volume and distribution, combined with methods such as three-dimensional scanning, to enhance surgical outcomes and patient satisfaction. Level of evidence iv: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to authors www.springer.com/00266 .
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-024-03985-4
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Zs.A 1296: Show issues

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Article ; Online: Influence of Prognostic Nutritional Index on the Surveillance After Surgery-Based Systematic Therapy for Breast Cancer.

Zhang, Xiaoyu / Liu, Yue / Mu, Dali

The American surgeon

2023 Volume 89, Issue 12, Page(s) 6157–6171

Abstract: Objective: Prognostic nutritional index (PNI) is a comprehensive reflection of the nutritional and immune status of the patient, which is closely related to the ability of the organism to clear tumor cells and reduce local recurrence. Several findings ... ...

Abstract	Objective: Prognostic nutritional index (PNI) is a comprehensive reflection of the nutritional and immune status of the patient, which is closely related to the ability of the organism to clear tumor cells and reduce local recurrence. Several findings suggested that PNI was a prognostic indicator for breast cancer, but the conclusions were conflicting. We aimed to comprehensively elucidate the prognostic value of PNI in breast cancer patients. Methods: Relevant studies in PubMed, Embase, Cochrane Library, and Web of Science databases were searched through March 2023. Data extraction and literature quality assessment of the screened studies were performed. The associations between PNI and overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) in breast cancer patients who received clinical treatment were assessed by hazard ratios ( Results: A total of 7 studies involving 2212 patients met the inclusion criteria. High PNI was a favorable independent predictor of prolonged OS and PFS after clinical treatment in breast cancer patients compared to low PNI (for OS: Conclusion: The PNI has a significant correlation with the prognosis of breast cancer patients. We suggest that individualized targeted treatment and long-term surveillance should be implemented for patients with different levels of PNI.
MeSH term(s)	Humans ; Female ; Nutrition Assessment ; Prognosis ; Breast Neoplasms/surgery ; Disease-Free Survival ; Proportional Hazards Models
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348231191200
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Article ; Online: Deferoxamine Mesylate Improves the Survival Rate of Transplanted Fat by Promoting Angiogenesis.

Lin, Yan / Zhang, Xiaoyu / Li, Haoran / Mu, Dali

Aesthetic surgery journal

2023 Volume 43, Issue 7, Page(s) 789–798

Abstract: Background: The volume retention rate after autologous fat transplantation is unpredictable and unstable. Deferoxamine mesylate (DFO) is a drug approved by the FDA that is safe, has antioxidant effects, and can promote angiogenesis.: Objectives: The ... ...

Abstract	Background: The volume retention rate after autologous fat transplantation is unpredictable and unstable. Deferoxamine mesylate (DFO) is a drug approved by the FDA that is safe, has antioxidant effects, and can promote angiogenesis. Objectives: The aim of this study was to transplant DFO-pretreated fat granules into nude mice to observe the proangiogenic effect of DFO and to evaluate whether this treatment could also improve the retention rate of fat transplantation. Methods: A total of 24 nude mice were transplanted with human adipose tissue that had been pretreated with different concentrations of DFO (0.5, 1, and 4 mM). Samples were collected at 1 and 3 months. After sampling, weight/volume retention rate, immunohistochemistry, and polymerase chain reaction were analyzed. The effects and mechanisms of DFO-pretreated fat grafts were evaluated. Results: The in vivo experimental results showed that DFO-pretreated adipose fat significantly improved the postoperative weight/volume retention rate. The results of the immunohistochemical staining indicated that the integrity and activity of the adipocytes in the DFO-pretreated groups were better than in the control group. The polymerase chain reaction results were consistent with the immunohistochemistry results (CD31), suggesting that DFO promoted angiogenesis in the grafts. Conclusions: The results of this study indicate that preconditioning fat grafts with DFO can improve the effect of fat transplantation by promoting vascular regeneration.
MeSH term(s)	Mice ; Animals ; Humans ; Deferoxamine/pharmacology ; Deferoxamine/therapeutic use ; Mice, Nude ; Survival Rate ; Adipose Tissue/transplantation ; Adipocytes
Chemical Substances	Deferoxamine (J06Y7MXW4D)
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad066
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 570: Show issues

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Article ; Online: Using Laser-Assisted Indocyanine Green Angiography to Assess Nipple-Areolar Complex Survival During Reduction Mammoplasty.

Li, Haoran / Zhang, Xiaoyu / Li, Zhengyao / Lin, Yan / Mu, Dali

Aesthetic surgery journal

2023 Volume 44, Issue 2, Page(s) NP149–NP158

MeSH term(s)	Humans ; Nipples/diagnostic imaging ; Nipples/surgery ; Indocyanine Green ; Mammaplasty ; Angiography ; Breast Diseases/surgery ; Lasers ; Retrospective Studies
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad327
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Research on the Frontier and Prospect of Service Robots in the Tourism and Hospitality Industry Based on International Core Journals: A Review.

Chen, Mengxi / Wang, Xiaoyu / Law, Rob / Zhang, Mu

Behavioral sciences (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: This paper used the mixed research method of bibliometric and content analysis to study 284 studies on service robots in the tourism and hospitality industry collected from the Web of Science database. Results show that research in this field started ... ...

Abstract	This paper used the mixed research method of bibliometric and content analysis to study 284 studies on service robots in the tourism and hospitality industry collected from the Web of Science database. Results show that research in this field started late, and that the COVID-19 pandemic has promoted the rapid growth of the number of research papers. The
Language	English
Publishing date	2023-07-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs13070560
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Article ; Online: Mastopexy with Autologous Augmentation in Women After Massive Weight Loss: A Randomized Clinical Trial.

Zhang, Xiaoyu / Mu, Dali

Aesthetic plastic surgery

2020 Volume 44, Issue 3, Page(s) 1075–1076

MeSH term(s)	Female ; Humans ; Mammaplasty ; Surgical Flaps ; Weight Loss
Language	English
Publishing date	2020-03-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-020-01688-0
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Zs.A 1296: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Explantation in Tissue Expander and Direct-to-Implant Reconstruction with Acellular Dermal Matrix: How to Avoid Early Reconstructive Failures.

Zhang, Xiaoyu / Mu, Dali / Huang, Yinxiang

Plastic and reconstructive surgery

2022 Volume 149, Issue 4, Page(s) 824e–825e

MeSH term(s)	Acellular Dermis ; Breast Implantation/adverse effects ; Breast Implants ; Breast Neoplasms ; Device Removal ; Female ; Humans ; Mammaplasty ; Postoperative Complications ; Retrospective Studies ; Tissue Expansion Devices
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000008898
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article ; Online: Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut-Brain Regulation in Zebrafish.

Mu, Xiyan / Liu, Zaiteng / Zhao, Xiaoyu / Yuan, Lilai / Li, Yingren / Wang, Chengju / Xiao, Guohua / Mu, Jiandong / Qiu, Jing / Qian, Yongzhong

Environmental science & technology

2024 Volume 58, Issue 2, Page(s) 1022–1035

Abstract: There is epidemiological evidence in humans that exposure to endocrine-disrupting chemicals such as bisphenol A (BPA) is tied to abnormal neuroendocrine function with both behavioral and intestinal symptoms. However, the underlying mechanism of this ... ...

Abstract	There is epidemiological evidence in humans that exposure to endocrine-disrupting chemicals such as bisphenol A (BPA) is tied to abnormal neuroendocrine function with both behavioral and intestinal symptoms. However, the underlying mechanism of this effect, particularly the role of gut-brain regulation, is poorly understood. We exposed zebrafish embryos to a concentration series (including environmentally relevant levels) of BPA and its analogues. The analogue bisphenol G (BPG) yielded the strongest behavioral impact on zebrafish larvae and inhibited the largest number of neurotransmitters, with an effective concentration of 0.5 μg/L, followed by bisphenol AF (BPAF) and BPA. In
MeSH term(s)	Animals ; Humans ; Zebrafish ; Neurosecretory Systems ; Benzhydryl Compounds/toxicity ; Brain ; Neurotransmitter Agents/metabolism ; Phenols
Chemical Substances	bisphenol A (MLT3645I99) ; Benzhydryl Compounds ; Neurotransmitter Agents ; Phenols
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c05282
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Article ; Online: Pedicle Selection and Design in Reduction Mammaplasty: The Role of Preoperative Fluorescence Imaging.

Lin, Yan / Li, Haoran / Li, Zhengyao / Chen, Lin / Xing, Wenshan / Zhang, Xiaoyu / Mu, Dali

Aesthetic surgery journal

2024

Abstract: Background: Breast reduction has a wide selection of pedicles but often relies on the surgeon's preference and experience. Necrosis of the nipple-areola complex (NAC) is a catastrophic complication of breast reduction surgery.: Objectives: To solve ... ...

Abstract	Background: Breast reduction has a wide selection of pedicles but often relies on the surgeon's preference and experience. Necrosis of the nipple-areola complex (NAC) is a catastrophic complication of breast reduction surgery. Objectives: To solve the above problem objectively, we applied fluorescence imaging technology to the pedicle selection and design of breast reduction surgery for the first time so that the dominant vessels of the NAC were included in the designed pedicle. Methods: We retrospectively enrolled 120 patients with breast reduction (a total of 239 breasts). We compared 60 patients who underwent breast reduction without fluorescence imaging for pedicle selection (group A) with 60 patients who underwent pedicle selection using fluorescence imaging (group B). The NAC blood supply was monitored after the operation. Results: This study analyzed the 60 group A cases (119 breasts) and 60 group B cases (120 breasts). There were no statistically significant differences in patient demographic data and intraoperative resection weights. There were seven cases of NAC necrosis in group A (one case of complete necrosis and six cases of partial necrosis), while no NAC necrosis occurred in group B. There was a significant difference in the rate of NAC necrosis between the two groups. Conclusions: Preoperative fluorescence imaging can guide the selection and design of breast reduction, significantly reducing postoperative NAC blood supply obstacles and necrosis.
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjae011
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