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Article ; Online: Unklare Minderung des Allgemeinzustandes bei Patientin mit Lungenkarzinom.

Brägelmann, J / Becker, S / Stenzel, D / Budahn, A

Innere Medizin (Heidelberg, Germany)

2024

Abstract: A 63-year-old female patient with lung cancer presented to our emergency room for the first time with a sudden reduction in general condition, vomiting and severe weakness. She stated that she was receiving chemotherapy for the lung cancer and reported ... ...

Title translation	Unexplained reduction in the general condition of a female lung cancer patient.
Abstract	A 63-year-old female patient with lung cancer presented to our emergency room for the first time with a sudden reduction in general condition, vomiting and severe weakness. She stated that she was receiving chemotherapy for the lung cancer and reported that she had no other relevant previous illnesses. Our initial suspected diagnosis was cytostatic-induced nausea and vomiting. Contrary to this suspected diagnosis, diagnostics carried out in the emergency room revealed the findings of ketoacidosis on the basis of an initial manifestation of diabetes mellitus with hyperglycemic decompensation as well as severe, manifest hypothyroidism. After obtaining the preliminary findings, it became evident that the patient was not receiving chemotherapy, but rather immune checkpoint therapy using durvalumab. The initial manifestations described were therefore to be viewed as immune reactions associated with durvalumab. After initiating diabetic recompensation therapy and substitution with L‑thyroxine, a rapid improvement in the patient's general condition was achieved.
Language	German
Publishing date	2024-01-19
Publishing country	Germany
Document type	English Abstract ; Journal Article
ISSN	2731-7099
ISSN (online)	2731-7099
DOI	10.1007/s00108-023-01652-5
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Article: Immunoglobulin variable region heptamer-nonamer recognition sequence joined to rearranged D-J segment: implications for the immunoglobulin recombinase mechanism.

Stenzel-Poore, M P / Rittenberg, M B

Journal of immunology (Baltimore, Md. : 1950)

1987 Volume 138, Issue 9, Page(s) 3055–3059

Abstract: ... in opposite transcriptional polarity to D. The latter is joined correctly at its 3' border to a joining (J ... chain variable region (VH) heptamer-nonamer recognition sequence is joined to the diversity segment (D ... the unusual joining event involving V-D. Linkage of the VH heptamer-nonamer recognition sequence to D has not ...

Abstract	We have found a novel immunoglobulin gene rearrangement in a murine hybridoma in which a heavy chain variable region (VH) heptamer-nonamer recognition sequence is joined to the diversity segment (D) through head-to-head fusion. The heptamer-nonamer recognition sequence and its adjacent 5' DNA are derived from the downstream flanking region of a germline VH gene. Sequence analysis indicates that this adjacent DNA is homologous to the downstream flank of VH108B, and it has characteristics of RNA processing that may suggest it was derived from an mRNA intermediate; these unusual features indicate that the segment is a processed gene. Because of head-to-head fusion, the recognition sequence and the flanking sequence are in opposite transcriptional polarity to D. The latter is joined correctly at its 3' border to a joining (J) gene segment. A gamma 1 constant region (but not mu) is located further downstream. Thus this fragment has several features common to normal immunoglobulin heavy chain gene rearrangement despite the unusual joining event involving V-D. Linkage of the VH heptamer-nonamer recognition sequence to D has not been observed previously. Although the recognition sequence described is inverted with respect to D and J, the endonucleolytic process that cleaved the recognition sequence at the 5' border of the heptamer before rearranging it to D was accurate. We suggest that of the three functions associated with the recombinase reaction; recognition, cutting, and ligation, only recognition and cutting may be limited to specific structures, and the ligation step may be less restricted because it is not confined to forming coding-to-coding or flank-to-flank joints. This aberrant ligation product suggests that the information leading to normal rearrangements may be found in structures that include more than the recognition sequences or coding regions alone, because the joining described here has spliced the incorrect end of a recognition sequence to a coding region to yield a nonproductive recombination.
MeSH term(s)	Animals ; Base Sequence ; DNA Nucleotidyltransferases/physiology ; Genes ; Hybridomas/physiology ; Immunoglobulin Heavy Chains/genetics ; Immunoglobulin Variable Region/genetics ; Mice ; Phosphorylcholine/immunology ; Recombination, Genetic ; Structure-Activity Relationship ; VDJ Recombinases
Chemical Substances	Immunoglobulin Heavy Chains ; Immunoglobulin Variable Region ; Phosphorylcholine (107-73-3) ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-)
Language	English
Publishing date	1987-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
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Article ; Online: 3D bioprinting of dual-crosslinked nanocellulose hydrogels for tissue engineering applications.

Monfared, Marzieh / Mawad, Damia / Rnjak-Kovacina, Jelena / Stenzel, Martina H

Journal of materials chemistry. B

2021 Volume 9, Issue 31, Page(s) 6163–6175

Abstract: Hydrogels based on cellulose nanofibrils (CNFs) have been widely used as scaffolds for biomedical applications, however, the poor mechanical properties of CNF hydrogels limit their use as ink for 3D bioprinting in order to generate scaffolds for tissue ... ...

Abstract	Hydrogels based on cellulose nanofibrils (CNFs) have been widely used as scaffolds for biomedical applications, however, the poor mechanical properties of CNF hydrogels limit their use as ink for 3D bioprinting in order to generate scaffolds for tissue engineering applications. In this study, a dual crosslinkable hydrogel ink composed of a poly(ethylene glycol) (PEG) star polymer and 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO)-oxidized nanocellulose fibers (CNFs) is presented. As the resulting hydrogel had low structural integrity, at first crosslinking of CNFs was introduced by Ca
MeSH term(s)	Animals ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Calcium/chemistry ; Cells, Cultured ; Cellulose/chemical synthesis ; Cellulose/chemistry ; Cross-Linking Reagents/chemical synthesis ; Cross-Linking Reagents/chemistry ; Hydrogels/chemical synthesis ; Hydrogels/chemistry ; Materials Testing ; Mice ; Molecular Structure ; Nanoparticles/chemistry ; Printing, Three-Dimensional ; Tissue Engineering ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Cross-Linking Reagents ; Hydrogels ; Cellulose (9004-34-6) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-07-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb00624j
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Article: The impact of full-fat

Tykałowski, Bartłomiej / Koncicki, Andrzej / Kowalczyk, Joanna / Śmiałek, Marcin / Bakuła, Tadeusz / Murawska, Daria / Sobotka, Wiesław / Stenzel, Tomasz

Journal of veterinary research

2023 Volume 67, Issue 2, Page(s) 197–207

Abstract: Introduction: Alternative protein sources have recently been attracting growing interest as potential components of livestock nutrition. This study evaluated the effect on broiler health of replacing the soybean protein component of poultry feed with ... ...

Abstract	Introduction: Alternative protein sources have recently been attracting growing interest as potential components of livestock nutrition. This study evaluated the effect on broiler health of replacing the soybean protein component of poultry feed with processed insect protein from farmed Material and methods: A total of 384 male broiler chicks were divided into four diet groups (eight pens/treatment and 12 birds/pen) and reared to the 42 Results: On the 42 Conclusion: The poorer production results and impaired health in experimental birds may indicate lower than 50% protein substitution with full-fat HI larvae meal to be optimal.
Language	English
Publishing date	2023-06-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.2478/jvetres-2023-0022
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Article: Advanced Ti-Nb-Ta Alloys for Bone Implants with Improved Functionality.

Sass, Jan-Oliver / Sellin, Marie-Luise / Kauertz, Elisa / Johannsen, Jan / Weinmann, Markus / Stenzel, Melanie / Frank, Marcus / Vogel, Danny / Bader, Rainer / Jonitz-Heincke, Anika

Journal of functional biomaterials

2024 Volume 15, Issue 2

Abstract: The additive manufacturing of titanium-niobium-tantalum alloys with nominal chemical compositions Ti-xNb-6Ta (x = 20, 27, 35) by means of laser beam powder bed fusion is reported, and their potential as implant materials is elaborated by mechanical and ... ...

Abstract	The additive manufacturing of titanium-niobium-tantalum alloys with nominal chemical compositions Ti-xNb-6Ta (x = 20, 27, 35) by means of laser beam powder bed fusion is reported, and their potential as implant materials is elaborated by mechanical and biological characterization. The properties of dense specimens manufactured in different build orientations and of open porous Ti-20Nb-6Ta specimens are evaluated. Compression tests indicate that strength and elasticity are influenced by the chemical composition and build orientation. The minimum elasticity is always observed in the 90° orientation. It is lowest for Ti-20Nb-6Ta (43.2 ± 2.7 GPa) and can be further reduced to 8.1 ± 1.0 GPa for open porous specimens (
Language	English
Publishing date	2024-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb15020046
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Article ; Online: An organotypic model of high-grade serous ovarian cancer to test the anti-metastatic potential of ROR2 targeted Polyion complex nanoparticles.

Joshi, Nidhi / Liu, Dongli / Dickson, Kristie-Ann / Marsh, Deborah J / Ford, Caroline E / Stenzel, Martina H

Journal of materials chemistry. B

2021 Volume 9, Issue 44, Page(s) 9123–9135

Abstract: High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy. Most patients are diagnosed at late stages when the tumour has metastasised throughout the peritoneal cavity. The Wnt receptor ROR2 has been identified as a promising ... ...

Abstract	High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological malignancy. Most patients are diagnosed at late stages when the tumour has metastasised throughout the peritoneal cavity. The Wnt receptor ROR2 has been identified as a promising therapeutic target in HGSOC, with limited targeting therapeutic options currently available. Small interfering RNA (siRNA)-based therapeutics hold great potential for inhibiting the function of specific biomarkers, however major challenges remain in efficient delivery and stability. The aim of this study was to investigate the ability of nanoparticles to deliver ROR2 siRNA into HGSOC cells, including platinum resistant models, and estimate the anti-metastatic effect
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Methacrylates/chemistry ; Nanoparticles/chemistry ; Nylons/chemistry ; Ovarian Neoplasms/drug therapy ; RNA, Small Interfering/chemistry ; RNA, Small Interfering/pharmacology ; Receptor Tyrosine Kinase-like Orphan Receptors/antagonists & inhibitors ; Receptor Tyrosine Kinase-like Orphan Receptors/genetics
Chemical Substances	Antineoplastic Agents ; Methacrylates ; Nylons ; RNA, Small Interfering ; poly(2-(dimethylamino)ethyl methacrylate) ; ROR2 protein, human (EC 2.7.10.1) ; Receptor Tyrosine Kinase-like Orphan Receptors (EC 2.7.10.1)
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb01837j
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Article: Effect of a Mineral-Microbial Deodorizing Preparation on the Functions of Internal Organs and the Immune System in Commercial Poultry.

Kowalczyk, Joanna / Tykałowski, Bartłomiej / Śmiałek, Marcin / Stenzel, Tomasz / Dziewulska, Daria / Koncicki, Andrzej

Animals : an open access journal from MDPI

2021 Volume 11, Issue 9

Abstract: Animal production is identified as one of the main sources of high concentrations of odours, which are related to air pollution, health problems of living organisms and indirect negative impact on production results. One common method for reducing ... ...

Abstract	Animal production is identified as one of the main sources of high concentrations of odours, which are related to air pollution, health problems of living organisms and indirect negative impact on production results. One common method for reducing emissions of ammonia is using preparations containing probiotics and hygroscopic or disinfecting compounds. This study was undertaken in order to determine the impact of innovative mineral-microbial deodorizing preparation, which reduces odorous gases, applying to the litter once a week in poultry houses on the physiological status of breeder chickens, broiler chickens and turkeys. Samples were collected after slaughter and analyzed using ELISA tests, flow cytometry and biochemical methods. Biochemical markers of the liver and kidney profile (ALT, AST, LDH, ALP, CK, TP, CALC, PHOS) and the titers of specific antibodies against AEV, aMPV, AAvV-1, IBDV, HEV, BA were analyzed in serum samples. The percentage contribution of T and B lymphocyte subpopulations was determined in the samples of tracheal mucosa, blood, and spleen. No significant differences were found between the control and experimental group with regard to all the analyzed parameters, with some exceptions for biochemistry. The results of our study indicated that mineral-microbial deodorizing preparation did not affect the physiological status of birds.
Language	English
Publishing date	2021-09-03
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11092592
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Article: Phytoncides in The Prevention and Therapy of Blackhead Disease and Their Effect on The Turkey Immune System.

Tykałowski, Bartłomiej / Śmiałek, Marcin / Kowalczyk, Joanna / Dziewulska, Daria / Stenzel, Tomasz / Koncicki, Andrzej

Journal of veterinary research

2021 Volume 65, Issue 1, Page(s) 79–85

Abstract: Introduction: Turkey histomonosis poses a serious threat to poultry production due to the ban on the use of effective drugs. The aim of the study was to evaluate the influence of a phytoncidal feed supplement on the course of histomonosis. The ... ...

Abstract	Introduction: Turkey histomonosis poses a serious threat to poultry production due to the ban on the use of effective drugs. The aim of the study was to evaluate the influence of a phytoncidal feed supplement on the course of histomonosis. The preparation was also analysed for immunomodulatory properties. Material and methods: Clinical observations and production monitoring were conducted in a flock of turkeys with histomonosis from their 11 Results: AdiCox Conclusion: AdiCox
Language	English
Publishing date	2021-01-29
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2855010-9
ISSN	2450-8608 ; 2450-7393
ISSN (online)	2450-8608
ISSN	2450-7393
DOI	10.2478/jvetres-2021-0010
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Article ; Online: MR Lymphangiography in Lymphatic Disorders: Clinical Applications, Institutional Experience, and Practice Development.

Negm, Ahmed S / Collins, Jeremy D / Bendel, Emily C / Takahashi, Edwin / Knavel Koepsel, Erica M / Gehling, Kathleen J / Burke, Courtney E / Barker, Devin R / Stenzel, Wayne S / Bathke, Angela M / Polites, Stephanie F / Abcejo, Arnoley S / Morris, Jonathan M / Favazza, Christopher / Lu, Aiming / François, Christopher J / Young, Phillip / Thompson, Scott M

Radiographics : a review publication of the Radiological Society of North America, Inc

2024 Volume 44, Issue 2, Page(s) e230075

Abstract: Lymphatic flow and anatomy can be challenging to study, owing to variable lymphatic anatomy in patients with diverse primary or secondary lymphatic pathologic conditions and the fact that lymphatic imaging is rarely performed in healthy individuals. The ... ...

Abstract	Lymphatic flow and anatomy can be challenging to study, owing to variable lymphatic anatomy in patients with diverse primary or secondary lymphatic pathologic conditions and the fact that lymphatic imaging is rarely performed in healthy individuals. The primary components of the lymphatic system outside the head and neck are the peripheral, retroperitoneal, mesenteric, hepatic, and pulmonary lymphatic systems and the thoracic duct. Multiple techniques have been developed for imaging components of the lymphatic system over the past century, with trade-offs in spatial, temporal, and contrast resolution; invasiveness; exposure to ionizing radiation; and the ability to obtain information on dynamic lymphatic flow. More recently, dynamic contrast-enhanced (DCE) MR lymphangiography (MRL) has emerged as a valuable tool for imaging both lymphatic flow and anatomy in a variety of congenital and acquired primary or secondary lymphatic disorders. The authors provide a brief overview of lymphatic physiology, anatomy, and imaging techniques. Next, an overview of DCE MRL and the development of an MRL practice and workflow in a hybrid interventional MRI suite incorporating cart-based in-room US is provided, with an emphasis on multidisciplinary collaboration. The spectrum of congenital and acquired lymphatic disorders encountered early in an MRL practice is provided, with emphasis on the diversity of imaging findings and how DCE MRL can aid in diagnosis and treatment of these patients. Methods such as DCE MRL for assessing the hepatic and mesenteric lymphatic systems and emerging technologies that may further expand DCE MRL use such as three-dimensional printing are introduced.
MeSH term(s)	Humans ; Lymphography/methods ; Contrast Media ; Magnetic Resonance Imaging/methods ; Lymphatic Diseases/diagnostic imaging ; Lymphatic Diseases/pathology ; Lymphatic System/pathology
Chemical Substances	Contrast Media
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.230075
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Article ; Online: Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands.

Zhang, Lin / Cao, Cheng / Kaushik, Natasha / Lai, Rebecca Y / Liao, Jiayan / Wang, Guannan / Ariotti, Nicholas / Jin, Dayong / Stenzel, Martina H

Biomacromolecules

2022 Volume 23, Issue 6, Page(s) 2572–2585

Abstract: The estrone ligand is used for modifying nanoparticle surfaces to improve their targeting effect on cancer cell lines. However, to date, there is no common agreement on the ideal linker length to be used for the optimum targeting performance. In this ... ...

Abstract	The estrone ligand is used for modifying nanoparticle surfaces to improve their targeting effect on cancer cell lines. However, to date, there is no common agreement on the ideal linker length to be used for the optimum targeting performance. In this study, we aimed to investigate the impact of poly(poly ethylene glycol methyl ether methacrylate) (PPEGMEMA) linker length on the cellular uptake behavior of polymer-coated upconverting nanoparticles (UCNPs). Different
MeSH term(s)	Estrone/pharmacology ; Humans ; Ligands ; Methacrylates ; Methyl Ethers ; Nanoparticles ; Polyethylene Glycols ; Polymers/pharmacology
Chemical Substances	Ligands ; Methacrylates ; Methyl Ethers ; Polymers ; Estrone (2DI9HA706A) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.2c00265
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