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  1. Article ; Online: Management of Pyogenic Liver Abscesses: Contemporary Strategies and Challenges.

    Lam, John C / Stokes, William

    Journal of clinical gastroenterology

    2023  Volume 57, Issue 8, Page(s) 774–781

    Abstract: Pyogenic liver abscesses (PLAs) are a suppurative infection of the hepatic parenchyma responsible for significant morbidity and mortality. PLAs are categorized into a variety of mechanisms: (1) via the portal vein, (2) through the biliary tract, (3) via ... ...

    Abstract Pyogenic liver abscesses (PLAs) are a suppurative infection of the hepatic parenchyma responsible for significant morbidity and mortality. PLAs are categorized into a variety of mechanisms: (1) via the portal vein, (2) through the biliary tract, (3) via the hepatic artery, (4) from trauma, (5) contiguously via direct extension, and (6) cryptogenically. The pathogenesis of PLA, which informs treatment, can often be discerned based on host factors, clinical presentation, and causative microorganisms. The Streptococcus anginosus group, hypervirulent Klebsiella pneumoniae , and multidrug-resistant gram-negative pathogens have emerged as microbiologically challenging organisms to treat. The identification of hypervirulent K. pneumoniae should prompt for assessment for metastatic spread and consideration of prolonged antimicrobial treatment. Abdominal imaging is indispensable in characterizing PLAs and facilitating source control interventions. Source control remains the most critical aspect of PLA management, followed by antimicrobial therapy. Empiric antibiotics for PLAs are informed by the suspected etiology of PLA formation. Duration of antimicrobial therapy is individualized and dependent on multiple components, including the success of achieving source control, host factors, mechanism of PLA development, and the illness course of the individual-factoring in clinical, biochemical, and radiographic parameters.
    MeSH term(s) Humans ; Liver Abscess, Pyogenic/diagnosis ; Liver Abscess, Pyogenic/therapy ; Liver Abscess, Pyogenic/etiology ; Anti-Bacterial Agents/therapeutic use ; Klebsiella pneumoniae ; Polyesters ; Retrospective Studies
    Chemical Substances Anti-Bacterial Agents ; Polyesters
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000001871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1523: Show issues Location:
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  2. Article ; Online: Bleeding and clotting while supported with ECMO: time to move forward.

    Pratt, Elias H / Stokes, John W / Fan, Eddy

    Intensive care medicine

    2022  Volume 48, Issue 8, Page(s) 1059–1061

    MeSH term(s) Blood Coagulation ; Extracorporeal Membrane Oxygenation/adverse effects ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Retrospective Studies
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06805-y
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  3. Article ; Online: Extracorporeal Carbon Dioxide Removal or Extracorporeal Membrane Oxygenation: Why Should We Care?

    Stokes, John W / Gannon, Whitney D / Rice, Todd W

    Critical care medicine

    2021  Volume 49, Issue 5, Page(s) e546–e547

    MeSH term(s) Carbon Dioxide ; Extracorporeal Circulation ; Extracorporeal Membrane Oxygenation ; Humans ; Respiratory Distress Syndrome/therapy
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004844
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  4. Article ; Online: The Reply.

    Lam, John C / Stokes, William

    The American journal of medicine

    2022  Volume 136, Issue 4, Page(s) e77

    Language English
    Publishing date 2022-12-23
    Publishing country United States
    Document type Letter
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.12.004
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  5. Article ; Online: The Golden Grapes of Wrath - Staphylococcus aureus Bacteremia: A Clinical Review.

    Lam, John C / Stokes, William

    The American journal of medicine

    2022  Volume 136, Issue 1, Page(s) 19–26

    Abstract: Staphylococcus aureus bacteremia is common and associated with fatality rates approximating 25%. We provide a brief overview of S. aureus bacteremia from a clinical and microbiological lens and review the relevant evidence and literature gaps in its ... ...

    Abstract Staphylococcus aureus bacteremia is common and associated with fatality rates approximating 25%. We provide a brief overview of S. aureus bacteremia from a clinical and microbiological lens and review the relevant evidence and literature gaps in its management. Using a case-based approach, evidence and clinical judgement are meshed to highlight and justify the 5 core interventions that ought to be performed for all cases of S. aureus bacteremia: 1) appropriate anti-staphylococcal therapy, 2) screening echocardiography, 3) assessment for metastatic phenomena and source control, 4) decision on duration of antimicrobial therapy, and 5) Infectious Diseases consultation.
    MeSH term(s) Humans ; Staphylococcus aureus ; Vitis
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2022.09.017
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  6. Article: Altitude, latitude and climate zone as determinants of mountain hare (

    Stokes, Allan W / Hofmeester, Tim R / Thorsen, Neri H / Odden, John / Linnell, John D C / Pedersen, Simen

    Ecology and evolution

    2023  Volume 13, Issue 10, Page(s) e10548

    Abstract: Local adaptation to annually changing environments has evolved in numerous species. Seasonal coat colour change is an adaptation that has evolved in multiple mammal and bird species occupying areas that experience seasonal snow cover. It has a critical ... ...

    Abstract Local adaptation to annually changing environments has evolved in numerous species. Seasonal coat colour change is an adaptation that has evolved in multiple mammal and bird species occupying areas that experience seasonal snow cover. It has a critical impact on fitness as predation risk may increase when an individual is mismatched against its habitat's background colour. In this paper, we investigate the correlation between landscape covariates and moult timing in a native winter-adapted herbivore, the mountain hare (
    Language English
    Publishing date 2023-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10548
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  7. Article ; Online: Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplant.

    Stokes, John W / Gannon, Whitney D / Bacchetta, Matthew

    Seminars in respiratory and critical care medicine

    2021  Volume 42, Issue 3, Page(s) 380–391

    Abstract: Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary technology capable of supporting cardiac and respiratory function in the presence of end-stage lung disease. Initial experiences using ECMO as a bridge to lung transplant (ECMO-BTLT) were ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary technology capable of supporting cardiac and respiratory function in the presence of end-stage lung disease. Initial experiences using ECMO as a bridge to lung transplant (ECMO-BTLT) were characterized by high rates of ECMO-associated complications and poor posttransplant outcomes. More recently, ECMO-BTLT has garnered success in preserving patients' physiologic condition and candidacy prior to lung transplant due to technological advances and improved management. Despite recent growth, clinical practice surrounding use of ECMO-BTLT remains variable, with little data to inform optimal patient selection and management. Although many questions remain, the use of ECMO-BTLT has shown promising outcomes suggesting that ECMO-BTLT can be an effective strategy to ensure that complex and rapidly decompensating patients with end-stage lung disease can be safely transplanted with good outcomes. Further studies are needed to refine and inform practice patterns, management, and lung allocation in this high-risk and fragile patient population.
    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Lung Diseases/therapy ; Lung Transplantation ; Patient Selection ; Treatment Outcome
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0041-1728795
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    Zs.A 1555: Show issues Location:
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  8. Article ; Online: Rebuttal From Ms Gannon and Drs Stokes and Bacchetta.

    Gannon, Whitney D / Stokes, John W / Bacchetta, Matthew

    Chest

    2020  Volume 158, Issue 1, Page(s) 40–41

    MeSH term(s) Extracorporeal Membrane Oxygenation ; Humans ; Lung Diseases ; Lung Transplantation
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.11.055
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    Zs.MO 349: Show issues

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  9. Article ; Online: POINT: Should Patients With Advanced Lung Disease Be Offered Extracorporeal Membrane Oxygenation as a Bridge to Transplant If They Have Not Yet Been Listed for Lung Transplant? Yes.

    Gannon, Whitney D / Stokes, John W / Bacchetta, Matthew

    Chest

    2020  Volume 158, Issue 1, Page(s) 35–38

    MeSH term(s) Critical Care ; Extracorporeal Membrane Oxygenation ; Humans ; Lung Diseases/therapy ; Lung Transplantation ; Patient Selection ; Tissue and Organ Procurement ; Waiting Lists
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.12.049
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  10. Article ; Online: Impact of anticoagulation intensity on blood transfusion for venoarterial extracorporeal membrane oxygenation during lung transplantation.

    Tucker, William D / Gannon, Whitney D / Petree, Brandon / Stokes, John W / Kertai, Miklos D / Demarest, Caitlin T / Lambright, Eric S / Chae, Alice / Lombard, Frederick W / Casey, Jonathan D / Trindade, Anil J / Bacchetta, Matthew

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2024  

    Abstract: Venoarterial extracorporeal membrane oxygenation is increasingly used for mechanical circulatory support during lung transplant. Optimal intensity of intraoperative anticoagulation would be expected to mitigate thromboembolism without increasing bleeding ...

    Abstract Venoarterial extracorporeal membrane oxygenation is increasingly used for mechanical circulatory support during lung transplant. Optimal intensity of intraoperative anticoagulation would be expected to mitigate thromboembolism without increasing bleeding and blood product transfusions. Yet, the optimal intensity of intraoperative anticoagulation is unknown. We performed a retrospective cohort study of 163 patients who received a bilateral lung transplant at a single center. We categorized the intensity of anticoagulation into 4 groups (very low to high) based on the bolus dose of unfractionated heparin given during lung transplant and compared the rates of intraoperative blood transfusions and the occurrence of thromboembolism between groups. When compared to the very low-intensity group, each higher intensity group was associated with higher red blood cell, fresh frozen plasma, and platelet transfusions. The occurrence of thromboembolism was similar across groups. These preliminary data suggest that lower intensity anticoagulation may reduce the rate of intraoperative blood transfusions, although further study is needed.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2024.02.008
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