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  1. Article ; Online: Viral neuromyopathy associated with acute hepatitis B infection.

    Maramattom, Boby Varkey / Syed, Akheel A

    BMJ case reports

    2022  Volume 15, Issue 1

    Abstract: ... been reported. A 67-year-old man with acute hepatitis B infection developed a severe myalgia and ... the first report of an acute neuromyopathy associated with acute hepatitis B viral infection and ...

    Abstract Viral myositis is commonly seen with influenza and COVID-19 infections. While it has been described with acute viral hepatitis, concomitant involvement of the peripheral nerves causing a neuromyopathy has not been reported. A 67-year-old man with acute hepatitis B infection developed a severe myalgia and lower limb weakness around 1 month into his illness. Investigations revealed a neuromyopathy and rhabdomyolysis. MRI whole body with short tau inversion recovery sequences showed scattered muscle hyperintensities in the upper and lower limbs. He was treated with intravenous immunoglobulin and improved. This is the first report of an acute neuromyopathy associated with acute hepatitis B viral infection and demonstration of muscle MRI abnormalities in this condition.
    MeSH term(s) Aged ; COVID-19 ; Hepatitis B/complications ; Hepatitis B/drug therapy ; Humans ; Male ; Myositis ; Neuromuscular Diseases ; SARS-CoV-2
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-247203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: 'What is your occupation?': historical snippets.

    Varkey, Basil

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 2, Page(s) 63–64

    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spirometry, computed tomography, comorbidities, oxygen therapy and other topics in chronic obstructive pulmonary disease and an update on silicosis.

    Joshi, Manish / Varkey, Basil

    Current opinion in pulmonary medicine

    2024  Volume 30, Issue 2, Page(s) 119–120

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive ; Silicosis ; Spirometry ; Tomography ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001045
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  4. Article ; Online: Editorial: Palliative care considerations and ethical issues in the care of Covid-19 patients.

    Varkey, Basil

    Current opinion in pulmonary medicine

    2021  Volume 27, Issue 2, Page(s) 64–65

    MeSH term(s) COVID-19/therapy ; Ethics, Medical ; Health Care Rationing/ethics ; Humans ; Palliative Care/ethics ; Palliative Care/methods ; Personal Autonomy ; SARS-CoV-2 ; Social Justice/ethics ; Surveys and Questionnaires
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000753
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  5. Article ; Online: The potential risks of Legionella arising from ligature-resistant fixtures.

    Tarabay, Jessica / Varkey, Jay B

    American journal of infection control

    2023  Volume 52, Issue 3, Page(s) 344–348

    Abstract: To provide a safe environment, behavioral health settings must adhere to "ligature-resistant" protocols for patients at risk of harm to themselves or others. However, certain bathroom ligature-resistant fixtures alter environmental controls, such as ... ...

    Abstract To provide a safe environment, behavioral health settings must adhere to "ligature-resistant" protocols for patients at risk of harm to themselves or others. However, certain bathroom ligature-resistant fixtures alter environmental controls, such as sinks and showerheads, and increase the risk of water-borne pathogens due to low water output settings, highlighting the importance of an interdisciplinary water management program. We describe how ligature-resistant water fixtures may have been associated with a possible case of hospital-associated Legionellosis.
    MeSH term(s) Humans ; Legionella ; Water Supply ; Legionellosis ; Water ; Toilet Facilities ; Water Microbiology
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2023.08.007
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  6. Article ; Online: A novel antibody discovery platform identifies anti-influenza A broadly neutralizing antibodies from human memory B cells.

    Xiao, Xiaodong / Chen, Yan / Varkey, Reena / Kallewaard, Nicole / Koksal, Adem C / Zhu, Qing / Wu, Herren / Chowdhury, Partha S / Dall'Acqua, William F

    mAbs

    2016  Volume 8, Issue 5, Page(s) 916–927

    Abstract: Monoclonal antibody isolation directly from circulating human B cells is a powerful tool ... a platform aimed at improving the efficiencies of B cell selection and V gene recovery. Here, memory B ... was used to analyze variable (V) genes recovered from each B cell sample and identify the relevant ...

    Abstract Monoclonal antibody isolation directly from circulating human B cells is a powerful tool to delineate humoral responses to pathological conditions and discover antibody therapeutics. We have developed a platform aimed at improving the efficiencies of B cell selection and V gene recovery. Here, memory B cells are activated and amplified using Epstein-Barr virus infection, co-cultured with CHO-muCD40L cells, and then assessed by functional screenings. An in vitro transcription and translation (IVTT) approach was used to analyze variable (V) genes recovered from each B cell sample and identify the relevant heavy/light chain pair(s). We achieved efficient amplification and activation of memory B cells, and eliminated the need to: 1) seed B cells at clonal level (≤1 cell/well) or perform limited dilution cloning; 2) immortalize B cells; or 3) assemble V genes into an IgG expression vector to confirm the relevant heavy/light chain pairing. Cross-reactive antibodies targeting a conserved epitope on influenza A hemagglutinin were successfully isolated from a healthy donor. In-depth analysis of the isolated antibodies suggested their potential uses as anti-influenza A antibody therapeutics and uncovered a distinct affinity maturation pathway. Importantly, our results showed that cognate heavy/light chain pairings contributed to both the expression level and binding abilities of our newly isolated VH1-69 family, influenza A neutralizing antibodies, contrasting with previous observations that light chains do not significantly contribute to the function of this group of antibodies. Our results further suggest the potential use of the IVTT as a powerful antibody developability assessment tool.
    MeSH term(s) Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/immunology ; Antibodies, Viral/isolation & purification ; B-Lymphocytes/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Humans ; Immunologic Memory/immunology ; Immunologic Techniques/methods ; Influenza A virus/immunology ; Influenza, Human/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus
    Keywords covid19
    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0870
    ISSN (online) 1942-0870
    DOI 10.1080/19420862.2016.1170263
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  7. Article ; Online: Principles of Clinical Ethics and Their Application to Practice.

    Varkey, Basil

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2020  Volume 30, Issue 1, Page(s) 17–28

    Abstract: An overview of ethics and clinical ethics is presented in this review. The 4 main ethical principles, that is beneficence, nonmaleficence, autonomy, and justice, are defined and explained. Informed consent, truth-telling, and confidentiality spring from ... ...

    Abstract An overview of ethics and clinical ethics is presented in this review. The 4 main ethical principles, that is beneficence, nonmaleficence, autonomy, and justice, are defined and explained. Informed consent, truth-telling, and confidentiality spring from the principle of autonomy, and each of them is discussed. In patient care situations, not infrequently, there are conflicts between ethical principles (especially between beneficence and autonomy). A four-pronged systematic approach to ethical problem-solving and several illustrative cases of conflicts are presented. Comments following the cases highlight the ethical principles involved and clarify the resolution of these conflicts. A model for patient care, with caring as its central element, that integrates ethical aspects (intertwined with professionalism) with clinical and technical expertise desired of a physician is illustrated.
    MeSH term(s) Beneficence ; Confidentiality/ethics ; Ethics, Clinical ; Humans ; Informed Consent/ethics ; Morals ; Negotiating ; Patient-Centered Care/ethics ; Personal Autonomy ; Problem Solving ; Social Justice ; Truth Disclosure/ethics
    Language English
    Publishing date 2020-06-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000509119
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    Zs.A 2486: Show issues Location:
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  8. Article ; Online: Defining Euthanasia and the Need to be Circumspect in the Usage of the Term.

    Varkey, Basil

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2020  Volume 29, Issue 5, Page(s) 499–500

    MeSH term(s) Attitude ; Humans ; Kuwait ; Physicians
    Language English
    Publishing date 2020-07-09
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000508791
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  9. Article ; Online: Editorial: Silicosis, asbestos-related diseases, war-site exposures and a variety of topics in chronic obstructive pulmonary disease.

    Joshi, Manish / Varkey, Basil

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 2, Page(s) 61–62

    MeSH term(s) Humans ; Silicosis/etiology ; Asbestos/toxicity ; Pulmonary Disease, Chronic Obstructive/etiology
    Chemical Substances Asbestos (1332-21-4)
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000936
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  10. Article ; Online: Editorial: COPD in the COVID-19 era, challenging concepts and developments in COPD, and occupational exposures and susceptibilities.

    Joshi, Manish / Varkey, Basil

    Current opinion in pulmonary medicine

    2023  Volume 28, Issue 2, Page(s) 73–75

    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000855
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