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Article ; Online: Research update for ferroptosis and cholangiocarcinoma.

Fu, Shengfeng / Zhang, Qinyang / Zhang, Changhe

2024 Volume 198, Page(s) 104356

Abstract: Cholangiocarcinoma (CCA) is the second most common hepatobiliary malignancy after hepatocellular carcinoma. Due to the poor treatment effect and high mortality rate of CCA, it is of great significance to explore new therapeutic targets. Ferroptosis is a ... ...

Abstract	Cholangiocarcinoma (CCA) is the second most common hepatobiliary malignancy after hepatocellular carcinoma. Due to the poor treatment effect and high mortality rate of CCA, it is of great significance to explore new therapeutic targets. Ferroptosis is a type of cell death caused by iron-dependent cell oxidative injury, which is closely related to the occurrence and development of numerous diseases. Novel ideas for the prevention and treatment of related diseases have been provided by ferroptosis, which has become a focus of research in recent years. This review introduces the underlying mechanisms related to ferroptosis, as well as a research update for ferroptosis in the occurrence and development of CCA. The clinical value of ferroptosis-related regulatory mechanisms in CCA will be elucidated.
Language	English
Publishing date	2024-04-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2024.104356
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Article ; Online: Spatiotemporal Changes in Frost-Free Season and Its Influence on Spring Wheat Potential Yield on the Qinghai–Tibet Plateau from 1978 to 2017

Zemin Zhang / Changhe Lu

International Journal of Environmental Research and Public Health, Vol 20, Iss 4198, p

2023 Volume 4198

Abstract: Accurately assessing the variation in the frost-free season (FFS) can provide decision support for improving agricultural adaptability and reducing frost harm; however, related studies were inadequate in terms of the Qinghai–Tibet Plateau (QTP). This ... ...

Abstract	Accurately assessing the variation in the frost-free season (FFS) can provide decision support for improving agricultural adaptability and reducing frost harm; however, related studies were inadequate in terms of the Qinghai–Tibet Plateau (QTP). This study analyzed the spatiotemporal changes in the first frost day in autumn (FFA), last frost day in spring (LFS), FFS length and effective accumulated temperature (EAT) during the 1978–2017 period, and their influences on spring wheat potential yield on the QTP, based on daily climatic data and the methodology of Sen’s slope and correlation analysis. The results showed that the annual average FFA and LFS occurred later and earlier from northwest to southeast, respectively, and both the FFS length and EAT increased. From 1978 to 2017, the average regional FFA and LFS were delayed and advanced at rates of 2.2 and 3.4 days per decade, and the FFS and EAT increased by 5.6 days and 102.7 °C·d per decade, respectively. Spatially, the increase rate of FFS length ranged from 2.8 to 11.2 days per decade throughout the QTP, and it was observed to be larger in northern Qinghai, central Tibet and Yunnan, and smaller mainly in eastern Sichuan and southern Tibet. Correspondingly, the increase rate for EAT ranged from 16.2 to 173.3 °C·d per decade and generally showed a downward trend from north to south. For a one-day increase in the FFS period, the spring wheat potential yield would decrease by 17.4 and 9.0 kg/ha in altitude ranges of <2000 m and 2000–3000 m, but decrease by 24.9 and 66.5 kg/ha in the ranges of 3000–4000 m and >4000 m, respectively. Future studies should be focused on exploring the influence of multiple climatic factors on crop production using experimental field data and model technologies to provide policy suggestions.
Keywords	frost-free season ; change trend ; spring wheat ; Qinghai–Tibet Plateau ; Medicine ; R
Subject code	550
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatiotemporal Changes in Frost-Free Season and Its Influence on Spring Wheat Potential Yield on the Qinghai-Tibet Plateau from 1978 to 2017.

Zhang, Zemin / Lu, Changhe

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract	Accurately assessing the variation in the frost-free season (FFS) can provide decision support for improving agricultural adaptability and reducing frost harm; however, related studies were inadequate in terms of the Qinghai-Tibet Plateau (QTP). This study analyzed the spatiotemporal changes in the first frost day in autumn (FFA), last frost day in spring (LFS), FFS length and effective accumulated temperature (EAT) during the 1978-2017 period, and their influences on spring wheat potential yield on the QTP, based on daily climatic data and the methodology of Sen's slope and correlation analysis. The results showed that the annual average FFA and LFS occurred later and earlier from northwest to southeast, respectively, and both the FFS length and EAT increased. From 1978 to 2017, the average regional FFA and LFS were delayed and advanced at rates of 2.2 and 3.4 days per decade, and the FFS and EAT increased by 5.6 days and 102.7 °C·d per decade, respectively. Spatially, the increase rate of FFS length ranged from 2.8 to 11.2 days per decade throughout the QTP, and it was observed to be larger in northern Qinghai, central Tibet and Yunnan, and smaller mainly in eastern Sichuan and southern Tibet. Correspondingly, the increase rate for EAT ranged from 16.2 to 173.3 °C·d per decade and generally showed a downward trend from north to south. For a one-day increase in the FFS period, the spring wheat potential yield would decrease by 17.4 and 9.0 kg/ha in altitude ranges of <2000 m and 2000-3000 m, but decrease by 24.9 and 66.5 kg/ha in the ranges of 3000-4000 m and >4000 m, respectively. Future studies should be focused on exploring the influence of multiple climatic factors on crop production using experimental field data and model technologies to provide policy suggestions.
MeSH term(s)	Tibet ; Seasons ; Triticum ; China ; Temperature
Language	English
Publishing date	2023-02-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054198
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Article ; Online: Reply to: "Critique on conclusions regarding toxic compounds in Jatropha curcas kernel cake".

Zhang, Changhe / Wang, Xing-Hong

Communications biology

2021 Volume 4, Issue 1, Page(s) 1349

MeSH term(s)	Jatropha
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Letter ; Comment
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-021-02871-y
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Article ; Online: Reply to

Changhe Zhang / Xing-Hong Wang

Communications Biology, Vol 4, Iss 1, Pp 1-

“Critique on conclusions regarding toxic compounds in Jatropha curcas kernel cake”

2021 Volume 3

Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessing influences of climate change on highland barley productivity in the Qinghai-Tibet Plateau during 1978–2017

Zemin Zhang / Changhe Lu

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 13

Abstract: Abstract Grain production is becoming increasingly vulnerable to climate change globally. Highland barley (HB) is the most important cereal crop in the Qinghai-Tibet Plateau (QTP), so assessing HB productivity and its response to climate change could ... ...

Abstract	Abstract Grain production is becoming increasingly vulnerable to climate change globally. Highland barley (HB) is the most important cereal crop in the Qinghai-Tibet Plateau (QTP), so assessing HB productivity and its response to climate change could help to understand the capacity of grain production and food security. This study simulated the potential yield of HB annually at 72 meteorological stations for 1978–2017 using the WOFOST model, and then analyzed the spatiotemporal changes of HB potential yield and climatic factors in the growing season. Further, the influence of climate change on HB potential yield was explored in different temperature zones (TZ). Results indicate that the annual average of HB potential yield ranged from 3.5 to 8.1 t/ha in the QTP, and it was averaged at 6.5 t/ha in TZ-3, higher than other zones. From 1978 to 2017, HB potential yield for the whole QTP decreased slightly by 2.1 kg/ha per year, and its change rates were 23.9, 10.1, − 15.9, − 23.8 and − 16.7 kg/ha/year from TZ-1 to TZ-5 (p < 0.05), respectively. In all zones, average (Tave), maximum (Tmax) and minimum temperature (Tmin) showed a significantly warming trend (p < 0.01), and Tmin increased by 0.53, 0.45, 0.44, 0.40 and 0.69 °C per decade, higher than that of Tave and Tmax. However, temperature diurnal range (TDR) and radiation (RA) showed a downward trend, and their decrease rates were far higher in TZ-5 and TZ-3. In TZ-1, ΔTDR was the critical factor to the change in HB potential yield, which would increase by 420.30 kg/ha for 1 °C increase of ΔTDR (p < 0.01). From TZ-2 to TZ-5, ΔRA was the critical factor, but the influence amplitude in terms of the elastic coefficient, decreased from 4.08 to 0.99 (p < 0.01). In addition, other factors such as ΔTmax in TZ-3 and ΔTmin in TZ-4 and TZ-5 also had an important influence on the potential yield. To improve the HB productivity in the QTP, suitable varieties should be developed and introduced to adapt the climate warming in different temperature zones. In addition, ...
Keywords	Medicine ; R ; Science ; Q
Subject code	550
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Robust Tunability and Newly Emerged

Huo, Changhe / Zhang, Xinyuan / Li, Cong / Xu, Hongtao / Yu, Pu / Cheng, Long / Zheng, Changlin / Gu, Zongquan

ACS applied materials & interfaces

2024

Abstract: The complex resonance of dielectric quality ... ...

Abstract	The complex resonance of dielectric quality factor
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c19131
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Article ; Online: Exploring the association between dietary Inflammatory Index and chronic pain in US adults using NHANES 1999-2004.

Qing, Lunxue / Zhu, Yingying / Yu, Changhe / Zhang, Yang / Ni, Jinxia

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8726

Abstract: Chronic pain, a substantial public health issue, may be influenced by dietary patterns through systemic inflammation. This cross-sectional study explored the association between Dietary Inflammatory Index (DII) and chronic pain among 2581 American adults ...

Abstract	Chronic pain, a substantial public health issue, may be influenced by dietary patterns through systemic inflammation. This cross-sectional study explored the association between Dietary Inflammatory Index (DII) and chronic pain among 2581 American adults from NHANES data. The DII, ranging from - 4.98 to 4.69, reflects the inflammatory potential of the diet, with higher scores indicating greater pro-inflammatory capacity. Our findings showed no significant association between the continuous DII score and chronic pain prevalence. However, a nonlinear relationship emerged. When the DII was categorized, a significant association between higher DII scores (DII ≥ 2.5) and chronic pain prevalence was observed. The analysis uncovered a U-shaped pattern, with an inflection point at a DII score of - 0.9, indicating an association between both low and high levels of dietary inflammation are associated with higher pain prevalence. This nuanced interaction between dietary inflammation and chronic pain indicates the possibility of incorporating dietary modification into pain management strategies and underscores the need for further research into the long-term effects of diet on chronic pain.
MeSH term(s)	Adult ; Humans ; United States/epidemiology ; Nutrition Surveys ; Chronic Pain/epidemiology ; Cross-Sectional Studies ; Diet/adverse effects ; Inflammation/epidemiology
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58030-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Assessing influences of climate change on highland barley productivity in the Qinghai-Tibet Plateau during 1978-2017.

Zhang, Zemin / Lu, Changhe

Scientific reports

2022 Volume 12, Issue 1, Page(s) 7625

Abstract: Grain production is becoming increasingly vulnerable to climate change globally. Highland barley (HB) is the most important cereal crop in the Qinghai-Tibet Plateau (QTP), so assessing HB productivity and its response to climate change could help to ... ...

Abstract	Grain production is becoming increasingly vulnerable to climate change globally. Highland barley (HB) is the most important cereal crop in the Qinghai-Tibet Plateau (QTP), so assessing HB productivity and its response to climate change could help to understand the capacity of grain production and food security. This study simulated the potential yield of HB annually at 72 meteorological stations for 1978-2017 using the WOFOST model, and then analyzed the spatiotemporal changes of HB potential yield and climatic factors in the growing season. Further, the influence of climate change on HB potential yield was explored in different temperature zones (TZ). Results indicate that the annual average of HB potential yield ranged from 3.5 to 8.1 t/ha in the QTP, and it was averaged at 6.5 t/ha in TZ-3, higher than other zones. From 1978 to 2017, HB potential yield for the whole QTP decreased slightly by 2.1 kg/ha per year, and its change rates were 23.9, 10.1, - 15.9, - 23.8 and - 16.7 kg/ha/year from TZ-1 to TZ-5 (p < 0.05), respectively. In all zones, average (Tave), maximum (Tmax) and minimum temperature (Tmin) showed a significantly warming trend (p < 0.01), and Tmin increased by 0.53, 0.45, 0.44, 0.40 and 0.69 °C per decade, higher than that of Tave and Tmax. However, temperature diurnal range (TDR) and radiation (RA) showed a downward trend, and their decrease rates were far higher in TZ-5 and TZ-3. In TZ-1, ΔTDR was the critical factor to the change in HB potential yield, which would increase by 420.30 kg/ha for 1 °C increase of ΔTDR (p < 0.01). From TZ-2 to TZ-5, ΔRA was the critical factor, but the influence amplitude in terms of the elastic coefficient, decreased from 4.08 to 0.99 (p < 0.01). In addition, other factors such as ΔTmax in TZ-3 and ΔTmin in TZ-4 and TZ-5 also had an important influence on the potential yield. To improve the HB productivity in the QTP, suitable varieties should be developed and introduced to adapt the climate warming in different temperature zones. In addition, efforts are needed to adjust the strategies of fertilizers and irrigation applications.
MeSH term(s)	Climate Change ; Edible Grain ; Hordeum ; Seasons ; Tibet
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-11711-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognostic model for oversurvival and tumor-specific survival prediction in patients with advanced extrahepatic cholangiocarcinoma: a population-based analysis.

Zhang, Yu / Qiao, Chunzhong / Zhao, Peng / Zhang, Changhe

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 422

Abstract: Background: The prognosis of patients with extrahepatic cholangiocarcinoma (ECCA) must be determined with precision. However, the usual TNM staging system has the drawback of ignoring age, adjuvant therapy, and gender and lacks the ability to more ... ...

Abstract	Background: The prognosis of patients with extrahepatic cholangiocarcinoma (ECCA) must be determined with precision. However, the usual TNM staging system has the drawback of ignoring age, adjuvant therapy, and gender and lacks the ability to more correctly predict patient prognosis. Therefore, we determine the risk factors of survival for patients with advanced ECCA patients and developed brand-new nomograms to forecast patients with advanced ECCA's overall survival (OS) and cancer-specific survival (CSS). Method: From the Epidemiology and End Results (SEER) database, patients with advanced ECCA were chosen and randomly assigned in a ratio of 6:4 to the training and validation subgroups. The cumulative incidence function (CIF) difference between groups was confirmed by applying Gray's and Fine test and competing risk analyses. Next, the cancer-specific survival (CSS) and overall survival (OS) nomograms for advanced ECCA were developed and validated. Results: In accordance with the selection criteria, 403 patients with advanced ECCA were acquired from the SEER database and then split at random into two groups: a training group (n = 241) and a validation group (n = 162). The 1-, 2-, and 3-year cancer-specific mortality rates were 58.7, 74.2, and 78.0%, respectively, while the matching mortality rates for the competition were 10.0, 13.8, and 15.0%. Nomograms were generated for estimating OS and CSS, and they were assessed using the ROC curve and the C-index. The calibration curves showed that there was a fair amount of agreement between the expected and actual probabilities of OS and CSS. Additionally, greater areas under the ROC curve were seen in the newly developed nomograms for OS and CSS when compared to the 7th AJCC staging system. The advanced ECCA patients were divided into groupings with an elevated risk and those with a low risk and the Kaplan-Meier method was used for the survival analysis, which showed that survival time was shorter in the high-risk group than in the low-risk group. Conclusion: The proposed nomograms have good predictive ability. The nomograms may can help doctors determine the prognosis of patients with advanced ECCA as well as provide more precise treatment plans for them.
MeSH term(s)	Humans ; Prognosis ; Cholangiocarcinoma ; Nomograms ; Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Neoplasm Staging
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-03017-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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