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  1. Article: Blocking PCNA interaction with NKp44 enhances primary natural killer cell-mediated lysis of triple-negative breast cancer cells.

    Marrufo, Armando M / Mathew, Stephen O / Chaudhary, Pankaj / Malaer, Joseph D / Ahmed, Nourhan / Vishwanatha, Jamboor K / Mathew, Porunelloor A

    American journal of cancer research

    2023  Volume 13, Issue 3, Page(s) 1082–1090

    Abstract: Among the innate immune cells, natural killer cells (NK) serve its role in cytolytic targeting against infected and cancerous cells. NK function is regulated by an intricate balance of signals from interactions between activating and inhibitory NK ... ...

    Abstract Among the innate immune cells, natural killer cells (NK) serve its role in cytolytic targeting against infected and cancerous cells. NK function is regulated by an intricate balance of signals from interactions between activating and inhibitory NK receptors and ligands expressed on target cells. As an immune evasion strategy, cancer cells, particularly triple-negative breast cancer cells (TNBCs), express ligands that interact with NK receptors to inhibit NK cell cytolytic function. Our studies have revealed that Proliferating Cell Nuclear Antigen (PCNA), normally expressed in the nucleus with DNA replication and repair roles, was present on the cell surface of TNBC cell lines MDA-MB-231, -436, and -468. To elucidate the function of cell surface PCNA, we blocked PCNA on TNBCs with antibodies which both disrupted interaction with NKp44 and enhanced lysis by primary NK cells. Furthermore, a combinational antibody treatment of TNBCs with α-LLT1 and α-PCNA antibodies augments NK-mediated lysis. These results together suggest that cell surface PCNA on TNBCs enables evasion from cytolytic killing by NK cells. Blocking PCNA-NKp44 interaction with antibodies may potentially open an additional avenue in treatment of TNBCs.
    Language English
    Publishing date 2023-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 2B4 (CD244, SLAMF4) and CS1 (CD319, SLAMF7) in systemic lupus erythematosus and cancer.

    Malaer, Joseph D / Marrufo, Armando M / Mathew, Porunelloor A

    Clinical immunology (Orlando, Fla.)

    2018  Volume 204, Page(s) 50–56

    Abstract: Signaling Lymphocyte Activation Molecule (SLAM) family receptors are expressed on different types of hematopoietic cells and play important role in immune regulation in health and disease. 2B4 (CD244, SLAMF4) and CS1 (CD319, CRACC, SLAMF7) were ... ...

    Abstract Signaling Lymphocyte Activation Molecule (SLAM) family receptors are expressed on different types of hematopoietic cells and play important role in immune regulation in health and disease. 2B4 (CD244, SLAMF4) and CS1 (CD319, CRACC, SLAMF7) were originally identified as NK cell receptors regulating NK cell cytolytic activity. 2B4 is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. Unlike other activating and inhibitory receptors, 2B4 (CD244) interaction with its ligand CD48 has been shown to mediate both activating and inhibitory functions. Defective signaling via 2B4 due to mutations in signaling adaptor SAP contributes to X-linked lymphoproliferative Disease (XLP). Expression of 2B4 and CS1 are altered in systemic lupus erythematosus (SLE). CS1 is overexpressed in multiple myeloma (MM) and anti-CS1 mab (Elotuzumab/Empliciti) has been approved by FDA as a breakthrough drug for treatment for MM patients. CAR -T cells or CAR- NK cells containing full length CS1 or the signaling domain of 2B4 with TCR-ζ have shown promising results to treat cancer and autoimmune diseases.
    MeSH term(s) Animals ; Humans ; Lupus Erythematosus, Systemic/immunology ; Neoplasms/immunology ; Signaling Lymphocytic Activation Molecule Family/immunology
    Chemical Substances CD244 protein, human ; SLAMF7 protein, human ; Signaling Lymphocytic Activation Molecule Family
    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2018.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Complete Genome Sequence of Salmonella enterica Serovar Heidelberg Siphophage Sepoy.

    Marrufo, Armando M / Zeng, Chi / O'Leary, Chandler / Lessor, Lauren / Kongari, Rohit / Gill, Jason / Liu, Mei

    Microbiology resource announcements

    2019  Volume 8, Issue 30

    Abstract: Phage Sepoy ... ...

    Abstract Phage Sepoy infects
    Language English
    Publishing date 2019-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00680-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Blocking LLT1 (CLEC2D, OCIL)-NKRP1A (CD161) interaction enhances natural killer cell-mediated lysis of triple-negative breast cancer cells.

    Marrufo, Armando M / Mathew, Stephen O / Chaudhary, Pankaj / Malaer, Joseph D / Vishwanatha, Jamboor K / Mathew, Porunelloor A

    American journal of cancer research

    2018  Volume 8, Issue 6, Page(s) 1050–1063

    Abstract: Triple-negative breast cancer (TNBC) is the most invasive form of breast cancer due to an absence of estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptors on the cell surface. TNBC accounts for approximately 12 to 20 ... ...

    Abstract Triple-negative breast cancer (TNBC) is the most invasive form of breast cancer due to an absence of estrogen (ER), progesterone (PR), and human epidermal growth factor-2 (HER2) receptors on the cell surface. TNBC accounts for approximately 12 to 20 percent of all breast cancer cases. The absence of ER, PR, and HER2 receptors on TNBCs and its ability to develop drug resistance renders it difficult to eradicate or retrogress tumor growth with hormonal therapy and chemotherapy. Triple-negative breast cancer is associated with poorer prognosis, increased chance of relapse, and lower chance of survival. Patients with TNBC have poorer outcome to conventional treatments than patients with other types of breast cancer. Natural killer cell-mediated immunotherapy is a promising therapeutic option for patients with TNBC. Natural killer cells contribute to the immune system by recognizing tumor cells through interactions between ligands on tumor cells and natural killer cell receptors. NK cell function is regulated by a net balance of signals from activating and inhibitory receptors interacting with ligands on target cells. Lectin-like Transcript-1 (LLT1, CLEC2D, OCIL) is a ligand that interacts with NK cell receptor NKRP1A (CD161) and inhibits NK cell activation. In this study, we have identified expression of LLT1 on TNBC cell lines MDA-MB-231 and MDA-MB-436 through flow cytometry, western blot, and confocal microscopy. We have demonstrated that blocking LLT1 on TNBCs with antibodies disrupts interaction with NKRP1A and enhances lysis of TNBCs by primary natural killer cells. We have also shown that a gene knockdown of
    Language English
    Publishing date 2018-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: SARS-CoV-2's brain impact: revealing cortical and cerebellar differences via cluster analysis in COVID-19 recovered patients.

    Romero-Molina, Angel Omar / Ramirez-Garcia, Gabriel / Chirino-Perez, Amanda / Fuentes-Zavaleta, David Alejandro / Hernandez-Castillo, Carlos Roberto / Marrufo-Melendez, Oscar / Lopez-Gonzalez, Diana / Rodriguez-Rodriguez, Mónica / Castorena-Maldonado, Armando / Rodriguez-Agudelo, Yaneth / Paz-Rodriguez, Francisco / Chavez-Oliveros, Mireya / Lozano-Tovar, Susana / Gutierrez-Romero, Alonso / Arauz-Gongora, Antonio / Garcia-Santos, Raul Anwar / Fernandez-Ruiz, Juan

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2024  Volume 45, Issue 3, Page(s) 837–848

    Abstract: Background: COVID-19 is a disease known for its neurological involvement. SARS-CoV-2 infection triggers neuroinflammation, which could significantly contribute to the development of long-term neurological symptoms and structural alterations in the gray ... ...

    Abstract Background: COVID-19 is a disease known for its neurological involvement. SARS-CoV-2 infection triggers neuroinflammation, which could significantly contribute to the development of long-term neurological symptoms and structural alterations in the gray matter. However, the existence of a consistent pattern of cerebral atrophy remains uncertain.
    Objective: Our study aimed to identify patterns of brain involvement in recovered COVID-19 patients and explore potential relationships with clinical variables during hospitalization.
    Methodology: In this study, we included 39 recovered patients and 39 controls from a pre-pandemic database to ensure their non-exposure to the virus. We obtained clinical data of the patients during hospitalization, and 3 months later; in addition we obtained T1-weighted magnetic resonance images and performed standard screening cognitive tests.
    Results: We identified two groups of recovered patients based on a cluster analysis of the significant cortical thickness differences between patients and controls. Group 1 displayed significant cortical thickness differences in specific cerebral regions, while Group 2 exhibited significant differences in the cerebellum, though neither group showed cognitive deterioration at the group level. Notably, Group 1 showed a tendency of higher D-dimer values during hospitalization compared to Group 2, prior to p-value correction.
    Conclusion: This data-driven division into two groups based on the brain structural differences, and the possible link to D-dimer values may provide insights into the underlying mechanisms of SARS-COV-2 neurological disruption and its impact on the brain during and after recovery from the disease.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/pathology ; SARS-CoV-2 ; Brain/diagnostic imaging ; Cerebellum/pathology ; Cluster Analysis
    Language English
    Publishing date 2024-01-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-07266-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Genetic Analysis of the Lambda Spanins Rz and Rz1: Identification of Functional Domains.

    Cahill, Jesse / Rajaure, Manoj / O'Leary, Chandler / Sloan, Jordan / Marrufo, Armando / Holt, Ashley / Kulkarni, Aneesha / Hernandez, Oscar / Young, Ry

    G3 (Bethesda, Md.)

    2017  Volume 7, Issue 2, Page(s) 741–753

    Abstract: Coliphage lambda proteins Rz and Rz1 are the inner membrane and outer membrane subunits of the spanin complex-a heterotetramer that bridges the periplasm and is essential for the disruption of the outer membrane during phage lysis. Recent evidence ... ...

    Abstract Coliphage lambda proteins Rz and Rz1 are the inner membrane and outer membrane subunits of the spanin complex-a heterotetramer that bridges the periplasm and is essential for the disruption of the outer membrane during phage lysis. Recent evidence suggests the spanin complex functions by fusing the inner and outer membrane. Here, we use a genetics approach to investigate and characterize determinants of spanin function. Because
    MeSH term(s) Amino Acid Sequence/genetics ; Bacteriophage lambda/genetics ; Escherichia coli/genetics ; Escherichia coli/virology ; Escherichia coli Proteins/genetics ; Membrane Fusion/genetics ; Membrane Proteins/genetics ; Mutation ; Viral Proteins/genetics
    Chemical Substances Escherichia coli Proteins ; Membrane Proteins ; Viral Proteins ; inner membrane protein, E coli ; Rz protein, bacteriophage lambda (150201-54-0)
    Language English
    Publishing date 2017-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1534/g3.116.037192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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