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  1. Article ; Online: BAX and BAK dynamics control mitochondrial DNA release during apoptosis.

    Yamazaki, Takahiro / Galluzzi, Lorenzo

    Cell death and differentiation

    2022  Volume 29, Issue 6, Page(s) 1296–1298

    MeSH term(s) Apoptosis/genetics ; DNA, Mitochondrial/genetics ; Mitochondria/genetics ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2-Associated X Protein/genetics
    Chemical Substances DNA, Mitochondrial ; bcl-2 Homologous Antagonist-Killer Protein ; bcl-2-Associated X Protein
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-022-00985-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 80: Show issues

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  2. Article ; Online: Molecular determinants of immunogenic cell death elicited by radiation therapy

    Galassi, Claudia / Klapp, Vanessa / Yamazaki, Takahiro / Galluzzi, Lorenzo

    Immunological Reviews. 2024 Jan., v. 321, no. 1 p.20-32

    2024  

    Abstract: Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell‐associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along ... ...

    Abstract Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell‐associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along with the emission of immunostimulatory cytokines and damage‐associated molecular patterns (DAMPs) that actively engage immune effector mechanisms (adjuvanticity), and (3) the microenvironment of dying cells is permissive for the initiation of adaptive immunity. Finally, ICD‐driven immune responses can only operate and exert cytotoxic effector functions if the microenvironment of target cancer cells enables immune cell infiltration and activity. Multiple forms of radiation, including non‐ionizing (ultraviolet) and ionizing radiation, elicit bona fide ICD as they increase both the antigenicity and adjuvanticity of dying cancer cells. Here, we review the molecular determinants of ICD as elicited by radiation as we critically discuss strategies to reinforce the immunogenicity of cancer cells succumbing to clinically available radiation strategies.
    Keywords adjuvants ; cell death ; cytokines ; cytotoxicity ; immunogenicity ; immunostimulants ; radiotherapy
    Language English
    Dates of publication 2024-01
    Size p. 20-32.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13271
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
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  3. Article ; Online: Multifaceted surgical approach of combined thoracoretroperitoneal incision and midline abdominal incision for a secondary aortoenteric fistula.

    Minami, Tomoyuki / Kojima, Takahiro / Yabu, Naoto / Yamazaki, Ichiya / Saito, Aya

    Journal of cardiothoracic surgery

    2024  Volume 19, Issue 1, Page(s) 29

    Abstract: Background: We report a one-stage surgery to the case of secondary aortoenteric fistula (sAEF) after prosthetic reconstruction of abdominal aortic aneurysm, by multifaceted approach.: Case presentation: A 63-year-old male was admitted to our unit ... ...

    Abstract Background: We report a one-stage surgery to the case of secondary aortoenteric fistula (sAEF) after prosthetic reconstruction of abdominal aortic aneurysm, by multifaceted approach.
    Case presentation: A 63-year-old male was admitted to our unit under diagnosed of sAEF after prosthetic reconstruction of abdominal aortic aneurysm, and a pseudoaneurysm of thoracoabdominal aorta due to infection. The patient underwent emergency operation. Firstly, we placed the patient in a modified right lateral decubitus position and performed thoracoabdominal aortic replacement with retroperitoneal approach by thoracoretroperitoneal incision which combined thoracotomy and pararectal incision, and secondly, we changed to a supine position and performed closure of the duodenal fistula and omental flap transposition by midline abdominal incision. The patient was doing well without complications.
    Conclusions: A one-stage, multifaceted surgical approach covering both prosthetic reconstruction of thoracoabdominal aorta and closure of sAEF with omentopexy is reasonable and useful strategy.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aortic Diseases/surgery ; Aortic Diseases/etiology ; Intestinal Fistula/etiology ; Intestinal Fistula/surgery ; Aortic Aneurysm, Abdominal/surgery ; Aortic Aneurysm, Abdominal/complications ; Aorta/surgery ; Duodenal Diseases/complications ; Duodenal Diseases/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Surgical Wound ; Vascular Fistula/surgery ; Vascular Fistula/complications ; Aorta, Abdominal/surgery
    Language English
    Publishing date 2024-01-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-024-02496-2
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  4. Article: A Rare Case of Spindle Cell Hemangioma in the Palmar Region.

    Yamazaki, Takahiro / Matsuura, Yusuke / Ohtori, Seiji

    Cureus

    2023  Volume 15, Issue 11, Page(s) e48524

    Abstract: Spindle cell hemangioma (SCH) is an exceptionally uncommon vascular neoplasm, primarily manifesting on the extremities. This article delves into a singular case of a 20-year-old female presenting with erythema and discomfort in the left palm, diagnosed ... ...

    Abstract Spindle cell hemangioma (SCH) is an exceptionally uncommon vascular neoplasm, primarily manifesting on the extremities. This article delves into a singular case of a 20-year-old female presenting with erythema and discomfort in the left palm, diagnosed with SCH. Post-consultation with a dermatologic neoplasm consortium, she underwent a comprehensive excision, followed by a bi-phasic skin graft. Despite non-clear surgical perimeters, the patient, five years post-procedure, has experienced neither re-emergence nor functional encumbrance. The discussion emphasizes the notable recurrence propensity of SCH, with a historical recurrence rate surpassing 50%, and underscores the importance of an interdisciplinary strategy, enduring surveillance, and bespoke therapeutic decisions for management. The paper concludes by advocating for augmented research and expansive case compilations to enhance therapeutic paradigms for such atypical vascular lesions.
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.48524
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  5. Article ; Online: Urban agriculture in walkable neighborhoods bore fruit for health and food system resilience during the COVID-19 pandemic.

    Iida, Akiko / Yamazaki, Takahiro / Hino, Kimihiro / Yokohari, Makoto

    npj urban sustainability

    2023  Volume 3, Issue 1, Page(s) 4

    Abstract: Urban agriculture is the key to creating healthy cities and developing resilient urban food systems in uncertain times. However, relevant empirical evidence is limited. This study quantitatively verified the association of access to local food through ... ...

    Abstract Urban agriculture is the key to creating healthy cities and developing resilient urban food systems in uncertain times. However, relevant empirical evidence is limited. This study quantitatively verified the association of access to local food through urban agriculture with subjective well-being, physical activity, and food security concerns of neighborhood communities in the context of the COVID-19 pandemic. The target was Tokyo, Japan, where small-scale local food systems are widespread in walkable neighborhoods. We found that diversity in local food access, ranging from self-cultivation to direct-to-consumer sales, was significantly associated with health and food security variables. In particular, the use of allotment farms was more strongly associated with subjective well-being than the use of urban parks, and it was more strongly associated with the mitigation of food security concerns than the use of food retailers. These findings provide robust evidence for the effectiveness of integrating urban agriculture into walkable neighborhoods.
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ISSN 2661-8001
    ISSN (online) 2661-8001
    DOI 10.1038/s42949-023-00083-3
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  6. Article ; Online: Molecular determinants of immunogenic cell death elicited by radiation therapy.

    Galassi, Claudia / Klapp, Vanessa / Yamazaki, Takahiro / Galluzzi, Lorenzo

    Immunological reviews

    2023  Volume 321, Issue 1, Page(s) 20–32

    Abstract: Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell-associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along ... ...

    Abstract Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune responses against dead cell-associated antigens, provided that (1) said antigens are not perfectly covered by central tolerance (antigenicity), (2) cell death occurs along with the emission of immunostimulatory cytokines and damage-associated molecular patterns (DAMPs) that actively engage immune effector mechanisms (adjuvanticity), and (3) the microenvironment of dying cells is permissive for the initiation of adaptive immunity. Finally, ICD-driven immune responses can only operate and exert cytotoxic effector functions if the microenvironment of target cancer cells enables immune cell infiltration and activity. Multiple forms of radiation, including non-ionizing (ultraviolet) and ionizing radiation, elicit bona fide ICD as they increase both the antigenicity and adjuvanticity of dying cancer cells. Here, we review the molecular determinants of ICD as elicited by radiation as we critically discuss strategies to reinforce the immunogenicity of cancer cells succumbing to clinically available radiation strategies.
    MeSH term(s) Humans ; Immunogenic Cell Death ; Neoplasms ; Cell Death ; Antineoplastic Agents ; Adaptive Immunity ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13271
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  7. Article ; Online: Venous outflow reconstruction in living-donor liver transplantation for Budd-Chiari syndrome involving vena cava.

    Hata, Koichiro / Nishio, Takahiro / Kumagai, Motoyuki / Masano, Yuki / Kageyama, Shoichi / Okumura, Shinya / Ito, Takashi / Yamazaki, Kazuhiro / Minatoya, Kenji / Hatano, Etsuro

    Journal of hepato-biliary-pancreatic sciences

    2024  

    Language English
    Publishing date 2024-03-24
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 2536236-7
    ISSN 1868-6982 ; 1868-6974
    ISSN (online) 1868-6982
    ISSN 1868-6974
    DOI 10.1002/jhbp.1430
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4024: Show issues Location:
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  8. Article ; Online: T cell-independent abscopal responses to radiotherapy.

    Guilbaud, Emma / Yamazaki, Takahiro / Galluzzi, Lorenzo

    Trends in cancer

    2022  Volume 9, Issue 2, Page(s) 93–95

    Abstract: When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral ... ...

    Abstract When used according to specific dose/fractionation schedules, focal radiotherapy can elicit a systemic anticancer immune response that limits the growth of distant, non-irradiated tumors. Recent data suggest that, at least in some settings, intratumoral macrophages can be educated by CD47 blockage to promote such an 'abscopal' response independent of CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Neoplasms/pathology ; Dose Fractionation, Radiation
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.12.005
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  9. Article: Insect growth-regulating activity of 1-benzyl-2-methylbenzimidazole derivatives on silkworms.

    Henmi, Shuhei / Sueyoshi, Ayumu / Ono, Hiroshi / Yamazaki, Toshimasa / Inoue, Konatsu / Shiotsuki, Takahiro

    Journal of pesticide science

    2023  Volume 48, Issue 3, Page(s) 99–106

    Abstract: Derivatives of 1-benzyl-2-methylbenzimidazoles (BMBIs) were synthesized to evaluate their biological activities ... ...

    Abstract Derivatives of 1-benzyl-2-methylbenzimidazoles (BMBIs) were synthesized to evaluate their biological activities against
    Language English
    Publishing date 2023-09-25
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 437867-2
    ISSN 1348-589X ; 2187-0365 ; 0916-9962 ; 0385-1559
    ISSN 1348-589X ; 2187-0365 ; 0916-9962 ; 0385-1559
    DOI 10.1584/jpestics.D23-010
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  10. Article ; Online: Cryptogenic organizing pneumonia in an infant.

    Sato, Shunsuke / Yamazaki, Susumu / Suzuki, Kyoko / Kudo, Takahiro / Ohtomo, Yoshiyuki / Shimizu, Toshiaki

    Pediatric pulmonology

    2023  Volume 58, Issue 4, Page(s) 1275–1277

    MeSH term(s) Humans ; Infant ; Organizing Pneumonia ; Cryptogenic Organizing Pneumonia/diagnostic imaging ; Cryptogenic Organizing Pneumonia/drug therapy ; Lung
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.26313
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