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  1. Article ; Online: Reconstruction of the left atrium for atrial fibrillation ablation using the machine learning CARTO 3 m-FAM software.

    Schwartz, Arie Lorin / Chorin, Ehud / Mann, Tomer / M, Yuval Levi / Hochstadt, Aviram / Margolis, Gilad / Viskin, Sami / Banai, Shmuel / Rosso, Raphael

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2021  Volume 64, Issue 1, Page(s) 39–47

    Abstract: ... LA) and pulmonary veins (PV). Model-based FAM (m-FAM) is a novel module recently developed ... the feasibility and safety of a m-FAM-guided AF ablation as well as the accuracy of LA reconstruction using ... referred for AF ablation.: Methods: Consecutive patients undergoing AF ablation. The m-FAM ...

    Abstract Purpose: Atrial fibrillation (AF) ablation requires a precise reconstruction of the left atrium (LA) and pulmonary veins (PV). Model-based FAM (m-FAM) is a novel module recently developed for the CARTO system which applies machine learning techniques to LA reconstruction. We aimed to evaluate the feasibility and safety of a m-FAM-guided AF ablation as well as the accuracy of LA reconstruction using the cardiac computed tomography angiography (CTA) of the same patient LA as the gold standard, in 32 patients referred for AF ablation.
    Methods: Consecutive patients undergoing AF ablation. The m-FAM reconstruction was performed with the ablation catheter (group 1) or a Pentaray and ablation catheters (group 2). The reconstruction accuracy was confirmed prior to the ablation by verification of pre-specified landmarks of the LA and PVs by an intracardiac echocardiogram (ICE) visualization and fluoroscopy. A cardiac CTA performed before the ablation was used as the gold standard of LA anatomy. For each patient, the m-FAM reconstruction was compared to his/her cardiac CTA.
    Results: The m-FAM reconstruction was accurate in all patients regardless of the catheter used for mapping. Twelve percent re-acquisition of the LA landmarks was necessary to improve the accuracy. m-FAM time was shorter in group 2 while the M-Fam fluoroscopy time was similar. Pulmonary vein isolation was achieved in 100% of patients without major complications. The m-FAM reconstructions accurately resemble the cardiac CTA of the same patients.
    Conclusions: The m-FAM module allows for rapid and precise reconstruction of the LA and PV anatomy, which can be safely used to guide AF ablation.
    MeSH term(s) Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Catheter Ablation/methods ; Female ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Humans ; Machine Learning ; Male ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Software ; Treatment Outcome
    Language English
    Publishing date 2021-08-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-021-01045-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Performance evaluation of the fully automated molecular system Alinity m in a high-throughput central laboratory.

    Galindo, Layla Testa / Hristov, Angélica Domingues / Gentil, Luciana Girotto / Scarpelli, Luciano / Santiago, José / Levi, José Eduardo

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2021  Volume 137, Page(s) 104786

    Abstract: ... To evaluate the analytical and clinical performance of the Alinity m system compared to the Abbott RealTime ... m2000 assay system in a large central molecular laboratory.: Study design: Alinity m HIV-1, HCV, and ... dilution panels. Clinical performance of the Alinity m and m2000 assay systems was compared using standard ...

    Abstract Background: New partially or fully automated molecular diagnostic testing platforms are being developed to address the growing demand for fast, accurate, and cost-effective testing.
    Objectives: To evaluate the analytical and clinical performance of the Alinity m system compared to the Abbott RealTime m2000 assay system in a large central molecular laboratory.
    Study design: Alinity m HIV-1, HCV, and HBV assay precision, reproducibility, and sensitivity were assessed using commercial customized dilution panels. Clinical performance of the Alinity m and m2000 assay systems was compared using standard lab protocols and residual, de-identified patient specimens. A workflow analysis of 1,068 samples compared turnaround times (TATs) on five m2000 systems and one Alinity m system running Alinity m HIV-1, HCV, HBV, HR HPV, and STI assays.
    Results: The Alinity m assay system demonstrated high detectability and precision at clinical decision points and excellent correlation with Abbott RealTime assay results. Processing TAT for 100 % of results was 117 min on Alinity m. Sample onboard TAT, from sample loading to 95 % of results, was 5:15 h for Alinity m and 7:30 h for m2000. 100 % of STAT samples were processed within 4 h on Alinity m. Total TAT for 100 % of results from all five assays was 80 h for m2000 versus 9 h for Alinity m.
    Conclusions: The Alinity m system produces assay results comparable to those of the Abbott RealTime m2000 system, but with significantly faster turnaround times due to continuous loading and the ability to run multiple assays simultaneously on the same sample.
    MeSH term(s) HIV-1/genetics ; Humans ; Laboratories ; Molecular Diagnostic Techniques ; Reproducibility of Results ; Sensitivity and Specificity
    Language English
    Publishing date 2021-03-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2021.104786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply to the letter to the editor 'European cancer mortality predictions for the year 2019 with focus on breast cancer, by Malvezzi M et al' by Marsden and Hamoda, On behalf of the British Menopause Society Medical Advisory Council.

    Malvezzi, M / Carioli, G / Bertuccio, P / Boffetta, P / Levi, F / La Vecchia, C / Negri, E

    Annals of oncology : official journal of the European Society for Medical Oncology

    2019  Volume 30, Issue 8, Page(s) 1394

    MeSH term(s) Breast Neoplasms ; Ethnic Groups ; Female ; Humans ; Menopause ; Rare Diseases
    Language English
    Publishing date 2019-05-09
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdz151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Levi Watkins, Jr., M.D.: In Memoriam.

    Watkins, Levi / Cason, Frederick D

    Journal of the National Medical Association

    2015  Volume 107, Issue 2, Page(s) 119–120

    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 419737-9
    ISSN 0027-9684
    ISSN 0027-9684
    DOI 10.1016/S0027-9684(15)30035-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Melphalan 200 mg/m(2) versus melphalan 100 mg/m(2) in newly diagnosed myeloma patients: a prospective, multicenter phase 3 study.

    Palumbo, Antonio / Bringhen, Sara / Bruno, Benedetto / Falcone, Antonietta Pia / Liberati, Anna Marina / Grasso, Mariella / Ria, Roberto / Pisani, Francesco / Cangialosi, Clotilde / Caravita, Tommaso / Levi, Anna / Meloni, Giovanna / Nozza, Andrea / Pregno, Patrizia / Gabbas, Attilio / Callea, Vincenzo / Rizzo, Manuela / Annino, Luciana / De Stefano, Valerio /
    Musto, Pellegrino / Baldi, Ileana / Cavallo, Federica / Petrucci, Maria Teresa / Massaia, Massimo / Boccadoro, Mario

    Blood

    2009  Volume 115, Issue 10, Page(s) 1873–1879

    Abstract: High-dose (200 mg/m(2), MEL200) and intermediate-dose melphalan (100 mg/m(2), MEL100) showed ...

    Abstract High-dose (200 mg/m(2), MEL200) and intermediate-dose melphalan (100 mg/m(2), MEL100) showed significant activity in myeloma. In a phase 3 study, 298 patients were randomly assigned to receive 2 autologous transplantations after conditioning with MEL200 or MEL100. Ninety-six of 149 (64%) completed MEL200 and 103 of 149 (69%) MEL100. Best response to MEL200 was: complete remission 22 of 149 (15%); partial remission 95 of 149 (64%), for an overall response rate of 79%. Best response to MEL100 was: complete remission 12 of 149 (8%); partial remission 95 of 149 (64%), for an overall response rate of 72%. Overall survival did not differ (P = .13); median progression-free survival (31.4 vs 26.2 months, P = .01), median time to progression (34.4 vs 27.0 months, P = .014) were longer in the MEL200. Treatment-related mortality was 3.1% in the MEL200 and 2.9% in the MEL100 group. Severe neutropenia and infections were marginally superior, whereas severe thrombocytopenia, mucositis, gastrointestinal adverse events, and the overall occurrence of at least 1 nonhematologic grade 3 or 4 adverse event were significantly higher in the MEL200 cohort. We conclude that MEL200 leads to longer remission duration and should be considered the standard conditioning regimen for autologous transplantation. This study was registered at www.clinicaltrials.gov as #NCT00950768.
    MeSH term(s) Adult ; Aged ; Algorithms ; Antigens, CD34/metabolism ; Antineoplastic Agents, Alkylating/administration & dosage ; Bone Marrow Transplantation/immunology ; Bone Marrow Transplantation/methods ; Combined Modality Therapy ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Melphalan/administration & dosage ; Middle Aged ; Multiple Myeloma/mortality ; Multiple Myeloma/therapy ; Myeloablative Agonists/administration & dosage ; Neoadjuvant Therapy ; Transplantation Conditioning/methods ; Transplantation, Autologous
    Chemical Substances Antigens, CD34 ; Antineoplastic Agents, Alkylating ; Myeloablative Agonists ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2009-12-01
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2009-09-241737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluación funcional no-invasiva de la reserva ante la fatiga y la estructura del diafragma mediante ecografía transtorácica en modos B y M.

    Orozco-Levi, Mauricio / Gayete, Angel / Rodríguez, Cristina / Ramírez-Sarmiento, Alba / Méndez, Raúl / Tous, Francesc / Vollmer, Ivan / Gea, Joaquim / Molina, Luis

    Archivos de bronconeumologia

    2010  Volume 46, Issue 11, Page(s) 571–579

    Abstract: Unlabelled: The diaphragm is the principal respiratory muscle. Its special characteristics have made it difficult to design instruments capable of performing a non-invasive evaluation of its structure and function in humans. The present study was ... ...

    Title translation Non-invasive functional evaluation of the reserve in fatigue and the diaphragm structure using transthoracic echography in B and M modes.
    Abstract Unlabelled: The diaphragm is the principal respiratory muscle. Its special characteristics have made it difficult to design instruments capable of performing a non-invasive evaluation of its structure and function in humans. The present study was designed to evaluate the potential use of echography as a non-invasive method to fulfil these objectives.
    Methods: The study consisted of three phases: (1) echographic study in autopsy samples (n=10) of a segment of the thoracic-abdominal wall, from the bottom to the parietal peritoneum (i.e., thoracic wall, diaphragm, pleura and peritoneum structures), (2) static echographic study of the previous structures and the diaphragm in healthy subjects (n=10) to standardised lung volumes; and (3) dynamic echographic study of the contraction-relaxation of the diaphragm in the same subjects, calculating its maximum velocity of relaxation (MVrdi, mm/sec) during a specific inspiratory resistance test.
    Results: The echography enabled the pleural and peritoneal limits of the diaphragm to be identified, and quantitate its thickness (Tdi), both ex-vivo and in-vivo, in all cases. The dynamic study of the Tdi showed a linear increase directly associated with the lung volume measurement, as well as a cyclical increase during inspiratory movements at rest. In the resistance test, the MVrdi was maximal with low loads and gradually decrease until reaching a minimum nadir (Δ≈-70% of the initial value) in claudication (fatigue). The MVrdi has a high precision in diagnosing claudication.
    Conclusions: Transthoracic echography of the diaphragm is a non-invasive method that gives promising results in the structural and functional evaluation (i.e. fatigue risk) of that muscle. These findings are of pathophysiological interest and could be of use in the clinical care context.
    MeSH term(s) Adult ; Cross-Sectional Studies ; Diaphragm/anatomy & histology ; Diaphragm/diagnostic imaging ; Diaphragm/physiology ; Echocardiography/methods ; Humans ; Male ; Muscle Fatigue/physiology ; Respiratory Function Tests
    Language Spanish
    Publishing date 2010-11
    Publishing country Spain
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2010.08.002
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  7. Article ; Online: Downs-Canner S, Zabor EC, Wind T, Cobovic A, McCormick B, Morrow M, Heerdt A-Radiation Therapy After Breast-Conserving Surgery in Women 70 Years of Age and Older: How Wisely Do We Choose? In Regard to Downs-Canner et al.

    Hannoun-Levi, Jean-Michel / Hannoun, Arthur

    Annals of surgical oncology

    2019  Volume 26, Issue Suppl 3, Page(s) 859–860

    MeSH term(s) Aged ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy, Segmental ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-019-07762-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Osorio García, M. y Á. López López (coord.

    Liliana López Levi

    Investigaciones Geográficas, Vol 0, Iss

    2012), Investigación turística. Hallazgos y aportaciones, Secretaría de Turismo-Centro de Estudios Superiores en Turismo, Facultad de Turismo y Gastronomía-Universidad Autónoma del Estado de México.

    2013  Volume 80

    Keywords Geography. Anthropology. Recreation ; G ; Geography (General) ; G1-922
    Language English
    Publishing date 2013-04-01T00:00:00Z
    Publisher Universidad Nacional Autónoma de México
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Osorio García, M. y Á. López López (coord.

    Liliana López Levi

    Investigaciones Geográficas, Iss 80, Pp 142-

    2012), Investigación turística. Hallazgos y aportaciones, Secretaría de Turismo-Centro de Estudios Superiores en Turismo, Facultad de Turismo y Gastronomía-Universidad Autónoma del Estado de México, Instituto de Geografía-Universidad Nacional Autónoma de México, Asociación Mexicana de Investigación Turística, México, 318 p., ISBN 978-607-422-269-2

    2013  Volume 144

    Keywords Geography (General) ; G1-922 ; Geography. Anthropology. Recreation ; G
    Language Spanish
    Publishing date 2013-01-01T00:00:00Z
    Publisher Universidad Nacional Autónoma de México
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Osorio García, M. y Á. López López (coord.

    Liliana López Levi

    Investigaciones Geográficas, Iss 80, Pp 142-

    2012), Investigación turística. Hallazgos y aportaciones, Secretaría de Turismo-Centro de Estudios Superiores en Turismo, Facultad de Turismo y Gastronomía-Universidad Autónoma del Estado de México, Instituto de Geografía-Universidad Nacional Autónoma de México, Asociación Mexicana de Investigación Turística, México, 318 p., ISBN 978-607-422-269-2

    2013  Volume 144

    Keywords Geography. Anthropology. Recreation ; G ; Geography (General) ; G1-922
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Universidad Nacional Autónoma de México
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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