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  1. Article ; Online: An interview with Janet Rossant. Interview by Catarina Vicente.

    Rossant, Janet

    Development (Cambridge, England)

    2013  Volume 140, Issue 21, Page(s) 4299–4300

    MeSH term(s) Awards and Prizes ; Career Choice ; Developmental Biology/history ; History, 20th Century ; History, 21st Century ; Stem Cell Research/ethics ; Stem Cell Research/history
    Language English
    Publishing date 2013-11
    Publishing country England
    Document type Historical Article ; Interview ; Portraits
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.102269
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  2. Article ; Online: Profile of Janet Rossant. Interview by Kristie Nybo.

    Rossant, Janet

    BioTechniques

    2012  Volume 53, Issue 3, Page(s) 129

    MeSH term(s) Animals ; Biomedical Research ; Developmental Biology ; Genetics ; Humans ; Mice
    Language English
    Publishing date 2012-09
    Publishing country England
    Document type Interview
    ZDB-ID 48453-2
    ISSN 1940-9818 ; 0736-6205
    ISSN (online) 1940-9818
    ISSN 0736-6205
    DOI 10.2144/000113918
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  3. Article ; Online: Why study human embryo development?

    Rossant, Janet

    Developmental biology

    2024  Volume 509, Page(s) 43–50

    Abstract: Understanding the processes and mechanisms underlying early human embryo development has become an increasingly active and important area of research. It has potential for insights into important clinical issues such as early pregnancy loss, origins of ... ...

    Abstract Understanding the processes and mechanisms underlying early human embryo development has become an increasingly active and important area of research. It has potential for insights into important clinical issues such as early pregnancy loss, origins of congenital anomalies and developmental origins of adult disease, as well as fundamental insights into human biology. Improved culture systems for preimplantation embryos, combined with the new tools of single cell genomics and live imaging, are providing new insights into the similarities and differences between human and mouse development. However, access to human embryo material is still restricted and extended culture of early embryos has regulatory and ethical concerns. Stem cell-derived models of different phases of human development can potentially overcome these limitations and provide a scalable source of material to explore the early postimplantation stages of human development. To date, such models are clearly incomplete replicas of normal development but future technological improvements can be envisaged. The ethical and regulatory environment for such studies remains to be fully resolved.
    MeSH term(s) Humans ; Pregnancy ; Adult ; Female ; Animals ; Mice ; Embryonic Development ; Embryo, Mammalian ; Blastocyst ; Stem Cells
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2024.02.001
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  4. Article ; Online: Studying human embryo development with E-assembloids.

    Rossant, Janet

    Cell research

    2023  Volume 33, Issue 10, Page(s) 737–738

    MeSH term(s) Humans ; Embryonic Development ; Embryo, Mammalian
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00863-7
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  5. Article ; Online: Celebrating scientific excellence and global health impact: The 2022 Canada Gairdner Awards.

    Rossant, Janet

    Cell

    2022  Volume 185, Issue 8, Page(s) 1287–1289

    Abstract: From mRNA vaccines to community interventions in global child health, the 2022 Canada Gairdner awards demonstrate the importance of fundamental science and its translation into improved human health and well-being. ...

    Abstract From mRNA vaccines to community interventions in global child health, the 2022 Canada Gairdner awards demonstrate the importance of fundamental science and its translation into improved human health and well-being.
    MeSH term(s) Awards and Prizes ; Biomedical Research ; Canada ; Child ; Family ; Global Health ; Humans
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.03.020
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  6. Article ; Online: Canada Gairdner Awards 2020: A Tightly Woven Tapestry of Discovery.

    Rossant, Janet

    Cell

    2020  Volume 181, Issue 3, Page(s) 507–508

    MeSH term(s) Awards and Prizes ; Biomedical Research/trends ; Canada ; History, 21st Century ; Humans
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2020.03.027
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  7. Article: Celebrating scientific excellence and global health impact: The 2022 Canada Gairdner Awards

    Rossant, Janet

    Cell. 2022 Apr. 14, v. 185, no. 8

    2022  

    Abstract: From mRNA vaccines to community interventions in global child health, the 2022 Canada Gairdner awards demonstrate the importance of fundamental science and its translation into improved human health and well- ... ...

    Abstract From mRNA vaccines to community interventions in global child health, the 2022 Canada Gairdner awards demonstrate the importance of fundamental science and its translation into improved human health and well-being
    Keywords cells ; child health ; community programs ; honors and awards ; social welfare ; vaccines ; Canada
    Language English
    Dates of publication 2022-0414
    Size p. 1287-1289.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.03.020
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  8. Article ; Online: Why researchers should use human embryo models with caution.

    Rossant, Janet / Fu, Jianping

    Nature

    2023  Volume 622, Issue 7983, Page(s) 454–456

    MeSH term(s) Embryo Research/ethics ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Human Embryonic Stem Cells/cytology ; Models, Biological ; Research Personnel/ethics ; Humans
    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-03062-x
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  9. Article ; Online: Early human embryonic development: Blastocyst formation to gastrulation.

    Rossant, Janet / Tam, Patrick P L

    Developmental cell

    2022  Volume 57, Issue 2, Page(s) 152–165

    Abstract: ... In this review, Rossant and Tam discuss new insights into human embryogenesis gathered from successes ...

    Abstract There has been recent renewed interest in studying human early embryonic development. The advent of improved culture conditions to maintain blastocysts in vitro for an extended period and the emerging stem-cell-based models of the blastocyst and peri-implantation embryos have provided new information that is relevant to early human embryogenesis. However, the mechanism of lineage development and embryonic patterning, and the molecular pathways involved in their regulation, are still not well understood. Interest in human embryonic development has been reinvigorated recently given numerous technical advances. In this review, Rossant and Tam discuss new insights into human embryogenesis gathered from successes in culturing human embryos in vitro and stem-cell-based embryo models. Then they outline what questions still need answering.
    MeSH term(s) Blastocyst/metabolism ; Blastocyst/physiology ; Body Patterning/physiology ; Cell Lineage ; Embryo Culture Techniques/methods ; Embryo, Mammalian/physiology ; Embryonic Development/physiology ; Embryonic Stem Cells/cytology ; Gastrulation/genetics ; Gastrulation/physiology ; Gene Expression Regulation, Developmental/genetics ; Humans
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.12.022
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  10. Article ; Online: Genetic Control of Early Cell Lineages in the Mammalian Embryo.

    Rossant, Janet

    Annual review of genetics

    2018  Volume 52, Page(s) 185–201

    Abstract: Establishing the different lineages of the early mammalian embryo takes place over several days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst contains the pluripotent cells of the epiblast, from which embryonic ... ...

    Abstract Establishing the different lineages of the early mammalian embryo takes place over several days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst contains the pluripotent cells of the epiblast, from which embryonic stem cells can be derived, as well as the extraembryonic lineages required for a mammalian embryo to survive in the uterine environment. The dynamics of the cellular and genetic interactions controlling the initiation and maintenance of these lineages in the mouse embryo are increasingly well understood through application of the tools of single-cell genomics, gene editing, and in vivo imaging. Exploring the similarities and differences between mouse and human development will be essential for translation of these findings into new insights into human biology, derivation of stem cells, and improvements in fertility treatments.
    MeSH term(s) Animals ; Cell Lineage/genetics ; Embryo, Mammalian ; Embryonic Development/genetics ; Embryonic Stem Cells/cytology ; Gene Editing ; Germ Layers/cytology ; Germ Layers/growth & development ; Humans ; Mice ; Pluripotent Stem Cells/cytology
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207928-8
    ISSN 1545-2948 ; 0066-4170 ; 0066-4197
    ISSN (online) 1545-2948
    ISSN 0066-4170 ; 0066-4197
    DOI 10.1146/annurev-genet-120116-024544
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